EKS-ORL-00309

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00309

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	290.8	9.1E-87	9	265	257

Status

Unreviewed

Ensembl Protein

ENSORLP00000007199

UniProt Accession

H2LMC8;

Protein Name

Protein Synonyms/Alias

Gene Name

CHEK1

Gene Synonyms/Alias

CHEK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000005727	ENSORLP00000007199	ENSORLT00000007200

Organism

Oryzias latipes

Functional Description

Protein Length

470

Protein Sequence
(FASTA)

MAVPFVQDWD VVQTLGEGAY GEVRLLVNRQ TEEAVAVKVI DTSQAEECAE NVKKEICIHK 60

ILNHCNIVRF FGHRREGTTV YLFLEYCTGG ELFDRIEPDV GMPERDAHRF FQQLIAAVEY 120

LHKLGITHRD IKPENILLDD KDNLKLTDFG LATMFRFKGR ERRLNRLCGT LPYVAPELLS 180

QSEYHAQPAD IWACGIVLTA MLAGELPWDQ PTESCQEYAD WLQRKTYLPP WKKIQPAPLS 240

LLSKLLQPNP NTRITGEELK KDRWFTQGIF LDKDIMKKIC ASSGCLSSGC SKVLHNNRDF 300

MFRASSDDRM QLSSSQPDFA AGGWEAMLVF GQSEGQVSFS QPTKPEHMLL GSQLLATPGA 360

SQSPWQKLVR RMTRFFTTVD ADATLSALKD TCDALALGFK LTCRQVTLNT LDKRNNPLVF 420

KVLLLHLNQK VLLDFRLSKG DGLEFKRLFV KIKQKLGDIV NSQKILLPVV 470

Nucleotide Sequence
(FASTA)

ATGGCGGTGC CTTTCGTGCA GGACTGGGAC GTGGTCCAGA CGCTGGGAGA AGGAGCTTAT 60

GGAGAAGTGA GGCTGCTGGT GAACAGGCAG ACGGAGGAGG CGGTGGCGGT AAAGGTGATC 120

GACACGTCAC AAGCAGAGGA GTGTGCAGAA AATGTCAAGA AAGAGATCTG CATCCATAAG 180

ATTCTCAACC ACTGCAACAT TGTAAGGTTT TTCGGTCATC GGAGAGAAGG AACAACCGTC 240

TATCTCTTCC TAGAATACTG CACTGGAGGG GAGCTGTTTG ACCGCATTGA ACCTGATGTG 300

GGGATGCCAG AGAGAGATGC TCATCGGTTT TTCCAGCAGC TCATCGCCGC TGTGGAATAC 360

CTCCACAAAC TCGGCATCAC CCACAGAGAC ATAAAACCTG AGAACATTCT TCTGGATGAC 420

AAAGACAATC TGAAGCTGAC CGACTTTGGC CTGGCTACCA TGTTTCGCTT CAAAGGACGC 480

GAGCGGCGTC TGAATCGACT CTGTGGAACT CTGCCTTATG TGGCTCCGGA ACTGCTCAGC 540

CAAAGCGAGT ACCACGCTCA GCCCGCAGAC ATCTGGGCGT GTGGGATCGT CCTCACTGCC 600

ATGCTGGCTG GAGAGCTGCC ATGGGACCAA CCCACTGAGA GCTGTCAGGA GTATGCAGAC 660

TGGCTTCAGA GGAAAACCTA CCTACCTCCC TGGAAGAAAA TACAACCAGC CCCCCTTAGC 720

TTGTTGTCCA AATTACTGCA ACCCAATCCC AATACCCGGA TCACTGGAGA AGAGCTAAAG 780

AAAGACCGCT GGTTTACACA AGGAATATTC TTGGATAAAG ATATAATGAA AAAAATCTGT 840

GCCTCCTCAG GATGTCTGAG CTCGGGCTGC AGCAAGGTTC TTCACAACAA CAGGGATTTT 900

ATGTTCCGTG CTAGCAGTGA CGACAGGATG CAGCTGTCCA GCTCTCAGCC TGATTTTGCC 960

GCTGGCGGCT GGGAAGCCAT GCTGGTGTTT GGGCAAAGCG AAGGTCAAGT CAGCTTCTCG 1020

CAGCCGACCA AGCCTGAGCA CATGCTGCTG GGTAGTCAGT TACTGGCCAC GCCTGGAGCC 1080

AGTCAGTCGC CGTGGCAGAA ATTAGTTCGG AGAATGACCC GTTTCTTCAC CACAGTGGAT 1140

GCTGATGCAA CTTTGTCTGC GCTGAAAGAC ACCTGTGATG CTCTTGCACT CGGTTTCAAA 1200

CTCACCTGCA GACAGGTAAC TCTGAACACG CTGGATAAAC GCAACAACCC GCTAGTCTTT 1260

AAGGTCCTGC TCCTGCATTT GAACCAGAAA GTGCTTCTGG ACTTCAGGCT GTCTAAGGGT 1320

GACGGTTTGG AGTTCAAGCG CCTCTTTGTG AAAATCAAGC AGAAGCTGGG CGACATTGTC 1380

AACAGTCAGA AGATTTTACT GCCTGTGGTG TGA 1413

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         +++++tlGeg++g+V+l ++++t+e+vavK+i++++++ e +e++k+Ei i+k+l+h ni

Q: 9     WDVVQTLGEGAYGEVRLLVNRQTEEAVAVKVIDTSQAE-ECAENVKKEICIHKILNHCNI  67

         889*******************************7776.5579*****************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ++++   ++ +++yl+ley++ggeLfd+ie +  ++e++a+++f+ql++av+Ylh+ gi+

Q: 68    VRFFGHRREGTTVYLFLEYCTGGELFDRIEPDVGMPERDAHRFFQQLIAAVEYLHKLGIT  127

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkeg...klletfcGsppYaaPellkgkkYegp  177

         HrD+KpeN+lld+k+n+k++DFGla++f+ +   + l++ cG++pY+aPell++++Y+++

Q: 128   HRDIKPENILLDDKDNLKLTDFGLATMFRFKgreRRLNRLCGTLPYVAPELLSQSEYHAQ  187

         **************************998776779*************************

S: 178   kvDvWslGvvLyalvtgklPfdee..nlkellekilkgkleipkk.lskelesLlrklLv  234

         ++D+W++G+vL a+++g+lP+d++  +++e+ ++++++++  p k +++   sLl+klL+

Q: 188   PADIWACGIVLTAMLAGELPWDQPteSCQEYADWLQRKTYLPPWKkIQPAPLSLLSKLLQ  247

         ***********************96678999999999888777768**************

S: 235   vdpekRatieeilkhewl  252

          +p++R+t ee++k++w+

Q: 248   PNPNTRITGEELKKDRWF  265

         *****************7

Domain Sequence
(FASTA)

WDVVQTLGEG AYGEVRLLVN RQTEEAVAVK VIDTSQAEEC AENVKKEICI HKILNHCNIV 60

RFFGHRREGT TVYLFLEYCT GGELFDRIEP DVGMPERDAH RFFQQLIAAV EYLHKLGITH 120

RDIKPENILL DDKDNLKLTD FGLATMFRFK GRERRLNRLC GTLPYVAPEL LSQSEYHAQP 180

ADIWACGIVL TAMLAGELPW DQPTESCQEY ADWLQRKTYL PPWKKIQPAP LSLLSKLLQP 240

NPNTRITGEE LKKDRWF 257

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013