EKS-ORL-00387
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00387
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20325.13.9E-971241241
StatusUnreviewed
Ensembl ProteinENSORLP00000002478
UniProt AccessionH2L9D7;
Protein NameMitogen-activated protein kinase kinase kinase kinase
Protein Synonyms/Alias
Gene NameMAP4K1
Gene Synonyms/Alias MAP4K1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000001987ENSORLP00000002478ENSORLT00000002479
OrganismOryzias latipes
Functional Description
Protein Length854
Protein Sequence
(FASTA)
ARNKQNGDLA AIKVIKMEPE DDFSIIQQEI VIVKSCKHPN IVAYYGSYIQ SNKLWICMEF 60
CGGGSLQDIY HVTGPLSELQ IAYICREMLQ GLDYLHAQKK IHRDIKGANI LLNDQGEVKL 120
ADFGISAQIT ATLARRMSFI GTPYWMAPEV AAVEIKGGYN ELCDIWSVGI TAIELAELQP 180
PLFDVHPLRV LFLMSKSGYQ PPKLKDKSRW SSTFYNFVKA MLVRNPKKRP SASKLLSHMF 240
LTQQGLSQEV TLKLLETYRN PEKLKACVHT DDDDMEVAPL ATLKRIQSIN KHNRAERTNS 300
DMSCKEISFI PPGLSVCEKL DSSYDTFRSK NDTAVKFSRG QKAEWIKEEN KEVLQTCAKE 360
LHYLRDQGSD SDDDYDDVDI SHTMPANEIP PPLPPKPKVR TSSEESVASE EDRSNSTFFA 420
VRLTDNPADD VPPELPPKGI RRRQLPPKVR VRINSFIFSL LNNNQVRDSA LKMSFFHQDS 480
ECVSPVTKKP PVSAPHPPFQ LFFYHVFLRK VFHGCPLKIN WSTTWENPTS KEQHLILGAE 540
EGIYTLNLNG PEATMELLYP GKCTWVYTIN NVLMSVSGKS SQLHSHSLKE LHEQARKDQR 600
LVPISTHRLL PSFFFRKCVV TFKIPDTKGC KTCSVVENMH RNCVFLCCAL ESSVLLLQWY 660
EPMHKFMLIK HFDFPLPNPL RVFEMVVAPQ QEYPLVCIGV SQGPDPSRPV CVDYINLNSS 720
SSWFTNTGME KPSPEVVQVQ QLDKNSLLVL MEKSVLCVGL NGEVKNLHHL PQQTTFFHEI 780
ESIVFFEDTL LTVWRHGWQR RGKGFTEVLE ELTDPRKIYR MVKSHRTVVM ETHPVEDQSG 840
LSNLYVLEIA EKYV 854
Nucleotide Sequence
(FASTA)
GCACGAAACA AGCAGAATGG AGACCTGGCA GCCATCAAAG TTATTAAAAT GGAACCAGAG 60
GACGACTTCT CCATCATCCA GCAGGAAATA GTCATTGTAA AGAGCTGCAA GCATCCCAAC 120
ATTGTGGCAT ATTATGGCAG CTACATTCAA TCCAATAAGC TGTGGATCTG TATGGAGTTC 180
TGTGGGGGCG GATCGCTTCA GGACATCTAC CACGTCACGG GTCCTCTGTC CGAACTGCAG 240
ATAGCCTACA TTTGCAGGGA GATGCTGCAG GGCCTGGACT ACCTCCATGC ACAGAAGAAG 300
ATCCACAGAG ACATCAAGGG CGCCAACATT CTCCTTAACG ATCAGGGCGA GGTCAAGCTG 360
GCGGATTTCG GGATCTCTGC TCAGATCACA GCCACTCTGG CCCGGAGGAT GTCTTTTATT 420
GGAACGCCAT ATTGGATGGC GCCGGAGGTG GCGGCCGTGG AGATCAAAGG TGGCTACAAT 480
GAGCTGTGTG ACATCTGGTC TGTCGGCATC ACCGCCATAG AGTTGGCTGA GCTTCAGCCT 540
CCTCTGTTTG ACGTCCATCC TCTGCGAGTC CTGTTTCTCA TGTCCAAAAG CGGGTACCAG 600
CCTCCAAAAC TGAAGGACAA GTCGAGATGG TCGTCCACGT TTTACAACTT TGTGAAGGCG 660
ATGCTGGTGA GGAACCCAAA GAAGAGGCCG AGTGCCTCCA AGTTGCTCTC GCACATGTTT 720
TTGACCCAGC AGGGCCTGAG CCAAGAGGTG ACCCTCAAAC TGCTGGAGAC CTACAGAAAT 780
CCTGAGAAAC TGAAGGCCTG CGTGCATACA GATGATGACG ACATGGAGGT GGCACCTCTT 840
GCAACTTTAA AGAGGATTCA ATCTATCAAC AAACACAACC GTGCGGAGAG AACCAACTCT 900
GACATGAGCT GTAAGGAAAT CTCATTCATA CCTCCTGGTT TATCCGTCTG TGAGAAACTG 960
GATTCTTCTT ATGACACTTT TAGATCTAAA AATGATACAG CTGTGAAATT TTCACGTGGG 1020
CAAAAGGCTG AGTGGATCAA GGAAGAAAAT AAAGAAGTGT TGCAGACCTG TGCAAAGGAG 1080
CTACATTATT TGCGGGATCA GGGATCAGAT TCAGATGACG ACTACGACGA TGTGGACATC 1140
AGTCACACAA TGCCAGCCAA TGAAATTCCA CCCCCACTTC CTCCAAAGCC CAAAGTGCGG 1200
ACCAGCTCAG AGGAAAGCGT GGCAAGTGAA GAGGATCGGT CAAATTCTAC TTTCTTTGCA 1260
GTTCGGCTGA CAGACAACCC AGCAGATGAC GTCCCACCTG AACTCCCCCC TAAAGGCATC 1320
CGCAGACGGC AACTGCCGCC AAAGGTAAGA GTGAGGATCA ACAGTTTTAT TTTTAGTTTG 1380
TTGAATAATA ACCAAGTTAG GGACTCTGCT TTAAAAATGT CCTTCTTCCA TCAGGACTCT 1440
GAGTGTGTCA GCCCCGTCAC AAAGAAACCT CCTGTGAGTG CCCCCCACCC CCCGTTTCAG 1500
CTGTTTTTCT ATCATGTCTT TTTGAGAAAG GTCTTCCATG GCTGCCCTCT AAAAATAAAT 1560
TGGTCCACAA CCTGGGAAAA CCCCACCTCC AAAGAACAGC ATCTGATCCT GGGGGCCGAA 1620
GAAGGAATCT ACACCCTGAA CCTGAACGGC CCTGAGGCCA CGATGGAGCT GCTTTATCCT 1680
GGGAAATGCA CCTGGGTTTA CACCATTAAT AACGTCCTCA TGTCTGTATC AGGTAAATCG 1740
TCGCAGCTTC ATTCTCACTC GCTGAAGGAG TTACACGAAC AGGCTCGGAA AGACCAGAGG 1800
TTGGTCCCCA TATCCACCCA CAGACTTCTA CCAAGTTTCT TTTTTAGAAA ATGTGTTGTC 1860
ACTTTTAAAA TACCCGACAC CAAAGGCTGC AAGACCTGTT CTGTTGTGGA GAACATGCAT 1920
CGAAACTGCG TGTTCCTGTG CTGCGCCCTG GAGTCCAGTG TGTTGCTGTT GCAGTGGTAC 1980
GAGCCCATGC ACAAATTCAT GCTAATCAAG CATTTTGACT TCCCCCTGCC CAACCCTCTG 2040
CGGGTGTTTG AGATGGTGGT GGCGCCGCAG CAGGAGTACC CTCTGGTGTG CATCGGCGTA 2100
TCACAGGGAC CAGACCCCAG CCGACCCGTC TGCGTAGATT ACATCAACCT GAACTCCAGC 2160
TCGTCCTGGT TCACCAACAC TGGCATGGAG AAACCCAGCC CAGAAGTAGT TCAAGTTCAA 2220
CAGCTGGACA AAAACTCTCT GCTTGTGCTC ATGGAAAAGT CGGTCCTTTG TGTTGGTCTG 2280
AACGGAGAGG TGAAGAACCT CCATCATCTT CCTCAGCAGA CCACTTTCTT CCATGAGATT 2340
GAATCTATAG TGTTTTTTGA AGACACCCTC CTGACAGTTT GGCGCCATGG TTGGCAGAGG 2400
AGAGGAAAAG GTTTCACGGA GGTGCTGGAG GAATTGACTG ACCCCCGAAA AATCTACAGA 2460
ATGGTGAAGT CCCACAGGAC CGTCGTCATG GAAACCCATC CAGTAGAGGA CCAATCAGGT 2520
CTGTCCAACC TGTACGTCCT GGAAATCGCT GAGAAGTATG TG 2562
Domain Profile
S: 18    arekktgelvaikkinlekqekleelqkeisvlkklkhpniveylesflkeeelwlvmey  77
         ar+k++g+l+aik+i++e +++ + +q+ei ++k++khpniv+y++s++++++lw++me+
Q: 1     ARNKQNGDLAAIKVIKMEPEDDFSIIQQEIVIVKSCKHPNIVAYYGSYIQSNKLWICMEF  60
         7899********************************************************
S: 78    lagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdikakniLlteegeV  137
         + gGsl+d+++  ++ +l+E qiayi+re+l++L+ylH++k+iHrdik++niLl+++geV
Q: 61    CGGGSLQDIYH--VTGPLSELQIAYICREMLQGLDYLHAQKKIHRDIKGANILLNDQGEV  118
         ***********..***********************************************
S: 138   kLsdfgvaaqlektrkkrktvvgtpywmAPEviaqe.ekgYdekaDiwslGItaielaeg  196
         kL+dfg++aq+++t ++r +++gtpywmAPEv a+e + gY+e +Diws+GItaielae 
Q: 119   KLADFGISAQITATLARRMSFIGTPYWMAPEVAAVEiKGGYNELCDIWSVGITAIELAEL  178
         ************************************999*********************
S: 197   epPfkdleplkallkilkne..ppklkskkkfskefkefvekclqknpekRpsasellkh  254
         +pP++d++pl++l++++k+   ppklk+k+++s++f +fv+++l +np+kRpsas+ll+h
Q: 179   QPPLFDVHPLRVLFLMSKSGyqPPKLKDKSRWSSTFYNFVKAMLVRNPKKRPSASKLLSH  238
         ******************98889*************************************
S: 255   kFl  257
          Fl
Q: 239   MFL  241
         *97
Domain Sequence
(FASTA)
ARNKQNGDLA AIKVIKMEPE DDFSIIQQEI VIVKSCKHPN IVAYYGSYIQ SNKLWICMEF 60
CGGGSLQDIY HVTGPLSELQ IAYICREMLQ GLDYLHAQKK IHRDIKGANI LLNDQGEVKL 120
ADFGISAQIT ATLARRMSFI GTPYWMAPEV AAVEIKGGYN ELCDIWSVGI TAIELAELQP 180
PLFDVHPLRV LFLMSKSGYQ PPKLKDKSRW SSTFYNFVKA MLVRNPKKRP SASKLLSHMF 240
L 241
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-GAA-00394
EKS-ICT-00303
EKS-ORN-00413
EKS-OTG-00330
EKS-SUS-00281
EKS-TAR-00417
EKS-TEN-00420
EKS-XIM-00401
Gene Ontology
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0005083; F:small GTPase regulator activity
KEGG
InterPros
IPR001180; Citron.
IPR011009; Kinase-like_dom.
IPR021160; MAPKKKK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF00780; CNH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00036; CNH; 1.
SM00220; S_TKc; 1.
Prosites
PS50219; CNH; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
Prints
Created Date20-Feb-2013