EKS-ORL-00471
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00471
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR542.74.9E-163594948355
StatusUnreviewed
Ensembl ProteinENSORLP00000006025
UniProt AccessionH2LJ41;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NamePDGFRB (1 of 2)
Gene Synonyms/Alias PDGFRB (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000004786ENSORLP00000006025ENSORLT00000006026
OrganismOryzias latipes
Functional Description
Protein Length1052
Protein Sequence
(FASTA)
LINLLSIAAA LLAFVVQTAA WLYFCSGARC LEVTPDEKEI VLAKGSELTL TCSGLMETTW 60
EYKKDDVPYF QVEKDQESHQ SYQSVNSGVF SSVLTLLKVS WQHTGVYQCI NRHTKETKEV 120
AVFVADPEVW FVRSDHGMVP KSEETIIPCM VTNPNISVTL HEKSSHSPIN GLYVPTEGFK 180
APLEARTYFC RGKLNGKVKD SQDFHVFSIF VQETFETYVN ASKTVLKQGE PLTVNCTVHG 240
VELVNFSWDT PSGELEEVDP LTEFLSSITM RSYLMFPGTT VAHSGTYVCH AHELVQDQEA 300
SASIDITVFE KGFVDVKPAQ SKNISTKVQE NVELRVEITA YPPPQILWAK DGATIKGDKS 360
ITIRQVNEIR YVTILTLVRV RMEQKGLYTV LIRNGDDSKE VAFDLEVHVP SQIKDLSDHH 420
LPANRHLVTC TAEGVPTPTI QWYSCDSMLK CSNQTSAWQP LVPHSEELSI QTNVSYSQAR 480
KLSRVRSQVT FLKPQQVTVR CETTNQAGLT DRRDIKLVSS TLFSQVTVLA AVLALVVIII 540
MSIIILIAVW RKKPRYEIRW KVIESVSQDG HEYIYVDPIH LPYDLAWEMR RDNLVLGRTL 600
GSGAFGRVVE ATAYGLTHSQ SSTKVAVKML KSTARRSETQ ALMSELKIMS HLGPHLNIVN 660
LLGACTKHGP LYLVTEYCRY GDLVDYLHRN KHTFLQYYAE KNQYDDCLIS RGSTPLSQRK 720
GYVSFGSESD GGYMDMSKDE PSIYVPMQEQ IDTIKYADIQ PSPYESPYQQ DLYQDQGSTS 780
LDLVISDCAS LTYEDLLGFS YQVAKGMEFL ASKNCVHRDL AARNVLICEG KLVKICDFGL 840
ARDIMHDSNY ISKGSTFLPL KWMAPESIFH NLYTTLSDVW SYGILLWEIF TLGGTPYPDL 900
PMNELFYNAL KRGYRMAKPP HASDEVYEIM KKCWDEKFEK RPEFSLLVHN VGNMLTDSYK 960
KKQRYSQVNE NFLKSDHPAV ARTKPRRTSP FPVADPTFGS LSPVAFSSSP GPTANNQSQR 1020
PGERRHEADG QEVVTSYNEY IIPIPDPKPE EA 1052
Nucleotide Sequence
(FASTA)
CTAATAAACC TGCTGTCAAT TGCAGCAGCT TTATTAGCTT TTGTTGTGCA AACTGCAGCC 60
TGGCTGTATT TCTGCTCTGG AGCGCGCTGT CTGGAGGTCA CACCTGATGA AAAAGAGATC 120
GTCCTGGCTA AAGGCTCTGA GCTAACGCTC ACGTGCTCCG GCTTAATGGA GACAACCTGG 180
GAGTATAAGA AGGACGACGT ACCCTACTTT CAGGTTGAGA AAGATCAAGA AAGTCATCAA 240
AGCTATCAGA GTGTAAATAG CGGCGTGTTC TCCAGTGTTC TCACCCTGCT AAAAGTGAGC 300
TGGCAGCACA CTGGGGTGTA TCAGTGCATT AATCGGCACA CTAAGGAAAC CAAGGAGGTG 360
GCTGTGTTTG TTGCAGACCC TGAGGTGTGG TTTGTGAGGA GTGACCACGG CATGGTACCC 420
AAAAGTGAGG AAACCATCAT CCCATGCATG GTCACCAACC CAAACATCAG CGTCACGCTG 480
CATGAGAAAA GCTCTCACTC GCCCATCAAC GGGCTGTATG TTCCCACTGA GGGGTTCAAA 540
GCACCCCTGG AGGCAAGGAC ATATTTCTGT CGTGGCAAGC TGAACGGCAA GGTGAAAGAC 600
TCTCAAGACT TCCATGTCTT CAGCATTTTT GTCCAAGAGA CCTTTGAAAC CTATGTCAAC 660
GCTTCAAAGA CGGTCCTGAA GCAGGGAGAG CCTCTGACTG TAAACTGCAC CGTGCACGGG 720
GTTGAACTGG TGAATTTTTC CTGGGATACT CCCAGCGGTG AGCTCGAGGA AGTTGATCCC 780
CTGACTGAAT TTCTGTCATC CATAACCATG CGCTCCTACC TGATGTTCCC TGGCACCACG 840
GTGGCGCACA GTGGAACCTA TGTATGCCAT GCTCACGAAC TCGTTCAAGA CCAGGAGGCC 900
AGCGCCAGCA TCGACATCAC AGTCTTTGAA AAAGGTTTTG TGGATGTGAA GCCAGCTCAG 960
TCAAAAAACA TTTCCACCAA AGTACAGGAG AATGTCGAAC TGCGAGTGGA AATCACTGCC 1020
TACCCGCCTC CTCAGATTCT GTGGGCCAAA GATGGCGCCA CCATCAAAGG AGACAAAAGC 1080
ATCACCATTA GACAAGTGAA TGAGATCAGG TACGTCACCA TTCTCACGTT GGTGAGGGTG 1140
AGGATGGAGC AGAAAGGACT CTACACTGTC CTCATTAGAA ATGGGGATGA CTCAAAGGAA 1200
GTGGCCTTTG ACCTGGAAGT ACATGTTCCC TCTCAGATTA AAGATCTGTC TGATCACCAC 1260
CTGCCAGCGA ACAGACACTT GGTGACCTGC ACCGCAGAGG GGGTCCCAAC TCCGACCATA 1320
CAGTGGTACA GCTGTGACAG CATGCTGAAG TGTAGTAACC AAACATCAGC ATGGCAGCCG 1380
CTGGTCCCAC ATTCAGAGGA GCTGAGCATC CAGACCAATG TGAGCTACAG CCAGGCACGA 1440
AAACTGAGTC GAGTGCGCAG CCAAGTGACC TTCCTCAAGC CCCAGCAGGT CACAGTTCGC 1500
TGTGAGACCA CCAACCAAGC CGGACTCACC GACCGGAGAG ACATCAAACT GGTGTCTAGC 1560
ACACTCTTCT CCCAGGTGAC TGTATTAGCT GCTGTTTTGG CATTAGTGGT CATCATTATT 1620
ATGTCCATCA TCATCCTCAT TGCTGTATGG AGGAAGAAAC CTCGCTATGA AATCAGATGG 1680
AAAGTCATTG AATCTGTGAG TCAGGATGGC CACGAGTACA TCTATGTGGA TCCCATCCAC 1740
CTGCCCTATG ACCTGGCCTG GGAAATGCGC AGAGACAACC TGGTTCTGGG TCGCACTCTT 1800
GGATCAGGAG CGTTTGGCAG GGTGGTCGAG GCAACCGCAT ACGGTCTCAC GCACTCCCAG 1860
TCCAGCACAA AGGTGGCAGT GAAAATGCTG AAATCCACTG CTAGGAGGAG TGAGACTCAG 1920
GCTCTCATGT CAGAACTGAA GATCATGAGC CACCTTGGTC CTCATCTCAA CATTGTCAAC 1980
TTGCTCGGAG CTTGTACCAA ACATGGCCCT CTCTATCTGG TGACCGAGTA CTGTCGCTAT 2040
GGTGATTTGG TGGATTACCT GCACAGGAAC AAACACACCT TCCTGCAGTA CTACGCCGAG 2100
AAGAACCAGT ACGACGACTG CCTCATTTCT AGAGGAAGCA CCCCTCTCAG TCAGAGAAAA 2160
GGCTATGTGT CCTTCGGCAG TGAGAGCGAT GGAGGCTACA TGGACATGAG CAAAGATGAG 2220
CCGTCAATCT ACGTGCCCAT GCAGGAGCAG ATAGACACCA TCAAATATGC TGACATCCAG 2280
CCTTCTCCAT ACGAGTCCCC CTACCAGCAG GACCTCTACC AAGATCAAGG AAGCACCAGC 2340
CTGGACTTAG TGATCAGTGA TTGTGCCAGC CTCACCTATG AAGACCTTCT AGGTTTCAGC 2400
TATCAGGTGG CAAAGGGGAT GGAGTTTCTC GCCTCCAAAA ATTGCGTCCA TCGTGACCTG 2460
GCTGCCAGGA ACGTGTTGAT CTGTGAAGGC AAGCTGGTGA AGATTTGCGA CTTTGGCCTG 2520
GCCAGAGACA TAATGCATGA TTCCAATTAC ATCTCCAAAG GAAGCACCTT CCTGCCCCTG 2580
AAGTGGATGG CACCAGAAAG CATTTTTCAT AATTTGTACA CCACCCTGAG TGATGTGTGG 2640
TCATACGGCA TACTCCTTTG GGAAATTTTC ACTCTGGGAG GAACCCCCTA CCCAGATTTG 2700
CCCATGAACG AACTGTTCTA CAACGCACTG AAAAGAGGAT ACCGCATGGC CAAACCTCCC 2760
CATGCTTCAG ATGAAGTGTA TGAAATCATG AAGAAGTGCT GGGATGAAAA GTTTGAGAAG 2820
AGGCCTGAGT TCTCCTTGTT GGTTCACAAC GTGGGAAACA TGCTGACAGA CAGCTATAAG 2880
AAGAAACAGA GATACAGCCA AGTGAACGAG AACTTCCTGA AGAGTGACCA CCCGGCAGTG 2940
GCCCGCACCA AACCCCGCCG GACCTCGCCC TTTCCCGTCG CTGACCCCAC ATTTGGCTCC 3000
CTGTCTCCTG TTGCCTTCTC CTCCTCTCCC GGTCCCACAG CCAACAACCA GAGCCAGAGG 3060
CCTGGAGAGC GCAGGCACGA AGCAGACGGG CAGGAAGTCG TAACTTCATA TAATGAGTAC 3120
ATCATTCCCA TCCCGGACCC CAAACCAGAG GAAGCT 3156
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lG++lGsGafG+vveatayGl++s+++ kvavkmlkstar se +almselki+shlG
Q: 594   LVLGRTLGSGAFGRVVEATAYGLTHSQSSTKVAVKMLKSTARRSETQALMSELKIMSHLG  653
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGactk Gp+y++teyc+yGdl++yl+r++++fl+ ++ek++ ++  ++  +
Q: 654   PHLNIVNLLGACTKHGPLYLVTEYCRYGDLVDYLHRNKHTFLQYYAEKNQYDDCLISRGS  713
         *********************************************999777666665555
S: 121   lladkslrsksslssesseeyvdlkkd................vsdvssskadklasekk  164
          +  ++ + ++s+ ses++ y+d++kd                ++d+++s ++++++++ 
Q: 714   TP-LSQRKGYVSFGSESDGGYMDMSKDepsiyvpmqeqidtikYADIQPSPYESPYQQDL  772
         54.455688999***********************************************9
S: 165   ksalerevkaaleeedsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGk  224
          + + ++  + ++ +   +l++edll fsyqvakGmeflaskncvhrdlaarnvl++eGk
Q: 773   YQDQGSTSLDLVISD-CASLTYEDLLGFSYQVAKGMEFLASKNCVHRDLAARNVLICEGK  831
         888888888877776.99******************************************
S: 225   vvkicdfGlardimkdsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifs  284
         +vkicdfGlardim+dsny++kG+++lp+kwmapesif++lyt+ sdvwsyGillweif+
Q: 832   LVKICDFGLARDIMHDSNYISKGSTFLPLKWMAPESIFHNLYTTLSDVWSYGILLWEIFT  891
         ************************************************************
S: 285   lGstpypgllvdskfyklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlv  341
         lG+tpyp+l++++ fy+++k+Gyrma+p +a++e+yeim+kcw++++ekrp f+ lv
Q: 892   LGGTPYPDLPMNELFYNALKRGYRMAKPPHASDEVYEIMKKCWDEKFEKRPEFSLLV  948
         *****************************************************9887
Domain Sequence
(FASTA)
LVLGRTLGSG AFGRVVEATA YGLTHSQSST KVAVKMLKST ARRSETQALM SELKIMSHLG 60
PHLNIVNLLG ACTKHGPLYL VTEYCRYGDL VDYLHRNKHT FLQYYAEKNQ YDDCLISRGS 120
TPLSQRKGYV SFGSESDGGY MDMSKDEPSI YVPMQEQIDT IKYADIQPSP YESPYQQDLY 180
QDQGSTSLDL VISDCASLTY EDLLGFSYQV AKGMEFLASK NCVHRDLAAR NVLICEGKLV 240
KICDFGLARD IMHDSNYISK GSTFLPLKWM APESIFHNLY TTLSDVWSYG ILLWEIFTLG 300
GTPYPDLPMN ELFYNALKRG YRMAKPPHAS DEVYEIMKKC WDEKFEKRPE FSLLV 355
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00377
EKS-ANC-00390
EKS-BOT-00403
EKS-CAJ-00406
EKS-CAF-00403
EKS-CAP-00431
EKS-DAR-00792
EKS-EQC-00395
EKS-FEC-00387
EKS-GAG-00340
EKS-GAA-00491
EKS-GOG-00395
EKS-HOS-00408
EKS-ICT-00382
EKS-LAC-00418
EKS-LOA-00411
EKS-MAM-00401
EKS-MEG-00334
EKS-MUM-00434
EKS-MUP-00396
EKS-MYL-00398
EKS-NOL-00367
EKS-OCP-00083
EKS-ORN-00513
EKS-ORC-00377
EKS-OTG-00404
EKS-PES-00358
EKS-POA-00393
EKS-RAN-00417
EKS-SAH-00371
EKS-SUS-00358
EKS-TAG-00472
EKS-TAR-00509
EKS-TEN-00510
EKS-XIM-00505
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013