EPS-ORL-00029

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-ORL-00029

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	274.1	1.7E-81	23	294	272

Status

Unreviewed

Ensembl Protein

ENSORLP00000005661

UniProt Accession

H2LI43;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1B (1 of 2)

Gene Synonyms/Alias

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000004504	ENSORLP00000005661	ENSORLT00000005662
ENSORLG00000004504	ENSORLP00000005663	ENSORLT00000005664
ENSORLG00000004504	ENSORLP00000005662	ENSORLT00000005663
ENSORLG00000004504	ENSORLP00000005656	ENSORLT00000005657

Organism

Oryzias latipes

Functional Description

Protein Length

389

Protein Sequence
(FASTA)

MGAFLDKPKT EKHNSHGEGN GVRYGLSSMQ GWRVEMEDAH TAVLGLQTPG MTDWSFFAVY 60

DGHAGSKVAN YCSKHLLEHI ITRSESSGGE IPAPCPPAVE AVKAGIRTGF LRIDEHMRSF 120

TDLRNGMDRS GSTAVGILLS PDHFFFINCG DSRAVLYRNS QVCFSTLDHK PCNPRERERI 180

QNAGGSVMIQ RVNGSLAVSR ALGDYDYKCV DGKGPTEQLV SPEPEVFVMV RAPEQDQFVI 240

LACDGIWDVM SNEDLCEFVK SRLEVCDDLE KVCNEVVDTC LHKGSRDNMS IVLVCLPNGP 300

KVSEEAVKKD AELNKYLETR VEEMLSRPGD EGLPDIVTVM RNLSTDSGMP PLPPGGGLAS 360

KRSVIEAVYN RLIPYKEEDG SGADVECPW 389

Nucleotide Sequence
(FASTA)

ATGGGTGCAT TCCTAGACAA ACCCAAAACG GAAAAGCATA ACTCGCACGG TGAAGGAAAC 60

GGTGTGCGCT ATGGGCTGAG CTCCATGCAG GGCTGGCGGG TGGAGATGGA GGACGCTCAT 120

ACAGCTGTGC TGGGGCTTCA GACCCCCGGT ATGACTGACT GGTCTTTTTT TGCTGTGTAC 180

GACGGTCATG CGGGATCAAA GGTTGCCAAC TACTGCTCTA AGCACCTTCT GGAACACATA 240

ATCACTAGAT CAGAAAGCTC TGGTGGTGAA ATTCCAGCCC CATGTCCTCC TGCAGTGGAG 300

GCAGTGAAAG CCGGGATCCG TACAGGCTTC TTGAGGATTG ACGAGCACAT GCGCAGCTTC 360

ACAGACCTTC GGAACGGCAT GGATCGCAGT GGATCCACCG CTGTGGGAAT TCTTCTATCA 420

CCTGATCACT TCTTCTTCAT CAACTGTGGG GATTCTCGAG CTGTTCTGTA CCGCAATTCC 480

CAGGTGTGCT TCTCTACACT CGACCACAAG CCTTGCAACC CACGTGAGAG GGAGCGAATC 540

CAGAATGCAG GGGGCTCAGT GATGATCCAG AGAGTTAATG GGTCACTGGC TGTGTCGAGA 600

GCCTTGGGGG ACTATGATTA CAAGTGTGTG GACGGCAAAG GGCCCACAGA GCAGCTGGTC 660

AGCCCTGAAC CCGAGGTGTT TGTTATGGTT CGGGCACCTG AACAGGATCA ATTTGTGATT 720

CTTGCTTGTG ACGGAATCTG GGATGTCATG TCCAATGAGG ACTTGTGTGA GTTTGTGAAA 780

TCTCGCCTTG AGGTGTGTGA TGACCTGGAG AAAGTCTGCA ATGAGGTGGT GGACACGTGC 840

CTTCACAAGG GAAGTCGGGA CAACATGAGT ATTGTGTTGG TGTGTTTGCC CAACGGTCCC 900

AAAGTATCAG AGGAAGCTGT GAAGAAAGAT GCTGAGCTCA ACAAATATTT AGAAACACGA 960

GTGGAAGAGA TGCTGTCTCG GCCCGGAGAT GAGGGCTTAC CAGACATCGT GACAGTGATG 1020

AGGAACCTGT CCACCGACAG TGGAATGCCC CCCCTACCAC CAGGGGGTGG TCTCGCCAGC 1080

AAACGCAGTG TTATTGAAGC AGTATACAAC CGTCTGATCC CATACAAGGA GGAAGATGGA 1140

AGTGGAGCAG ATGTGGAGTG TCCCTGGTAG 1170

Domain Profile

S: 2     lvgvvsvngrrnemedavtsspnflkspekkdrlaffgvyDGhggsevakfcseklheil  61

         ++g++s++g+r emeda+t++ ++  + +    ++ff+vyDGh+gs+va++cs++l e++

Q: 23    RYGLSSMQGWRVEMEDAHTAVLGLQTP-GM-TDWSFFAVYDGHAGSKVANYCSKHLLEHI  80

         79****************986665554.43.44***********************9999

S: 62    aeele........sseseerkvkkalakaFlstdeelkvleeksldidksGstavvalik  113

          +  e           +  + vk+ ++++Fl++de+++ + + ++ +d+sGstav +l++

Q: 81    ITRSEssggeipaPCPPAVEAVKAGIRTGFLRIDEHMRSFTDLRNGMDRSGSTAVGILLS  140

         99988889998887778889999*************************************

S: 114   dsklyvanvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLa  173

         +++++++n+GdSravL rn +++  + dHkp +++E+eRi++aggsv+ +   Rv+G+La

Q: 141   PDHFFFINCGDSRAVLYRNSQVCFSTLDHKPCNPRERERIQNAGGSVMIQ---RVNGSLA  197

         **************************************************...*******

S: 174   vsRalGdlylk.........pyvtpePevtshrltsede.fliLasDGlwdvvsneeavs  223

         vsRalGd+++k         ++v+pePev+++ + +e++ f+iLa+DG+wdv+sne++++

Q: 198   VSRALGDYDYKcvdgkgpteQLVSPEPEVFVMVRAPEQDqFVILACDGIWDVMSNEDLCE  257

         **********************************998888********************

S: 224   lvrdvlekkeaeqeaakkLvklalargskdnvsaivv  260

         +v+++le  ++++++++++v+++l++gs+dn+s+++v

Q: 258   FVKSRLEVCDDLEKVCNEVVDTCLHKGSRDNMSIVLV  294

         ********************************98875

Domain Sequence
(FASTA)

RYGLSSMQGW RVEMEDAHTA VLGLQTPGMT DWSFFAVYDG HAGSKVANYC SKHLLEHIIT 60

RSESSGGEIP APCPPAVEAV KAGIRTGFLR IDEHMRSFTD LRNGMDRSGS TAVGILLSPD 120

HFFFINCGDS RAVLYRNSQV CFSTLDHKPC NPRERERIQN AGGSVMIQRV NGSLAVSRAL 180

GDYDYKCVDG KGPTEQLVSP EPEVFVMVRA PEQDQFVILA CDGIWDVMSN EDLCEFVKSR 240

LEVCDDLEKV CNEVVDTCLH KGSRDNMSIV LV 272

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000287	; F:magnesium ion binding
GO:0030145	; F:manganese ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0006470	; P:protein dephosphorylation

KEGG

InterPros

IPR001932	; PP2C-like.
IPR012911	; PP2C_C.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481	; PP2C; 1.
PF07830	; PP2C_C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013