EKS-ORL-00173
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00173
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR516.81.2E-155391667277
StatusUnreviewed
Ensembl ProteinENSORLP00000000391
UniProt AccessionH2L3R3;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1 (2 of 2)
Gene Synonyms/Alias FGFR1 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000000321ENSORLP00000000391ENSORLT00000000391
OrganismOryzias latipes
Functional Description
Protein Length691
Protein Sequence
(FASTA)
LWRWRLLLPL ALLLHAGWVQ SRPTVEDPDP DAVKSSEDEE DDESSSEENK LSNELSASSE 60
NLQPMAPQWV MPEKMEKQLH AVPASMTVRF RCPATGNPVP TLHWLKNGEE FSRDQRIGGF 120
KIKDHTWSLI MESVVPSDEG NYTCVVENEH GSLRHTYQLD IVERSPHRPI LQAGLPANQT 180
AVVGGDAQFV CRVFSDPQPH IQWLKHIVVN GSREGPEGHS FVQVLKTAGL NSTDKEMEVL 240
TLRNVTLEDA GVYTCLAQNS IGMSYHSAWL TVLSVFLPPE PPPSAVPSQT FLDIFFYCLG 300
FSVIIVLAIA AVICRLYCTP KKSDFSSQLA VQKLEKSITL RKQVSVESSS SPQSGSMRPS 360
RLSSTATSVL AGVSEYELPY DPAWELPRDR LTLGKPLGEG CFGQVVLAEA VGLDRSKPAR 420
LTKVAVKMLK ADASEKDLSD LISEMEMMKM IGKHKNIINL LGACTQEGPL YVVVEYASKG 480
NLREYLRARR PVGGEYWSGA RQPLLGGVEI RELVSAAYQV ARGMSYLASK KCIHRDLAAR 540
NVLVTEDDVM KIADFGLARD IHHIDYYKKT TNGRLPVKWM APEALFDRIY THQSDVWSFG 600
VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH RMEKPSACTQ ELYLMMRDCW HAVPSRRPTF 660
QQLVEDLDRT LSLMSNQEYL DLSVPLIQYP P 691
Nucleotide Sequence
(FASTA)
CTCTGGCGCT GGAGGCTGCT CCTCCCCCTT GCGCTCCTCC TCCATGCTGG CTGGGTTCAG 60
TCCAGACCCA CGGTGGAGGA CCCCGACCCC GATGCAGTCA AATCCTCCGA GGATGAAGAA 120
GACGACGAGT CTTCCTCCGA GGAGAACAAG CTGTCCAATG AGCTGTCGGC GAGCAGCGAG 180
AACCTGCAGC CGATGGCGCC GCAGTGGGTG ATGCCAGAGA AGATGGAGAA GCAGCTCCAC 240
GCCGTTCCCG CCAGCATGAC AGTCCGGTTT CGTTGCCCGG CAACGGGGAA CCCAGTTCCC 300
ACGCTGCACT GGCTGAAGAA CGGGGAGGAG TTCAGCCGAG ATCAGCGCAT CGGAGGTTTC 360
AAGATCAAAG ACCACACCTG GAGTCTGATC ATGGAGTCGG TGGTTCCGTC TGATGAAGGT 420
AACTACACCT GCGTGGTGGA GAACGAACAC GGCAGCCTGA GACACACCTA CCAGCTGGAC 480
ATCGTGGAGC GTTCTCCCCA CCGGCCCATC CTGCAGGCCG GCCTGCCGGC CAATCAGACG 540
GCCGTGGTCG GCGGCGACGC CCAGTTCGTC TGCAGAGTGT TCAGCGACCC ACAGCCTCAC 600
ATCCAGTGGC TCAAACACAT CGTGGTCAAC GGCAGCAGGG AGGGGCCGGA GGGACACTCC 660
TTTGTCCAGG TTCTGAAGAC TGCAGGTCTG AACTCCACCG ATAAGGAGAT GGAGGTTTTG 720
ACCCTGAGGA ACGTCACTCT GGAAGATGCC GGCGTCTACA CCTGCCTGGC GCAGAACTCC 780
ATCGGGATGT CCTACCACTC TGCGTGGCTC ACCGTGCTCA GCGTCTTTTT GCCTCCAGAG 840
CCGCCGCCGT CCGCGGTGCC CTCGCAGACC TTCCTGGACA TTTTCTTCTA CTGCCTGGGG 900
TTTTCCGTCA TCATCGTCCT CGCCATCGCC GCCGTCATCT GCCGGCTCTA CTGCACTCCC 960
AAAAAGAGCG ACTTCAGCAG CCAGCTGGCG GTCCAGAAGT TAGAGAAGAG CATCACTCTG 1020
CGGAAACAGG TGTCAGTGGA GTCCTCGTCC TCCCCGCAGT CAGGGTCGAT GCGTCCGTCC 1080
CGTCTGTCCA GCACCGCCAC AAGCGTCCTG GCGGGGGTGT CCGAGTACGA GCTGCCCTAC 1140
GACCCGGCGT GGGAGCTGCC ACGAGATCGG TTGACGTTGG GGAAGCCTCT GGGGGAGGGC 1200
TGCTTCGGCC AGGTGGTGCT GGCCGAGGCT GTGGGGCTGG ACAGGAGCAA GCCCGCGCGC 1260
CTCACCAAGG TGGCGGTGAA GATGCTGAAA GCCGACGCCT CAGAGAAAGA CCTGTCCGAC 1320
CTGATCTCTG AGATGGAGAT GATGAAGATG ATCGGGAAGC ACAAGAACAT CATCAACCTG 1380
CTGGGCGCCT GCACTCAGGA GGGCCCTCTG TACGTGGTGG TGGAGTACGC CTCCAAGGGG 1440
AATCTGAGGG AGTACCTGCG AGCGCGCCGG CCGGTCGGGG GGGAGTACTG GAGCGGCGCG 1500
CGGCAGCCGC TGCTGGGGGG GGTGGAGATC AGGGAGCTGG TGTCTGCAGC CTACCAGGTG 1560
GCGAGAGGGA TGTCGTACCT GGCCTCAAAG AAGTGCATTC ACAGAGACCT GGCAGCCAGG 1620
AACGTGCTGG TCACTGAAGA CGACGTGATG AAGATCGCCG ACTTTGGCCT GGCCAGAGAC 1680
ATTCACCACA TCGATTACTA CAAGAAGACC ACCAATGGCC GCCTGCCGGT CAAGTGGATG 1740
GCGCCTGAAG CTCTGTTTGA CCGCATCTAC ACCCACCAGA GCGACGTGTG GTCGTTCGGC 1800
GTCCTGCTCT GGGAGATCTT CACCCTGGGC GGATCTCCGT ATCCCGGCGT TCCGGTGGAG 1860
GAGCTGTTCA AGCTGCTGAA GGAGGGTCAC CGCATGGAGA AGCCCTCAGC GTGCACGCAG 1920
GAGCTGTATC TGATGATGAG GGATTGCTGG CACGCCGTTC CGTCCCGAAG GCCGACGTTC 1980
CAGCAGCTGG TGGAAGATCT GGACCGGACG CTCTCGCTCA TGTCCAACCA GGAGTACCTG 2040
GACCTGTCCG TCCCGCTGAT CCAATACCCT CCA 2073
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l+lgk+lGeG+fGqvv aea+gld++k+++ ++vavkmlk da++kdl+dl+seme++k+
Q: 391   LTLGKPLGEGCFGQVVLAEAVGLDRSKPARLTKVAVKMLKADASEKDLSDLISEMEMMKM  450
         79**********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactqeGplyv+veya+kGnlre+lrarrp g e+ + +++     +  
Q: 451   IGKHKNIINLLGACTQEGPLYVVVEYASKGNLREYLRARRPVGGEYWSGARQPLLGGVEI  510
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         ++lvs ayqvarGm ylaskkcihrdlaarnvlvted+v+kiadfGlard+h+idyykkt
Q: 511   RELVSAAYQVARGMSYLASKKCIHRDLAARNVLVTEDDVMKIADFGLARDIHHIDYYKKT  570
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 571   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  630
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rmekp+ ct+ely +mr+cwha++s rptf+qlvedl
Q: 631   RMEKPSACTQELYLMMRDCWHAVPSRRPTFQQLVEDL  667
         ***********************************97
Domain Sequence
(FASTA)
LTLGKPLGEG CFGQVVLAEA VGLDRSKPAR LTKVAVKMLK ADASEKDLSD LISEMEMMKM 60
IGKHKNIINL LGACTQEGPL YVVVEYASKG NLREYLRARR PVGGEYWSGA RQPLLGGVEI 120
RELVSAAYQV ARGMSYLASK KCIHRDLAAR NVLVTEDDVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMEKPSACTQ ELYLMMRDCW HAVPSRRPTF QQLVEDL 277
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00176
EKS-ORN-00185
EKS-TAR-00194
EKS-TEN-00187
EKS-XIM-00179
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008284; P:positive regulation of cell proliferation
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013