EKS-ORL-00356
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00356
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR499.22.7E-150566822257
StatusUnreviewed
Ensembl ProteinENSORLP00000002975
UniProt AccessionH2LAR3;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4 (1 of 2)
Gene Synonyms/Alias ERBB4 (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000002392ENSORLP00000002975ENSORLT00000002976
OrganismOryzias latipes
Functional Description
Protein Length948
Protein Sequence
(FASTA)
EILNGGVYVD QNKFLCHADT IHWQDVIKNP QAELLVVPSN NSNNGCRRCH RSCNGRCWGH 60
QEDQCQTLTK TVCAEQCDGR CFGPYVSDCC HRECAGGCFG PKDTDCFACT NFNDSGACVT 120
QCPQPFVYNP TSFQLEHNPR AKYTYGAFCV RECPHNFVVD HSSCVRACPS NKMEVEENRI 180
KMCIPCTDIC PKVCDGIGTG SLQTAQTVDA SNIDKFVNCT KINGNLIFLI TGIKGDMYHG 240
IGPLDPERLN VFRTVKEITG FLNIQSWPEN MTDLSVFSNL VTIGGRSLYS GSGISLLILK 300
QRRISSFQFQ SLNEISAGNV YIFNNSRLCF YNTINWTSLF RTPSQKVLIR NNREPMQQMI 360
CDRMCSEDGC WGPGPDQCLS CRYFKRGRTC VESCNLFNGE VREFANGSVC LECDSQCEKM 420
DGNSLTCLGQ GPDQCVKCLN FKDGPNCVEK CPDGLQGANS FIFKYAKANN ECHPCHVNCT 480
QGCIGPRIQD CVGMMDRTPL IAAGIIGGLF IIVIVALTVA IYARRKSIKK KRALRRFLET 540
ELVEPLTPSG TAPNQAQLRI LKETELKRVK ILGSGAFGTV YKGIWVPEGE TVKIPVAIKI 600
LNEATGPKAN VEFMDEALIM ASVEHPHLVR LLGVCLSPTI QLVTQLMPHG CLLDYVHEHK 660
DNIGSQLLLN WCVQIAKGMM YLEERRLVHR DLAARNVLVK SPNHIKITDF GLARLLDADE 720
KEYNADGGKM PIKWMALECI HYRKFTHQSD VWSYGVTIWE LMTFGGKPYD GIPTREIPDI 780
LEKGERLPQP PICTIDVYMV MVKCWMIDAD SRPKFKELAA EFCRMARDPQ RYLVIQGDDR 840
MKLPSPNDSK FFKSLLDEED LDDLMDAEEY LVPRGFNAAS TSSTRPRVDS NKGWSHLLKR 900
EDSGAQRYSA DPTIFLGERA TRGDTDEDGY MTPMKDKSSS GTSIIFPN 948
Nucleotide Sequence
(FASTA)
GAGATTCTCA ATGGCGGTGT TTATGTCGAC CAGAACAAAT TCCTATGTCA CGCCGACACC 60
ATACATTGGC AGGACGTGAT CAAGAACCCC CAGGCAGAGC TTCTGGTGGT CCCATCCAAC 120
AATAGCAACA ATGGATGCAG ACGATGCCAT CGTTCATGTA ACGGACGCTG CTGGGGCCAT 180
CAGGAGGACC AATGTCAAAC CTTGACAAAA ACGGTGTGTG CAGAGCAGTG TGACGGTCGA 240
TGCTTCGGGC CTTACGTCAG CGACTGCTGC CATCGCGAAT GTGCTGGTGG CTGCTTCGGT 300
CCCAAGGACA CGGACTGCTT TGCTTGCACC AATTTCAACG ACTCTGGCGC GTGCGTGACC 360
CAGTGCCCTC AACCGTTTGT GTACAACCCT ACATCTTTCC AGCTCGAGCA CAACCCCCGA 420
GCCAAGTACA CCTACGGAGC CTTCTGTGTC AGGGAATGCC CCCACAACTT TGTGGTGGAC 480
CACAGCTCCT GTGTTAGGGC ATGTCCAAGC AACAAGATGG AAGTGGAGGA GAACAGAATC 540
AAAATGTGTA TCCCTTGTAC TGATATCTGT CCTAAAGTGT GTGATGGGAT TGGGACCGGC 600
AGCCTGCAGA CAGCTCAAAC AGTGGACGCC AGCAACATTG ATAAATTTGT GAACTGCACA 660
AAAATCAACG GCAACCTCAT CTTTCTCATC ACTGGCATTA AAGGCGACAT GTATCATGGC 720
ATTGGACCTT TGGATCCTGA GCGTCTCAAC GTTTTTCGTA CAGTGAAGGA GATTACAGGA 780
TTCCTTAACA TCCAGTCTTG GCCTGAAAAC ATGACAGACC TGAGTGTTTT TTCCAACCTG 840
GTAACAATTG GAGGCAGAAG TCTCTACAGT GGAAGTGGTA TATCTCTTCT GATCCTGAAA 900
CAGCGCCGGA TCTCCTCTTT CCAGTTCCAG TCGTTGAATG AGATCAGCGC CGGTAACGTC 960
TACATCTTCA ACAACAGCCG CTTGTGTTTT TACAACACCA TCAACTGGAC GTCACTATTC 1020
AGGACGCCAT CCCAGAAAGT CCTCATCCGC AACAACAGAG AACCAATGCA GCAGATGATA 1080
TGCGATCGAA TGTGTTCGGA AGATGGTTGC TGGGGGCCCG GACCCGACCA GTGTCTCTCC 1140
TGTCGGTATT TCAAACGCGG ACGCACCTGT GTTGAGTCCT GCAACCTCTT CAATGGGGAA 1200
GTGCGAGAGT TTGCCAATGG TTCTGTGTGC CTGGAGTGCG ACAGTCAGTG TGAGAAAATG 1260
GATGGGAACA GCTTGACATG TCTTGGACAG GGCCCAGACC AATGCGTGAA ATGCCTCAAT 1320
TTCAAAGACG GGCCCAACTG CGTGGAGAAG TGCCCTGACG GGTTGCAGGG CGCCAACAGT 1380
TTCATCTTCA AATACGCCAA GGCCAACAAC GAATGCCATC CCTGCCATGT CAACTGCACC 1440
CAGGGGTGCA TCGGGCCAAG AATTCAGGAT TGTGTTGGGA TGATGGACAG GACTCCTCTT 1500
ATTGCAGCAG GAATCATTGG AGGATTGTTT ATCATTGTTA TTGTGGCACT CACTGTGGCG 1560
ATTTATGCAC GCCGCAAAAG CATCAAGAAG AAGAGGGCAT TGCGACGCTT CCTGGAAACA 1620
GAGCTGGTGG AGCCCCTGAC CCCAAGTGGA ACCGCCCCCA ACCAAGCTCA GCTGCGCATC 1680
CTCAAAGAGA CAGAGCTCAA GAGGGTCAAG ATTCTTGGTT CGGGAGCTTT TGGAACAGTC 1740
TACAAGGGCA TCTGGGTCCC CGAAGGTGAA ACAGTGAAGA TCCCCGTTGC CATTAAAATC 1800
CTCAACGAGG CCACCGGCCC AAAAGCCAAT GTGGAGTTCA TGGACGAGGC CTTGATCATG 1860
GCCAGCGTGG AGCATCCTCA TTTGGTGCGT CTGCTGGGCG TCTGCCTGAG CCCTACCATC 1920
CAATTGGTCA CCCAGCTGAT GCCCCACGGC TGCCTCCTGG ACTACGTGCA CGAGCACAAG 1980
GATAACATCG GCTCACAGCT TCTGCTCAAC TGGTGTGTCC AAATAGCCAA GGGGATGATG 2040
TACCTGGAGG AGAGGAGATT GGTCCACAGG GACCTGGCAG CTCGGAACGT GCTGGTGAAG 2100
TCCCCCAATC ACATTAAGAT CACAGACTTT GGCCTGGCGC GCCTGCTGGA CGCCGACGAG 2160
AAAGAGTACA ACGCAGACGG CGGCAAGATG CCTATTAAGT GGATGGCTCT AGAGTGCATC 2220
CACTACAGGA AGTTCACCCA TCAGAGTGAC GTCTGGAGCT ACGGAGTGAC CATCTGGGAG 2280
CTGATGACGT TCGGAGGCAA ACCGTACGAC GGCATCCCCA CAAGAGAAAT ACCCGACATC 2340
CTGGAGAAAG GGGAGCGCTT GCCCCAGCCG CCCATATGCA CAATCGACGT CTACATGGTC 2400
ATGGTCAAAT GTTGGATGAT TGATGCAGAC AGCAGACCGA AGTTCAAGGA GCTAGCTGCT 2460
GAGTTCTGCA GAATGGCGCG TGACCCCCAG CGATACCTGG TCATCCAGGG AGATGATCGG 2520
ATGAAGCTTC CCAGTCCCAA TGACAGCAAG TTTTTCAAAA GCCTACTAGA CGAAGAGGAC 2580
CTTGATGACC TGATGGATGC TGAGGAGTAT CTGGTTCCCA GAGGTTTCAA CGCAGCTTCG 2640
ACGTCTTCAA CTAGGCCGCG AGTGGATTCC AATAAAGGTT GGTCACATTT ATTGAAAAGA 2700
GAGGACAGCG GGGCCCAAAG ATACAGTGCT GACCCTACCA TCTTCCTGGG GGAGAGAGCA 2760
ACCAGAGGAG ACACAGATGA GGATGGTTAC ATGACCCCAA TGAAGGACAA GAGCTCCTCA 2820
GGTACTTCAA TCATATTTCC AAAC 2844
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++k+lGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as++h
Q: 566   LKRVKILGSGAFGTVYKGIWVPEGETVKIPVAIKILNEATGPKANVEFMDEALIMASVEH  625
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 626   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  685
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnh+kitdfGla+ll+adeke++a+ggk+pikw+ale+i++rk+
Q: 686   RLVHRDLAARNVLVKSPNHIKITDFGLARLLDADEKEYNADGGKMPIKWMALECIHYRKF  745
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipd+lekGerl+qppictidvymv+vkcw
Q: 746   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDILEKGERLPQPPICTIDVYMVMVKCW  805
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mida+srpkfkela+ef
Q: 806   MIDADSRPKFKELAAEF  822
         ***************99
Domain Sequence
(FASTA)
LKRVKILGSG AFGTVYKGIW VPEGETVKIP VAIKILNEAT GPKANVEFMD EALIMASVEH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHI KITDFGLARL LDADEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDILEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Equus caballus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAE-00255
EKS-CAJ-00303
EKS-CAF-00303
EKS-DAR-00650
EKS-EQC-00288
EKS-GAG-00250
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-MAM-00300
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-ORN-00385
EKS-ORA-00263
EKS-ORC-00279
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-RAN-00313
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00388
EKS-TEN-00384
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 1.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013