EKS-ORL-00440

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00440

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	429.8	3.7E-129	188	438	251

Status

Unreviewed

Ensembl Protein

ENSORLP00000002943

UniProt Accession

H2LAN1;

Protein Name

Protein Synonyms/Alias

Gene Name

HCK

Gene Synonyms/Alias

HCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000002368	ENSORLP00000002943	ENSORLT00000002944

Organism

Oryzias latipes

Functional Description

Protein Length

453

Protein Sequence
(FASTA)

FLTALGESVA IALYDYEAIH EGDLGFKKGD RLKILEESGE WWKAKSISSG QEGFIPSNYV 60

AKDTLETEDW FFKGVSRKDA ERQLLASGNK TGSFMIRDSE TTRGSYSLSV RDHDPQAGDT 120

VKHYKIRTLD NGGFYISPRI TFRTLQELVS HYKKQGDGLC QSLTSPCLSP KPEKPWEKDA 180

WEIPRSSLKL EKKLGAGQFG EVWMATYNKH TKVAVKTMKP GSMSVEAFMM EANLMKRLQH 240

DKLVRLNAVV TKEEPIYIIT EFMEKGSLLD FLKSDEGNRV QLPKLIDFSA QIAEGMAYIE 300

QNNYIHRDLR AANILVNKAL VCKIADFGLA RIIEDNEYTA REGAKFPIKW TAPEAINYGS 360

FTIKSDVWSF GILLTEIISY GRTPYPGMTN PEVIRSLEKG YRMQRLESCP TELYDIMLDC 420

WKNKAEERPT FDYLQSILED FFTATESQYQ QQP 453

Nucleotide Sequence
(FASTA)

TTTTTGACCG CTTTAGGGGA GAGTGTTGCC ATCGCATTGT ATGACTATGA AGCCATTCAC 60

GAGGGAGACC TGGGCTTCAA AAAGGGCGAC AGGCTTAAAA TTTTGGAAGA ATCAGGCGAA 120

TGGTGGAAAG CCAAGTCCAT CAGCTCAGGC CAGGAAGGCT TCATCCCCAG CAATTATGTC 180

GCAAAAGACA CTCTAGAGAC AGAGGATTGG TTTTTTAAAG GGGTAAGTCG GAAAGATGCT 240

GAGAGGCAGT TGCTGGCCTC TGGGAACAAA ACAGGCTCCT TCATGATCCG AGACAGCGAG 300

ACCACAAGAG GAAGCTACTC CCTTTCAGTG AGAGACCACG ATCCCCAAGC CGGTGACACA 360

GTTAAACATT ATAAGATCAG AACGCTGGAC AATGGAGGGT TCTACATCTC ACCCCGCATC 420

ACATTTAGAA CCCTGCAAGA ACTGGTCAGC CATTACAAGA AGCAAGGAGA TGGCCTCTGT 480

CAATCCCTGA CCTCCCCATG TCTGAGCCCC AAACCTGAGA AGCCCTGGGA GAAAGATGCA 540

TGGGAAATCC CACGATCATC ACTTAAACTG GAGAAAAAGC TTGGTGCTGG ACAGTTTGGA 600

GAAGTCTGGA TGGCCACTTA TAATAAGCAC ACCAAGGTAG CAGTGAAAAC CATGAAGCCT 660

GGCAGCATGT CCGTGGAAGC CTTCATGATG GAAGCCAATC TGATGAAGAG ACTGCAGCAC 720

GATAAACTGG TTCGACTTAA CGCCGTGGTC ACAAAGGAGG AGCCCATCTA CATCATCACT 780

GAATTCATGG AAAAAGGCAG TCTGCTGGAC TTCTTGAAAA GTGATGAAGG GAACCGTGTT 840

CAGCTTCCAA AGCTCATCGA CTTCTCTGCT CAGATTGCAG AGGGAATGGC TTACATTGAG 900

CAGAATAACT ACATTCACAG AGACCTGCGA GCAGCCAACA TTCTGGTCAA CAAGGCTTTA 960

GTTTGCAAGA TTGCAGACTT TGGATTAGCT CGTATCATTG AGGATAACGA GTACACAGCT 1020

CGAGAAGGAG CCAAATTCCC CATCAAATGG ACAGCACCAG AAGCCATTAA CTACGGGTCT 1080

TTCACTATTA AATCTGATGT CTGGTCTTTC GGTATTCTGC TGACGGAGAT CATCAGCTAT 1140

GGACGCACTC CATACCCTGG GATGACCAAC CCAGAAGTGA TCCGCTCCCT GGAGAAAGGC 1200

TACCGAATGC AGCGCTTGGA GAGCTGTCCT ACCGAACTCT ATGACATAAT GTTGGATTGC 1260

TGGAAGAATA AAGCAGAGGA GCGCCCCACC TTTGACTACC TGCAGAGCAT TCTGGAAGAT 1320

TTCTTCACAG CCACTGAGAG CCAGTATCAG CAGCAGCCTT GA 1362

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s eaf+ ea+++k+l+h+klv+l

Q: 188   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFMMEANLMKRLQHDKLVRLN  247

         689*********************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avv++eePiyi+te+m+kGslldflk++eg++++lpkl+d++aq+aeGmay+e++n+ihr

Q: 248   AVVTKEEPIYIITEFMEKGSLLDFLKSDEGNRVQLPKLIDFSAQIAEGMAYIEQNNYIHR  307

         ************************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lv++ lv+k+adfGlar+ied+eyta+egak+PikWtaPeai++g+ftiksdv

Q: 308   DLRAANILVNKALVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINYGSFTIKSDV  367

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGilltei+++G++PypGmtn ev++++e+gyr+ r e+cp+ely+++l cwk+++ee

Q: 368   WSFGILLTEIISYGRTPYPGMTNPEVIRSLEKGYRMQRLESCPTELYDIMLDCWKNKAEE  427

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtf++lq++l

Q: 428   RPTFDYLQSIL  438

         *******9875

Domain Sequence
(FASTA)

LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVEA FMMEANLMKR LQHDKLVRLN 60

AVVTKEEPIY IITEFMEKGS LLDFLKSDEG NRVQLPKLID FSAQIAEGMA YIEQNNYIHR 120

DLRAANILVN KALVCKIADF GLARIIEDNE YTAREGAKFP IKWTAPEAIN YGSFTIKSDV 180

WSFGILLTEI ISYGRTPYPG MTNPEVIRSL EKGYRMQRLE SCPTELYDIM LDCWKNKAEE 240

RPTFDYLQSI L 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013