EKS-ORL-00383

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00383

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	330.4	9.5E-99	207	455	249

Status

Unreviewed

Ensembl Protein

ENSORLP00000001860

UniProt Accession

H2L7P5;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK4

Gene Synonyms/Alias

PAK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000001503	ENSORLP00000001865	ENSORLT00000001866
ENSORLG00000001503	ENSORLP00000001860	ENSORLT00000001861
ENSORLG00000001503	ENSORLP00000001862	ENSORLT00000001863

Organism

Oryzias latipes

Functional Description

Protein Length

482

Protein Sequence
(FASTA)

KKKKSRIEIS APSNFEHRVH TDFDEQEQKF VGLPRQWQSL IEDTAQRPKP FIDASVITTV 60

EPRKVRVNKQ SSNFKSSEEN LGPVRAHADR DEGSLSRPQQ QPRGQEPSRA PKDRIGSGPP 120

PPPHRDRGPR KQIQISRKTL AHAEQPNGQQ SESIPACKHE APSPAALLRD TARSPQREPQ 180

RISHEQFRAA LQMVVDPGDP RTYLDHYIKI GEGSTGIVCI ATVKTTGKLV AVKKMDLKKQ 240

QRRELLFNEV VIMRDYHHEN VVEMYNSYLV GDELWVVMEF LEGGALTDIV THTRMNEEQI 300

ATVCVSVLKA LSVLHSQGVI HRDIKSDSIL LTHDGRVKLS DFGFCAQVSK EVQRRKSLVG 360

TPYWMAPELI SRLPYGPEVD IWSLGIMVIE MVDGEPPYFN EPPLKAMKMI RDNSPPKLKN 420

LHKVSPLLKG FLDRMLVREP AQRATASELL KHPFLAKSGP PSCIVPLMRQ NRMKFTLKNK 480

EE 482

Nucleotide Sequence
(FASTA)

AAGAAGAAAA AGTCTCGCAT CGAGATCTCG GCTCCGTCCA ACTTCGAGCA CCGCGTGCAC 60

ACGGACTTCG ATGAGCAGGA GCAGAAATTT GTGGGGTTGC CGCGGCAATG GCAGTCGCTC 120

ATCGAGGACA CGGCCCAAAG GCCCAAACCT TTCATCGACG CCTCGGTCAT CACCACTGTG 180

GAGCCACGAA AGGTGAGAGT TAACAAGCAA TCCTCAAATT TCAAGTCATC TGAGGAGAAT 240

CTCGGCCCGG TTAGAGCTCA CGCTGATAGG GATGAGGGCA GCCTGAGTCG GCCCCAGCAG 300

CAGCCTCGAG GCCAGGAGCC CAGCAGGGCT CCCAAGGACA GAATTGGCTC TGGACCTCCC 360

CCTCCCCCCC ACAGAGACAG AGGACCTCGA AAGCAGATAC AAATCTCCCG GAAGACACTC 420

GCTCACGCAG AGCAGCCGAA CGGACAGCAG TCCGAATCCA TCCCTGCCTG CAAACATGAA 480

GCTCCGAGTC CGGCTGCTCT GCTCAGAGAC ACGGCTCGCT CACCACAGAG AGAGCCCCAA 540

AGGATTTCAC ACGAGCAATT CCGAGCGGCG CTACAGATGG TGGTCGATCC CGGTGACCCG 600

CGGACCTATC TGGACCATTA CATCAAGATA GGGGAGGGGT CCACGGGCAT CGTGTGCATC 660

GCCACGGTGA AGACCACTGG CAAACTGGTG GCAGTGAAAA AGATGGACCT GAAGAAGCAG 720

CAACGCAGAG AGCTTCTCTT TAACGAGGTG GTGATCATGC GGGATTACCA TCACGAGAAC 780

GTGGTGGAGA TGTACAACAG CTACCTGGTG GGAGACGAAC TCTGGGTCGT CATGGAGTTC 840

TTGGAGGGCG GAGCTCTGAC TGACATCGTG ACGCATACGA GAATGAACGA GGAGCAGATA 900

GCCACGGTGT GCGTCTCCGT CCTGAAGGCG CTGTCGGTCC TCCACTCCCA GGGCGTCATC 960

CACCGAGACA TAAAGAGCGA CTCCATCCTT CTCACTCACG ACGGTCGGGT GAAGCTGTCG 1020

GACTTTGGTT TCTGCGCTCA AGTGTCCAAA GAGGTGCAGA GACGCAAGTC TCTGGTGGGA 1080

ACGCCGTACT GGATGGCGCC CGAGCTCATC TCCAGACTGC CGTACGGACC TGAGGTGGAC 1140

ATCTGGTCTC TGGGCATCAT GGTCATAGAG ATGGTGGACG GGGAGCCGCC GTACTTCAAC 1200

GAGCCGCCGC TCAAAGCCAT GAAGATGATC CGGGACAACT CTCCTCCCAA ACTGAAGAAC 1260

CTGCACAAGG TCTCCCCGTT GCTCAAAGGC TTCCTGGACA GGATGCTGGT TCGAGAGCCG 1320

GCTCAGAGGG CCACGGCCAG CGAGCTCCTC AAACACCCCT TCCTCGCCAA GTCGGGCCCG 1380

CCGTCCTGCA TCGTCCCGCT GATGAGGCAG AACCGAATGA AGTTCACCTT AAAAAACAAA 1440

GAAGAA 1446

Domain Profile

S: 4     leeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyle  63

         + +ig+G++g v++a+ k+tg+lva+kk++l+kq++ e+l++e+ ++++++h+n+ve+++

Q: 207   YIKIGEGSTGIVCIATVKTTGKLVAVKKMDLKKQQRRELLFNEVVIMRDYHHENVVEMYN  266

         568*********************************************************

S: 64    sflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrd  123

         s+l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vlkaL+ lHs++viHrd

Q: 267   SYLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCVSVLKALSVLHSQGVIHRD  323

         *************************...9*******************************

S: 124   ikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDi  183

         ik+++iLlt++g+VkLsdfg++aq++k++++rk++vgtpywmAPE+i+  +  Y  ++Di

Q: 324   IKSDSILLTHDGRVKLSDFGFCAQVSKEVQRRKSLVGTPYWMAPELIS--RLPYGPEVDI  381

         ************************************************..9*********

S: 184   wslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpe  243

         wslGI++ie+++gepP+++++plka+ +i +n+ppklk+ +k+s+ +k f++++l ++p+

Q: 382   WSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNSPPKLKNLHKVSPLLKGFLDRMLVREPA  441

         ************************************************************

S: 244   kRpsasellkhkFl  257

         +R++asellkh+Fl

Q: 442   QRATASELLKHPFL  455

         *************7

Domain Sequence
(FASTA)

YIKIGEGSTG IVCIATVKTT GKLVAVKKMD LKKQQRRELL FNEVVIMRDY HHENVVEMYN 60

SYLVGDELWV VMEFLEGGAL TDIVTHTRMN EEQIATVCVS VLKALSVLHS QGVIHRDIKS 120

DSILLTHDGR VKLSDFGFCA QVSKEVQRRK SLVGTPYWMA PELISRLPYG PEVDIWSLGI 180

MVIEMVDGEP PYFNEPPLKA MKMIRDNSPP KLKNLHKVSP LLKGFLDRML VREPAQRATA 240

SELLKHPFL 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013