EPS-ORL-00091

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORL-00091

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
DSP/PTEN	141.7	3.8E-41	400	557	158

Status

Unreviewed

Ensembl Protein

ENSORLP00000001720

UniProt Accession

H2L7B0;

Protein Name

Protein Synonyms/Alias

Gene Name

GAK

Gene Synonyms/Alias

GAK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000001381	ENSORLP00000001720	ENSORLT00000001721

Organism

Oryzias latipes

Functional Description

Protein Length

1334

Protein Sequence
(FASTA)

MSLFQSALDF LAGPGSTGAA SRDQNDFVGQ IVELGDMKLR IKRVIAEGGF AFVYEAQDLS 60

GGKDYALKRL LSYEEEKNKE IIQEICFMKK LSGHPNVVQF CSAASISKEE SDTGQAEFLI 120

LTELCKGQLV DFVKRVEQRA PLSCDTVMKV FYQTCRAVQH MHKQKPPIIH RDLKIENLLI 180

SNQGTIKLCD FGSSTTVSHY PDFSWSAQKR SMVEDEITRN TTPAYRTPEM IDLYSNYPIN 240

EKQDIWALGC ILYLLCFKQH PFEEGAKLQI VNGKYSIPQN DAKYNVYHDL IRAMLKVNPE 300

ERLSITELVN QLQEIAAARN VNPKSPVTEL LEQNGGFGNN GAQPKCEVQM HSSGLMCVYD 360

PDQAGSGLLD ILRGGTERFL TNIKDTSSKV IQSVASYAKG DLDISYITSR IAVMSFPAEG 420

VESAIKNNIE DVRLFLDSRH AGHYAVYNLS KRSYRPSRFH NRVSECNWQV RRAPNLRSLF 480

NVCKSMHQWL KQDQRNICIV HCLDGRAASA VAVCSFLCFC RLFTTAEAAV YMFSMKRCPP 540

GIAPSHKRYI EYMCDMMAEE PIVPHSKPVT IHSIVMTPVP LFNKQRNGCR PFCEVYVGDE 600

RVLSTSQEYD RMKDFKMEDG KAEIPLNVTV QGDVLVVIYH ARSTLGGRLQ AKMASMKMFQ 660

IQFHTGFVPR NATTVKFAKY DLDACDIQEK YPDLFQVHLD IDVEPRDRPS TKTPPWEGVQ 720

TKGLNPKILF SSRDEQQEIL SKFGKPELPR QPGSSASYDS ESPQPAQTPD DASTTEPESP 780

VSGDGNPANF FQTLDWEDSR GTQDAPDDQR RGSLNTQEDM SDQSDEESYS YSAPSAEPLS 840

RDQSEHLFDA DFQVTFIFYV AIPFCLPLPQ TAQEPPAGDT ADLLGLNSDA EPPSASLTSS 900

SAPPPAEQGG MKAASSNSDL LNDLFAPPAG QTGAVQEDLF FSGPATHTSL SPLMLFVIRL 960

FFAAAVGDLF DPFGMGSGSG VGSSVSSSRQ TSGTDLFGDL LGSDSSATSG FSSAPSNPTP 1020

ASNSSLFNLT DKVVKDVPKM TSSASQPDLL GGWDSWTAGG TAGKSTAANK PTFTNTGGFA 1080

ASGMSSMSKA KSQTFDPFAD LGNLSSNLPG SSSGHFSRPS FSTKPSSKPQ TQPWQSDKPI 1140

SAQNKSWMSA SGSAPRGAAP PAATQPTKPN YNLNFPSVIG GREERGVRGP GFGPKPKVKA 1200

SDFEDLVSNQ GFAFKPDKRG PKTIAEMRRQ ELTKDMDPLK LQILDWIEGK ERNIRALLST 1260

LHTVLWEGET RWRPVGMADL VTPDQVKKCY RKAALVVHPD KATGKPYEHY AKMIFMELND 1320

AWSEFENQGS KALF 1334

Nucleotide Sequence
(FASTA)

ATGTCACTCT TCCAGTCGGC ACTTGATTTC CTCGCCGGGC CCGGTTCTAC CGGAGCAGCC 60

AGCAGGGACC AGAATGACTT CGTTGGACAA ATCGTGGAGC TCGGAGACAT GAAATTAAGG 120

ATCAAGCGGG TGATCGCGGA GGGTGGATTT GCCTTTGTGT ATGAAGCTCA GGACTTGAGC 180

GGTGGCAAAG ACTACGCTCT TAAGAGATTG CTGTCCTACG AGGAGGAAAA GAACAAGGAA 240

ATCATCCAGG AAATCTGCTT CATGAAAAAA CTGTCTGGTC ATCCAAATGT GGTGCAGTTC 300

TGCTCCGCTG CTTCCATCAG CAAAGAAGAG TCTGACACCG GGCAGGCGGA GTTCCTGATC 360

CTCACTGAGC TGTGCAAAGG TCAGCTGGTG GACTTCGTAA AGCGGGTGGA GCAGAGAGCT 420

CCTCTGTCAT GCGACACTGT GATGAAAGTC TTCTACCAGA CTTGCCGCGC CGTGCAGCAC 480

ATGCACAAGC AGAAGCCTCC GATCATACAC AGAGACCTCA AGATCGAGAA CCTCCTGATT 540

AGTAACCAGG GCACCATCAA GCTTTGTGAC TTTGGCAGCT CCACCACGGT GTCACATTAC 600

CCCGACTTCA GCTGGTCGGC ACAGAAAAGG TCCATGGTGG AGGATGAGAT AACGAGGAAT 660

ACCACTCCAG CGTACCGCAC ACCAGAAATG ATTGATCTGT ACTCCAACTA TCCAATCAAT 720

GAGAAACAAG ACATCTGGGC CCTGGGATGC ATCCTCTACC TGCTGTGTTT TAAGCAGCAT 780

CCCTTTGAGG AAGGAGCGAA GCTGCAAATA GTCAACGGAA AATACTCCAT TCCTCAGAAT 840

GACGCCAAAT ACAACGTGTA TCACGATCTC ATTCGTGCCA TGTTGAAGGT AAATCCAGAG 900

GAGCGTCTGT CAATCACAGA GTTGGTCAAC CAGCTCCAGG AAATAGCGGC AGCTCGCAAC 960

GTCAACCCCA AGTCTCCAGT GACAGAGCTC CTGGAGCAGA ACGGAGGCTT CGGCAACAAC 1020

GGAGCGCAGC CGAAGTGTGA GGTCCAGATG CATTCCAGTG GTCTAATGTG CGTGTACGAT 1080

CCTGATCAGG CGGGCAGCGG CCTCTTGGAT ATCCTGAGGG GGGGGACGGA GCGTTTCCTG 1140

ACCAACATAA AGGACACGTC CTCGAAGGTC ATCCAGTCAG TAGCCAGTTA CGCCAAAGGA 1200

GACCTGGATA TTTCCTACAT CACCTCCAGA ATAGCAGTCA TGTCTTTTCC AGCTGAAGGG 1260

GTGGAGTCAG CGATAAAGAA CAACATTGAG GATGTGCGTT TGTTCCTGGA TTCGCGCCAC 1320

GCCGGACACT ACGCTGTGTA CAACCTCTCC AAACGATCAT ACAGGCCCTC CCGCTTTCAC 1380

AACAGGGTCT CGGAGTGTAA CTGGCAGGTC CGCCGTGCCC CAAACCTCCG CAGTCTTTTC 1440

AACGTTTGCA AGAGCATGCA TCAGTGGCTG AAACAGGACC AGAGGAACAT CTGTATAGTG 1500

CACTGTCTGG ATGGCAGAGC CGCATCGGCC GTGGCGGTTT GCTCCTTCCT GTGTTTCTGC 1560

CGCCTTTTTA CCACGGCCGA AGCGGCGGTC TACATGTTCT CAATGAAACG CTGCCCACCT 1620

GGCATAGCAC CTTCACACAA GAGGTACATT GAGTATATGT GCGACATGAT GGCTGAGGAG 1680

CCCATCGTCC CCCACAGCAA GCCGGTCACT ATTCACTCCA TCGTCATGAC GCCCGTGCCG 1740

CTGTTCAACA AGCAGCGCAA CGGGTGCAGG CCGTTCTGTG AGGTCTACGT CGGAGACGAG 1800

CGGGTCCTCA GCACATCGCA GGAGTACGAC AGGATGAAGG ACTTTAAGAT GGAAGACGGG 1860

AAAGCAGAGA TCCCCCTCAA CGTTACAGTT CAGGGAGACG TGCTGGTCGT GATTTATCAT 1920

GCCAGATCAA CACTGGGAGG ACGTCTACAG GCGAAGATGG CATCCATGAA AATGTTTCAG 1980

ATCCAGTTTC ACACAGGATT TGTTCCAAGA AACGCAACCA CCGTCAAGTT TGCTAAGTAT 2040

GACTTGGACG CCTGTGACAT TCAGGAGAAG TACCCAGACT TGTTCCAAGT CCACCTAGAC 2100

ATTGACGTGG AGCCCAGAGA CCGACCCAGC ACCAAGACGC CACCATGGGA GGGCGTGCAA 2160

ACCAAGGGCC TTAACCCAAA AATCCTCTTC TCATCTCGGG ATGAGCAGCA GGAAATACTG 2220

AGCAAATTTG GAAAACCGGA GCTTCCACGG CAGCCGGGCT CCTCTGCTTC TTATGACTCC 2280

GAGTCCCCAC AGCCAGCTCA GACTCCAGAC GATGCCAGCA CAACAGAACC GGAATCTCCC 2340

GTCAGCGGCG ACGGCAATCC CGCCAACTTC TTCCAAACGC TGGACTGGGA GGATTCCCGC 2400

GGCACTCAGG ATGCCCCAGA CGACCAAAGA AGAGGGTCCC TGAACACCCA GGAGGACATG 2460

AGTGACCAGT CAGACGAGGA GTCGTACTCC TACTCTGCCC CAAGTGCTGA GCCCCTGTCA 2520

CGTGACCAAA GCGAACACCT ATTCGATGCC GACTTCCAGG TGACTTTTAT ATTTTATGTT 2580

GCGATCCCCT TTTGTTTGCC TCTCCCCCAG ACCGCACAGG AACCTCCTGC CGGTGACACC 2640

GCTGACCTCC TAGGGTTAAA CTCCGACGCT GAACCTCCCT CTGCGTCGTT AACCTCCTCG 2700

TCTGCTCCTC CTCCTGCAGA GCAGGGAGGA ATGAAAGCTG CTTCCAGCAA CAGCGATCTT 2760

CTGAACGACC TGTTTGCACC TCCTGCAGGT CAGACGGGTG CAGTACAGGA GGATTTGTTC 2820

TTCAGCGGGC CAGCGACTCA CACGTCTCTT TCACCTTTGA TGCTATTTGT AATACGTCTG 2880

TTCTTTGCTG CAGCTGTGGG CGACCTTTTT GACCCGTTCG GGATGGGCTC CGGCTCTGGC 2940

GTCGGCTCTA GCGTCAGTTC GTCACGGCAG ACTTCGGGAA CGGACCTGTT TGGAGACCTG 3000

TTGGGCTCCG ACAGTTCAGC GACCAGCGGG TTCAGCTCGG CTCCCAGCAA TCCAACCCCT 3060

GCTTCCAACA GCAGCCTTTT TAACCTCACG GATAAGGTTG TGAAAGACGT TCCTAAGATG 3120

ACCTCATCAG CCAGCCAGCC GGACCTGCTC GGGGGGTGGG ACAGCTGGAC GGCTGGCGGC 3180

ACCGCTGGAA AGAGCACCGC CGCTAACAAA CCTACTTTTA CCAACACAGG TGGCTTTGCA 3240

GCTTCTGGTA TGTCGTCTAT GTCAAAAGCC AAATCTCAGA CTTTTGATCC GTTCGCCGAC 3300

CTTGGAAATC TGAGCTCCAA TTTGCCAGGT TCTTCCAGTG GTCACTTTTC CAGGCCTTCC 3360

TTTAGCACAA AGCCTTCCTC AAAGCCTCAG ACTCAACCCT GGCAGTCTGA CAAACCCATT 3420

TCAGCACAGA ATAAATCCTG GATGTCTGCG TCTGGATCAG CACCGCGAGG AGCCGCTCCG 3480

CCTGCTGCCA CACAGCCCAC CAAACCCAAT TACAACCTGA ACTTCCCAAG CGTCATTGGT 3540

GGAAGAGAGG AGAGGGGGGT CCGAGGGCCT GGGTTCGGCC CCAAACCAAA GGTGAAAGCC 3600

AGCGATTTTG AAGACCTGGT GTCCAACCAA GGCTTTGCTT TCAAGCCTGA TAAGAGGGGA 3660

CCAAAGACCA TCGCTGAAAT GAGGAGACAG GAGCTGACAA AAGACATGGA TCCCCTCAAA 3720

CTACAGATTC TGGACTGGAT TGAGGGGAAA GAGCGAAACA TTCGGGCGCT GCTGTCGACG 3780

CTTCACACGG TGCTGTGGGA GGGGGAAACT CGCTGGAGGC CTGTGGGCAT GGCCGACCTC 3840

GTGACCCCGG ATCAGGTCAA GAAGTGTTAC AGGAAGGCGG CGCTGGTGGT CCACCCAGAT 3900

AAGGCGACGG GGAAGCCTTA CGAGCACTAC GCCAAGATGA TCTTCATGGA ATTGAACGAC 3960

GCCTGGTCGG AGTTTGAGAA CCAGGGCTCC AAAGCACTCT TCTGA 4005

Domain Profile

S: 8     fdldltyvteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltk  67

          dld+ y+t ri  +sfPae+ e+  +nn+++v  +lds+h ++y +ynl s r y +++

Q: 400   GDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDSRHAGHYAVYNL-SKRSYRPSR  458

         59************************************************.*********

S: 68    lnakvaefgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayll  127

         ++++v+e  ++  +aP+l  l  +ck +++Wl +d++n+ ++hc  g+    v vc++l

Q: 459   FHNRVSECNWQVRRAPNLRSLFNVCKSMHQWLKQDQRNICIVHCLDGRAASAVAVCSFLC  518

         ************************************************************

S: 128   aseisakadealdtfgerrtredkvagvkqPsqrryvsyfsqll  171

         + + +++a+ a+++f+++r           Ps +ry++y + ++

Q: 519   FCRLFTTAEAAVYMFSMKRCPPG-----IAPSHKRYIEYMCDMM  557

         ******************97654.....59*********98775

Domain Sequence
(FASTA)

GDLDISYITS RIAVMSFPAE GVESAIKNNI EDVRLFLDSR HAGHYAVYNL SKRSYRPSRF 60

HNRVSECNWQ VRRAPNLRSL FNVCKSMHQW LKQDQRNICI VHCLDGRAAS AVAVCSFLCF 120

CRLFTTAEAA VYMFSMKRCP PGIAPSHKRY IEYMCDMM 158

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR001623	; DnaJ_N.
IPR011009	; Kinase-like_dom.
IPR014019	; Phosphatase_tensin-typ.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR014020	; Tensin_phosphatase_C2-dom.

Pfam

PF00226	; DnaJ; 1.
PF00069	; Pkinase; 1.
PF10409	; PTEN_C2; 1.

SMARTs

SM00271

; DnaJ; 1.

Prosites

PS51182	; C2_TENSIN; 1.
PS50076	; DNAJ_2; 1.
PS51181	; PPASE_TENSIN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013