EKS-ORL-00543

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00543

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	306.0	2.7E-91	21	311	291

Status

Unreviewed

Ensembl Protein

ENSORLP00000006070

UniProt Accession

H2LJ84;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK4

Gene Synonyms/Alias

MAPK4;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000004822	ENSORLP00000006070	ENSORLT00000006071

Organism

Oryzias latipes

Functional Description

Protein Length

640

Protein Sequence
(FASTA)

MASLDTPLFL IGFELSGHFS DPRPLGTGVT GLVLSATDQR TGQRVAIKKL GMRDAVTVKH 60

ALREAKITQR LRHENIVRVH EVVAPYGRPL PLDPTQIDAL YIVQECMETD LARLLELGPL 120

PTGHATLLFY QLLRGLKFIH SANVLHRDLK PANIFINTDQ LLLKIGDFGL ARIVDPHYSH 180

KGYLSEGLVT KWYCSPRLLL SPNNYTKAID MWAAGCILAE MLTGRTLFAG AHELEQMQLI 240

LNTVPVQREE DRQELLQVMP SYVSHGWRVK TPVSELLPEV DAQAVDCLER ILTFNPMDRL 300

TAEAALSHPF LQQYSCPEDE PISSNPFHIE DELESLISQQ SLSASSSHTS SIHWDRYDNS 360

LSTGMCWQQS ADRCRCIPAG QVRSDLGDNS ENEEVRRDPR ASFSSLAEEA QVDPRKYSHS 420

SSAERFLENS HSSLERVCGV GLGELDCGRS CDYKVGSPSY LDKIAWREGK PQHYSEPKLI 480

LDLSHWNMED LGKMKEEEAS KDEEESENLF QEISRWVEST QCRFHSPSPS PSSEQRSCYT 540

SSPPLPLSPT DLQTPVFHNL PSLFPSSPTG LLSPDVTERL LPSDTLHSQH KESQPPSSTS 600

SLAPSVKADS LESLPVKHKE RLLDLDAFIS RALQLCRQNK 640

Nucleotide Sequence
(FASTA)

ATGGCTAGCC TAGACACCCC TCTCTTTCTC ATTGGCTTTG AGCTCAGCGG TCACTTTTCT 60

GACCCGCGGC CTCTTGGCAC AGGAGTTACG GGCCTGGTCC TGTCAGCTAC GGACCAGCGA 120

ACTGGACAGC GTGTAGCAAT AAAGAAATTA GGGATGCGAG ATGCTGTGAC AGTAAAGCAC 180

GCCCTGCGTG AGGCAAAAAT CACCCAGAGA CTGCGCCATG AAAACATTGT ACGGGTCCAT 240

GAGGTTGTAG CACCATATGG ACGTCCACTG CCCCTGGACC CCACCCAAAT CGATGCCCTC 300

TACATCGTCC AGGAGTGCAT GGAAACGGAT CTGGCTCGAC TGTTGGAGCT TGGACCTCTG 360

CCCACAGGTC ATGCCACTCT GCTGTTCTAC CAGCTGTTGA GGGGACTGAA GTTCATCCAC 420

TCTGCCAATG TCCTGCACAG AGACCTGAAA CCTGCGAACA TTTTCATCAA CACAGACCAA 480

CTGCTCCTCA AGATTGGAGA CTTTGGACTA GCCAGAATAG TCGATCCTCA TTACTCCCAT 540

AAGGGCTATC TGTCTGAGGG TTTGGTCACT AAATGGTATT GCTCTCCCCG CCTCCTCCTG 600

TCACCCAACA ACTACACGAA GGCCATAGAC ATGTGGGCCG CCGGCTGCAT TCTGGCTGAG 660

ATGCTCACTG GACGCACACT GTTTGCAGGA GCTCATGAGC TGGAACAGAT GCAGCTGATC 720

CTCAACACAG TGCCTGTGCA GAGGGAGGAA GACAGACAAG AGCTATTACA GGTCATGCCT 780

TCATATGTCA GTCATGGATG GAGAGTCAAG ACTCCCGTCT CAGAATTGCT GCCTGAAGTG 840

GATGCTCAGG CTGTGGACTG TCTTGAGCGC ATCTTGACCT TTAACCCCAT GGATCGTCTG 900

ACAGCTGAAG CAGCACTGTC CCACCCTTTC CTTCAGCAGT ACTCCTGTCC TGAAGATGAA 960

CCCATTTCAT CCAATCCCTT TCACATCGAG GATGAGCTGG AGAGCCTCAT CTCACAGCAG 1020

AGCCTAAGCG CCAGCAGCAG TCACACCTCC AGCATCCACT GGGATAGGTA TGACAACAGT 1080

TTATCAACTG GCATGTGCTG GCAACAGTCA GCTGACAGGT GTCGCTGCAT CCCCGCTGGT 1140

CAAGTTCGAT CTGATCTGGG AGATAACTCA GAGAATGAAG AGGTGCGCAG AGATCCACGG 1200

GCCAGTTTCA GCTCGCTGGC AGAGGAGGCT CAGGTTGACC CACGCAAATA CTCTCACAGC 1260

AGCTCAGCCG AGCGCTTCCT CGAGAACTCT CACTCCTCGC TGGAAAGAGT TTGTGGTGTC 1320

GGTTTGGGGG AGTTAGACTG CGGCCGCTCG TGCGACTACA AAGTGGGCTC CCCTTCATAT 1380

CTCGATAAAA TTGCCTGGCG AGAGGGAAAG CCTCAACATT ACTCCGAGCC TAAGCTGATT 1440

CTGGATCTGT CTCACTGGAA CATGGAAGAC CTGGGGAAAA TGAAGGAAGA AGAAGCAAGT 1500

AAGGATGAGG AGGAGAGTGA GAATCTGTTT CAAGAAATTT CTCGCTGGGT GGAGAGCACG 1560

CAGTGTCGTT TTCACTCTCC TAGTCCCAGT CCTTCATCAG AGCAACGCTC CTGCTACACC 1620

TCTTCTCCAC CTCTCCCGCT CTCTCCCACT GATCTCCAAA CACCCGTCTT CCATAATCTT 1680

CCCTCCCTTT TCCCCTCATC ACCAACAGGT CTTCTCTCTC CGGACGTAAC TGAAAGACTT 1740

TTACCTTCCG ACACTCTCCA CTCTCAACAT AAGGAATCTC AACCCCCTTC CTCCACCTCC 1800

TCTTTAGCTC CGTCAGTAAA AGCTGACTCT TTGGAGTCTC TGCCTGTTAA GCATAAGGAG 1860

CGACTGCTTG ACCTGGACGC TTTTATATCT CGGGCACTCC AACTATGCCG GCAGAATAAG 1920

Domain Profile

S: 3     slkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNiik  62

         + +plg+G  g+v+sa+d+rt++rvaikkl   +++++++k++lRE k+ ++l+heNi++

Q: 21    DPRPLGTGVTGLVLSATDQRTGQRVAIKKLG--MRDAVTVKHALREAKITQRLRHENIVR  78

         5689**************************9..9**************************

S: 63    lldvftpee.....eleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglky  117

         + +v+ p       + ++++ +Y+v+e metdL+++++   l   h+ ll+yq+lrglk+

Q: 79    VHEVVAPYGrplplDPTQIDALYIVQECMETDLARLLELGPLPTGHATLLFYQLLRGLKF  138

         *******9988888999*******************************************

S: 118   lHsanviHrDlKPsNllvnedce.lkildFGlarsadkekekk..lteyvatrwYraPei  174

         +Hsanv+HrDlKP+N+++n+d   lki dFGlar+ d+++++k  l+e ++t+wY +P++

Q: 139   IHSANVLHRDLKPANIFINTDQLlLKIGDFGLARIVDPHYSHKgyLSEGLVTKWYCSPRL  198

         *******************998648***************9999****************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         lls ++ytka+D+W++GCIlaE+ltg++lf+g++e++q+++il++++  +ee+ +++ +

Q: 199   LLSPNNYTKAIDMWAAGCILAEMLTGRTLFAGAHELEQMQLILNTVPVQREEDRQELLQV  258

         **********************************************************95

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

          + +y+++ ++ k+ +++el+p+ + +a+d le++L+++p++R+++e aL+hp+l

Q: 259   -MPSYVSHGWRVKT-PVSELLPEVDAQAVDCLERILTFNPMDRLTAEAALSHPFL  311

         .99***99887766.9*************************************97

Domain Sequence
(FASTA)

DPRPLGTGVT GLVLSATDQR TGQRVAIKKL GMRDAVTVKH ALREAKITQR LRHENIVRVH 60

EVVAPYGRPL PLDPTQIDAL YIVQECMETD LARLLELGPL PTGHATLLFY QLLRGLKFIH 120

SANVLHRDLK PANIFINTDQ LLLKIGDFGL ARIVDPHYSH KGYLSEGLVT KWYCSPRLLL 180

SPNNYTKAID MWAAGCILAE MLTGRTLFAG AHELEQMQLI LNTVPVQREE DRQELLQVMP 240

SYVSHGWRVK TPVSELLPEV DAQAVDCLER ILTFNPMDRL TAEAALSHPF L 291

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Danio rerio"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR008350	; MAPK_ERK3/4.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR01771

; ERK3ERK4MAPK.

Created Date

20-Feb-2013