EKS-ORL-00411

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00411

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PEK	310.8	1.1E-92	187	607	421

Status

Unreviewed

Ensembl Protein

ENSORLP00000004354

UniProt Accession

H2LEI2;

Protein Name

Protein Synonyms/Alias

Gene Name

EIF2AK1

Gene Synonyms/Alias

EIF2AK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000003499	ENSORLP00000004354	ENSORLT00000004355

Organism

Oryzias latipes

Functional Description

Protein Length

653

Protein Sequence
(FASTA)

MFGSPSNHGV GRSEECSGSS RNLLVHRSSL RRREVESSLL SLSSEEDEEV QFDTSDTDCN 60

GELLMAGRHY PSIQEFASAI PNHLLLGSLL EHLCCVYESN PARSRMLFKV IGQRLAAMNL 120

LSPLAVSDEF STIRLQHNRA FAELLNAASS SLYPQGQQIL SSNTNNPSVR PKEGLFLGQT 180

SRYLSEFEEI CRLGKGSYGN VFKVRNKLDA QFYAVKKILI KKVSKEDCMK VLREVKVLSS 240

LHHVNVVGYH TAWMEHVQPA PVLPENSSLP ALESAEQDSQ DHSSSSSSIV FQSLSQPLAD 300

PEGLSLETQP AGALVSTQEG HVVCPKTLRR IPENYIPCVF LGQGRAVNGS KCPAMGFDSS 360

ALQEPSNRNS PELNNNPCMD KECRQQMDRR QRKTNKEVQF HLMLYIQMQL CDRSLKDWIS 420

ERNSWSKEED ISRGHYDCVD AEHTLSLLRH VLEGVEYIHA KGIMHRDLKP RNIFLQGPDC 480

HVRIGDFGLA CRDILVDGYK RSNSSGSDSI HTSGVGTFVY ASPEQLKGSH YDSKSDMYSI 540

GVIALELFQP FGTEMERVRT LGDLREGKVP DSFHQRWPVL SKYIKNLTSK EPSVRLTATQ 600

LLQSELFSSK DMVIHGLQRR VEEQREEIMQ LRLQISRLQS SRVTVTFSEL DKT 653

Nucleotide Sequence
(FASTA)

ATGTTCGGTT CGCCGTCCAA CCACGGAGTC GGTCGCTCGG AGGAATGTTC TGGCAGCAGC 60

CGCAACCTGT TGGTTCACCG CAGTTCATTA AGGAGGCGGG AGGTGGAAAG TAGCCTGTTA 120

AGTTTATCAA GCGAAGAGGA CGAAGAGGTT CAGTTTGATA CCTCAGACAC AGATTGTAAC 180

GGCGAGCTGC TGATGGCTGG AAGGCATTAC CCGTCCATCC AGGAGTTCGC CTCGGCCATC 240

CCCAACCACC TCCTCCTGGG CTCCCTGCTG GAACACCTGT GCTGCGTCTA CGAGAGCAAC 300

CCGGCGCGCT CCCGCATGCT GTTCAAAGTC ATTGGCCAGC GTTTAGCCGC CATGAACCTC 360

CTCTCGCCGT TGGCGGTGAG CGACGAGTTC AGCACCATCA GGCTCCAGCA CAACCGTGCC 420

TTCGCTGAGC TGCTGAACGC TGCCAGCTCC TCGCTGTATC CGCAGGGCCA GCAAATTCTC 480

AGTTCAAACA CAAATAATCC TTCTGTAAGA CCAAAGGAGG GACTGTTTCT AGGACAGACA 540

TCCAGGTACC TCAGCGAGTT TGAAGAAATC TGCAGACTTG GGAAAGGATC TTACGGGAAT 600

GTTTTTAAGG TTAGAAATAA GCTAGACGCA CAGTTTTACG CGGTGAAGAA GATTCTCATC 660

AAAAAAGTCT CAAAGGAAGA CTGCATGAAG GTTCTGCGAG AGGTGAAAGT GTTGTCCAGC 720

CTGCATCACG TAAACGTTGT GGGTTACCAC ACGGCGTGGA TGGAGCACGT TCAGCCGGCT 780

CCAGTTTTAC CTGAAAATTC CAGTCTACCT GCTCTCGAAT CTGCAGAACA GGACAGCCAG 840

GATCACAGCA GCTCCAGCTC CTCCATAGTC TTTCAAAGCC TCAGTCAGCC TCTAGCCGAT 900

CCCGAAGGAC TCTCCTTAGA GACGCAGCCG GCGGGGGCTC TGGTCTCAAC CCAAGAGGGA 960

CACGTCGTCT GTCCCAAGAC GCTGCGCCGC ATCCCTGAGA ACTACATCCC CTGTGTGTTC 1020

CTGGGACAGG GAAGGGCCGT GAACGGCTCC AAATGTCCCG CCATGGGGTT TGACAGCTCA 1080

GCACTGCAGG AGCCGAGCAA CAGGAACAGC CCCGAACTCA ACAACAACCC CTGCATGGAT 1140

AAGGAGTGTC GACAACAGAT GGACAGACGC CAAAGGAAGA CAAATAAAGA GGTGCAGTTC 1200

CACCTGATGC TTTATATTCA GATGCAGCTA TGCGATCGTT CCTTGAAGGA CTGGATTTCC 1260

GAGAGGAACT CTTGGTCCAA AGAAGAAGAC ATTTCAAGAG GTCACTATGA CTGTGTTGAT 1320

GCTGAACACA CACTCAGCTT GTTGAGGCAC GTCCTTGAAG GAGTGGAGTA CATCCACGCC 1380

AAAGGAATCA TGCACAGAGA CCTCAAGCCA AGGAACATTT TTCTTCAAGG CCCAGACTGC 1440

CACGTTCGAA TCGGGGACTT CGGTTTGGCC TGTAGAGACA TTTTAGTGGA CGGCTATAAG 1500

AGATCCAACT CTTCTGGCAG TGATTCCATT CATACTTCAG GAGTTGGGAC ATTTGTGTAC 1560

GCTTCCCCAG AGCAACTAAA AGGATCTCAT TATGATTCAA AATCAGATAT GTACAGTATT 1620

GGAGTTATAG CTCTGGAGCT CTTCCAGCCT TTTGGAACAG AGATGGAGCG TGTCCGGACT 1680

CTAGGAGACC TGAGGGAAGG GAAGGTTCCT GACTCGTTCC ATCAGAGGTG GCCGGTTCTG 1740

TCAAAATATA TCAAAAATCT GACGAGTAAA GAGCCCAGCG TTCGTCTCAC GGCCACCCAA 1800

CTCCTTCAGA GTGAACTCTT CAGCAGTAAA GACATGGTAA TTCACGGTTT GCAGAGAAGA 1860

GTCGAGGAGC AGAGAGAGGA GATCATGCAG CTGAGGCTGC AGATAAGCCG GCTTCAGAGT 1920

TCACGAGTCA CTGTGACGTT TTCTGAACTG GACAAGACCT GA 1962

Domain Profile

S: 1     feeikvlGkGgfgvVlkaknkldkkeyaikriklnkakke.lekverevkaLaklehpni  59

         feei+ lGkG++g V+k++nkld + ya+k+i ++k +ke ++kv+revk+L++l+h n+

Q: 187   FEEICRLGKGSYGNVFKVRNKLDAQFYAVKKILIKKVSKEdCMKVLREVKVLSSLHHVNV  246

         89**********************************************************

S: 60    vrYfaawleekeesltd.sseveaeaeleesesseesdtk....................  98

         v Y++aw+e+ +      +++   + e++e++s+++s+++

Q: 247   VGYHTAWMEHVQPAPVLpENSSLPALESAEQDSQDHSSSSssivfqslsqpladpeglsl  306

         **********98766344555555555555444444444467899999999999999999

S: 99    ............................................................  98

Q: 307   etqpagalvstqeghvvcpktlrripenyipcvflgqgravngskcpamgfdssalqeps  366

         999999999999999999999999999999999999999999999999999999999999

S: 99    ....................................llyiqmelceketLkdwiderk..  120

                                             +lyiqm+lc+ ++Lkdwi+er+

Q: 367   nrnspelnnnpcmdkecrqqmdrrqrktnkevqfhlMLYIQMQLCD-RSLKDWISERNsw  425

         99999999999999999999999***********************.9*********977

S: 121   ...........llesrselvm.......rlfkqllegleylHskgliHrdLkpsniFld.  161

                             +        l++ +leg+ey+H kg++HrdLkp+niFl+

Q: 426   skeedisrghyD--------CvdaehtlSLLRHVLEGVEYIHAKGIMHRDLKPRNIFLQg  477

         766444444332........356666668******************************8

S: 162   sddqvKigDFgLatalaealkedvkqdaqskeakhtgqvgtklymsPeqleksqYnkkvD  221

          d +v+igDFgLa++++     +  +++  +++ ht+ vgt  y+sPeql++s+Y++k+D

Q: 478   PDCHVRIGDFGLACRDILVDGYKRSNSSG-SDSIHTSGVGTFVYASPEQLKGSHYDSKSD  536

         899************88776654455444.4469**************************

S: 222   ifsLGlilfeLlypfstemervetltelrdgkipedfddkvpkekkllqkllsrdpkeRp  281

         ++s+G+i++eL++pf temerv+tl +lr+gk+p++f+++ p+  k++++l+s++p+ R+

Q: 537   MYSIGVIALELFQPFGTEMERVRTLGDLREGKVPDSFHQRWPVLSKYIKNLTSKEPSVRL  596

         ************************************************************

S: 282   sasellksell  292

         +a++ll+sel+

Q: 597   TATQLLQSELF  607

         ********986

Domain Sequence
(FASTA)

FEEICRLGKG SYGNVFKVRN KLDAQFYAVK KILIKKVSKE DCMKVLREVK VLSSLHHVNV 60

VGYHTAWMEH VQPAPVLPEN SSLPALESAE QDSQDHSSSS SSIVFQSLSQ PLADPEGLSL 120

ETQPAGALVS TQEGHVVCPK TLRRIPENYI PCVFLGQGRA VNGSKCPAMG FDSSALQEPS 180

NRNSPELNNN PCMDKECRQQ MDRRQRKTNK EVQFHLMLYI QMQLCDRSLK DWISERNSWS 240

KEEDISRGHY DCVDAEHTLS LLRHVLEGVE YIHAKGIMHR DLKPRNIFLQ GPDCHVRIGD 300

FGLACRDILV DGYKRSNSSG SDSIHTSGVG TFVYASPEQL KGSHYDSKSD MYSIGVIALE 360

LFQPFGTEME RVRTLGDLRE GKVPDSFHQR WPVLSKYIKN LTSKEPSVRL TATQLLQSEL 420

F 421

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006950	; P:response to stress

KEGG

InterPros

IPR015516	; Haem-reg_EIF2A_Kinase.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 2.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013