EKS-ORL-00473
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00473
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR510.82.5E-153591919329
StatusUnreviewed
Ensembl ProteinENSORLP00000006110
UniProt AccessionH2LJC3;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameCSF1R (1 of 2)
Gene Synonyms/Alias CSF1R (1 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000004849ENSORLP00000006110ENSORLT00000006111
OrganismOryzias latipes
Functional Description
Protein Length978
Protein Sequence
(FASTA)
MRPYLTLLLL MVVPATSVER RRPVIKLNSR LVGSTEVVIK TGNILDLRCE GNEPVNWQPR 60
LAKHKRYVSR GSGNVRTFKV DRATAEFTGT YKCFYAAKSQ YSNLTSWVHV YVKDPNRVFW 120
TSSTSLRVVK KEGEDYLLPC LLTDPSATEL GLRMDNGTSV PPGMNFTINR YQGILIHSLH 180
PNFNADYVCT ARLNGVEKTS KAFSINVIQR LRIPPYVFLE QEEYIRIVGE EIRIPCTTHN 240
PNFYYNVTWK YTTKSNPKIE EKVRSNGENR LDIESILSIT AVDLADTGNI SCVGTNEAGV 300
NSSTTYLLVV DKPYIRLSPQ LSPKLAHQGL SVEVNEGEDL ELGVLIEAYP RITEHQWHTP 360
TSPNTHTQEH KFIRYNNRYQ ATLQLKRMNI HEQGEYTFNA RSKLANASIT FQVQMYQRPV 420
AVVRWENVTT LTCTSFGYPA PRIIWYQCLG IRPTCNENTT GLQLAIPLQA PTVEVQREEY 480
GAVEVESILT VGPSSQRMTV ECVAFNVVGV SRDTFAMEVS DKLFTSTLTG AAGVLAIFLI 540
LLVVLLYKYK QKPRYEIRWR IIEARDGNNY TFIDPTQMPY NDKWEFPRDK LKLGKILGAG 600
AFGKVVEATA YGLGKDDNAM RVAVKMLKTS AHSDEREALM SELKILSHLG HHKNIVNLLG 660
ACTYGGPVLV ITEYCSLGDL LNFLRLKAET FANFVLNVPD VEESSIDYKN VCSQKQFIRS 720
DSGISSSASS SYLEMRPCLL PNTDLSQESE CEESGEWPLD MDDLLRFSYQ VAQGLQFLAE 780
KNCIHRDVAA RNVLLTSHRE AKICDFGLAR DIMNDSNYVV KGNARLPVKW MAPESIFDCI 840
YTVQSDVWSY GILLWEIFSL GKSPYPSMAV DSRFYKMVKC GYQMPQPDFA PPEMYEIMRM 900
CWNLEPTERP TFSKISQMIE QQLGGQLEPG QVMYQNMQQQ VTEGEECDEL KCYNIPCDQS 960
CDNEEEEQLL MKTNNYQF 978
Nucleotide Sequence
(FASTA)
ATGCGGCCCT ACCTCACGCT GTTGTTGTTG ATGGTGGTGC CTGCTACTTC AGTGGAACGG 60
AGGCGTCCTG TGATCAAACT GAATTCTCGG TTGGTGGGGA GCACTGAAGT GGTGATAAAA 120
ACTGGGAACA TTCTAGATTT GAGATGTGAA GGTAATGAAC CGGTGAACTG GCAACCCAGA 180
CTTGCCAAAC ACAAACGCTA CGTGTCCCGG GGCAGTGGGA ATGTCCGCAC CTTCAAGGTG 240
GATCGCGCCA CTGCAGAATT CACTGGAACG TACAAATGCT TCTATGCTGC CAAATCCCAA 300
TACTCCAACC TGACCTCCTG GGTACACGTC TATGTGAAAG ATCCAAACCG GGTGTTCTGG 360
ACCAGCAGCA CATCTCTAAG AGTGGTGAAG AAGGAGGGGG AAGATTATCT GCTGCCCTGC 420
CTGCTCACTG ACCCCTCAGC TACAGAGCTG GGCCTCAGGA TGGACAACGG CACCAGCGTC 480
CCGCCAGGAA TGAACTTTAC CATCAACAGG TACCAAGGCA TCCTCATCCA CAGCCTCCAC 540
CCCAACTTTA ACGCGGACTA CGTCTGCACA GCCAGGCTCA ATGGAGTGGA GAAGACCTCG 600
AAGGCCTTTT CCATCAATGT TATTCAGAGG CTTCGAATCC CTCCGTACGT CTTCCTGGAA 660
CAAGAAGAAT ATATACGAAT TGTCGGGGAA GAAATTAGGA TTCCCTGCAC GACACACAAT 720
CCCAACTTCT ACTACAATGT CACTTGGAAG TACACTACCA AATCAAACCC AAAAATAGAA 780
GAGAAGGTTC GCTCCAATGG GGAGAATCGC CTGGACATAG AGAGCATACT GAGCATTACT 840
GCAGTGGACC TTGCAGACAC AGGAAACATC TCCTGTGTTG GTACTAATGA AGCTGGAGTG 900
AACAGTTCAA CCACATACCT GTTAGTTGTG GACAAACCCT ACATCAGGCT GTCACCCCAG 960
CTGTCACCCA AACTGGCTCA CCAGGGTCTA TCAGTGGAGG TGAATGAAGG AGAAGATCTC 1020
GAGCTGGGCG TGCTCATTGA AGCCTATCCT CGTATTACAG AGCACCAATG GCACACCCCT 1080
ACATCCCCCA ACACACACAC ACAGGAACAC AAGTTCATCC GATACAACAA CAGATACCAA 1140
GCTACCTTGC AGCTGAAGAG AATGAACATA CATGAGCAAG GAGAGTACAC CTTTAACGCC 1200
CGCAGCAAGT TGGCCAACGC GTCTATCACA TTTCAAGTTC AGATGTACCA GAGACCTGTT 1260
GCTGTGGTGC GATGGGAAAA TGTAACCACG CTGACTTGCA CTTCTTTCGG GTACCCGGCT 1320
CCGAGAATCA TCTGGTATCA GTGTTTGGGA ATAAGACCCA CGTGCAATGA AAACACCACA 1380
GGCTTGCAGT TGGCGATCCC CCTCCAGGCT CCCACTGTTG AGGTTCAGAG GGAAGAGTAT 1440
GGGGCTGTGG AAGTGGAGAG CATCCTCACT GTGGGGCCGT CCAGCCAGAG GATGACAGTT 1500
GAATGCGTGG CTTTTAACGT TGTTGGCGTG AGCAGGGACA CCTTTGCTAT GGAGGTCTCT 1560
GACAAACTGT TTACTTCCAC CCTGACCGGA GCAGCAGGTG TTCTGGCAAT CTTTCTCATT 1620
CTGCTGGTTG TATTGCTTTA CAAGTACAAG CAGAAACCCA GGTATGAGAT TCGTTGGAGG 1680
ATTATAGAGG CTAGAGATGG CAACAACTAC ACCTTCATTG ACCCGACACA AATGCCCTAC 1740
AATGACAAGT GGGAGTTTCC AAGAGACAAG CTCAAACTAG GGAAGATCCT GGGTGCTGGA 1800
GCGTTTGGGA AGGTTGTTGA GGCCACAGCT TATGGTCTGG GAAAGGATGA CAACGCGATG 1860
CGTGTAGCTG TGAAAATGTT AAAAACCAGT GCGCACTCAG ATGAAAGGGA GGCTCTAATG 1920
TCTGAGCTCA AGATCCTCAG CCACCTTGGG CATCACAAGA ATATAGTCAA TCTACTCGGA 1980
GCTTGCACCT ACGGAGGACC TGTTCTTGTG ATAACTGAGT ACTGCAGCCT TGGCGACCTC 2040
CTGAACTTTC TTCGCCTGAA GGCAGAGACA TTTGCAAATT TTGTTTTGAA TGTCCCCGAT 2100
GTGGAGGAGA GCTCAATCGA CTACAAGAAT GTCTGCAGTC AGAAACAGTT TATTAGAAGT 2160
GACAGCGGGA TTTCCAGTTC AGCCTCCAGC AGTTACCTGG AGATGAGGCC CTGCCTGCTG 2220
CCGAACACAG ACTTGTCACA AGAGTCAGAA TGTGAGGAAA GTGGCGAGTG GCCGCTGGAC 2280
ATGGATGACC TGCTGAGATT CTCATATCAA GTTGCTCAAG GCCTTCAGTT TTTGGCCGAA 2340
AAAAATTGCA TTCACAGAGA TGTAGCAGCA AGAAATGTCC TCCTTACCAG CCACAGAGAG 2400
GCAAAGATTT GTGACTTTGG CCTGGCGAGG GACATCATGA ATGACTCCAA CTATGTGGTG 2460
AAAGGCAACG CCCGTCTGCC TGTGAAGTGG ATGGCTCCAG AAAGCATCTT TGACTGCATC 2520
TACACTGTCC AGAGTGACGT CTGGTCTTAC GGCATCCTCC TGTGGGAGAT CTTCTCTTTA 2580
GGCAAAAGCC CTTATCCAAG CATGGCGGTG GACTCCAGGT TCTACAAGAT GGTAAAGTGT 2640
GGCTACCAGA TGCCTCAGCC AGACTTTGCT CCACCTGAAA TGTATGAGAT CATGAGGATG 2700
TGCTGGAACC TGGAACCTAC GGAGCGCCCG ACTTTTAGCA AAATCAGTCA GATGATTGAG 2760
CAGCAGCTTG GTGGCCAGCT TGAGCCGGGT CAGGTAATGT ACCAGAATAT GCAGCAGCAG 2820
GTCACTGAGG GTGAGGAGTG TGATGAGCTC AAGTGCTACA ACATCCCCTG TGACCAGTCT 2880
TGTGACAATG AGGAAGAGGA GCAGCTTTTA ATGAAGACTA ACAACTATCA GTTT 2934
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l+lGk+lG+GafGkvveatayGl+k+d +++vavkmlk++a+s+e+ealmselkilshlG
Q: 591   LKLGKILGAGAFGKVVEATAYGLGKDDNAMRVAVKMLKTSAHSDEREALMSELKILSHLG  650
         78**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h+nivnllGact gGp++viteyc  Gdlln+lr k+e+f +  l+    +e+++d+k+
Q: 651   HHKNIVNLLGACTYGGPVLVITEYCSLGDLLNFLRLKAETFANFVLNVPDVEESSIDYKN  710
         ************************************************9999********
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         +  +++ +rs+s +ss++s++y+++++ +      ++d   s++          ++ ee 
Q: 711   VcSQKQFIRSDSGISSSASSSYLEMRPCL----LPNTDL--SQE----------SECEES  754
         *7788899*******************32....222222..222..........224456
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
          + +l+++dll fsyqva+G++fla knc+hrd+aarnvllt+ + +kicdfGlardim+
Q: 755   GEWPLDMDDLLRFSYQVAQGLQFLAEKNCIHRDVAARNVLLTSHREAKICDFGLARDIMN  814
         6799********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pyp + vds+f
Q: 815   DSNYVVKGNARLPVKWMAPESIFDCIYTVQSDVWSYGILLWEIFSLGKSPYPSMAVDSRF  874
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         yk++k Gy+m qp++a+ e+yeim+ cw+ ep++rp+f+++++++
Q: 875   YKMVKCGYQMPQPDFAPPEMYEIMRMCWNLEPTERPTFSKISQMI  919
         *****************************************9986
Domain Sequence
(FASTA)
LKLGKILGAG AFGKVVEATA YGLGKDDNAM RVAVKMLKTS AHSDEREALM SELKILSHLG 60
HHKNIVNLLG ACTYGGPVLV ITEYCSLGDL LNFLRLKAET FANFVLNVPD VEESSIDYKN 120
VCSQKQFIRS DSGISSSASS SYLEMRPCLL PNTDLSQESE CEESGEWPLD MDDLLRFSYQ 180
VAQGLQFLAE KNCIHRDVAA RNVLLTSHRE AKICDFGLAR DIMNDSNYVV KGNARLPVKW 240
MAPESIFDCI YTVQSDVWSY GILLWEIFSL GKSPYPSMAV DSRFYKMVKC GYQMPQPDFA 300
PPEMYEIMRM CWNLEPTERP TFSKISQMI 329
KeywordATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAG-00342
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0005021; F:vascular endothelial growth factor-activated receptor activity
GO:0048010; P:vascular endothelial growth factor receptor signaling pathway
GO:0038084; P:vascular endothelial growth factor signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
IPR009134; Tyr_kinase_VEGFR_rcpt_N.
Pfam
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
PR01832; VEGFRECEPTOR.
Created Date20-Feb-2013