EKS-ORL-00124
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00124
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec450.61.6E-135399649251
StatusUnreviewed
Ensembl ProteinENSORLP00000001032
UniProt AccessionH2L5G0;
Protein Name
Protein Synonyms/Alias
Gene NameBTK
Gene Synonyms/Alias BTK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000000842ENSORLP00000001032ENSORLT00000001033
OrganismOryzias latipes
Functional Description
Protein Length657
Protein Sequence
(FASTA)
MSENILEDLF IKRSQQKKKT SPLNYKERLF VLTAEKLAYY DYDADKGKRK GLRGSVDVEK 60
IKCVETVETE PNAPQERRSE TVSDEPGDFR TMQVLPMSQS PHPPEVVYDE GPLYIFAKSE 120
NSRTEWITKL KELVRYNKDL MQKYHPCFWA DGVWLCCQQE VKQAMGCKIL DKNEGYASRT 180
RSTRKPLPPT PSEEKPSPSR RLPPQPESAA PSSSMTVIAE YDYTPMTAQD LELRTNEEYT 240
ILEKSDPNWW RARDKYGKEG YIPSNYVAEA ESGLERFHWY CKNMNRSQAE QLLKSENKDG 300
GFLVRDSSKA GKYTVSLFAK SGAETGGSCR HYNICTTPQG QFYLSEKHNF DTIPELINYH 360
QHNAAGMVCR LKHIVSNRAR PPSTAGLGYG VWEIDPHYLT FIKELGTGQF GVVKYGKWQG 420
QHDVAIKMIK EGSMSEDDFI EEAKIMMKLR HENLVQLYGV CTKQRPIYIV TEFLANGCLL 480
TYLKEGLIQH PTADQLLEMC KDVSEGMAYL ESQQYIHRDL AARNCLVDAN GTVKVTDFGL 540
SRYVLDDEYT SSVGSKFPVR WSPPEVLLYS KFSSKSDIWA YGVLMWEVYT LGRLPYERLN 600
NSEIVDQVSH GFRLYRPQLA NERVYKIMTS CWHDKPDERP TFQDLVLIVQ DLLYELQ 657
Nucleotide Sequence
(FASTA)
ATGTCAGAAA ACATCCTGGA AGATCTCTTC ATCAAAAGAT CTCAGCAGAA GAAGAAGACA 60
TCTCCTCTGA ACTACAAGGA GAGATTATTC GTTCTGACGG CAGAAAAATT AGCCTACTAC 120
GACTATGATG CAGACAAAGG GAAGCGAAAA GGTCTGAGGG GTTCCGTTGA TGTTGAGAAG 180
ATAAAGTGTG TGGAGACGGT CGAGACAGAG CCCAACGCTC CACAGGAGCG AAGAAGTGAA 240
ACTGTCTCAG ATGAACCAGG GGATTTCAGA ACAATGCAGG TGTTGCCAAT GAGTCAATCT 300
CCACATCCTC CTGAAGTGGT CTACGATGAA GGGCCTCTAT ACATCTTTGC AAAGTCTGAG 360
AACAGTCGTA CCGAGTGGAT TACAAAGCTA AAAGAACTGG TGCGCTACAA CAAAGACCTG 420
ATGCAAAAGT ATCACCCCTG TTTCTGGGCT GATGGCGTGT GGCTGTGCTG CCAACAGGAA 480
GTTAAACAAG CTATGGGTTG CAAAATATTG GATAAGAATG AAGGTTATGC ATCTAGAACG 540
AGGTCGACTA GAAAGCCTCT TCCACCGACC CCATCAGAGG AAAAGCCCAG TCCCAGTCGC 600
CGTCTTCCAC CGCAGCCTGA GTCAGCTGCT CCTTCTTCAA GCATGACTGT CATAGCTGAG 660
TATGATTACA CGCCCATGAC AGCCCAAGAC CTGGAGCTGA GGACGAATGA GGAGTACACC 720
ATTCTGGAGA AGTCAGACCC CAACTGGTGG AGAGCCAGAG ACAAATACGG GAAAGAAGGC 780
TACATACCAA GTAATTATGT TGCAGAAGCA GAGTCCGGCC TTGAAAGATT TCATTGGTAC 840
TGCAAGAACA TGAACCGCAG TCAAGCAGAA CAGCTGTTAA AGTCTGAGAA CAAAGACGGC 900
GGTTTCTTGG TGCGGGACTC AAGCAAAGCT GGGAAATACA CCGTATCTTT ATTTGCCAAG 960
AGTGGCGCGG AAACAGGTGG AAGCTGCAGA CATTACAACA TCTGCACAAC CCCACAGGGC 1020
CAGTTTTATC TGTCAGAGAA GCACAACTTT GACACCATCC CAGAGCTCAT CAACTATCAT 1080
CAGCACAATG CCGCCGGTAT GGTTTGCAGG CTGAAGCATA TTGTGTCTAA TCGGGCGCGA 1140
CCTCCGTCAA CGGCAGGACT CGGCTATGGC GTGTGGGAGA TTGACCCCCA CTACCTCACC 1200
TTCATCAAAG AGCTCGGCAC GGGCCAGTTT GGAGTGGTGA AGTATGGGAA ATGGCAGGGC 1260
CAGCACGACG TAGCCATCAA GATGATTAAA GAGGGCTCCA TGTCAGAAGA TGATTTCATT 1320
GAGGAAGCCA AAATCATGAT GAAGCTTCGC CATGAGAACC TGGTGCAGCT GTACGGTGTC 1380
TGCACCAAGC AGAGACCTAT TTATATCGTG ACTGAGTTTC TTGCAAATGG GTGTCTGCTG 1440
ACATATCTCA AGGAAGGCCT GATCCAGCAC CCAACTGCCG ACCAGCTCTT GGAGATGTGT 1500
AAGGATGTAT CTGAGGGCAT GGCCTACCTC GAGTCACAGC AGTATATCCA CAGAGACCTG 1560
GCTGCCAGGA ACTGCTTAGT AGATGCAAAT GGCACAGTCA AAGTGACTGA CTTTGGTCTA 1620
TCAAGATACG TTTTAGATGA TGAGTACACA AGTTCTGTTG GCTCAAAGTT CCCAGTTCGA 1680
TGGTCTCCCC CTGAAGTCCT CCTCTACAGC AAATTCAGCA GCAAGTCAGA CATCTGGGCT 1740
TACGGGGTGC TGATGTGGGA GGTGTACACT TTGGGTAGAC TTCCATATGA ACGCCTCAAC 1800
AACTCAGAAA TTGTGGACCA GGTTTCACAT GGCTTCCGTC TCTACCGCCC TCAGCTGGCC 1860
AACGAAAGAG TCTACAAAAT TATGACAAGC TGCTGGCATG ATAAACCAGA CGAAAGGCCC 1920
ACCTTTCAAG ACCTGGTGCT GATTGTCCAG GATCTTCTGT ATGAGCTCCA GTAG 1974
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt++kelg+gqfgvvk+gkw++++dvaik+ikeg+mse+dfieeak+mmkl h++lvqly
Q: 399   LTFIKELGTGQFGVVKYGKWQGQHDVAIKMIKEGSMSEDDFIEEAKIMMKLRHENLVQLY  458
         79**********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekk.kklekelllemckdvcegmeylerksfihr  119
         gvc+kq+piyivte+l+ngcll yl+e   ++ ++++llemckdv+egm+yle++++ihr
Q: 459   GVCTKQRPIYIVTEFLANGCLLTYLKEGLiQHPTADQLLEMCKDVSEGMAYLESQQYIHR  518
         **************************97615567899***********************
S: 120   dlaarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdv  179
         dlaarnclvd + +vkv+dfgl+ryvldd+y+ssvg+kfpv+wsppevl ysk+ssksd+
Q: 519   DLAARNCLVDANGTVKVTDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLLYSKFSSKSDI  578
         ************************************************************
S: 180   wafgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpee  239
         wa+gvlmwev+++g+lpye+ +nse+v++vs+g+rlyrp+la+++vy++m+scw++kp+e
Q: 579   WAYGVLMWEVYTLGRLPYERLNNSEIVDQVSHGFRLYRPQLANERVYKIMTSCWHDKPDE  638
         ************************************************************
S: 240   rptfkellsal  250
         rptf++l+  +
Q: 639   RPTFQDLVLIV  649
         ******98655
Domain Sequence
(FASTA)
LTFIKELGTG QFGVVKYGKW QGQHDVAIKM IKEGSMSEDD FIEEAKIMMK LRHENLVQLY 60
GVCTKQRPIY IVTEFLANGC LLTYLKEGLI QHPTADQLLE MCKDVSEGMA YLESQQYIHR 120
DLAARNCLVD ANGTVKVTDF GLSRYVLDDE YTSSVGSKFP VRWSPPEVLL YSKFSSKSDI 180
WAYGVLMWEV YTLGRLPYER LNNSEIVDQV SHGFRLYRPQ LANERVYKIM TSCWHDKPDE 240
RPTFQDLVLI V 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00098
EKS-ANC-00100
EKS-BOT-00108
EKS-CAJ-00109
EKS-CAF-00109
EKS-CAP-00103
EKS-CIS-00119
EKS-DAR-00355
EKS-DAN-00037
EKS-DRM-00050
EKS-EQC-00104
EKS-FEC-00102
EKS-GAM-00052
EKS-GAG-00088
EKS-GAA-00127
EKS-GOG-00110
EKS-HOS-00110
EKS-ICT-00102
EKS-LAC-00112
EKS-LOA-00102
EKS-MAM-00103
EKS-MEG-00083
EKS-MOD-00109
EKS-MUM-00109
EKS-MUP-00110
EKS-MYL-00121
EKS-NOL-00100
EKS-ORN-00132
EKS-ORA-00087
EKS-ORC-00099
EKS-OTG-00109
EKS-PAT-00098
EKS-PES-00092
EKS-PEM-00054
EKS-POA-00100
EKS-PTV-00097
EKS-RAN-00109
EKS-SAH-00100
EKS-SOA-00057
EKS-SUS-00094
EKS-TAG-00136
EKS-TAR-00136
EKS-TEN-00126
EKS-XET-00090
EKS-XIM-00130
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013