EKS-ORL-00360
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00360
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR480.02.0E-144695951257
StatusUnreviewed
Ensembl ProteinENSORLP00000007170
UniProt AccessionH2LM99;
Protein Name
Protein Synonyms/Alias
Gene NameERBB2
Gene Synonyms/Alias ERBB2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000005702ENSORLP00000007172ENSORLT00000007173
ENSORLG00000005702ENSORLP00000007170ENSORLT00000007171
OrganismOryzias latipes
Functional Description
Protein Length1234
Protein Sequence
(FASTA)
VCRGTDMKLA LPSSLENHYN TLKLLYTDCQ VVHGNLEITH LHGNPDLSFL QGIIEVQGYV 60
LVANVSVSLV PLDNLRIIRG SQLFDSQYAI AVLNNTQGNR GLRTLRLRSL TEILQGGINI 120
WQNPYLCFPD PRSIDWSDIL DKQSNQSKIP KLQPRAPNYS GPSCSSACAK GCWGETSQDC 180
QTLTGNCASG CQRCKGPLTS DCCHKQCAAG CTGPRDSDCL ACRHFNDSGV CKENCPEPTI 240
YDPNNYQAKP NANKKFYFGA FCVKTCPNNY LAMEVACILY CSQSNQEVIT INPDGTETQK 300
CEKCEGNCPN VCYGLGMDNN GVIDNHGITV VTSANVKQFS NCKKIFGSLA FRAQSFERDP 360
VTNASGLTVE QLQTFKNLEE IAGYLYIDAW PEELSNLNVF ENLRVIRGRM LYMGVFSLAI 420
QSLNIESLGL RSLRSVSGGL VMVYNNSQLC YVDDGLLKNL SHHGEGSKII ISNTKQPQVC 480
ESEGHVCHSL CKGGCWGPGP RQCLSCMFLR RGTECVEHCN INDGPVREFE HNSVCTPCHE 540
ECRPLNGTAS CKGPGPEDCT ECRHFRDGKV CVEQCPSGVK EEHQTIWKYS NATGHCLPCN 600
TNCTLSFSCS VKDERGCPID TRTGPGTTIA AAVGGVVLFF ILLALLVFYL RRQSKLKRKE 660
TVRRYLQEQE LVEPLTPSGA SPNQAQMRIL KETELKKLRV LGAGAFGTVH KGVWTPEGET 720
VKIPVAIKVL RENTSPKANK EILDEAYVMA GVTSPYVCRL LGICLTSTVQ LVTQLMPYGC 780
LLDYVRENKD CIGSQFLLNW CVQIAKGMSY LEDIRLVHRD LAARNVLVKN PNHVKITDFG 840
LARLLDIDET EYHADGGKVP IKWMALESIM HRRFTHQSDV WSYGVTVWEL MTFGSKPYDT 900
IPARKIPDVL EGGERLPQPP ICTIDVYMIM VKCWMIDPDS RPKFKELVQE FTAMARDPPR 960
YLVIKNDEHM STSNPVDSRF YRMLLEEGDN MGEMMDAEDY LVPQPNLFPR TNGDEHQANG 1020
PSRRQSHRVG TSATNGAWPP YPVLARSTSA GGQSDSVFLD AVPDGLAVSP LSPGRYCKDP 1080
THPSEGQDLE IGGLNGFQPH PHHTLPRRTR INNPNCAPPE YVNQDVPDFK PGISERPTTL 1140
PRKGRKADRL LPNGLSSGHS VENPGYLVPV SSPAFDNPYY LDLESKSDPE AGVADASPTL 1200
ESNGRVPKQV NGFVTPTAEN PEYLGLTDTW SGHT 1234
Nucleotide Sequence
(FASTA)
GTCTGCCGGG GCACGGACAT GAAGCTGGCC CTGCCCTCCA GCCTGGAAAA TCACTACAAC 60
ACCCTGAAGC TCCTGTACAC CGACTGCCAA GTTGTCCATG GCAACCTAGA GATTACACAC 120
CTCCATGGAA ACCCTGACCT CTCCTTCCTG CAGGGGATTA TAGAGGTGCA GGGTTATGTC 180
CTCGTTGCTA ATGTCTCAGT GAGTCTTGTG CCTTTGGACA ACCTTCGGAT CATAAGAGGC 240
AGCCAGCTGT TCGACTCCCA ATATGCAATT GCTGTCCTGA ATAACACTCA GGGAAATCGG 300
GGGCTGAGGA CCCTCCGTCT CCGCAGCCTA ACGGAGATCC TGCAGGGTGG GATTAACATT 360
TGGCAGAACC CCTACCTGTG CTTCCCCGAC CCCCGGAGTA TAGATTGGAG CGACATACTG 420
GATAAGCAGA GCAACCAATC CAAAATCCCC AAACTGCAGC CGCGGGCCCC TAACTATTCA 480
GGTCCAAGCT GCTCCTCTGC ATGTGCGAAA GGTTGCTGGG GAGAAACGTC GCAAGATTGC 540
CAAACGTTGA CGGGAAATTG CGCGTCTGGC TGTCAGCGAT GTAAAGGCCC TCTGACCAGT 600
GACTGCTGCC ACAAGCAGTG TGCTGCCGGC TGCACCGGAC CCAGAGACTC GGACTGTCTG 660
GCATGTCGTC ACTTCAACGA CAGTGGTGTG TGCAAGGAGA ACTGTCCCGA GCCCACCATT 720
TACGATCCCA ACAACTACCA GGCCAAGCCC AACGCAAACA AAAAGTTTTA CTTCGGAGCC 780
TTTTGCGTCA AGACGTGTCC CAATAACTAC CTGGCTATGG AAGTGGCCTG CATTTTATAT 840
TGTTCACAAT CCAACCAGGA AGTGATCACC ATCAATCCTG ATGGAACGGA GACTCAGAAG 900
TGTGAAAAGT GTGAAGGAAA TTGTCCAAAC GTGTGCTATG GTCTGGGTAT GGACAACAAC 960
GGTGTCATCG ACAACCATGG AATCACCGTG GTAACATCCG CTAACGTGAA GCAATTCAGC 1020
AACTGCAAGA AGATTTTTGG AAGTCTTGCG TTCCGCGCCC AGAGCTTTGA GAGGGATCCT 1080
GTAACCAACG CATCCGGCCT CACTGTGGAG CAGCTCCAAA CTTTCAAGAA CTTGGAGGAG 1140
ATTGCAGGTT ATCTGTACAT TGATGCATGG CCTGAGGAGC TGAGTAACCT GAATGTCTTT 1200
GAGAACCTGC GTGTGATCAG AGGCAGGATG CTTTACATGG GTGTGTTTTC ACTGGCCATC 1260
CAAAGCCTAA ACATCGAGTC TCTTGGGCTA CGTTCACTGC GCAGCGTCAG CGGGGGTCTG 1320
GTTATGGTAT ACAACAACTC ACAGTTGTGT TATGTTGATG ATGGGCTCTT GAAGAATCTG 1380
TCCCATCACG GTGAGGGGTC CAAAATCATC ATAAGCAACA CCAAGCAACC CCAAGTCTGT 1440
GAGTCGGAGG GGCATGTCTG CCACTCGTTG TGTAAAGGAG GCTGTTGGGG CCCGGGGCCC 1500
AGACAGTGTC TGTCCTGCAT GTTTCTCCGG CGTGGAACTG AATGTGTGGA GCACTGTAAC 1560
ATCAATGATG GGCCTGTGCG TGAATTTGAA CACAACTCTG TGTGCACCCC CTGTCACGAG 1620
GAGTGCCGAC CTCTCAACGG CACCGCCTCC TGCAAGGGTC CGGGTCCGGA GGACTGTACG 1680
GAGTGTCGAC ACTTCCGGGA CGGAAAGGTT TGTGTGGAGC AGTGTCCGAG TGGTGTGAAG 1740
GAGGAACATC AGACCATATG GAAATACAGC AACGCTACCG GCCACTGTCT GCCATGCAAC 1800
ACTAACTGCA CCCTCTCTTT CAGCTGCTCA GTGAAGGATG AGCGGGGCTG CCCTATTGAC 1860
ACCAGGACAG GACCTGGCAC TACTATAGCA GCAGCAGTGG GTGGAGTGGT CCTCTTCTTC 1920
ATCCTTCTGG CTCTCCTGGT TTTCTATCTG AGGCGACAGA GTAAACTGAA AAGGAAGGAG 1980
ACGGTGAGGA GGTACCTGCA GGAGCAGGAG CTAGTAGAGC CTTTGACTCC CAGTGGCGCA 2040
TCTCCTAACC AAGCCCAGAT GCGCATCCTG AAGGAGACCG AGCTGAAGAA GCTGAGGGTT 2100
CTGGGTGCAG GGGCCTTCGG CACCGTCCAC AAGGGCGTTT GGACTCCTGA AGGGGAAACT 2160
GTTAAAATAC CTGTAGCTAT TAAGGTGTTG CGGGAGAACA CCTCTCCAAA GGCCAACAAA 2220
GAAATCCTGG ATGAGGCCTA TGTGATGGCG GGGGTCACCA GCCCCTACGT CTGTCGCCTT 2280
CTGGGAATTT GTCTGACCTC CACCGTGCAG CTGGTCACTC AGCTGATGCC GTACGGCTGT 2340
CTCCTGGATT ACGTCCGGGA GAACAAGGAC TGCATCGGTT CGCAGTTTCT CCTGAACTGG 2400
TGTGTCCAGA TCGCTAAGGG CATGAGTTAC CTGGAGGACA TCCGGTTGGT CCACAGAGAT 2460
CTGGCCGCCC GCAACGTTCT GGTAAAGAAC CCGAACCACG TGAAGATCAC GGACTTTGGT 2520
CTGGCCCGTC TGCTCGATAT AGACGAGACC GAGTATCATG CTGATGGAGG GAAGGTACCC 2580
ATTAAATGGA TGGCTTTGGA GTCAATAATG CACAGAAGGT TCACTCATCA GAGCGACGTG 2640
TGGAGCTACG GAGTGACTGT TTGGGAGCTA ATGACCTTTG GATCAAAGCC TTATGACACG 2700
ATCCCAGCAA GGAAAATTCC TGATGTCCTC GAGGGGGGAG AGCGTCTTCC TCAGCCCCCC 2760
ATCTGCACCA TCGACGTCTA CATGATAATG GTCAAATGTT GGATGATCGA TCCGGACAGC 2820
AGGCCCAAGT TCAAAGAACT GGTCCAGGAG TTTACCGCCA TGGCTAGAGA TCCACCTCGC 2880
TATTTAGTCA TTAAGAACGA CGAACACATG AGCACCAGCA ATCCAGTGGA CAGCCGCTTT 2940
TATAGGATGC TTCTGGAGGA GGGGGATAAC ATGGGGGAAA TGATGGACGC GGAGGATTAC 3000
CTGGTGCCCC AGCCAAACCT CTTCCCACGC ACGAACGGAG ACGAGCATCA GGCCAACGGG 3060
CCGTCCAGGC GCCAGTCACA CAGGGTGGGC ACCAGCGCCA CAAACGGCGC ATGGCCGCCG 3120
TACCCTGTTC TGGCCCGCAG CACGTCAGCA GGGGGCCAGT CGGACTCTGT TTTCCTGGAC 3180
GCGGTTCCGG ACGGCCTCGC CGTTTCCCCG CTCTCCCCGG GGCGCTACTG CAAAGATCCC 3240
ACCCATCCCA GCGAAGGCCA GGACCTGGAA ATTGGCGGGC TAAACGGTTT TCAGCCCCAC 3300
CCCCATCACA CACTGCCCAG GCGGACTCGT ATCAATAATC CCAACTGCGC TCCGCCAGAA 3360
TATGTGAATC AGGACGTTCC GGATTTTAAG CCGGGGATTT CCGAGCGACC CACCACACTT 3420
CCACGCAAAG GCCGCAAAGC AGACAGACTC TTGCCTAACG GTCTGAGCTC TGGCCACAGT 3480
GTGGAGAACC CCGGCTACCT GGTTCCTGTC AGTTCTCCCG CCTTTGATAA TCCATACTAC 3540
CTGGACCTGG AGTCCAAATC TGACCCTGAA GCTGGGGTGG CAGATGCCAG TCCCACGCTT 3600
GAAAGCAATG GCAGAGTTCC CAAGCAAGTC AACGGGTTTG TGACTCCCAC TGCAGAAAAT 3660
CCCGAGTATC TTGGACTAAC AGACACCTGG AGTGGACATA CTTGA 3705
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lkkl+vlG+GafGtv+kG+w pege+vkipvaikvl+e+t++kanke+ldea+v+a + +
Q: 695   LKKLRVLGAGAFGTVHKGVWTPEGETVKIPVAIKVLRENTSPKANKEILDEAYVMAGVTS  754
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++++rllg+cl+st+qlvtql+p+Gclldyvre+kd +Gsq llnwcvqiakGmsyle+ 
Q: 755   PYVCRLLGICLTSTVQLVTQLMPYGCLLDYVRENKDCIGSQFLLNWCVQIAKGMSYLEDI  814
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvk+pnhvkitdfGla+ll+ de+e++a+ggkvpikw+alesi++r++
Q: 815   RLVHRDLAARNVLVKNPNHVKITDFGLARLLDIDETEYHADGGKVPIKWMALESIMHRRF  874
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvtvwel+tfG+kpyd+ipa++ipd+le Gerl+qppictidvym++vkcw
Q: 875   THQSDVWSYGVTVWELMTFGSKPYDTIPARKIPDVLEGGERLPQPPICTIDVYMIMVKCW  934
         ************************************************************
S: 241   midaesrpkfkelaeef  257
         mid++srpkfkel++ef
Q: 935   MIDPDSRPKFKELVQEF  951
         ****************9
Domain Sequence
(FASTA)
LKKLRVLGAG AFGTVHKGVW TPEGETVKIP VAIKVLRENT SPKANKEILD EAYVMAGVTS 60
PYVCRLLGIC LTSTVQLVTQ LMPYGCLLDY VRENKDCIGS QFLLNWCVQI AKGMSYLEDI 120
RLVHRDLAAR NVLVKNPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESIMHRRF 180
THQSDVWSYG VTVWELMTFG SKPYDTIPAR KIPDVLEGGE RLPQPPICTI DVYMIMVKCW 240
MIDPDSRPKF KELVQEF 257
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00280
EKS-ANC-00289
EKS-BOT-00298
EKS-CAF-00305
EKS-CAP-00334
EKS-DAR-00646
EKS-EQC-00290
EKS-FEC-00284
EKS-GAA-00370
EKS-GOG-00296
EKS-ICT-00281
EKS-LAC-00310
EKS-LOA-00309
EKS-MOD-00293
EKS-MUM-00330
EKS-MUP-00296
EKS-MYL-00300
EKS-NOL-00275
EKS-ORN-00389
EKS-ORC-00281
EKS-OTG-00303
EKS-PAT-00284
EKS-RAN-00315
EKS-SAH-00280
EKS-SUS-00262
EKS-TAR-00391
EKS-TEN-00386
EKS-XET-00372
EKS-XIM-00379
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR021157; Cyt_c1_TM_anchor_C.
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 3.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013