EPS-ORL-00055

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORL-00055

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPP/PP7	462.0	1.0E-138	125	487	363

Status

Unreviewed

Ensembl Protein

ENSORLP00000004449

UniProt Accession

H2LES3;

Protein Name

Serine/threonine-protein phosphatase

Protein Synonyms/Alias

Gene Name

PPEF1

Gene Synonyms/Alias

PPEF1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000003571	ENSORLP00000004449	ENSORLT00000004450

Organism

Oryzias latipes

Functional Description

Protein Length

687

Protein Sequence
(FASTA)

MRHLCCHRNT VKRQKTTIKA AVLIQRWYRR YMARLEMRRR YTWNIFQSIE YAGEQDQLQL 60

SSFFSFMLDN FTQLSGNGPD LITQLLDPVV DPWLDREICY NLVPVPDSYT GPRISFPLGV 120

SDTNTLLSAF KEQQILHARY VLQLLYEAKK LLKQMPNINH LSTSYTKDIT ICGSDLHGHL 180

DDLLLIFYKN GLPSAETPYV FNGDFVDRGK KSVEVVIMLF AYFLLYPDYM HLNRGNHEDP 240

IMNLRYGFTK EVMQKYKIHG REILQLFQDV FSLLPIATVI DGKVLIVHGG ISDQTDLNLL 300

SSIKRHKVKS ALRFPRYSLE KLDIGQSCRH VKRMRSMDSS CSSSRSYSRS QGTPGQSLSC 360

KVLQVPYLDS LSSIPLPSPP QHEQEWKQIV DILWSDPKTQ EGCSPNLFRG GGCYFGPDVT 420

QKLLLQHGLQ MLIRSHECKQ EGYEICHGGK VITIFSASNY YEEGSNRGAY IKLGRELVPR 480

FYQYQVSRIT RKLTLTQRIR AAEGSALRAL KEKLFAHRSE LVGSFQQYDP DNTGTVSVCE 540

WAQVLECVLR LDLPWRTLRP HLARLASDGS VEYQSCFEDM EPGATLPKVT PNLAETLFRY 600

RTDIEIIFNI IDKDHSGLIS IEEFRHTWRL FSAHLGVAID DRAIDDLARS IDFNKDGSID 660

FTEFLEAFRV VHKLDKDAQL SKKMDKE 687

Nucleotide Sequence
(FASTA)

ATGCGGCACC TCTGTTGCCA CAGAAACACA GTAAAAAGAC AAAAAACCAC TATAAAAGCA 60

GCTGTTTTGA TCCAGAGGTG GTATCGACGC TACATGGCCC GGCTGGAGAT GAGACGCAGG 120

TACACCTGGA ACATCTTCCA GTCCATTGAA TATGCTGGAG AGCAAGACCA GCTGCAGCTT 180

TCCAGTTTCT TCAGTTTCAT GCTGGACAAC TTCACTCAGC TCAGTGGGAA TGGACCAGAC 240

CTGATTACCC AGCTGCTGGA TCCCGTGGTT GACCCTTGGT TGGACCGAGA GATCTGCTAC 300

AATTTAGTCC CTGTCCCAGA CTCCTACACT GGACCCCGAA TATCGTTTCC TCTCGGTGTC 360

TCTGATACAA ACACTCTCCT CAGTGCCTTC AAGGAGCAGC AGATTCTCCA TGCCAGATAT 420

GTTCTGCAGC TGCTTTACGA AGCCAAAAAG CTCCTCAAAC AGATGCCAAA CATCAACCAT 480

TTGTCAACAT CCTATACCAA GGACATCACC ATATGTGGAA GTGATCTGCA TGGACATCTT 540

GATGACTTAC TACTTATATT TTACAAGAAT GGGCTCCCTT CTGCTGAGAC GCCATACGTG 600

TTTAACGGAG ACTTTGTGGA TCGAGGTAAA AAGTCAGTGG AAGTTGTGAT CATGCTTTTT 660

GCCTACTTTC TGCTTTACCC GGATTACATG CACCTCAACC GGGGAAACCA TGAAGATCCC 720

ATTATGAACC TCAGATATGG CTTCACAAAA GAAGTAATGC AGAAATATAA GATTCACGGC 780

CGTGAGATTC TTCAGCTGTT CCAGGACGTT TTCAGCTTGC TGCCCATTGC AACAGTCATT 840

GATGGGAAGG TTCTGATAGT GCATGGCGGG ATTTCAGACC AGACGGACTT GAACCTCCTT 900

AGCTCAATAA AAAGACATAA GGTCAAATCT GCTCTAAGGT TTCCCAGGTA CAGTTTAGAG 960

AAGCTTGACA TTGGTCAATC CTGCAGACAC GTCAAGAGAA TGAGATCCAT GGACAGCTCC 1020

TGCAGCAGCA GTCGCAGCTA CAGCAGGAGC CAAGGAACTC CTGGCCAGAG CTTGTCGTGT 1080

AAAGTCCTTC AAGTGCCCTA CCTGGACTCT CTGTCTTCTA TTCCCCTTCC ATCACCTCCA 1140

CAGCATGAAC AGGAATGGAA GCAGATTGTA GATATTCTGT GGAGTGACCC TAAAACTCAA 1200

GAAGGCTGCA GTCCCAACTT GTTCAGAGGC GGAGGCTGCT ACTTCGGCCC TGATGTCACT 1260

CAGAAACTGC TGCTTCAGCA TGGACTGCAG ATGCTCATTC GCTCTCATGA GTGCAAGCAG 1320

GAGGGGTACG AGATCTGCCA TGGTGGAAAG GTGATCACCA TCTTCTCTGC ATCTAACTAT 1380

TATGAAGAGG GAAGCAACCG AGGGGCTTAC ATTAAACTGG GCAGAGAACT GGTTCCACGC 1440

TTTTACCAGT ACCAAGTCAG CCGCATAACA CGCAAACTCA CCCTGACCCA GAGAATTCGC 1500

GCTGCTGAAG GCTCGGCTCT GCGGGCCCTA AAAGAAAAGT TGTTCGCTCA TCGCTCTGAG 1560

CTCGTGGGAA GCTTCCAGCA GTATGATCCA GATAACACCG GTACTGTATC AGTATGTGAA 1620

TGGGCTCAGG TGTTGGAGTG TGTACTGAGG CTGGACCTGC CTTGGCGGAC ACTTCGCCCA 1680

CATTTAGCCC GCCTAGCATC AGATGGCAGC GTTGAGTATC AGTCCTGCTT TGAGGATATG 1740

GAGCCCGGAG CCACTCTGCC TAAGGTCACT CCAAACCTCG CTGAAACTTT ATTTAGATAC 1800

AGAACAGACA TTGAAATCAT TTTCAACATC ATCGACAAAG ACCATTCAGG CCTCATCTCC 1860

ATCGAGGAGT TCCGTCACAC CTGGCGCCTT TTCAGTGCTC ACCTGGGGGT GGCCATTGAT 1920

GACAGAGCCA TTGATGACTT GGCCCGCAGT ATTGACTTCA ACAAGGACGG CAGCATAGAT 1980

TTTACTGAGT TCCTGGAAGC TTTCAGAGTG GTGCACAAAC TGGACAAAGA TGCACAACTT 2040

AGCAAAAAGA TGGACAAGGA G 2061

Domain Profile

S: 3     lllevfkkkrilhakyvlevlfeakkvlkqlpnishvstavskevtvvG.dlhGklddll  61

          ll +fk+++ilha+yvl++l+eakk lkq+pni+h+st+ +k++t++G dlhG+lddll

Q: 125   TLLSAFKEQQILHARYVLQLLYEAKKLLKQMPNINHLSTSYTKDITICGsDLHGHLDDLL  184

         5899********************************************989*********

S: 62    lvlkknGlPsernpyvfnGdfvdrGkrglevllvllslflvfPnavylnrGnhedkvmna  121

         l+++knGlPs + pyvfnGdfvdrGk+++ev+++l ++fl++P+ ++lnrGnhed +mn+

Q: 185   LIFYKNGLPSAETPYVFNGDFVDRGKKSVEVVIMLFAYFLLYPDYMHLNRGNHEDPIMNL  244

         ************************************************************

S: 122   ryGfekevlskykrkgkrilrileevyewlPlgsivdsrvlvvhGGlsestsldllksve  181

         ryGf+kev++kyk +g+ il++ ++v+  lP+++++d++vl+vhGG+s+ t+l+ll s++

Q: 245   RYGFTKEVMQKYKIHGREILQLFQDVFSLLPIATVIDGKVLIVHGGISDQTDLNLLSSIK  304

         ************************************************************

S: 182   rkkrksvllpPeessrd...........................................  198

         r+k+ks l+ P  s  +

Q: 305   RHKVKSALRFPRYSLEKldigqscrhvkrmrsmdsscsssrsysrsqgtpgqslsckvlq  364

         ************8888899*****************************************

S: 199   ...lgrldtdgepreslteteweqiidilwsdPratnGlvPntlrGaGvyfGPdvtedfl  255

            l +l     p+   +e+ew+qi+dilwsdP++++G++Pn  rG+G+yfGPdvt+++l

Q: 365   vpyLDSLSSIPLPSPPQHEQEWKQIVDILWSDPKTQEGCSPNLFRGGGCYFGPDVTQKLL  424

         999777777777778899******************************************

S: 256   kkyelklvirsheckpegyeilhdgkvvtifsasnyyeegsnkgayiklnsqltprfvqy  315

          ++ l+++irsheck egyei+h gkv+tifsasnyyeegsn+gayikl  +l+prf+qy

Q: 425   LQHGLQMLIRSHECKQEGYEICHGGKVITIFSASNYYEEGSNRGAYIKLGRELVPRFYQY  484

         ************************************************************

S: 316   iva  318

+v+

Q: 485   QVS  487

*86

Domain Sequence
(FASTA)

TLLSAFKEQQ ILHARYVLQL LYEAKKLLKQ MPNINHLSTS YTKDITICGS DLHGHLDDLL 60

LIFYKNGLPS AETPYVFNGD FVDRGKKSVE VVIMLFAYFL LYPDYMHLNR GNHEDPIMNL 120

RYGFTKEVMQ KYKIHGREIL QLFQDVFSLL PIATVIDGKV LIVHGGISDQ TDLNLLSSIK 180

RHKVKSALRF PRYSLEKLDI GQSCRHVKRM RSMDSSCSSS RSYSRSQGTP GQSLSCKVLQ 240

VPYLDSLSSI PLPSPPQHEQ EWKQIVDILW SDPKTQEGCS PNLFRGGGCY FGPDVTQKLL 300

LQHGLQMLIR SHECKQEGYE ICHGGKVITI FSASNYYEEG SNRGAYIKLG RELVPRFYQY 360

QVS 363

Keyword

Calcium; Complete proteome; Hydrolase; Iron; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>

Gene Ontology

GO:0005509	; F:calcium ion binding
GO:0005506	; F:iron ion binding
GO:0030145	; F:manganese ion binding
GO:0004721	; F:phosphoprotein phosphatase activity
GO:0050906	; P:detection of stimulus involved in sensory perception

KEGG

InterPros

IPR011992	; EF-hand-like_dom.
IPR018247	; EF_Hand_1_Ca_BS.
IPR018249	; EF_HAND_2.
IPR002048	; EF_hand_Ca-bd.
IPR000048	; IQ_motif_EF-hand-BS.
IPR004843	; Metallo_PEstase_dom.
IPR013235	; PPP_dom.
IPR012008	; Ser/Thr-Pase_EF-hand_contain.
IPR006186	; Ser/Thr-sp_prot-phosphatase.

Pfam

PF13202	; EF_hand_3; 1.
PF00612	; IQ; 1.
PF00149	; Metallophos; 1.
PF08321	; PPP5; 1.

SMARTs

SM00054	; EFh; 3.
SM00015	; IQ; 1.
SM00156	; PP2Ac; 1.

Prosites

PS00018	; EF_HAND_1; 3.
PS50222	; EF_HAND_2; 3.
PS50096	; IQ; 1.
PS00125	; SER_THR_PHOSPHATASE; 1.

Prints

PR00114

; STPHPHTASE.

Created Date

20-Feb-2013