EKS-ORL-00472
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00472
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR533.53.2E-160583915333
StatusUnreviewed
Ensembl ProteinENSORLP00000000707
UniProt AccessionH2L4L2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameKIT
Gene Synonyms/Alias KIT;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000000569ENSORLP00000000707ENSORLT00000000707
OrganismOryzias latipes
Functional Description
Protein Length987
Protein Sequence
(FASTA)
MEYHWILLFV FLQFTFPSGN TKPTIIPAKP QLVVELNQEF ELQCWSDNKT HWRREERTKP 60
LRASQINGKL TLAFQKADPA SMGRYICVDE GTKEQASIYV FVKDPKNPFR KPLVPKILTR 120
EGDPASIPCL ATDPNLSNLS LETCSRGPLA FGLQFTANLE QGILIHNTRK AYGGCYRCTG 180
TLQRQTVESN EYELTVRPVP DEPPVVEMHQ PTQVILTRNQ TLSLTCNTTN VNGDITLRWI 240
VPPGSQPAKV DGTARIQLEK FTHTRSSTLH IAAVRPEDTG SYKCEARNEK GISTKSVWLD 300
VYERGFISLT PSANRTINVR SGESLSLKVS MHAYPSLHTV SWSFKNYELK NTSDHVISTT 360
HSNGYSYSSE LRLVRLKMSE GGVYTFQASN GDASVNETFT IYVISKPEIV YHEGPVDGRV 420
RCKAEGFPAP QIKWYYCEKT HVRCSKQVNA TQEKKNVITI TLTSPKFGKQ GVESWVNISR 480
GRFKFLECLA TGKEESDQDF LLFSINADRS TSHELFTPVL ICTVSTAGIL CLVLIVLFYK 540
YMQKPKYQIQ WKVIDGIYGN SYVYIDPTQL PYDHQREFPR NNLRFGKTLG SGAFGKVVEA 600
TAYGLSETDS VMTVAVKMLK ASAHATEKEA LMSELKVLSY LGNHMNIVNL LGACTVGGPT 660
LVITEYCCFG DLLNFLRRKR ESFINFKLEE DSYYRNISQQ KVRDGDSLNG YMAMKPSSAG 720
NTPLSTTPES RLSQRKDGSL GDANEECEWF DGDELALDTE DLLSFSYQVA KGMEFLASKN 780
CIHRDLAARN ILLTQGKVAK ICDFGLARDI TTDSNYVVKG NARLPVKWMS PESIFECVYT 840
FESDVWSYGI LLWEIFSLGN SPYPGMPVDA KFYKQIKEGY RMGAPEFAPS EMYEVMSSCW 900
KAEPFNRPPF KKIVESIEQQ LSDSTKHIYL NFNSRLPVMF GARKEPSSQS PAFQSLNSVR 960
NHNNPTQPLL LQHEVFLERT ALEAQWV 987
Nucleotide Sequence
(FASTA)
ATGGAATACC ACTGGATACT GCTGTTTGTT TTTTTACAGT TTACCTTCCC CTCAGGCAAC 60
ACCAAGCCCA CCATCATCCC AGCAAAGCCC CAACTTGTGG TGGAGCTCAA CCAAGAATTT 120
GAGCTGCAGT GCTGGAGTGA TAACAAGACA CACTGGAGGC GGGAGGAACG AACAAAGCCA 180
TTAAGAGCAA GCCAGATCAA TGGAAAACTC ACGTTGGCTT TTCAAAAGGC TGATCCTGCA 240
TCAATGGGCC GCTACATCTG TGTGGACGAG GGCACCAAAG AGCAAGCTTC CATCTACGTC 300
TTTGTGAAGG ATCCTAAAAA TCCGTTCCGA AAACCATTGG TGCCCAAAAT TCTCACTCGT 360
GAGGGAGATC CAGCTTCTAT CCCCTGCCTG GCAACAGATC CAAATCTTAG CAATCTGAGC 420
TTGGAAACAT GTTCGAGAGG ACCCCTGGCC TTCGGCCTCC AGTTTACTGC GAACCTGGAG 480
CAAGGCATCC TCATCCACAA CACAAGAAAG GCTTATGGAG GCTGCTACAG GTGCACAGGG 540
ACACTCCAAA GACAGACCGT GGAATCGAAT GAGTACGAGC TGACAGTGAG ACCAGTGCCT 600
GATGAGCCTC CCGTGGTGGA GATGCATCAG CCAACGCAAG TGATTCTGAC GCGCAACCAG 660
ACTCTGTCTC TCACCTGCAA CACCACTAAT GTCAATGGAG ATATCACCTT GAGGTGGATC 720
GTCCCACCTG GCTCGCAACC AGCAAAGGTT GATGGCACTG CACGTATCCA GCTGGAGAAA 780
TTCACTCACA CGCGCAGCTC CACGTTGCAC ATTGCAGCAG TTCGGCCTGA AGATACTGGG 840
AGCTACAAAT GTGAAGCTAG GAACGAAAAA GGAATCAGCA CAAAGTCGGT GTGGCTCGAT 900
GTTTACGAAA GAGGATTCAT CAGCTTGACT CCCTCCGCGA ACAGAACCAT CAATGTCCGC 960
TCGGGCGAGA GCTTGTCTCT GAAAGTCAGC ATGCACGCAT ATCCAAGCCT GCACACCGTC 1020
TCCTGGAGCT TCAAGAACTA CGAACTGAAG AACACCAGTG ATCATGTCAT CAGCACGACG 1080
CACAGTAATG GATACAGTTA CAGCAGTGAG CTGCGGCTGG TCCGGCTCAA AATGTCAGAG 1140
GGTGGTGTTT ATACCTTTCA AGCCTCCAAT GGTGACGCAT CAGTAAATGA GACCTTTACC 1200
ATCTATGTGA TCAGTAAACC TGAGATTGTT TATCATGAAG GTCCGGTGGA TGGGCGGGTG 1260
CGTTGTAAAG CTGAAGGGTT CCCTGCTCCC CAGATCAAGT GGTATTACTG TGAGAAAACG 1320
CACGTCAGGT GCTCTAAGCA AGTGAATGCC ACCCAAGAAA AAAAGAATGT CATCACCATC 1380
ACATTAACCA GCCCCAAATT TGGGAAGCAA GGGGTGGAGA GCTGGGTGAA CATCAGCAGG 1440
GGGCGGTTCA AGTTCCTGGA GTGTTTGGCT ACAGGAAAGG AGGAATCGGA TCAAGACTTC 1500
TTACTCTTTT CTATCAATGC AGACAGAAGT ACTTCCCATG AACTCTTCAC GCCTGTGTTA 1560
ATTTGCACTG TGTCTACAGC AGGCATCCTC TGCCTGGTTC TTATTGTGCT GTTCTACAAG 1620
TACATGCAGA AACCAAAATA CCAGATTCAG TGGAAAGTCA TTGATGGCAT CTATGGAAAC 1680
AGCTATGTGT ACATTGACCC CACACAGCTG CCGTACGATC ACCAGAGGGA ATTTCCAAGG 1740
AACAACTTGC GTTTCGGGAA GACACTGGGA TCTGGTGCAT TTGGAAAAGT GGTGGAAGCC 1800
ACAGCATATG GACTCTCTGA AACAGATTCA GTCATGACTG TTGCTGTGAA AATGCTGAAA 1860
GCAAGTGCTC ACGCCACAGA GAAAGAGGCT CTGATGTCAG AGCTGAAGGT CCTCAGTTAC 1920
TTAGGAAACC ACATGAACAT CGTCAACCTG CTGGGGGCAT GCACTGTTGG AGGCCCCACA 1980
CTGGTGATCA CAGAGTACTG CTGCTTTGGA GACCTTCTTA ACTTTCTACG CAGAAAGAGA 2040
GAGTCTTTTA TCAACTTCAA GCTTGAAGAA GACTCCTACT ACCGCAACAT CAGCCAACAG 2100
AAAGTTAGAG ATGGCGACAG CTTGAATGGC TACATGGCCA TGAAGCCTTC TAGTGCTGGC 2160
AACACGCCGC TCAGCACAAC CCCGGAGAGC AGACTCTCTC AGCGCAAAGA TGGCTCTCTT 2220
GGTGACGCAA ATGAAGAATG CGAGTGGTTT GATGGGGACG AGTTGGCCCT CGACACTGAG 2280
GATCTTCTCA GTTTCTCCTA TCAAGTGGCC AAAGGCATGG AGTTTTTAGC TTCCAAAAAT 2340
TGTATTCACA GAGATCTTGC TGCCAGAAAC ATCCTGTTAA CTCAAGGAAA AGTGGCAAAA 2400
ATCTGTGATT TTGGTCTTGC TCGCGACATC ACCACAGACT CCAACTATGT GGTCAAAGGG 2460
AACGCCCGTC TTCCAGTGAA ATGGATGTCC CCAGAAAGTA TCTTTGAGTG TGTGTACACA 2520
TTCGAGAGTG ACGTGTGGTC CTATGGGATC CTGCTCTGGG AAATCTTCTC TCTTGGAAAC 2580
AGCCCGTACC CTGGTATGCC GGTGGATGCC AAGTTCTACA AACAGATAAA AGAAGGTTAC 2640
AGAATGGGGG CTCCAGAGTT TGCACCCAGT GAAATGTATG AGGTCATGAG CTCCTGCTGG 2700
AAGGCTGAGC CCTTCAACAG ACCCCCCTTC AAAAAGATCG TGGAGAGCAT TGAGCAACAG 2760
CTGTCAGACT CCACCAAGCA TATTTATCTG AACTTCAACT CAAGGCTCCC TGTGATGTTT 2820
GGAGCCAGGA AGGAGCCCAG TTCTCAGAGC CCAGCATTTC AAAGTCTAAA TTCAGTCAGA 2880
AATCACAACA ATCCAACACA GCCCTTACTG CTCCAGCATG AGGTTTTCTT GGAAAGAACA 2940
GCCCTGGAAG CTCAGTGGGT GTAG 2964
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lGsGafGkvveatayGls++d+v++vavkmlk +a+++ekealmselk+ls+lG
Q: 583   LRFGKTLGSGAFGKVVEATAYGLSETDSVMTVAVKMLKASAHATEKEALMSELKVLSYLG  642
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact+gGp++viteycc+Gdlln+lrrkresf++ +le      e+ ++++
Q: 643   NHMNIVNLLGACTVGGPTLVITEYCCFGDLLNFLRRKRESFINFKLE------EDSYYRN  696
         ******************************************65554......4788888
S: 121   lladkslrsksslssesseeyvdlkkd...vsdvssskadklasekkksalerevkaale  177
         +       +++    +s + y+ +k++    + +s++ +++l+++k  s+ + + + +  
Q: 697   I------SQQKVRDGDSLNGYMAMKPSsagNTPLSTTPESRLSQRKDGSLGDANEECEWF  750
         8......3333445688899******9444456778888888888889999999999***
S: 178   eedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardi  237
         + d+ +l+ edllsfsyqvakGmeflasknc+hrdlaarn+llt+Gkv+kicdfGlardi
Q: 751   DGDELALDTEDLLSFSYQVAKGMEFLASKNCIHRDLAARNILLTQGKVAKICDFGLARDI  810
         ************************************************************
S: 238   mkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvds  297
         ++dsnyvvkGnarlpvkwm+pesif+++yt++sdvwsyGillweifslG +pypg++vd+
Q: 811   TTDSNYVVKGNARLPVKWMSPESIFECVYTFESDVWSYGILLWEIFSLGNSPYPGMPVDA  870
         ************************************************************
S: 298   kfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlve  342
         kfyk+ikeGyrm  p++a++e+ye+m +cw+aep +rp+fk++ve
Q: 871   KFYKQIKEGYRMGAPEFAPSEMYEVMSSCWKAEPFNRPPFKKIVE  915
         ******************************************997
Domain Sequence
(FASTA)
LRFGKTLGSG AFGKVVEATA YGLSETDSVM TVAVKMLKAS AHATEKEALM SELKVLSYLG 60
NHMNIVNLLG ACTVGGPTLV ITEYCCFGDL LNFLRRKRES FINFKLEEDS YYRNISQQKV 120
RDGDSLNGYM AMKPSSAGNT PLSTTPESRL SQRKDGSLGD ANEECEWFDG DELALDTEDL 180
LSFSYQVAKG MEFLASKNCI HRDLAARNIL LTQGKVAKIC DFGLARDITT DSNYVVKGNA 240
RLPVKWMSPE SIFECVYTFE SDVWSYGILL WEIFSLGNSP YPGMPVDAKF YKQIKEGYRM 300
GAPEFAPSEM YEVMSSCWKA EPFNRPPFKK IVE 333
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00374
EKS-ANC-00389
EKS-BOT-00402
EKS-CAJ-00407
EKS-CAF-00402
EKS-CAP-00432
EKS-DAR-00787
EKS-EQC-00394
EKS-FEC-00386
EKS-GAG-00341
EKS-GAA-00515
EKS-GOG-00394
EKS-HOS-00409
EKS-ICT-00381
EKS-LAC-00419
EKS-LOA-00412
EKS-MAM-00402
EKS-MEG-00335
EKS-MOD-00391
EKS-MUM-00435
EKS-MUP-00399
EKS-MYL-00397
EKS-NOL-00368
EKS-ORN-00514
EKS-ORA-00347
EKS-ORC-00378
EKS-OTG-00405
EKS-PAT-00381
EKS-PES-00357
EKS-POA-00394
EKS-PTV-00114
EKS-RAN-00418
EKS-SAH-00372
EKS-SUS-00353
EKS-TAG-00473
EKS-TAR-00510
EKS-TEN-00511
EKS-XET-00515
EKS-XIM-00506
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013