EKS-ORL-00323

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00323

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	444.7	2.3E-133	113	433	321

Status

Unreviewed

Ensembl Protein

ENSORLP00000004246

UniProt Accession

H2LE79;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1B

Gene Synonyms/Alias

DYRK1B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000003415	ENSORLP00000004246	ENSORLT00000004247

Organism

Oryzias latipes

Functional Description

Protein Length

621

Protein Sequence
(FASTA)

MTSQHTHTHP SFSSIHSMAE QQQVLSDMTI LQRRIPPSFR DPASAPLRKL SVDLIKTYKH 60

INEVYYTKKK RRAQQVPPED SSTKKERKVY NDGYDDDNYD YIVKNGEKWL DRYEIDSLIG 120

KGSFGQVVKA YDHHEQEWVA IKIIKNKKAF LNQAQIELRL LELMNKHDTE MKYYIVHLKR 180

HFMFRNHLCL VFELLSYNLY DLLRNTNFRG VSLNLTRKFA QQLCTALLFL ATPELSIIHC 240

DLKPENILLC NPKRSAIKIV DFGSSCQLGQ RIYQYIQSRF YRSPEVLLGM PYDLAIDMWS 300

LGCILVEMHT GEPLFSGSNE VDQMNKIVEV LGVPPSHMLD AAPKARKYFD KLSDGLWTVK 360

KNKDVKKEYK PPATRRLHEI LGVETGGPGG RRAGEPGHAP CDYLKFKDLI LRMLDYDPKS 420

RITPFYALQH NFFKKTTDEG TNTSSSTSTS PAMDHSHSTS TTSSVSSSGG SSGSSNDNRN 480

YRYSNRYYNS AVTLSDYEMT SPQAPSQQQM RMWSGSDSGG QDPAYTQLLL HKPAATQQHQ 540

RHFLDPPHHP HPTYSHHGNS GRGLRQGGQG SSPQMSDSMD VGVSLGLHHL GAVSSMEGSQ 600

FGSASLPLAL PIGLSAFRTR T 621

Nucleotide Sequence
(FASTA)

ATGACCAGCC AGCACACTCA TACTCACCCC TCCTTCAGCT CCATCCACTC CATGGCCGAG 60

CAGCAGCAGG TGCTGTCTGA CATGACCATA CTTCAGAGGA GGATCCCCCC TAGTTTTAGA 120

GACCCTGCCA GCGCCCCCTT GAGGAAGCTC TCTGTAGACC TCATCAAAAC TTACAAGCAC 180

ATCAATGAGG TGTACTATAC CAAGAAGAAG CGGCGGGCAC AGCAGGTTCC TCCTGAAGAC 240

AGCAGCACGA AGAAGGAGAG GAAAGTTTAC AATGACGGCT ACGATGATGA CAACTATGAT 300

TACATCGTAA AGAACGGAGA GAAGTGGCTG GACCGCTATG AGATTGACTC TCTGATTGGG 360

AAGGGCTCCT TTGGACAGGT GGTGAAGGCC TACGACCACC ATGAGCAGGA GTGGGTGGCC 420

ATCAAGATCA TCAAGAACAA GAAAGCCTTC CTGAATCAGG CTCAGATTGA GCTGCGTCTG 480

CTGGAGCTGA TGAATAAGCA TGACACGGAG ATGAAGTATT ACATCGTCCA CCTGAAGCGT 540

CACTTTATGT TTAGGAACCA TCTCTGCTTG GTGTTTGAGT TGTTGAGCTA CAACCTGTAC 600

GACCTGCTGA GGAACACCAA CTTCAGAGGA GTCTCCCTCA ACCTCACTAG GAAGTTTGCA 660

CAGCAGCTCT GCACAGCATT GTTATTCCTG GCCACTCCAG AGCTGTCAAT CATTCACTGC 720

GACCTGAAAC CAGAGAACAT CCTGCTGTGT AACCCCAAAA GATCTGCCAT TAAGATCGTG 780

GACTTTGGAT CATCCTGCCA GCTGGGACAG AGGATTTACC AGTACATTCA GAGCAGGTTC 840

TACCGTTCTC CAGAGGTTCT TCTGGGAATG CCATACGACC TGGCCATTGA CATGTGGTCT 900

CTAGGATGTA TCCTGGTTGA AATGCACACA GGGGAGCCTC TCTTCAGCGG CTCCAATGAG 960

GTGGACCAGA TGAATAAAAT TGTAGAAGTT CTGGGAGTTC CACCTAGCCA CATGCTGGAT 1020

GCAGCTCCTA AAGCCAGGAA GTACTTTGAC AAGCTGTCAG ACGGACTGTG GACTGTGAAG 1080

AAGAACAAGG ATGTGAAGAA GGAGTATAAG CCCCCAGCCA CACGCCGCCT CCACGAGATA 1140

TTGGGTGTAG AGACTGGGGG TCCAGGAGGC CGGCGGGCCG GAGAGCCGGG ACACGCCCCC 1200

TGCGACTACC TGAAGTTCAA AGATTTGATC CTCCGCATGC TGGACTACGA CCCCAAGAGT 1260

CGCATCACGC CCTTCTACGC CCTGCAGCAC AACTTCTTCA AAAAGACCAC TGATGAGGGA 1320

ACCAACACCA GCTCATCCAC CTCAACCTCC CCTGCCATGG ACCACTCCCA CTCCACCTCC 1380

ACTACAAGCT CTGTGTCCAG CTCTGGTGGA TCAAGCGGTT CTTCCAACGA CAACCGTAAC 1440

TACCGGTACA GCAACCGCTA TTACAACTCT GCTGTGACCC TGTCTGACTA CGAGATGACC 1500

AGTCCACAGG CGCCCTCGCA ACAGCAGATG AGAATGTGGT CTGGCAGTGA CAGTGGGGGT 1560

CAGGATCCAG CATACACCCA ACTGCTCCTC CACAAGCCAG CCGCTACCCA GCAGCACCAG 1620

CGCCACTTCT TGGACCCGCC GCACCACCCC CACCCCACCT ACTCGCACCA CGGAAACAGC 1680

GGGCGGGGAC TGAGGCAGGG TGGGCAGGGA TCCTCACCCC AAATGAGTGA CAGCATGGAT 1740

GTGGGCGTGT CCCTTGGGCT GCATCACCTG GGGGCGGTGT CTTCCATGGA GGGGTCTCAG 1800

TTTGGCTCCG CCTCCCTTCC CCTCGCTCTG CCCATCGGAC TCTCCGCCTT CCGGACTCGG 1860

ACA 1863

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d++++e+vaikiiknkk+f++qaq+E+++Le +nk+d+e+k

Q: 113   YEIDSLIGKGSFGQVVKAYDHHEQEWVAIKIIKNKKAFLNQAQIELRLLELMNKHDTEMK  172

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfells+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 173   YYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLAt  232

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 233   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  291

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++l++a ka+k+f+k

Q: 292   YDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNKIVEVLGVPPSHMLDAAPKARKYFDK  351

         ************************************************************

S: 239   keapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.f  288

          ++  +++k++          ++r+ +++l+v++ +     p+ +++ge+ +   d+l f

Q: 352   LSDGLWTVKKNkdvkkeykpPATRRLHEILGVETGG-----PGGRRAGEPGHAPCDYLkF  406

         ********9986766666555555666666665555.....999**********99999*

S: 289   kdllkrmleldpakRitpkealkhpfv  315

         kdl+ rml++dp++Ritp +al+h+f+

Q: 407   KDLILRMLDYDPKSRITPFYALQHNFF  433

         **************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD HHEQEWVAIK IIKNKKAFLN QAQIELRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTNFRGVS LNLTRKFAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMNKIVEVLG VPPSHMLDAA PKARKYFDKL 240

SDGLWTVKKN KDVKKEYKPP ATRRLHEILG VETGGPGGRR AGEPGHAPCD YLKFKDLILR 300

MLDYDPKSRI TPFYALQHNF F 321

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Oreochromis niloticus"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013