EKS-ORL-00273

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00273

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	380.7	4.5E-114	72	366	295

Status

Unreviewed

Ensembl Protein

ENSORLP00000006223

UniProt Accession

H2LJN3;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K2

Gene Synonyms/Alias

MAP2K2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000004940	ENSORLP00000006223	ENSORLT00000006224

Organism

Oryzias latipes

Functional Description

Protein Length

397

Protein Sequence
(FASTA)

MAPKRRPVPL NITPIGEGQT TSNTIDAASE ANLEALQKKL GELDLDEQQR KRLEAFLTQK 60

AQVGELKDED FEPICELGAG NGGVVNKVRH KPSGLVMARK LIHLEIKPAI RNQIIRELQV 120

LHECNSPYIV GFYGAFYSDG EISICMEHMD GGSLDQVLKE ARRIPEEILG KVSIAVLRGL 180

AYLREKHQIM HRDVKPSNIL VNSRGEIKLC DFGVSGQLID SMANSFVGTR SYMSPERLQG 240

THYSVQSDVW SMGLSLVELA IGRYPIPPPD AKELEAIFGF AILDGAEGEP HTQRPRPPGR 300

PVSGHGVDSR PAMAIFELLD YIVNEPPPKL PHGVFTSDFQ DFVTKCLIKN PAERADLKML 360

MSHTFIKRSE VDGVDFAGWL CKTMTLNQPS TPTRVTE 397

Nucleotide Sequence
(FASTA)

ATGGCCCCCA AAAGGAGACC CGTTCCCCTG AACATCACAC CCATCGGGGA GGGACAGACC 60

ACGTCCAACA CCATCGATGC TGCGTCCGAA GCCAACCTAG AGGCCTTACA GAAGAAGCTG 120

GGAGAGCTGG ACCTGGATGA ACAGCAGAGG AAGCGTCTGG AGGCCTTCCT CACCCAGAAG 180

GCTCAGGTGG GAGAGCTGAA GGACGAAGAC TTCGAACCCA TCTGTGAGCT GGGGGCAGGA 240

AACGGGGGCG TGGTCAACAA GGTCCGCCAC AAGCCCTCGG GTCTCGTCAT GGCCCGCAAG 300

CTAATCCACC TGGAAATCAA ACCTGCCATC AGGAACCAGA TCATCAGGGA GCTGCAGGTG 360

CTCCACGAAT GCAACTCCCC CTACATCGTG GGCTTCTACG GGGCTTTCTA CAGCGATGGA 420

GAGATCAGCA TCTGCATGGA GCACATGGAT GGTGGATCCT TGGATCAGGT CCTAAAGGAA 480

GCCCGGAGAA TCCCTGAGGA GATTCTTGGA AAAGTCAGCA TAGCGGTGTT GAGGGGGCTG 540

GCTTACCTGC GGGAGAAGCA CCAGATCATG CACAGAGACG TCAAGCCCTC CAACATCCTG 600

GTCAACTCCC GCGGGGAGAT CAAGCTGTGC GACTTTGGCG TGAGCGGCCA GCTCATCGAT 660

TCCATGGCCA ACTCCTTTGT GGGGACGCGC TCCTACATGT CTCCGGAGAG ACTGCAGGGG 720

ACGCACTACT CTGTTCAGTC GGACGTTTGG AGCATGGGGC TGTCCTTGGT GGAGCTGGCG 780

ATCGGCCGCT ATCCCATCCC CCCACCCGAC GCCAAAGAGC TGGAGGCAAT CTTCGGATTC 840

GCCATTCTGG ACGGAGCCGA AGGAGAGCCG CACACGCAAA GGCCGAGACC CCCCGGCAGG 900

CCTGTGAGCG GACACGGCGT GGACAGCAGG CCGGCCATGG CCATCTTTGA ACTCCTGGAC 960

TACATCGTGA ATGAGCCCCC CCCAAAACTG CCTCATGGTG TCTTCACCAG TGACTTCCAG 1020

GACTTTGTGA CTAAATGTTT GATCAAGAAC CCGGCTGAGA GGGCAGATCT GAAGATGCTG 1080

ATGAGTCACA CGTTCATCAA GCGATCAGAG GTGGACGGCG TGGACTTTGC CGGCTGGCTG 1140

TGCAAAACGA TGACCCTGAA CCAGCCGAGC ACCCCTACCC GCGTCACCGA GTGA 1194

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         e + elGaGnggvV+kv+hk+sg ++a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 72    EPICELGAGNGGVVNKVRHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  130

         56789************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlk+    ++ripe++lgk+++av+++l+yl+ek

Q: 131   GFYGAFYSDGEISICMEHMDGGSLDQVLKE----ARRIPEEILGKVSIAVLRGLAYLREK  186

         *****************************9....79************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         ++i+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 187   HQIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  245

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sdvWs+Gl+lvela+gryp++++++

Q: 246   QSDVWSMGLSLVELAIGRYPIPPPDAkeleaifgfaildgaegephtqrprppgrpvsgh  305

         ************************999*********************************

S: 208   .........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhaf  258

                  i+ell++ivne+ppklp+  f+++fq+fv+kCl+k+++eR++lk+l++h+f

Q: 306   gvdsrpamaIFELLDYIVNEPPPKLPHGVFTSDFQDFVTKCLIKNPAERADLKMLMSHTF  365

         ***********************************************************9

S: 259   i  259

Q: 366   I  366

Domain Sequence
(FASTA)

EPICELGAGN GGVVNKVRHK PSGLVMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKEA RRIPEEILGK VSIAVLRGLA YLREKHQIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDVWS 180

MGLSLVELAI GRYPIPPPDA KELEAIFGFA ILDGAEGEPH TQRPRPPGRP VSGHGVDSRP 240

AMAIFELLDY IVNEPPPKLP HGVFTSDFQD FVTKCLIKNP AERADLKMLM SHTFI 295

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013