EKS-ORL-00466

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00466

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	458.2	9.9E-138	495	754	260

Status

Unreviewed

Ensembl Protein

ENSORLP00000001378

UniProt Accession

H2L6D2;

Protein Name

Protein Synonyms/Alias

Gene Name

AXL

Gene Synonyms/Alias

AXL;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000001116	ENSORLP00000001378	ENSORLT00000001379

Organism

Oryzias latipes

Functional Description

Protein Length

823

Protein Sequence
(FASTA)

EPPDVLWLKD GMPLDFAETN QFQIRTGSSS WTVRSMLKIE KVQLSDMGSY RCAVQSESGR 60

LLSEEGVIQL EGIPHFSVEP RHMSVVANVS FSLRCAAHGP PDPVRVIWLQ DGAPLNSLDD 120

HMALSPSTLN LTGLNRTSTF SCEAHNSKGV STSKSGTITV LPSPPQNVSA VETNQTALRL 180

SWQPGFGGDY PIVRCSVQAQ AQQNGANIWI GPFIESPDQM ILNQNVHIPA ATVLMEELEP 240

HSLYAARVAC QSSQGLSEWS PWVELQTAEG VPENPPSNVT ATPNGTEVLL AWEVPRGKLN 300

GELQGFLVEY STPSAENKGP AFSSSSRTVS TGLDTVLSIN LTAPLSNVTF RVCAYTATGL 360

GPWTPMQTLV LTPSEMLPKH RACDPPPSGT PPAFSWHWWY VVMAIAGAMA IAVLMAVYVA 420

KLRRKETRFG EAFEPMMESG ELVVRYRARR TYSRRTTEAT RNDVNSLIIV MENLINTFKC 480

AENNQHKIYR PWAGGAGGVG KVSQGTKNMM EDVLKVSPVN GFSAVAICTR SEMEDFLREA 540

ACMKEFDHGN VMRLLGVCLQ TVESEGYPSP VVILPYMKHG DLHSYLLYSR LGDCPVYLPS 600

KMLIKFMTDI ARGMEYLSSK NFIHRDLAAR NCMLNENMNV CVADFGLSKK IYNGDYYRQG 660

RISKMPVKWI AIESLADRVY TTKSDVWSFG VTMWEIATRG QTPYPGVENS EIYDYLRQGN 720

RLKQPPDCLD LIYSLMFSCW LLSPKDRPSF EALRCELEKA LEDLPDPQDP DEILYVNMDE 780

SSTELGAVGG RDPLGGLPPF CLKGRDTVTT VEVHHPNRYV LCP 823

Nucleotide Sequence
(FASTA)

GAACCCCCGG ATGTCCTCTG GCTAAAAGAC GGGATGCCGC TCGACTTTGC AGAAACCAAC 60

CAGTTTCAAA TTCGCACGGG CAGCAGCAGT TGGACCGTCA GAAGCATGCT AAAAATCGAG 120

AAGGTCCAGC TGTCAGACAT GGGCTCCTAC AGATGTGCTG TTCAGTCAGA AAGCGGGCGC 180

CTCCTCTCTG AGGAGGGGGT CATCCAGCTG GAAGGTATTC CTCATTTCTC CGTGGAGCCT 240

CGGCACATGT CGGTGGTGGC CAACGTCTCC TTCAGCCTGA GATGTGCGGC CCACGGACCT 300

CCGGACCCGG TCAGGGTCAT CTGGTTGCAG GACGGCGCTC CGCTCAACTC TCTGGACGAT 360

CACATGGCGT TGTCCCCCTC CACGCTCAAC CTCACAGGTC TGAACAGAAC CAGCACCTTT 420

TCCTGTGAGG CCCACAACAG CAAAGGCGTG AGCACCTCAA AATCCGGCAC CATCACGGTT 480

CTGCCATCGC CGCCGCAGAA CGTGAGCGCC GTGGAGACCA ATCAGACCGC GCTGCGTTTA 540

TCCTGGCAGC CCGGTTTTGG AGGCGACTAC CCGATTGTTC GCTGCTCTGT TCAGGCCCAG 600

GCTCAGCAGA ATGGGGCAAA TATCTGGATT GGACCCTTCA TTGAGAGCCC AGACCAGATG 660

ATCCTCAACC AGAACGTCCA CATCCCAGCT GCCACCGTCC TGATGGAGGA GCTGGAGCCC 720

CACAGCCTGT ACGCCGCCAG GGTGGCCTGT CAGAGCAGCC AGGGCCTGTC GGAGTGGTCG 780

CCATGGGTGG AGCTGCAGAC CGCAGAAGGA GTGCCGGAGA ACCCGCCGAG CAACGTGACG 840

GCCACACCCA ACGGGACCGA GGTGCTGCTG GCGTGGGAGG TTCCTCGGGG GAAGCTGAAC 900

GGAGAACTCC AGGGCTTTTT GGTGGAGTAC AGCACCCCCT CTGCAGAGAA CAAGGGACCT 960

GCTTTCTCCT CCTCCTCCCG GACTGTTAGC ACCGGATTGG ACACGGTGCT GTCCATCAAC 1020

CTGACTGCCC CCCTGTCCAA CGTGACGTTC CGGGTGTGCG CCTACACGGC GACGGGGCTG 1080

GGGCCCTGGA CCCCCATGCA GACGCTGGTG CTCACGCCTT CCGAGATGCT GCCTAAACAC 1140

CGGGCATGTG ATCCCCCCCC CTCAGGGACG CCTCCGGCTT TTTCCTGGCA CTGGTGGTAT 1200

GTGGTGATGG CCATCGCCGG CGCCATGGCC ATCGCTGTGC TCATGGCCGT TTACGTGGCC 1260

AAGCTGCGGC GCAAAGAGAC GCGCTTCGGG GAGGCCTTCG AGCCCATGAT GGAGAGCGGG 1320

GAGCTGGTGG TCAGGTACCG GGCGCGGCGC ACCTACAGCC GCAGGACGAC CGAAGCCACG 1380

CGAAATGACG TCAACAGTTT AATAATAGTC ATGGAAAATC TAATTAATAC ATTTAAATGT 1440

GCAGAAAATA ATCAACATAA AATTTACAGA CCATGGGCTG GGGGGGCTGG GGGGGTCGGG 1500

AAAGTGTCAC AGGGTACAAA AAATATGATG GAGGACGTAT TAAAAGTCTC ACCTGTGAAC 1560

GGCTTCTCTG CAGTTGCCAT CTGCACTCGC TCAGAGATGG AGGATTTCCT GCGCGAAGCC 1620

GCCTGCATGA AGGAGTTCGA CCACGGCAAC GTCATGAGGC TGCTGGGTGT GTGTCTGCAG 1680

ACGGTGGAGA GCGAAGGTTA CCCGTCTCCC GTGGTCATCC TGCCCTACAT GAAACACGGA 1740

GACCTGCACA GCTATCTGCT GTACTCCAGG CTGGGGGACT GTCCTGTGTA CCTCCCATCA 1800

AAAATGCTGA TCAAGTTCAT GACCGACATT GCCCGAGGGA TGGAGTACCT CAGCAGCAAG 1860

AACTTCATCC ACAGAGACCT CGCTGCACGG AACTGCATGC TGAACGAGAA CATGAACGTT 1920

TGTGTCGCCG ACTTTGGCCT CTCCAAGAAG ATCTACAACG GCGATTACTA CAGGCAGGGC 1980

CGCATCTCCA AGATGCCGGT CAAATGGATC GCCATCGAAA GCCTGGCCGA TCGCGTCTAC 2040

ACCACGAAGA GCGACGTGTG GTCATTCGGG GTCACCATGT GGGAAATCGC CACACGGGGT 2100

CAGACGCCGT ATCCCGGTGT GGAAAACAGC GAGATTTACG ACTATCTGAG GCAGGGAAAC 2160

CGCCTCAAAC AGCCGCCAGA CTGCCTGGAC TTGATATATT CTCTCATGTT CTCCTGCTGG 2220

CTGCTGAGCC CCAAGGACCG CCCCTCCTTT GAGGCGCTGC GCTGCGAGCT GGAAAAGGCG 2280

CTGGAGGACC TGCCGGATCC TCAGGACCCC GACGAGATTC TGTACGTCAA CATGGACGAG 2340

TCCTCCACGG AGCTGGGAGC CGTGGGTGGC CGTGACCCCC TTGGGGGACT GCCCCCCTTC 2400

TGCCTGAAAG GCCGCGACAC GGTGACCACG GTGGAGGTCC ACCACCCCAA CCGCTACGTC 2460

CTCTGCCCC 2469

Domain Profile

S: 8     gegefgsvmegqlkqedgsilkva.vkt.lkldiiarseieeflseaacmkefdhpnvir  65

         g g  g v +g  +  +  +lkv+ v+    ++i++rse+e+fl+eaacmkefdh nv+r

Q: 495   GAGGVGKVSQGTKNMME-DVLKVSpVNGfSAVAICTRSEMEDFLREAACMKEFDHGNVMR  553

         67888888888777654.467775355415689***************************

S: 66    lvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvdiasg  125

         l+gv+l++ e +  p pvvilp+mk+gdlh++llysrlg+ pvylp ++l+kfm dia g

Q: 554   LLGVCLQTVESEGYPSPVVILPYMKHGDLHSYLLYSRLGDCPVYLPSKMLIKFMTDIARG  613

         ************************************************************

S: 126   meylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkwiaie  185

         meylss+nfihrdlaarncml+e+m vcvadfglskkiy+gdyyrqgri+k+pvkwiaie

Q: 614   MEYLSSKNFIHRDLAARNCMLNENMNVCVADFGLSKKIYNGDYYRQGRISKMPVKWIAIE  673

         ************************************************************

S: 186   sladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedcldely  245

         sladrvyt+ksdvw+fgvtmweiatrgqtpy+gven+eiydyl+qgnrlkqp+dcld +y

Q: 674   SLADRVYTTKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPPDCLDLIY  733

         ************************************************************

S: 246   dlmyrcweadpkdrpsfsvlr  266

         +lm++cw + pkdrpsf  lr

Q: 734   SLMFSCWLLSPKDRPSFEALR  754

         *****************9998

Domain Sequence
(FASTA)

GAGGVGKVSQ GTKNMMEDVL KVSPVNGFSA VAICTRSEME DFLREAACMK EFDHGNVMRL 60

LGVCLQTVES EGYPSPVVIL PYMKHGDLHS YLLYSRLGDC PVYLPSKMLI KFMTDIARGM 120

EYLSSKNFIH RDLAARNCML NENMNVCVAD FGLSKKIYNG DYYRQGRISK MPVKWIAIES 180

LADRVYTTKS DVWSFGVTMW EIATRGQTPY PGVENSEIYD YLRQGNRLKQ PPDCLDLIYS 240

LMFSCWLLSP KDRPSFEALR 260

Keyword

Complete proteome; Disulfide bond; Immunoglobulin domain; Membrane; Receptor; Reference proteome; Repeat; Transmembrane; Transmembrane helix.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Equus caballus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR013098	; Ig_I-set.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07679	; I-set; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013