EKS-ORL-00180

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00180

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	360.3	8.5E-108	64	325	262

Status

Unreviewed

Ensembl Protein

ENSORLP00000002818

UniProt Accession

H2LAB1;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB2

Gene Synonyms/Alias

RPS6KB2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000002272	ENSORLP00000002818	ENSORLT00000002819

Organism

Oryzias latipes

Functional Description

Protein Length

444

Protein Sequence
(FASTA)

MAGVFDIDLE TEDVSDTEVN RVKALNSQSD QAIIFVLNIN KTEEVELTSE IVNRDSERVG 60

PDCFELLTVL GKGAYGKVFQ VRKVQGLQIG KIFAMKVLKK AKIVRNAKDT AHTRAEREIL 120

ETVRHPFIVD LLYAFQTGGK LYLILECLSG GELFMQLEKE GIFMEDTACF YLGEITLALG 180

HLHSNGIIYR DLKPENIMLN HQGHIKLTDF GLCKESIHDG SVTHTFCGTI EYMAPEILTR 240

SGHNRAVDWW SLGALMYDMM TGSPPFTAEN RKKTIDKILK CKLNLPPYLT IDARELIKKL 300

LKKNPAQRLG SGKADAADIQ KHSFFKQINW DDLLNKRVEP PYKPQLHSEE DVSQFDTRFT 360

RQTPVDSPDD SRLSHSAELA FAGFTYVAPS VLESLKEGFS FEPKSRHMRR HNSSPHTPIS 420

PLKFSPAGPF KAALDGEPDL FSPT 444

Nucleotide Sequence
(FASTA)

ATGGCTGGGG TGTTCGACAT CGACTTGGAG ACGGAGGACG TCAGCGACAC AGAGGTTAAT 60

AGAGTAAAGG CTTTGAACAG CCAATCAGAT CAGGCGATTA TTTTTGTCTT AAATATAAAT 120

AAGACGGAGG AGGTGGAGCT GACCAGCGAG ATCGTGAACA GGGACAGCGA GAGAGTTGGA 180

CCGGACTGCT TTGAGCTCCT AACGGTTCTG GGAAAGGGAG CCTACGGCAA GGTCTTCCAG 240

GTGAGGAAGG TTCAAGGTCT TCAGATTGGG AAGATATTCG CCATGAAGGT CCTAAAAAAG 300

GCTAAGATAG TGCGAAACGC CAAAGACACA GCCCACACGC GAGCGGAGCG GGAGATCCTG 360

GAAACGGTGC GGCACCCCTT CATCGTGGAC CTGCTGTACG CTTTCCAGAC CGGAGGAAAG 420

CTCTACCTCA TCCTGGAGTG TCTGAGCGGA GGAGAACTGT TCATGCAGCT AGAGAAGGAA 480

GGCATCTTCA TGGAGGACAC GGCCTGCTTT TATCTGGGTG AGATCACTCT GGCTCTGGGT 540

CACCTTCACT CCAACGGGAT CATCTATCGA GACCTAAAAC CAGAAAACAT CATGCTCAAC 600

CACCAAGGAC ACATCAAGCT GACGGACTTC GGTCTCTGCA AGGAGTCGAT TCATGACGGA 660

TCCGTCACGC ACACCTTCTG CGGCACCATC GAGTACATGG CTCCAGAGAT CCTAACCCGC 720

TCAGGTCACA ACAGAGCCGT GGACTGGTGG AGCCTCGGCG CCCTCATGTA TGACATGATG 780

ACGGGATCGC CTCCGTTCAC GGCTGAAAAC AGGAAAAAGA CCATCGATAA GATCTTAAAG 840

TGTAAGCTCA ATCTGCCTCC GTACCTGACT ATCGATGCCA GGGAGCTCAT CAAGAAGCTG 900

CTGAAGAAGA ATCCAGCCCA AAGACTCGGC TCTGGCAAGG CAGACGCTGC AGACATTCAG 960

AAACATTCCT TCTTCAAGCA AATCAACTGG GACGACCTGC TGAACAAGAG AGTGGAGCCT 1020

CCATACAAAC CCCAGCTGCA TTCAGAGGAG GATGTGAGCC AGTTTGATAC CCGCTTCACT 1080

CGGCAGACGC CGGTGGACAG TCCGGACGAC TCCAGGCTCA GCCACAGCGC AGAGCTCGCC 1140

TTCGCTGGCT TCACTTACGT GGCTCCGTCG GTCCTGGAAA GCCTGAAAGA AGGCTTCTCC 1200

TTCGAGCCCA AATCCCGTCA CATGCGCCGG CACAACAGCA GTCCTCACAC ACCCATCAGT 1260

CCTCTGAAAT TCTCCCCCGC CGGACCCTTC AAGGCCGCCC TGGACGGAGA GCCGGATCTA 1320

TTCTCGCCAA CC 1332

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkGaygkvf+vrkv++ + gk++a+Kvlkka++v+  k++++t++ereiLe+v

Q: 64    FELLTVLGKGAYGKVFQVRKVQGLQIGKIFAMKVLKKAKIVRnaKDTAHTRAEREILETV  123

         89***************************************999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+k+++f+e++a+f+l e++lal +lH

Q: 124   RHPFIVDLLYAFQTGGKLYLILECLSGGELFMQLEKEGIFMEDTACFYLGEITLALGHLH  183

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         s+g++yrDLkpeNi+l+++gh+kltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 184   SNGIIYRDLKPENIMLNHQGHIKLTDFGLCKESI-HDGSVTHTFCGTIEYMAPEILTRSG  242

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+m+tG++Pft+e+rk+t+++ilk+k  l+lp +  l+ +a++l+k

Q: 243   HNRAVDWWSLGALMYDMMTGSPPFTAENRKKTIDKILKCK--LNLPPY--LTIDARELIK  298

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLkk+pa+Rlg+   +a++i++h+f+

Q: 299   KLLKKNPAQRLGSgkaDAADIQKHSFF  325

         ************99999********97

Domain Sequence
(FASTA)

FELLTVLGKG AYGKVFQVRK VQGLQIGKIF AMKVLKKAKI VRNAKDTAHT RAEREILETV 60

RHPFIVDLLY AFQTGGKLYL ILECLSGGEL FMQLEKEGIF MEDTACFYLG EITLALGHLH 120

SNGIIYRDLK PENIMLNHQG HIKLTDFGLC KESIHDGSVT HTFCGTIEYM APEILTRSGH 180

NRAVDWWSLG ALMYDMMTGS PPFTAENRKK TIDKILKCKL NLPPYLTIDA RELIKKLLKK 240

NPAQRLGSGK ADAADIQKHS FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Dipodomys ordii"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013