EKS-ORL-00475
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00475
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Trk546.61.1E-164566834269
StatusUnreviewed
Ensembl ProteinENSORLP00000006595
UniProt AccessionH2LKP1;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameNTRK2 (2 of 2)
Gene Synonyms/Alias NTRK2 (2 of 2);
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000005227ENSORLP00000006595ENSORLT00000006596
OrganismOryzias latipes
Functional Description
Protein Length852
Protein Sequence
(FASTA)
MSAYQPGSWA LSGSESWRCL LWWWFLSWGL AVGSGDPWMS AEACRSSCSC SSTRISCVDP 60
ETGISSFPSL QSDAEMENIT DIYIANQSGF SSINDKDLHR YKNLRNLTVT NSRLTYVTKL 120
AFQNNLKLQY LNLKDNNLSS LSWRIFKHLN ISYLILSGNP LRCSCENMWI KLLLGEEADI 180
QELRCTEDGG ARKLLSRLTL PNCEVPMATL SPSKTSVKEG ENLELSCTTS GVPAPELNWS 240
MALATNYEIE TSGQISVLRL SNLSSLDHNS KISCIAENIV GEKESSLQLD ILFPPKITKL 300
SDAIPDHHWC IPFSVAGNPV PHFQWYLNEN EVTEGAYIMT MIHDITEREY HGCLQLDNPT 360
HLNNGRYRLV VTNEYGMDQK EVDAHFMRQP WEELGPDTAY YVLLYFDFGF IINYYHNFTN 420
ILSHSPTVNP PEDRVAVSHL SVYVVVGIAA VAFTGFLLML VILKFGGNSK FGIKVFSFYF 480
CFSFANMKDR KGQSPSSVIS NDDDSASPLH HVSNGSNTPS SSEMGADAVI IGMTKIPVIE 540
NPQYFRSTNS LLKTDTFVQH IKRHNIVLKR ELGEGAFGKV FLAECYNLSP DQEKILVAVK 600
TLKEASENAR KDFHREAELL TNLQHEHIVT FYGVCVESDP LIMVFEYMKH GDLNKFLRAH 660
GPDAVLMAEG QTTRPVELTQ SQMLHIAQQI ASGMVYLASQ HFVHRDLATR NCLVGENLLV 720
KIGDFGMSRD VYSTDYYRVG GHTMLPIRWM PPESIMYRKF TTESDVWSLG VVLWEIFTYG 780
KQPWYQLSNN EVIECITQGR VLQRPRTCPK EVYDLMLGCW QREPHMRLNI KEIHGLLLNL 840
AKASPVYLDI LG 852
Nucleotide Sequence
(FASTA)
ATGAGCGCGT ACCAACCCGG GAGCTGGGCT CTCTCTGGGT CTGAGTCATG GCGGTGCTTG 60
TTGTGGTGGT GGTTTTTGTC ATGGGGGCTG GCTGTGGGCT CGGGAGATCC TTGGATGTCG 120
GCGGAGGCAT GCCGATCGTC TTGTTCTTGC AGCAGCACCA GGATTTCCTG CGTGGACCCG 180
GAGACTGGGA TCAGCAGTTT CCCCTCCCTG CAGAGCGACG CGGAGATGGA AAACATCACC 240
GACATTTACA TCGCAAACCA GAGTGGCTTC TCCTCCATCA ATGACAAAGA TCTGCACCGC 300
TACAAGAACC TCAGGAATTT AACGGTGACC AACAGCAGAC TAACCTACGT AACAAAGCTG 360
GCCTTTCAGA ACAACCTCAA GCTGCAATAT CTGAATCTGA AAGATAACAA CCTCTCATCT 420
CTGTCCTGGA GGATATTCAA ACACCTCAAC ATCTCATATC TTATTCTGTC AGGGAACCCT 480
CTGCGCTGCT CCTGTGAGAA CATGTGGATC AAGCTGTTGT TAGGGGAAGA AGCAGACATT 540
CAGGAGTTGC GCTGCACTGA GGATGGAGGA GCCCGGAAGC TGCTGTCAAG ACTGACACTG 600
CCTAACTGTG AGGTTCCCAT GGCAACGCTG AGCCCATCCA AAACGAGCGT AAAAGAAGGG 660
GAGAACTTGG AGCTGTCCTG CACGACTTCT GGAGTGCCCG CACCTGAGCT GAACTGGAGC 720
ATGGCACTGG CCACTAACTA TGAGATTGAG ACGTCAGGAC AGATTTCGGT GCTGCGGCTG 780
TCCAACCTGT CGTCACTGGA TCACAACAGC AAGATCAGCT GCATAGCTGA GAACATTGTA 840
GGGGAGAAGG AGTCCTCTCT GCAGCTGGAC ATTCTTTTTC CTCCTAAAAT CACAAAGTTA 900
AGTGATGCAA TTCCTGACCA CCATTGGTGC ATCCCATTTA GTGTTGCAGG AAACCCGGTG 960
CCCCACTTTC AGTGGTATCT AAATGAAAAT GAGGTAACAG AGGGCGCCTA CATCATGACG 1020
ATGATCCATG ACATCACAGA GAGAGAATAT CACGGCTGCC TGCAACTCGA CAACCCCACA 1080
CACCTCAACA ACGGCCGATA CAGACTTGTG GTTACAAACG AATACGGGAT GGATCAGAAA 1140
GAAGTGGATG CTCACTTCAT GAGGCAACCT TGGGAAGAGT TAGGGCCAGA CACAGCCTAC 1200
TATGTTTTAC TTTATTTTGA CTTTGGGTTT ATTATTAATT ATTATCATAA TTTTACAAAT 1260
ATACTGTCGC ACAGCCCCAC TGTAAATCCA CCAGAAGACA GAGTAGCTGT AAGTCACCTT 1320
TCAGTGTATG TCGTGGTGGG CATCGCTGCT GTGGCCTTCA CGGGTTTCCT TTTGATGCTG 1380
GTTATTCTCA AGTTTGGAGG GAACTCCAAA TTTGGCATCA AAGTATTTTC TTTTTATTTT 1440
TGTTTTTCCT TTGCTAATAT GAAAGACAGG AAAGGACAAA GTCCCTCCTC AGTGATCAGC 1500
AATGACGACG ATTCTGCCTC TCCACTGCAT CACGTCTCCA ATGGTAGCAA CACCCCCTCC 1560
TCCTCAGAGA TGGGGGCTGA CGCAGTCATC ATCGGGATGA CCAAGATCCC CGTGATAGAG 1620
AACCCTCAGT ACTTCAGGAG CACCAACAGT CTGCTTAAGA CCGACACATT CGTACAGCAC 1680
ATAAAGAGGC ACAACATCGT GCTGAAGAGA GAACTTGGAG AAGGAGCATT TGGAAAAGTA 1740
TTTTTGGCTG AATGTTACAA CCTTTCACCT GACCAGGAGA AGATACTGGT GGCTGTCAAG 1800
ACACTCAAAG AGGCCAGTGA AAATGCAAGG AAGGATTTTC ACAGAGAAGC AGAGCTGTTG 1860
ACCAACCTGC AGCATGAACA CATTGTCACG TTTTATGGAG TCTGCGTGGA AAGCGACCCC 1920
CTCATCATGG TGTTTGAGTA CATGAAACAT GGAGACTTAA ACAAGTTCCT CAGGGCTCAC 1980
GGACCAGATG CAGTGCTGAT GGCAGAAGGC CAGACTACAA GACCAGTAGA ACTGACCCAG 2040
TCTCAGATGC TGCACATCGC TCAGCAGATA GCTTCTGGAA TGGTCTACCT GGCATCACAG 2100
CACTTTGTCC ACCGTGACTT AGCCACAAGG AATTGCTTGG TGGGTGAGAA CCTGCTGGTA 2160
AAAATTGGAG ATTTTGGGAT GTCCAGAGAT GTCTACAGCA CTGACTACTA CAGGGTTGGA 2220
GGTCACACCA TGCTGCCCAT CCGCTGGATG CCTCCTGAAA GCATCATGTA TAGGAAGTTC 2280
ACGACGGAGA GTGACGTGTG GAGTCTGGGA GTTGTTCTCT GGGAAATCTT CACTTATGGA 2340
AAGCAGCCTT GGTACCAGCT CTCCAACAAT GAGGTGATAG AGTGTATAAC TCAAGGCAGG 2400
GTGTTGCAGC GCCCTCGGAC CTGTCCTAAA GAGGTGTATG ACCTGATGCT GGGATGCTGG 2460
CAGCGAGAAC CGCACATGAG ACTCAACATT AAAGAAATCC ACGGTCTGCT GCTAAATCTG 2520
GCCAAAGCCT CACCCGTATA TCTGGATATA CTTGGCTGA 2559
Domain Profile
S: 1     ivlkrelgegafgkvflaecynllpekdkllvavkalkdaseaarkdfkreaelltnlqh  60
         ivlkrelgegafgkvflaecynl+p+++k+lvavk+lk+ase+arkdf+reaelltnlqh
Q: 566   IVLKRELGEGAFGKVFLAECYNLSPDQEKILVAVKTLKEASENARKDFHREAELLTNLQH  625
         89**********************************************************
S: 61    ehivklyGvctegdplllvfeymkhGdlnkflrahgpdakllvegep..kgelglsqlla  118
         ehiv +yGvc+e+dpl++vfeymkhGdlnkflrahgpda+l++eg+   + el++sq+l+
Q: 626   EHIVTFYGVCVESDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGQTtrPVELTQSQMLH  685
         *********************************************998899*********
S: 119   iakqiaaGlvylasqhfvhrdlatrnclvgedllvkigdfgmsrdvystdyyrvggrtml  178
         ia+qia+G+vylasqhfvhrdlatrnclvge+llvkigdfgmsrdvystdyyrvgg+tml
Q: 686   IAQQIASGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTML  745
         ************************************************************
S: 179   pirwlppesilyrkfttesdvwslGvvlweiltyGkqpfyqlsnteviecitqGrvlerp  238
         pirw+ppesi+yrkfttesdvwslGvvlwei+tyGkqp+yqlsn+eviecitqGrvl+rp
Q: 746   PIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRP  805
         ************************************************************
S: 239   racpkevydlmlgcwqrepqkrlnikeiy  267
         r+cpkevydlmlgcwqrep++rlnikei+
Q: 806   RTCPKEVYDLMLGCWQREPHMRLNIKEIH  834
         ****************************9
Domain Sequence
(FASTA)
IVLKRELGEG AFGKVFLAEC YNLSPDQEKI LVAVKTLKEA SENARKDFHR EAELLTNLQH 60
EHIVTFYGVC VESDPLIMVF EYMKHGDLNK FLRAHGPDAV LMAEGQTTRP VELTQSQMLH 120
IAQQIASGMV YLASQHFVHR DLATRNCLVG ENLLVKIGDF GMSRDVYSTD YYRVGGHTML 180
PIRWMPPESI MYRKFTTESD VWSLGVVLWE IFTYGKQPWY QLSNNEVIEC ITQGRVLQRP 240
RTCPKEVYDL MLGCWQREPH MRLNIKEIH 269
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00381
EKS-ANC-00398
EKS-BOT-00410
EKS-CAJ-00414
EKS-CAF-00410
EKS-DIO-00067
EKS-EQC-00402
EKS-FEC-00393
EKS-GAM-00238
EKS-GAG-00346
EKS-GAA-00496
EKS-GOG-00401
EKS-HOS-00416
EKS-ICT-00389
EKS-LAC-00425
EKS-LOA-00420
EKS-MAM-00408
EKS-MEG-00342
EKS-MOD-00399
EKS-MUM-00442
EKS-MUP-00405
EKS-MYL-00405
EKS-NOL-00372
EKS-ORN-00521
EKS-ORC-00385
EKS-OTG-00412
EKS-PAT-00388
EKS-PES-00363
EKS-PEM-00224
EKS-POA-00401
EKS-PTV-00117
EKS-RAN-00424
EKS-SUS-00363
EKS-TEN-00521
EKS-XET-00523
EKS-XIM-00511
Gene Ontology
GO:0005887; C:integral to plasma membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR011009; Kinase-like_dom.
IPR000372; LRR-contain_N.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR020777; Tyr_kinase_NGF_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00013; LRRNT; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR01939; NTKRECEPTOR.
PR00109; TYRKINASE.
Created Date20-Feb-2013