EKS-ORL-00076

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00076

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.5	3.1E-111	645	937	293

Status

Unreviewed

Ensembl Protein

ENSORLP00000004297

UniProt Accession

H2LEC8;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK12

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000003457	ENSORLP00000004297	ENSORLT00000004298

Organism

Oryzias latipes

Functional Description

Protein Length

1219

Protein Sequence
(FASTA)

MPGSERHHGT KRKPDFSSGV LHQPQGPAHT SESAKRKRHK STKHNRESSA ALRTEGFTLG 60

DTAPPGVNTV KPLVEYDDIS SDSDTFSDPP SSRPSDRGGV DRFDPSPEYD REELEVDRQI 120

ESREERPPRK KSKDPNKVRD PGNGEHGYKK RSSKDQEKGS SLKSRAQVQP AASVGSTTSS 180

TSSSRSKESG RSGKGRKDKQ RREGRGDGSH TSSQRSRTDR THRRSSKSHK SSPKGKSSSR 240

GSSRRKGVGS ALSPSPRRRP GSESPLGGNY GQQGEDSYSR RRMVQQSPSP TRDMSRRSRQ 300

RSDSPYGSRH RSSSYERDSS PYSRRRSISP YGTRRSSSTS PLSRRSGRSR SRTPLHYSSS 360

CRSSSRSRSG GSSHTGRPAS RSPPSSRLPP NSSLGAELSR RKKERQAAEA AARASAPANA 420

CPLPLMRKAG VAPSSRPAKA EAPQLEKESA AAESQLPASA QLSTDAEEHA ATLPASSAAL 480

PTPPPPEPSP PVPPGPTTQP PLPPPPAESA AQPPTNPPPQ PKSPAPIPTR SPARQQPLHK 540

TSTLPPLPLP PALLGNTQDS PKKSTPPQRL SRKDRELRSR PSIIDLPLPP TLAGGESSPP 600

QSPVRQPPPL LPQMTLKKRP KICCPRYGER KHNLSDWGKR CVDKFDIIGI IGEGTYGQVY 660

KAKDKDTGEL VALKKVRLDN EKEGFPITAI REIKILRQLK HRSVVNMKEI VTDKQDALDF 720

KKDKGAFYLV FEYMDHDLMG LLESGLVQFS HEHVRSFMRQ LMEGLDYCHK NNFLHRDIKC 780

SNILLNNRGQ IKLADFGLAR LYNSEESRPY TNKVITLWYR PPELLLGEER YSPAIDVWSC 840

GCILGELFTK KPIFQANQEL LQLELISRLC GSPCPAVWPD VIKLPLFNTM KPKKQYRRRL 900

REEFAFLPTP ALDLLDRMLT LDPARRCTSE QALTSDFLCD VEPSKMPPPD LPHHQDCHEL 960

WSKKRRRARQ SAVTEDVPVP KVPRKDVTGT SGGENSRSQS SPAPPPPPPA KPPSTANLCS 1020

GLGAAAEQLN QTELAVLLNL LQGQTDLSVN QVAQLLNPSN PENLSQLLST LGEASDQQGA 1080

PEEQAQPASV PQPPEPPPEP QEVSPTPGEP SSLSQEEQAN LLALILGQII KPQNEEQGDE 1140

SNGVRAEEAL SRGSSTSTTD CKVNQLPPPG EQRPPSPPGP PPSASIFGNS SDAEAQPSQD 1200

FSPAVAAALL QLISQQDSE 1219

Nucleotide Sequence
(FASTA)

ATGCCTGGGT CGGAGCGACA TCATGGGACC AAGAGGAAGC CGGATTTTAG CAGCGGTGTG 60

TTACACCAGC CCCAAGGCCC TGCCCATACC TCTGAGTCTG CAAAACGTAA GCGGCATAAA 120

TCAACCAAAC ATAATCGGGA GTCATCGGCG GCTTTGAGGA CCGAAGGTTT TACCCTCGGC 180

GATACGGCGC CTCCTGGTGT CAATACGGTG AAGCCTCTGG TGGAGTACGA TGATATCAGC 240

TCGGACTCGG ACACTTTCTC AGATCCACCG TCCTCCAGAC CTTCTGATAG AGGGGGCGTG 300

GACCGATTTG ATCCATCACC GGAGTACGAT CGAGAAGAAT TAGAAGTAGA CAGACAAATT 360

GAGAGTAGAG AAGAAAGGCC ACCCCGAAAG AAGTCCAAGG ACCCGAATAA AGTTAGGGAC 420

CCTGGAAATG GGGAGCATGG GTACAAAAAG AGGAGCAGCA AAGATCAGGA GAAAGGGAGC 480

TCCTTGAAGA GCAGAGCCCA GGTGCAGCCT GCAGCCAGTG TGGGCAGCAC CACTTCCTCC 540

ACATCCTCAT CCCGCAGCAA GGAGAGCGGG CGCTCCGGGA AGGGCCGCAA AGACAAACAG 600

CGCAGAGAAG GCAGAGGAGA TGGAAGCCAC ACTTCTTCTC AGAGGAGCCG CACAGACAGG 660

ACCCACCGCC GGTCCTCCAA GAGTCACAAG TCAAGCCCCA AAGGCAAGTC TTCAAGTAGA 720

GGTAGTTCTC GCAGGAAAGG AGTGGGCTCT GCTCTGTCAC CCAGTCCCCG AAGAAGACCT 780

GGCAGTGAGA GCCCACTAGG CGGTAACTAC GGACAACAGG GAGAAGACAG TTATTCCAGG 840

AGAAGAATGG TTCAGCAAAG CCCCAGTCCC ACCAGGGACA TGTCCCGGCG CAGCAGACAA 900

AGATCTGACA GCCCTTATGG TAGTAGACAT AGGTCCTCCA GCTATGAGAG GGACAGCAGC 960

CCTTACTCCA GAAGGCGCTC CATCAGCCCC TACGGTACCC GGAGGTCCTC CAGCACCAGC 1020

CCGTTGTCTC GGCGCTCTGG CCGCTCCAGA AGTCGAACCC CCCTGCATTA CTCTTCATCT 1080

TGCCGCTCCT CTTCCCGCTC TAGAAGCGGG GGAAGCTCCC ACACCGGCCG GCCAGCGAGT 1140

CGCTCTCCCC CATCTTCCCG TCTGCCCCCC AACTCTAGTT TGGGCGCAGA GCTTAGTCGA 1200

AGGAAAAAGG AGCGCCAGGC TGCTGAGGCG GCCGCTCGTG CCAGCGCCCC CGCCAATGCG 1260

TGCCCGCTCC CGTTGATGCG AAAAGCCGGA GTCGCCCCGT CATCACGGCC TGCGAAAGCC 1320

GAGGCCCCAC AGCTGGAAAA GGAGTCGGCA GCTGCAGAAA GTCAGCTTCC GGCATCTGCA 1380

CAGCTTTCCA CTGATGCTGA GGAACACGCC GCTACTCTAC CCGCTTCCTC TGCCGCCTTA 1440

CCGACACCAC CTCCTCCTGA GCCCTCCCCT CCTGTCCCGC CCGGCCCAAC GACTCAGCCG 1500

CCATTGCCAC CACCACCGGC AGAGTCGGCC GCTCAGCCTC CAACAAACCC TCCACCTCAA 1560

CCCAAATCTC CGGCGCCGAT TCCCACACGC AGCCCGGCTC GACAGCAACC CCTTCACAAA 1620

ACATCAACGC TGCCCCCCCT GCCTTTACCG CCTGCACTGC TGGGAAATAC TCAGGACAGT 1680

CCAAAGAAGT CCACCCCTCC TCAGAGACTT TCACGAAAAG ACAGAGAACT TCGCAGCCGC 1740

CCATCCATCA TCGACCTTCC TCTGCCCCCG ACCCTGGCAG GAGGGGAGTC TTCCCCACCA 1800

CAGTCCCCTG TTCGCCAGCC TCCTCCACTG TTACCCCAAA TGACCCTCAA GAAGAGACCA 1860

AAGATATGTT GCCCTCGATA TGGCGAGCGT AAACACAACC TGAGTGACTG GGGCAAACGC 1920

TGTGTAGATA AATTTGACAT TATTGGGATC ATAGGAGAAG GCACCTACGG CCAAGTGTAC 1980

AAGGCAAAGG ATAAAGACAC AGGCGAGTTG GTTGCTTTGA AGAAAGTGCG CTTGGACAAT 2040

GAAAAGGAAG GATTCCCCAT CACAGCCATA AGAGAGATCA AGATCTTACG GCAGCTGAAG 2100

CACCGCAGTG TTGTCAACAT GAAGGAGATT GTCACGGACA AGCAGGATGC ACTTGACTTT 2160

AAAAAGGATA AAGGTGCTTT TTACTTGGTC TTCGAGTACA TGGACCATGA CCTGATGGGC 2220

CTGCTGGAGT CTGGCCTGGT GCAGTTCTCC CATGAGCATG TTCGCAGCTT CATGCGCCAG 2280

CTGATGGAGG GCCTGGACTA CTGCCACAAG AACAATTTTC TGCACAGAGA TATCAAATGC 2340

TCCAACATCC TGCTGAACAA CAGAGGTCAG ATCAAGCTGG CTGACTTTGG TTTGGCTCGA 2400

CTTTACAATT CAGAGGAAAG TCGGCCGTAC ACTAATAAAG TAATCACACT ATGGTACCGC 2460

CCCCCTGAAC TTCTGCTGGG GGAGGAGAGG TACAGCCCAG CCATTGATGT TTGGAGCTGT 2520

GGGTGCATCC TTGGAGAACT TTTCACCAAG AAGCCCATCT TCCAGGCGAA CCAGGAACTT 2580

CTACAGCTGG AGCTCATCAG CCGTCTGTGT GGAAGTCCCT GTCCTGCAGT TTGGCCAGAT 2640

GTGATTAAGC TTCCTCTTTT CAACACCATG AAACCCAAAA AGCAGTACAG ACGGCGACTA 2700

CGAGAGGAGT TTGCCTTTTT ACCTACTCCT GCTCTGGACC TGCTGGACCG AATGCTGACC 2760

CTGGACCCCG CACGCCGTTG CACATCAGAG CAAGCTCTCA CCAGTGACTT CCTGTGTGAC 2820

GTGGAGCCCA GCAAGATGCC TCCACCCGAC CTCCCGCATC ACCAGGACTG CCACGAGCTG 2880

TGGAGCAAGA AGAGGAGGCG TGCACGGCAG AGCGCGGTAA CCGAGGATGT GCCTGTGCCC 2940

AAAGTGCCCC GTAAAGATGT GACTGGGACC TCGGGTGGGG AAAACAGTCG ATCTCAAAGC 3000

AGCCCGGCTC CCCCACCCCC TCCCCCAGCA AAACCCCCCT CCACAGCCAA CTTGTGTTCA 3060

GGTCTGGGAG CGGCTGCAGA GCAGTTGAAT CAAACCGAGT TGGCCGTGCT GCTGAACCTC 3120

CTCCAGGGCC AAACGGATCT CAGCGTGAAC CAGGTGGCCC AGCTCCTCAA CCCCTCCAAC 3180

CCAGAGAACC TCAGCCAGCT GTTGTCCACT CTTGGTGAGG CCTCCGACCA GCAGGGGGCC 3240

CCGGAGGAAC AGGCCCAGCC TGCATCGGTG CCCCAGCCTC CTGAGCCACC CCCTGAGCCT 3300

CAGGAAGTCT CACCAACGCC TGGAGAACCC TCCTCCCTCA GCCAGGAGGA GCAGGCCAAC 3360

CTGCTGGCTC TCATTTTGGG GCAAATCATA AAACCACAAA ATGAGGAACA AGGAGATGAG 3420

AGCAATGGCG TTCGGGCAGA AGAAGCGCTG TCGCGCGGTT CGTCCACTTC TACTACTGAT 3480

TGCAAGGTCA ACCAGCTGCC TCCACCTGGT GAACAACGTC CACCGTCTCC ACCCGGGCCG 3540

CCCCCGTCAG CTTCCATCTT CGGGAACTCG TCTGATGCCG AGGCGCAGCC CAGCCAGGAC 3600

TTCAGCCCGG CCGTGGCAGC TGCCCTGCTT CAGCTCATTT CTCAGCAGGA CTCAGAA 3657

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++lkh+ +

Q: 645   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLKHRSV  704

         667889******************************************************

S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111

         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s+e+v+s+++ql+e

Q: 705   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-QFSHEHVRSFMRQLME  763

         ****************8899********************999.****************

S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170

         gl+y+H+n++lHRD+K++N+L++++g++klaDfGlar ++s+++  yt++v+TlwYr+Pe

Q: 764   GLDYCHKNNFLHRDIKCSNILLNNRGQIKLADFGLARLYNSEESrPYTNKVITLWYRPPE  823

         ***************************************7766527**************

S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230

         lLlg+++Ys a+D+Ws+gcil el+t+kp+fq+++e  qle i++l+g+p  +vwp+v k

Q: 824   LLLGEERYSPAIDVWSCGCILGELFTKKPIFQANQELLQLELISRLCGSPCPAVWPDVIK  883

         ************************************************************

S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhky  283

         lp +++  pkk+++ +l+e++  l + aldll+++l+ldp++R+++++al++++

Q: 884   LPLFNTMKPKKQYRrRLREEFAFLPTPALDLLDRMLTLDPARRCTSEQALTSDF  937

         *****7777777777******999999***********************9988

Domain Sequence
(FASTA)

FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLKHRSV 60

VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVQFSHEHV RSFMRQLMEG 120

LDYCHKNNFL HRDIKCSNIL LNNRGQIKLA DFGLARLYNS EESRPYTNKV ITLWYRPPEL 180

LLGEERYSPA IDVWSCGCIL GELFTKKPIF QANQELLQLE LISRLCGSPC PAVWPDVIKL 240

PLFNTMKPKK QYRRRLREEF AFLPTPALDL LDRMLTLDPA RRCTSEQALT SDF 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013