EKS-ORL-00322

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00322

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/DYRK	445.9	9.8E-134	110	429	320

Status

Unreviewed

Ensembl Protein

ENSORLP00000006827

UniProt Accession

H2LLB3;

Protein Name

Protein Synonyms/Alias

Gene Name

DYRK1A

Gene Synonyms/Alias

DYRK1A;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000005417	ENSORLP00000006824	ENSORLT00000006825
ENSORLG00000005417	ENSORLP00000006827	ENSORLT00000006828

Organism

Oryzias latipes

Functional Description

Protein Length

670

Protein Sequence
(FASTA)

YSDRHQPTTD QSVTVLPYSD QTPQLTANQR HMPQCFRDPT SAPLRKLSID LIKTYKHINE 60

VYYAKKKRRH QQGQGEDSSH KKERKVFNDG YDDDNYDYIV KNGEKWMDRY EIDSLIGKGS 120

FGQVVKAYDR VEQEWVAIKI IKNKKAFLNQ AQIEVRLLEL MNKHDTEMKY YIVHLKRHFM 180

FRNHLCLVFE MLSYNLYDLL RNTNFRGVSL NLTRKFAQQL CTALLFLATP ELSIIHCDLK 240

PENILLCNPK RSAIKIVDFG SSCQLGQRIY QYIQSRFYRS PEVLLGMPYD LAIDMWSLGC 300

ILVEMHTGEP LFSGANEVDQ MNKIVEVLGI PPNHIMDLAP KARKFFEKLS DGTWSVKKTK 360

DGKRYKPPAS RKLHSILGVE TGGPGGRRAG ESGHAVADYL KFKDLILRML DYDPKSRIQP 420

YYALQHSFFK KTADEGTNTS SSVSTSPALE QSQSSGTTSS TSSSSGKVSG KSNDKRVSHR 480

YTNRMHACRI LMLCLQITPT FSRQQQARQP YPPPLVWGGG VGPESVTGET HPVQETTFHV 540

PPQHPKALHP HSHSHHHHGQ MMATRPRPRH YTSPTHSSST QDSMEVVHGH LSMTSLSSSA 600

SSSSTSSSST GNHGNQAYQL RHLPAGALDF GQNGGLSMGL EGHLGMRQGM DREESPMTGV 660

CVQQSSMASS 670

Nucleotide Sequence
(FASTA)

TACAGTGACC GCCACCAGCC AACCACTGAC CAATCTGTTA CGGTTTTACC GTACAGCGAC 60

CAGACACCAC AGCTCACTGC CAATCAGAGG CACATGCCCC AGTGCTTTCG TGACCCAACT 120

TCAGCTCCCC TGAGGAAGCT CTCCATCGAC CTTATCAAAA CATACAAACA CATCAATGAG 180

GTTTATTATG CAAAAAAGAA GCGGCGGCAC CAACAGGGTC AGGGTGAAGA CTCCAGTCAC 240

AAAAAGGAGA GGAAGGTTTT CAATGATGGC TATGACGATG ATAACTATGA CTACATCGTC 300

AAGAATGGGG AGAAGTGGAT GGACCGCTAT GAGATCGATT CCTTAATAGG AAAAGGATCA 360

TTCGGACAGG TTGTGAAAGC TTATGACCGA GTAGAGCAAG AATGGGTTGC CATTAAGATC 420

ATTAAGAACA AGAAAGCTTT CCTTAATCAA GCCCAGATTG AAGTGCGCCT TCTGGAGCTT 480

ATGAACAAAC ATGATACGGA GATGAAATAC TATATTGTCC ACCTGAAACG TCACTTCATG 540

TTCCGTAACC ATCTCTGCCT CGTGTTTGAA ATGCTGTCAT ATAATTTATA CGACCTGCTT 600

CGAAATACCA ACTTCCGCGG CGTCTCACTC AATCTCACCC GGAAGTTTGC CCAGCAGCTA 660

TGCACGGCAC TACTCTTCCT GGCCACCCCC GAGCTCAGCA TCATCCACTG TGACCTGAAG 720

CCCGAGAACA TCCTCCTTTG TAACCCCAAG AGGAGTGCCA TCAAAATAGT GGACTTTGGC 780

AGTTCATGCC AACTGGGACA AAGGATATAC CAGTATATCC AGAGTCGCTT CTACCGTTCT 840

CCAGAAGTGT TGCTGGGAAT GCCCTATGAC CTGGCCATCG ACATGTGGTC CTTGGGTTGC 900

ATCTTGGTAG AGATGCATAC CGGAGAGCCT CTATTTAGTG GAGCCAATGA GGTGGACCAG 960

ATGAACAAAA TAGTCGAGGT TCTTGGCATC CCACCCAATC ACATAATGGA CCTAGCCCCA 1020

AAAGCCAGGA AGTTCTTTGA GAAGCTTTCA GATGGTACAT GGAGTGTTAA GAAGACCAAA 1080

GATGGCAAAA GGTATAAGCC TCCAGCTTCG CGGAAGCTCC ACTCCATCTT AGGTGTGGAG 1140

ACGGGCGGTC CTGGTGGCCG ACGGGCAGGG GAGTCTGGCC ACGCTGTTGC TGACTACTTG 1200

AAGTTCAAGG ACCTGATCCT CCGGATGTTG GACTATGACC CCAAGAGCCG CATCCAGCCG 1260

TACTATGCCC TACAGCACAG CTTCTTCAAG AAGACTGCGG ACGAGGGGAC CAATACAAGT 1320

AGTAGTGTGT CGACAAGCCC CGCATTAGAG CAATCCCAGT CGTCAGGAAC CACCTCCAGC 1380

ACCTCCTCCA GTTCAGGTAA AGTATCAGGA AAATCTAATG ATAAAAGGGT TTCACACAGA 1440

TACACAAACC GCATGCATGC CTGCCGGATC CTAATGCTTT GCCTGCAAAT AACACCAACG 1500

TTTTCTCGAC AACAACAGGC AAGACAGCCT TACCCGCCCC CACTGGTGTG GGGAGGGGGC 1560

GTCGGACCAG AGTCGGTCAC TGGGGAAACT CACCCAGTCC AGGAGACCAC CTTCCATGTT 1620

CCCCCTCAGC ACCCCAAGGC CCTGCATCCC CACTCTCATA GTCATCACCA CCACGGGCAA 1680

ATGATGGCCA CTCGTCCACG TCCACGCCAC TACACCTCCC CGACACACAG CTCCTCGACA 1740

CAGGACTCCA TGGAGGTGGT TCATGGCCAT CTGTCCATGA CCTCCCTGTC TTCCTCTGCC 1800

TCCTCTTCCT CTACATCGTC CTCTTCCACT GGGAACCATG GCAACCAGGC CTACCAGCTT 1860

CGCCATTTGC CTGCTGGAGC CCTTGACTTT GGTCAGAATG GTGGGCTGAG CATGGGACTA 1920

GAAGGCCACC TGGGTATGAG GCAGGGCATG GACCGGGAGG AGTCTCCAAT GACTGGAGTA 1980

TGTGTGCAGC AGAGTTCTAT GGCCAGCTCG TGA 2013

Domain Profile

S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60

         ye++++igkGsfgqVvka+d+ ++e+vaikiiknkk+f++qaq+Ev++Le +nk+d+e+k

Q: 110   YEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMK  169

         9***********************************************************

S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLk.  119

         y++v+l+++f+frnhlclvfe+ls+nLy+ll++++f+g+sl+l+rk+aqq+++aL +L+

Q: 170   YYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLAt  229

         **********************************************************99

S: 120   .elkiiHaDlKPeNillvekkrsevkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178

          el+iiH+DlKPeNill+++krs++k++DFGss++  q+ iy+yiqsrfYr+PE++lg++

Q: 230   pELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQR-IYQYIQSRFYRSPEVLLGMP  288

         99*************************************.********************

S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkfftk  238

         yd aiDmWSlGc+l+E++tG+pLf+G+nevdq+++ivevlg+pp+++++ a ka+kff+k

Q: 289   YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPNHIMDLAPKARKFFEK  348

         ************************************************************

S: 239   keapkyilktk........ksdrkkklvlnvkkaakkrkaplskelgealkekedkl.fk  289

          ++ ++ +k++         ++rk + +l+v++ +     p+ +++ge+ + ++d+l fk

Q: 349   LSDGTWSVKKTkdgkrykpPASRKLHSILGVETGG-----PGGRRAGESGHAVADYLkFK  403

         ********999766666666666666666666666.....99******************

S: 290   dllkrmleldpakRitpkealkhpfv  315

         dl+ rml++dp++Ri+p++al+h+f+

Q: 404   DLILRMLDYDPKSRIQPYYALQHSFF  429

         *************************7

Domain Sequence
(FASTA)

YEIDSLIGKG SFGQVVKAYD RVEQEWVAIK IIKNKKAFLN QAQIEVRLLE LMNKHDTEMK 60

YYIVHLKRHF MFRNHLCLVF EMLSYNLYDL LRNTNFRGVS LNLTRKFAQQ LCTALLFLAT 120

PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGMPY 180

DLAIDMWSLG CILVEMHTGE PLFSGANEVD QMNKIVEVLG IPPNHIMDLA PKARKFFEKL 240

SDGTWSVKKT KDGKRYKPPA SRKLHSILGV ETGGPGGRRA GESGHAVADY LKFKDLILRM 300

LDYDPKSRIQ PYYALQHSFF 320

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013