EPS-ORL-00047

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORL-00047

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP5	590.6	6.6E-178	184	495	312

Status

Unreviewed

Ensembl Protein

ENSORLP00000001596

UniProt Accession

H2L6Y8;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPP5C

Gene Synonyms/Alias

PPP5C;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000001301	ENSORLP00000001596	ENSORLT00000001597
ENSORLG00000001301	ENSORLP00000001598	ENSORLT00000001599
ENSORLG00000001301	ENSORLP00000001599	ENSORLT00000001600

Organism

Oryzias latipes

Functional Description

Protein Length

498

Protein Sequence
(FASTA)

HVKKTDYMTH KPEVVTEEKM AEAANEAELL KEKANNYFKE KDYENAIKFY SEALELNPSN 60

AIYYSNRSLA YLRTECYGYA LADATKALEV DKNYIKGYYR RATSNMALGK FKAALKDYET 120

VVRVRPNDKD AKMKYQECNK IVKQKAFERA IASDETKKSV VDSLDIESMT IEDDYAGPKL 180

EDGKVTVSFM TDMMEWFKEQ KKLHRKCAYQ ILVQVKDVLS KLPSLVEITL KETDKLTICG 240

DTHGQYYDLL NIFKLNGLPS DANPYLFNGD FVDRGSFSLE VILTLFGFKL LYPDNFHLLR 300

GNHETDNMNQ MYGFEGEVKA KYTAQMFQLF SEVFQWLPLA QCINSKVLVM HGGLFSEDGV 360

TLDDIRKIDR NRQPPDSGPM CDLLWSDPQP QNGRSVSKRG VSCQFGPDVT ESFLEKNKLD 420

YIIRSHEVKA EGYEVTHSGK CITVFSAPNY CDQMGNKGAY IHLRGSDLKP EFHQFTAVPH 480

PNVKPMAYAN TLMQLGMM 498

Nucleotide Sequence
(FASTA)

CACGTTAAGA AAACTGACTA TATGACGCAC AAACCGGAAG TCGTCACAGA AGAGAAGATG 60

GCGGAAGCGG CTAATGAAGC GGAGCTACTC AAGGAGAAGG CGAATAACTA CTTTAAAGAG 120

AAAGATTATG AAAATGCCAT CAAGTTCTAC TCAGAGGCTT TGGAGCTCAA TCCGTCCAAC 180

GCCATCTACT ACAGCAACCG CAGCCTGGCC TACCTGCGCA CCGAGTGCTA TGGCTACGCC 240

CTGGCGGACG CTACCAAGGC CCTGGAGGTG GACAAGAACT ACATTAAAGG CTACTACCGC 300

CGCGCCACCT CCAACATGGC TCTGGGGAAG TTCAAAGCTG CTCTGAAGGA CTATGAGACG 360

GTCGTGAGGG TTCGACCGAA CGACAAGGAC GCCAAGATGA AGTACCAGGA GTGCAACAAG 420

ATCGTGAAGC AGAAAGCCTT CGAGCGAGCC ATCGCCAGCG ACGAGACGAA AAAGTCTGTG 480

GTGGACTCTC TGGACATCGA GAGCATGACC ATCGAGGACG ACTATGCCGG CCCCAAACTT 540

GAGGATGGAA AGGTGACGGT CAGCTTCATG ACGGACATGA TGGAGTGGTT CAAAGAGCAG 600

AAGAAGCTGC ACAGGAAGTG TGCGTACCAG ATTTTGGTGC AGGTTAAAGA CGTTCTGTCG 660

AAGTTACCCA GTCTGGTTGA AATCACGTTA AAGGAGACAG ATAAGTTAAC TATTTGTGGG 720

GACACCCACG GCCAGTACTA CGACCTCCTC AACATTTTCA AGCTGAACGG CTTACCGTCA 780

GACGCCAACC CTTACCTGTT CAACGGGGAC TTTGTGGACC GCGGCTCCTT CTCCCTCGAG 840

GTCATCCTCA CTCTCTTTGG CTTCAAGCTG CTCTACCCCG ACAACTTTCA CCTACTGAGA 900

GGAAACCACG AGACGGACAA CATGAACCAG ATGTACGGGT TTGAAGGGGA GGTCAAAGCC 960

AAGTACACGG CGCAGATGTT CCAGCTGTTC AGCGAGGTCT TCCAGTGGCT TCCTCTCGCT 1020

CAGTGCATCA ACAGCAAAGT GCTGGTGATG CACGGCGGAC TTTTCAGTGA AGACGGCGTC 1080

ACGTTGGACG ACATTAGGAA GATCGACAGA AATCGACAAC CTCCAGACTC AGGTCCCATG 1140

TGCGACCTCC TCTGGTCAGA CCCGCAGCCT CAGAACGGCC GGTCGGTCAG CAAGAGGGGA 1200

GTGAGCTGTC AGTTCGGACC GGACGTGACG GAGAGCTTCC TGGAGAAGAA CAAGCTGGAC 1260

TACATCATCC GCAGTCACGA GGTCAAAGCT GAGGGTTACG AGGTCACCCA CTCAGGGAAG 1320

TGCATCACCG TGTTCTCAGC GCCCAACTAC TGTGATCAGA TGGGAAATAA AGGAGCTTAC 1380

ATCCACCTCA GGGGATCAGA CCTCAAGCCA GAATTTCACC AGTTCACAGC TGTGCCTCAT 1440

CCGAATGTCA AGCCCATGGC GTACGCTAAC ACGCTAATGC AGCTGGGGAT GATGTAG 1497

Domain Profile

S: 2     kvsiefikklvndlklkkkllrkkavailvsvadvlfklevelennskedvkitvcGdth  61

         kv+++f++++++++k++kkl+rk+a++ilv+v+dvl+kl  ++e ++ke+ k+t+cGdth

Q: 184   KVTVSFMTDMMEWFKEQKKLHRKCAYQILVQVKDVLSKLPSLVEITLKETDKLTICGDTH  243

         799*********************************************************

S: 62    GqfydllnifelnGlpseknpylfnGdfvdrGsfsveviltlfglkllyPdhffllrGnh  121

         Gq+ydllnif+lnGlps+ npylfnGdfvdrGsfs eviltlfg+kllyPd+f+llrGnh

Q: 244   GQYYDLLNIFKLNGLPSDANPYLFNGDFVDRGSFSLEVILTLFGFKLLYPDNFHLLRGNH  303

         ************************************************************

S: 122   esdnmnkiyGfegevkakytaklyelfaevfewlPlaqlingkvlvmhGGlfsedgvtld  181

         e+dnmn++yGfegevkakyta++++lf+evf+wlPlaq+in kvlvmhGGlfsedgvtld

Q: 304   ETDNMNQMYGFEGEVKAKYTAQMFQLFSEVFQWLPLAQCINSKVLVMHGGLFSEDGVTLD  363

         ************************************************************

S: 182   dirkiernaqPPeeGalcellWsdPqeanGrgvskrGvglqfGpdvtkrfleenkldyii  241

         dirki+rn+qPP++G++c+llWsdPq++nGr+vskrGv++qfGpdvt+ fle+nkldyii

Q: 364   DIRKIDRNRQPPDSGPMCDLLWSDPQPQNGRSVSKRGVSCQFGPDVTESFLEKNKLDYII  423

         ************************************************************

S: 242   rshevkaegveveqkgklvtvfsapnycdsqgnlasvihvrnddlrliietfeavehpdv  301

         rshevkaeg+ev+++gk++tvfsapnycd++gn++++ih+r++dl++ +++f+av+hp+v

Q: 424   RSHEVKAEGYEVTHSGKCITVFSAPNYCDQMGNKGAYIHLRGSDLKPEFHQFTAVPHPNV  483

         ************************************************************

S: 302   kpmaysngllgl  313

         kpmay+n+l++l

Q: 484   KPMAYANTLMQL  495

         *********987

Domain Sequence
(FASTA)

KVTVSFMTDM MEWFKEQKKL HRKCAYQILV QVKDVLSKLP SLVEITLKET DKLTICGDTH 60

GQYYDLLNIF KLNGLPSDAN PYLFNGDFVD RGSFSLEVIL TLFGFKLLYP DNFHLLRGNH 120

ETDNMNQMYG FEGEVKAKYT AQMFQLFSEV FQWLPLAQCI NSKVLVMHGG LFSEDGVTLD 180

DIRKIDRNRQ PPDSGPMCDL LWSDPQPQNG RSVSKRGVSC QFGPDVTESF LEKNKLDYII 240

RSHEVKAEGY EVTHSGKCIT VFSAPNYCDQ MGNKGAYIHL RGSDLKPEFH QFTAVPHPNV 300

KPMAYANTLM QL 312

Keyword

Complete proteome; Hydrolase; Iron; Metal-binding; Reference proteome; Repeat; TPR repeat.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0046872	; F:metal ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR006186	; Ser/Thr-sp_prot-phosphatase.
IPR011236	; Ser/Thr_PPase_5.
IPR001440	; TPR-1.
IPR013026	; TPR-contain_dom.
IPR011990	; TPR-like_helical.
IPR019734	; TPR_repeat.

Pfam

PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.
PF00515	; TPR_1; 1.

SMARTs

SM00156	; PP2Ac; 1.
SM00028	; TPR; 3.

Prosites

PS00125	; SER_THR_PHOSPHATASE; 1.
PS50005	; TPR; 3.
PS50293	; TPR_REGION; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013