EKS-ORL-00499

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00499

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/WEE	348.2	3.2E-104	276	544	269

Status

Unreviewed

Ensembl Protein

ENSORLP00000001371

UniProt Accession

H2L6C5;

Protein Name

Protein Synonyms/Alias

Gene Name

WEE1

Gene Synonyms/Alias

WEE1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000001112	ENSORLP00000001371	ENSORLT00000001372

Organism

Oryzias latipes

Functional Description

Protein Length

622

Protein Sequence
(FASTA)

MSTCTRRRLG TPPKSLHIRQ KLQFTSSDGE EDSIEDVNSS IGGESGFTDM DSPMPVRRGA 60

AADKLRGTSN SSPLNHSGGD DDVELWDEES LDSPSSHLQS PNSVIYTNCP SPRKSPRLYG 120

GSPEHSFVQD DGEGSSSPIP DCPDTPPHKT FRKLRLFDTP HTPKSLLSRA RGSGSLSSSR 180

RIALFKKVES PGKSATDSTR RRQQVPLVNF NPFTPDSLLI QSATQQRNNR KRAHWNDSCG 240

EDMEASDSEG VDEILPPSKR ITMMESNMMS RYTSEFLELE KIGCGEFGAV FKCVKRLDGC 300

IYAIKRSKKP LAGSVDEQNA LREVYAHAVL GQHPHVVRYY SAWAEDDHML IQNEYCNGGT 360

LSDVIAENYR RLSYFTELEL KDLLLQVGRG LKYIHSTSLV HMDIKPSNIF ISRKPVASFD 420

ECDEVDGLAT SVIYKIGDLG HVTTANNPQV EEGDSRYLAN EVLQEDYSNL TKADIFALAL 480

TVVGASGADP LPSNGEKWHE IRKGKLPSIP QVLSPDFLSL LKLMIHPDQV RRPSASDLIR 540

HPVLLTSARM SADQLRVELN AEKFKNALLQ KELKKAQMAR AAAEEKVLST DRVLTRSTLQ 600

SNLRTSRLIG KKMNRSVSLT IY 622

Nucleotide Sequence
(FASTA)

ATGTCGACTT GCACTCGAAG ACGTCTCGGA ACTCCTCCCA AGAGCCTCCA CATTCGCCAG 60

AAACTGCAGT TCACATCCAG CGACGGAGAG GAGGATTCTA TTGAGGATGT TAACAGCAGC 120

ATTGGGGGCG AGTCCGGCTT CACGGACATG GATTCCCCCA TGCCAGTCCG ACGGGGCGCC 180

GCCGCCGACA AGCTGCGGGG AACTAGCAAC AGCAGCCCCC TGAATCACTC TGGAGGGGAC 240

GACGACGTGG AGCTGTGGGA CGAAGAGAGC CTCGACTCCC CGTCGTCGCA CCTGCAGTCA 300

CCGAACAGTG TCATTTACAC GAACTGCCCA TCGCCGAGGA AGAGCCCCAG GTTGTACGGG 360

GGCTCGCCGG AGCATAGCTT CGTCCAGGAC GACGGGGAAG GATCCAGCTC TCCCATCCCG 420

GACTGCCCGG ACACCCCTCC ACACAAAACC TTCCGAAAAC TCAGACTTTT TGACACACCG 480

CATACACCAA AGAGTTTGCT CTCCAGAGCT CGGGGCTCCG GCTCCCTGTC CTCCAGCAGG 540

AGAATCGCCC TGTTCAAAAA GGTGGAGTCT CCTGGAAAGT CAGCCACAGA CAGCACCAGG 600

AGGAGACAGC AGGTTCCCCT GGTGAACTTT AACCCCTTCA CCCCAGACTC CCTGCTCATT 660

CAGTCTGCCA CACAGCAAAG AAACAACAGA AAAAGAGCGC ACTGGAACGA CTCTTGCGGA 720

GAAGACATGG AGGCGAGCGA CAGTGAAGGA GTGGATGAGA TCCTCCCACC ATCCAAGAGA 780

ATCACCATGA TGGAGAGCAA CATGATGTCT CGCTACACCT CGGAGTTTCT CGAGCTGGAG 840

AAAATAGGCT GTGGCGAGTT TGGAGCCGTG TTCAAATGTG TGAAGAGACT CGACGGTTGT 900

ATTTATGCCA TCAAGAGGTC AAAGAAACCT CTGGCGGGAT CAGTAGACGA ACAAAATGCC 960

TTGCGGGAGG TGTACGCTCA CGCCGTGCTG GGCCAGCACC CTCACGTGGT GCGGTACTAC 1020

TCGGCCTGGG CCGAGGACGA CCACATGCTC ATCCAGAACG AGTACTGCAA CGGCGGCACG 1080

CTCTCAGACG TGATCGCGGA AAACTACAGA CGGCTCAGCT ACTTCACTGA GCTGGAACTT 1140

AAAGATCTGC TGCTGCAGGT TGGACGAGGG CTGAAGTACA TCCACTCCAC TTCTCTGGTG 1200

CACATGGACA TTAAGCCTAG TAACATTTTC ATATCGCGGA AGCCTGTGGC CAGCTTTGAT 1260

GAATGTGATG AGGTGGATGG ACTAGCAACC AGCGTTATTT ACAAAATAGG TGATCTTGGT 1320

CATGTGACTA CAGCGAACAA TCCACAGGTG GAGGAAGGTG ACAGTCGATA TTTGGCTAAT 1380

GAAGTTTTGC AAGAGGACTA CAGTAACCTG ACAAAAGCAG ACATATTTGC TTTAGCTCTT 1440

ACTGTTGTTG GTGCTTCTGG CGCTGACCCT TTACCCTCCA ATGGGGAAAA GTGGCACGAA 1500

ATCAGAAAGG GTAAACTGCC CTCCATCCCT CAGGTGCTTT CTCCAGACTT CCTCTCTCTA 1560

CTCAAGCTGA TGATCCACCC TGACCAGGTC AGACGACCTT CGGCCTCCGA CCTCATTAGA 1620

CACCCGGTGC TCCTGACCTC TGCCAGAATG AGTGCAGACC AGCTACGAGT GGAGTTGAAC 1680

GCTGAAAAAT TCAAGAATGC TTTGCTTCAG AAGGAGCTGA AAAAAGCCCA GATGGCCAGA 1740

GCAGCTGCTG AGGAGAAGGT TCTGTCCACC GACAGAGTCC TGACCCGCTC CACTCTCCAG 1800

TCCAACCTCC GAACCTCAAG ACTAATTGGA AAAAAGATGA ACCGCTCAGT CAGCCTGACA 1860

ATCTACTAA 1869

Domain Profile

S: 1     FeevekiGkGefgevfkvvkredgklyAikkskkplkglskekkalrEvtahavlgqhen  60

         F e+ekiG Gefg vfk+vkr+dg++yAik+skkpl+g+++e++alrEv+ahavlgqh++

Q: 276   FLELEKIGCGEFGAVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNALREVYAHAVLGQHPH  335

         7899********************************************************

S: 61    vvryisaWeeddslyiqtElCeggsLeaalqeceakkkaleeaelkkilldlllglrylH  120

         vvry+saW+edd+++iq+E+C+gg L++++ e+++  ++++e elk++ll++ +gl+y+H

Q: 336   VVRYYSAWAEDDHMLIQNEYCNGGTLSDVIAENYRRLSYFTELELKDLLLQVGRGLKYIH  395

         ************************************************************

S: 121   ssslvHlDikpenifi.................tkevtlklgDlGlvtelnsedkskveE  163

         s+slvH+Dikp+nifi                  ++v++k+gDlG+vt+    ++++veE

Q: 396   STSLVHMDIKPSNIFIsrkpvasfdecdevdglATSVIYKIGDLGHVTTA---NNPQVEE  452

         *********************************99*************99...9******

S: 164   GDsrylakEilqeeyskl.kaDiFslgltilevaanvelPsnGeaWhklRkgklpdeilk  222

         GDsryla+E+lqe+ys+l kaDiF+l+lt++ ++++ +lPsnGe+Wh++Rkgklp  i +

Q: 453   GDSRYLANEVLQEDYSNLtKADIFALALTVVGASGADPLPSNGEKWHEIRKGKLP-SIPQ  511

         *******************************************************.****

S: 223   elsedlrellklmlepdperRptaeellkhevl  255

         +ls d+ +llklm++pd+ rRp+a++l++h+vl

Q: 512   VLSPDFLSLLKLMIHPDQVRRPSASDLIRHPVL  544

         ******************************986

Domain Sequence
(FASTA)

FLELEKIGCG EFGAVFKCVK RLDGCIYAIK RSKKPLAGSV DEQNALREVY AHAVLGQHPH 60

VVRYYSAWAE DDHMLIQNEY CNGGTLSDVI AENYRRLSYF TELELKDLLL QVGRGLKYIH 120

STSLVHMDIK PSNIFISRKP VASFDECDEV DGLATSVIYK IGDLGHVTTA NNPQVEEGDS 180

RYLANEVLQE DYSNLTKADI FALALTVVGA SGADPLPSNG EKWHEIRKGK LPSIPQVLSP 240

DFLSLLKLMI HPDQVRRPSA SDLIRHPVL 269

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004715	; F:non-membrane spanning protein tyrosine kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007067	; P:mitosis

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR017164	; Wee1-like_protein_kinase.

Pfam

PF00069

; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013