EKS-ORL-00315

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00315

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	420.0	4.2E-126	15	267	253

Status

Unreviewed

Ensembl Protein

ENSORLP00000005969

UniProt Accession

H2LIY4;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK2

Gene Synonyms/Alias

PLK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000004740	ENSORLP00000005969	ENSORLT00000005970
ENSORLG00000004740	ENSORLP00000005968	ENSORLT00000005969
ENSORLG00000004740	ENSORLP00000005967	ENSORLT00000005968

Organism

Oryzias latipes

Functional Description

Protein Length

537

Protein Sequence
(FASTA)

EMARIITDPA TGKCYCRGKV LGKGGFAKCY EMTDLSTSKV YAAKIIPHAR VSKPHQREKI 60

DREIELHRAL NHRHVVHFYH HFEDKENIYI LLEYCSRKSL AHILKARKVL TEPEVRYYLR 120

QIVSGLKYLH EQEILHRDLK LGNFFVSESM ELKVGDFGLA AKLEPVGNRR KTICGTPNYL 180

SPEVLNKQGH GCESDIWALG CVMYTMLLGR PPFETTNLKE TYKCIREARY SLPSSLSPQA 240

KQLISSLLAK IPEDRPNLDH ILRHDFFTQG FSPERLPVSC CHSAPDFHIS SPAKSFFKKA 300

AAALFGGKRD KVRYYETLSL EDNTTGSVAD TVATVLRGCL ENMPTTNDIP LTSSSCSLQW 360

VTKWVDYSNK YGFGYQLSDN TVGVLFNNGT HMSLLPDRKT IHYYAELGQC SVFPTCEVPE 420

HFVGQVTVLK YFSLYMEENL MDGGDLGTVT DTHMPRLYLL QWLKSDRALM MLFNDGTFQV 480

NFYHDHTKII LCCQRDEYVL TYINEERVSK TYKLSSLLTS GCPTDLHQRL LYSLNML 537

Nucleotide Sequence
(FASTA)

GAAATGGCAA GGATCATCAC TGATCCTGCC ACGGGGAAGT GCTACTGCCG TGGAAAAGTT 60

TTGGGAAAGG GGGGCTTTGC TAAATGCTAC GAGATGACCG ACCTCTCCAC CAGCAAAGTT 120

TACGCAGCCA AGATCATCCC ACATGCGCGC GTCTCCAAAC CGCACCAGCG GGAGAAGATT 180

GACAGGGAAA TTGAGTTGCA CAGAGCTCTG AACCACAGAC ACGTTGTCCA CTTTTATCAC 240

CATTTTGAAG ACAAGGAGAA CATTTACATC CTGCTGGAGT ATTGCAGTAG AAAATCACTT 300

GCCCACATTC TGAAGGCTCG CAAAGTACTC ACAGAACCAG AGGTGCGGTA TTACCTGAGA 360

CAAATCGTCT CTGGACTGAA ATACCTGCAT GAACAAGAAA TTCTTCACAG AGACCTTAAG 420

CTAGGTAACT TTTTTGTGAG TGAGTCCATG GAACTGAAAG TTGGAGACTT TGGTCTGGCT 480

GCCAAGTTGG AGCCAGTGGG AAACAGGAGG AAGACGATCT GTGGGACTCC CAACTACCTG 540

TCCCCCGAGG TGCTCAACAA GCAGGGTCAT GGCTGTGAAT CTGACATTTG GGCCTTGGGC 600

TGTGTAATGT ACACCATGCT GTTAGGCAGA CCTCCATTTG AAACCACCAA CCTGAAGGAG 660

ACATACAAGT GTATCAGAGA GGCGCGTTAT TCCCTCCCAT CCTCCCTGTC ACCACAGGCC 720

AAACAGCTAA TTTCTAGCCT CCTGGCCAAA ATTCCAGAGG ACAGACCCAA CCTGGACCAC 780

ATTCTGAGGC ATGACTTCTT CACTCAGGGC TTCAGTCCAG AGCGTCTGCC AGTAAGTTGC 840

TGCCATTCAG CACCAGATTT CCACATCTCC AGTCCCGCCA AGAGTTTCTT TAAGAAAGCT 900

GCTGCCGCGC TTTTTGGTGG GAAGAGGGAC AAAGTCAGAT ACTACGAGAC TCTGAGCTTG 960

GAAGACAACA CAACAGGGAG TGTGGCAGAT ACTGTTGCTA CTGTGTTAAG GGGATGTCTG 1020

GAGAACATGC CTACAACAAA CGACATTCCT TTGACCTCAA GCAGCTGCAG TCTTCAGTGG 1080

GTGACTAAAT GGGTGGACTA CTCCAACAAG TATGGCTTTG GCTACCAGCT GTCTGATAAC 1140

ACTGTGGGGG TTCTCTTCAA TAACGGCACT CACATGAGCC TCCTGCCTGA CAGAAAGACC 1200

ATCCATTATT ATGCAGAGTT GGGCCAGTGT TCAGTCTTCC CCACCTGTGA AGTTCCTGAG 1260

CACTTTGTGG GCCAAGTGAC TGTCCTCAAA TACTTTTCTC TTTACATGGA AGAGAATCTG 1320

ATGGATGGAG GTGACCTCGG TACAGTCACA GATACACACA TGCCCAGACT CTACCTTTTA 1380

CAGTGGTTGA AGTCTGACCG CGCCCTCATG ATGCTGTTCA ATGATGGCAC TTTTCAGGTC 1440

AACTTCTACC ACGATCACAC AAAGATCATT CTGTGTTGCC AGAGGGATGA GTACGTGCTG 1500

ACATACATTA ATGAGGAACG GGTCTCCAAA ACCTATAAAC TCAGCTCGCT GTTGACGTCA 1560

GGCTGCCCCA CTGACCTGCA CCAACGCTTG CTATACTCCC TCAACATGCT T 1611

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y+rgk+lGkGgfakcye++dl+t++v+a+k++p++++ k++qrek+++eie+hr l+h++

Q: 15    YCRGKVLGKGGFAKCYEMTDLSTSKVYAAKIIPHARVSKPHQREKIDREIELHRALNHRH  74

         99**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         +v++y++fedken+y++le+csr+sla++lk+rk+ltepevryylrqivsglkylhe++i

Q: 75    VVHFYHHFEDKENIYILLEYCSRKSLAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEI  134

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         lhrdlklgn+f++e++e+k+gdfGla++le+ ++r+kt+cGtPny++Pevl+k+gh++e+

Q: 135   LHRDLKLGNFFVSESMELKVGDFGLAAKLEPVGNRRKTICGTPNYLSPEVLNKQGHGCES  194

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         diW+lGc++yt+l+G+PPfet++lkety++i++a+yslPssls++ak+li++ll+k Pe+

Q: 195   DIWALGCVMYTMLLGRPPFETTNLKETYKCIREARYSLPSSLSPQAKQLISSLLAKIPED  254

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+l+++l+++f+

Q: 255   RPNLDHILRHDFF  267

         ************8

Domain Sequence
(FASTA)

YCRGKVLGKG GFAKCYEMTD LSTSKVYAAK IIPHARVSKP HQREKIDREI ELHRALNHRH 60

VVHFYHHFED KENIYILLEY CSRKSLAHIL KARKVLTEPE VRYYLRQIVS GLKYLHEQEI 120

LHRDLKLGNF FVSESMELKV GDFGLAAKLE PVGNRRKTIC GTPNYLSPEV LNKQGHGCES 180

DIWALGCVMY TMLLGRPPFE TTNLKETYKC IREARYSLPS SLSPQAKQLI SSLLAKIPED 240

RPNLDHILRH DFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Ornithorhynchus anatinus"; ?>Pan troglodytes"; ?>Procavia capensis"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013