EKS-ORL-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	382.6	1.2E-114	115	380	266

Status

Unreviewed

Ensembl Protein

ENSORLP00000001285

UniProt Accession

H2L641;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K4 (2 of 2)

Gene Synonyms/Alias

MAP2K4 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000001042	ENSORLP00000001285	ENSORLT00000001286

Organism

Oryzias latipes

Functional Description

Protein Length

412

Protein Sequence
(FASTA)

MATPRPNNQT TPIGNNAGSA PHLHLKCVFI QTMSHLNFSE SNTCWRCQSE TGKRKALKLN 60

FANPSIKPMT RFSLNTAGPQ FQNPHIERLR THSIESSGKL KISAEQHWDF TAEDLKDLGE 120

IGRGAYGSVN KMVHKPSNQI MAVKRIRSTV DEKEQKQLLM DLDVVVRSSD CPYIVQFYGA 180

LFREGDCWIC MELMATSLDK FYKFVYCSLD DVIPEEILGK ITLATVKALN HLKENLKIIH 240

RDIKPSNILL DRKGNIKLCD FGISGQLVDS IAKTRDAGCR PYMAPERIDP SASRQGYDVR 300

SDVWSLGITL YELATGRFPY PKWNSVFDQL TQVVRGDPPQ LSNSDERRFS PKFISFVNVC 360

LTKEESKRPK YRELLRDPFI QMYEERSVDV AGYVCRIMDQ MPASPSSPMY MD 412

Nucleotide Sequence
(FASTA)

ATGGCGACTC CCCGTCCTAA CAACCAAACA ACACCCATCG GCAACAACGC GGGGTCCGCC 60

CCGCACCTGC ACCTAAAGTG TGTTTTTATT CAAACGATGT CCCATCTGAA CTTTTCAGAG 120

TCCAACACTT GCTGGAGGTG TCAAAGTGAA ACAGGTAAAC GCAAAGCCCT GAAGCTGAAC 180

TTTGCCAACC CTTCCATTAA ACCCATGACC CGGTTCTCCC TGAACACCGC CGGGCCTCAG 240

TTCCAGAACC CTCACATAGA GCGGCTGAGG ACTCACAGCA TCGAGTCGTC CGGGAAGCTG 300

AAGATCTCCG CGGAGCAGCA CTGGGACTTC ACAGCCGAGG ATCTCAAAGA CCTGGGGGAG 360

ATCGGCCGAG GGGCTTACGG CTCCGTCAAC AAGATGGTGC ACAAGCCGAG TAACCAGATC 420

ATGGCGGTCA AGAGGATTCG GTCGACGGTG GATGAGAAGG AGCAGAAGCA GCTGCTCATG 480

GACCTGGACG TGGTCGTGAG GAGCAGCGAC TGTCCCTACA TCGTGCAGTT TTACGGCGCT 540

CTGTTCCGAG AGGGCGACTG TTGGATTTGC ATGGAACTCA TGGCTACCTC GTTAGACAAA 600

TTTTACAAGT TTGTGTATTG CTCGTTAGAC GACGTGATTC CAGAGGAAAT ATTAGGGAAA 660

ATAACGTTAG CTACTGTGAA AGCACTAAAT CACTTAAAAG AAAACTTGAA AATCATACAC 720

AGAGACATAA AGCCTTCAAA CATCCTGCTG GACCGGAAGG GCAACATCAA GCTGTGCGAC 780

TTTGGCATCA GCGGCCAGCT GGTCGACTCC ATCGCCAAAA CCAGAGACGC CGGCTGCAGG 840

CCGTACATGG CGCCGGAGCG AATAGATCCC AGTGCGTCCA GGCAGGGCTA CGACGTGCGG 900

TCTGATGTCT GGAGTTTGGG AATCACACTG TACGAGCTGG CCACGGGCCG GTTCCCCTAC 960

CCCAAGTGGA ACAGCGTGTT CGACCAGCTG ACCCAGGTGG TCCGAGGAGA TCCTCCACAG 1020

CTCAGCAACT CTGACGAGAG GCGGTTCTCC CCCAAGTTCA TCTCCTTTGT CAACGTGTGC 1080

CTTACAAAGG AAGAATCAAA GAGGCCAAAG TACAGAGAAC TGCTGAGGGA CCCGTTCATC 1140

CAGATGTACG AGGAGCGCTC GGTCGACGTT GCCGGTTACG TCTGCAGGAT CATGGATCAG 1200

ATGCCTGCTT CTCCCAGCTC CCCCATGTAT ATGGACTGA 1239

Domain Profile

S: 1     lekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyi  60

         l++l+e+G+G++g+V+k++hk+s++i+avK+ir++++++eqkq+l++l+v+ +ss++pyi

Q: 115   LKDLGEIGRGAYGSVNKMVHKPSNQIMAVKRIRSTVDEKEQKQLLMDLDVVVRSSDCPYI  174

         68899*******************************************************

S: 61    vkfyGafvsegdvsicmelmdgtsldkvlkkvlek.kkripekvlgkiavavvkaleylk  119

         v+fyGa+++egd++icmelm  tsldk++k v+ + ++ ipe++lgki++a+vkal++lk

Q: 175   VQFYGALFREGDCWICMELMA-TSLDKFYKFVYCSlDDVIPEEILGKITLATVKALNHLK  233

         *********************.**********9999************************

S: 120   eklkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksa.vGtksYmaPErieg...  175

         e+lkiiHRD+KPsNiL+++kG++KlCDFG+sgqlvdsiAk++ +G+++YmaPEri++

Q: 234   ENLKIIHRDIKPSNILLDRKGNIKLCDFGISGQLVDSIAKTRdAGCRPYMAPERIDPsas  293

         *********************************************************999

S: 176   kkkYsvksdvWslGltlvelatgrypyeklkeilellkaivneeppklpee...efseef  232

         ++ Y+v+sdvWslG+tl+elatgr+py+k+++ +++l+++v+++pp+l+++   +fs++f

Q: 294   RQGYDVRSDVWSLGITLYELATGRFPYPKWNSVFDQLTQVVRGDPPQLSNSderRFSPKF  353

         9***********************************************9888889*****

S: 233   qefvskClkkdekeRpklkellkhafi  259

         ++fv+ Cl+k+e++Rpk++ell+ +fi

Q: 354   ISFVNVCLTKEESKRPKYRELLRDPFI  380

         ************************997

Domain Sequence
(FASTA)

LKDLGEIGRG AYGSVNKMVH KPSNQIMAVK RIRSTVDEKE QKQLLMDLDV VVRSSDCPYI 60

VQFYGALFRE GDCWICMELM ATSLDKFYKF VYCSLDDVIP EEILGKITLA TVKALNHLKE 120

NLKIIHRDIK PSNILLDRKG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA PERIDPSASR 180

QGYDVRSDVW SLGITLYELA TGRFPYPKWN SVFDQLTQVV RGDPPQLSNS DERRFSPKFI 240

SFVNVCLTKE ESKRPKYREL LRDPFI 266

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013