EKS-ORL-00359
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00359
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR480.01.9E-144688945258
StatusUnreviewed
Ensembl ProteinENSORLP00000004470
UniProt AccessionH2LEU2;
Protein Name
Protein Synonyms/Alias
Gene NameEGFR (2 of 2)
Gene Synonyms/Alias EGFR (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000003577ENSORLP00000004470ENSORLT00000004471
ENSORLG00000003577ENSORLP00000004468ENSORLT00000004469
OrganismOryzias latipes
Functional Description
Protein Length993
Protein Sequence
(FASTA)
VCQGTSNLLT LLGTREYHYE SMVRMYSNCS VVLENLEITY TLENQDLSFL QSIQEVGGYV 60
LIAMNDVATV PLVNLRLIRG QNLYDKFALL VMSNYHSNNI TGAPRYTSGL RQLQLSRLTE 120
ILNGGVKVTN NPLLCNMEKI QWWDIVDKAR NFSVLLKFDD YKRDCERCDP GCVNDSCWAA 180
GPDHCQKFTK LVCAEQCGPG RCSGPKPLDC CNQHCAAGCT GPLATDCLAC KNFNDDGICK 240
DSCPPLNLYN HKSQQVVENP NAKYSFGATC VKACPHNYVV TEGSCVRACS PNTYEVEENG 300
VQRCKRCEGP CPKACDGVGV GRLTNTIAVN SSNIESFRNC TKINGDIVFL KSSFSGDQHY 360
NIPPMDPKKL EYFRTVKEIT GHLLIQTWPE NMTSLSVFEN LEIIRGRSLF VNKYSFVVVG 420
ADNLHWLGLR SLKELSAGNV RLKDNKLLCY SKAMNWSYLF RDKTQIVDQT PPVDVCEGQN 480
QTCDQQCSSK GCWGPGTNMC LSCQYFNRKQ HCVERCNLLQ GEPREVEVEG SCVECHPECL 540
VMTGTQTCHG PGPDQCSQCA HFKDGSHCVR MCPHGVLDDE NMLIWKYADQ NGQCQLCHQN 600
CSQGCSGPGL SGCSRTTTHS SLAVGVVSGL LVAVIVLLFV LVYVRRQRIK KKRTLRRLLQ 660
EKELVEPLTP SGQAPNQALL RILKETEFKK VRVLGSGAFG TVFKGLWVPE GENVRIPVAI 720
KVLREATSPK ANQEVLDEAY VMASVDHPHV CRLLGICLTS SVQLVTQLMP YGCLLDYVRQ 780
HKDRICAQWL LNWCVQIAKG MNYLEERHLV HRDLAARNVL LKNPNHIKIT DFGLAKLLTA 840
DEKEYHADGG KVPIKWMALE SILQWTYTHQ SDVWSYGVTV WELMTFGSKP YDGIAASEIA 900
TVLERGERLP QPPICTIDVY MIMVKCWMID PSSRPKFKEL IMEFSQMARD PSRYLVIRGD 960
LPSPSDSRFF SRLLSSDDME EIADADEYLL PNK 993
Nucleotide Sequence
(FASTA)
GTATGCCAGG GGACGAGTAA CCTCCTGACT CTGCTGGGAA CTCGGGAATA CCATTACGAA 60
AGCATGGTGA GGATGTACTC CAACTGCTCT GTGGTTCTGG AGAACCTGGA GATCACGTAC 120
ACTCTGGAAA ACCAGGACCT GTCCTTCCTG CAGTCAATCC AGGAAGTTGG GGGCTACGTT 180
CTGATCGCCA TGAACGATGT GGCGACCGTC CCGCTGGTCA ATCTAAGGCT GATCCGAGGA 240
CAAAACCTCT ACGACAAGTT TGCTCTGCTT GTGATGTCCA ACTACCACAG CAACAACATT 300
ACTGGAGCGC CCAGATACAC CAGCGGCCTG CGGCAGCTGC AGCTCAGCCG CCTGACCGAG 360
ATTTTAAATG GAGGGGTGAA GGTAACCAAC AATCCTCTTT TGTGTAACAT GGAGAAAATC 420
CAGTGGTGGG ACATCGTTGA CAAAGCCAGA AATTTCAGCG TGCTTCTGAA GTTTGACGAC 480
TACAAGCGAG ATTGTGAGAG GTGTGACCCC GGGTGTGTCA ACGACTCATG TTGGGCAGCG 540
GGACCGGATC ACTGTCAAAA ATTCACCAAG CTAGTGTGTG CTGAGCAGTG TGGGCCCGGG 600
AGGTGTAGCG GCCCCAAACC CTTGGACTGT TGTAACCAAC ACTGTGCTGC AGGCTGCACT 660
GGACCTCTAG CCACTGACTG CCTGGCCTGC AAAAACTTTA ATGATGATGG TATCTGTAAG 720
GACTCCTGTC CTCCTTTAAA CCTCTATAAC CACAAAAGCC AGCAGGTGGT CGAAAACCCC 780
AACGCCAAGT ACAGCTTTGG AGCAACGTGT GTTAAGGCCT GCCCACACAA TTACGTGGTG 840
ACTGAGGGCT CATGTGTCCG GGCCTGCAGC CCCAACACAT ATGAGGTGGA GGAGAATGGA 900
GTCCAACGCT GCAAAAGATG CGAAGGGCCT TGTCCTAAAG CCTGTGATGG AGTCGGCGTT 960
GGTAGACTCA CCAACACAAT CGCTGTCAAC TCTTCAAACA TCGAATCTTT TAGGAATTGC 1020
ACAAAGATCA ATGGAGACAT CGTTTTCCTC AAATCTTCCT TTTCGGGAGA TCAGCACTAC 1080
AACATCCCAC CCATGGACCC TAAGAAGCTG GAATACTTCA GGACAGTGAA GGAAATCACA 1140
GGGCACCTCT TGATCCAGAC CTGGCCAGAG AACATGACGT CTCTGTCTGT GTTCGAAAAC 1200
CTGGAGATCA TCAGAGGGAG GTCCCTGTTT GTGAATAAAT ACAGCTTTGT GGTGGTGGGT 1260
GCCGATAACC TGCATTGGTT AGGCCTGCGG TCCCTGAAGG AGCTGAGTGC CGGGAACGTG 1320
CGCCTGAAGG ACAACAAACT GCTGTGTTAC TCCAAAGCCA TGAACTGGTC CTACCTTTTC 1380
AGAGACAAAA CACAAATAGT GGATCAAACT CCCCCAGTGG ACGTGTGCGA AGGGCAGAAT 1440
CAAACCTGTG ACCAGCAGTG CTCGAGCAAG GGCTGCTGGG GTCCAGGCAC CAACATGTGT 1500
CTGTCCTGCC AGTACTTTAA CCGCAAGCAG CACTGTGTGG AGCGCTGCAA CTTGCTACAG 1560
GGTGAACCTC GGGAGGTGGA GGTGGAAGGC AGCTGTGTCG AGTGTCACCC AGAATGTTTG 1620
GTGATGACTG GGACCCAGAC CTGCCACGGA CCGGGGCCAG ACCAGTGTTC CCAGTGTGCC 1680
CACTTTAAGG ATGGTTCCCA CTGCGTACGG ATGTGCCCCC ATGGAGTTCT TGATGACGAA 1740
AACATGTTGA TTTGGAAATA TGCTGATCAG AATGGCCAGT GCCAGCTGTG CCATCAGAAC 1800
TGCTCTCAGG GGTGTTCTGG ACCAGGACTG TCGGGGTGCT CGAGAACCAC TACACACTCC 1860
TCTCTGGCAG TGGGCGTGGT CAGCGGGCTT CTGGTCGCAG TAATCGTCTT ACTGTTTGTC 1920
CTTGTGTATG TGCGCCGGCA GCGAATTAAG AAGAAGAGGA CTTTACGGCG CTTGTTGCAG 1980
GAGAAGGAGC TGGTGGAACC TCTAACTCCA AGTGGTCAAG CTCCCAACCA GGCGCTGCTG 2040
AGGATCCTGA AGGAGACAGA GTTCAAGAAG GTCAGGGTGC TCGGCTCAGG TGCATTTGGG 2100
ACAGTCTTCA AGGGTCTGTG GGTTCCCGAG GGGGAGAACG TTAGGATCCC AGTTGCCATC 2160
AAAGTCCTTC GAGAGGCCAC ATCACCCAAA GCAAATCAAG AAGTCCTAGA TGAGGCGTAT 2220
GTGATGGCGA GCGTGGATCA CCCTCACGTG TGTCGTCTGC TTGGCATCTG CCTGACATCC 2280
TCCGTTCAGC TTGTGACTCA GTTGATGCCG TACGGCTGTT TGCTGGACTA TGTCCGGCAG 2340
CACAAGGACC GCATCTGTGC CCAGTGGCTG CTCAACTGGT GTGTCCAGAT CGCCAAGGGC 2400
ATGAACTACC TGGAGGAGCG CCACCTTGTG CATCGAGATC TGGCAGCAAG GAACGTCCTG 2460
CTGAAAAATC CAAACCATAT TAAGATCACA GACTTTGGCC TGGCCAAGCT GCTGACAGCT 2520
GATGAGAAAG AATACCATGC AGATGGAGGA AAGGTTCCCA TAAAGTGGAT GGCCTTAGAG 2580
TCAATCCTAC AGTGGACCTA CACTCATCAG AGCGACGTGT GGAGCTATGG GGTGACTGTT 2640
TGGGAGCTGA TGACATTTGG TTCCAAACCC TATGACGGCA TCGCGGCCAG TGAGATCGCC 2700
ACAGTGCTGG AAAGGGGAGA GCGTCTGCCT CAGCCACCGA TTTGCACCAT TGACGTCTAC 2760
ATGATAATGG TTAAATGCTG GATGATTGAC CCATCTAGTC GTCCCAAGTT TAAAGAGCTG 2820
ATCATGGAGT TCTCTCAAAT GGCTCGTGAC CCATCCAGAT ACCTCGTCAT CAGGGGAGAT 2880
TTGCCGAGTC CGTCAGACTC CAGGTTTTTC TCCCGCCTGC TGAGCTCAGA TGACATGGAG 2940
GAAATAGCTG ATGCAGATGA ATACCTGCTA CCAAACAAA 2979
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         +kk++vlGsGafGtv+kG+w+pegenv+ipvaikvl+e+t++kan+e+ldea+v+as+dh
Q: 688   FKKVRVLGSGAFGTVFKGLWVPEGENVRIPVAIKVLREATSPKANQEVLDEAYVMASVDH  747
         599*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+s++qlvtql+p+Gclldyvr+hkd++ +q llnwcvqiakGm+ylee+
Q: 748   PHVCRLLGICLTSSVQLVTQLMPYGCLLDYVRQHKDRICAQWLLNWCVQIAKGMNYLEER  807
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         +lvhrdlaarnvl+k+pnh+kitdfGlakll+adeke++a+ggkvpikw+alesil+ +y
Q: 808   HLVHRDLAARNVLLKNPNHIKITDFGLAKLLTADEKEYHADGGKVPIKWMALESILQWTY  867
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpydgi+a+ei  +le+Gerl+qppictidvym++vkcw
Q: 868   THQSDVWSYGVTVWELMTFGSKPYDGIAASEIATVLERGERLPQPPICTIDVYMIMVKCW  927
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mid++srpkfkel+ efs
Q: 928   MIDPSSRPKFKELIMEFS  945
         ****************96
Domain Sequence
(FASTA)
FKKVRVLGSG AFGTVFKGLW VPEGENVRIP VAIKVLREAT SPKANQEVLD EAYVMASVDH 60
PHVCRLLGIC LTSSVQLVTQ LMPYGCLLDY VRQHKDRICA QWLLNWCVQI AKGMNYLEER 120
HLVHRDLAAR NVLLKNPNHI KITDFGLAKL LTADEKEYHA DGGKVPIKWM ALESILQWTY 180
THQSDVWSYG VTVWELMTFG SKPYDGIAAS EIATVLERGE RLPQPPICTI DVYMIMVKCW 240
MIDPSSRPKF KELIMEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-ANC-00290
EKS-BOT-00297
EKS-CAJ-00304
EKS-CAF-00304
EKS-CAP-00333
EKS-DRM-00152
EKS-EQC-00289
EKS-FEC-00283
EKS-GAA-00371
EKS-GOG-00295
EKS-HOS-00304
EKS-ICT-00280
EKS-LOA-00308
EKS-MAM-00301
EKS-MEG-00239
EKS-MOD-00292
EKS-MUM-00329
EKS-MUP-00295
EKS-NOL-00274
EKS-ORN-00388
EKS-ORA-00262
EKS-ORC-00280
EKS-OTG-00304
EKS-PAT-00283
EKS-PES-00265
EKS-POA-00289
EKS-RAN-00314
EKS-TAG-00314
EKS-TAR-00392
EKS-TEN-00388
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013