EKS-ORL-00292

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00292

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	385.0	1.7E-115	61	312	252

Status

Unreviewed

Ensembl Protein

ENSORLP00000007222

UniProt Accession

H2LMF1;

Protein Name

Protein Synonyms/Alias

Gene Name

MARK2

Gene Synonyms/Alias

MARK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000005740	ENSORLP00000007222	ENSORLT00000007223

Organism

Oryzias latipes

Functional Description

Protein Length

766

Protein Sequence
(FASTA)

VGARGKPTRT QLETELTESC PTGYKTMHYE QKSSSGRHSM SRCRNSVATT TSDEQPHIGQ 60

YRLLKTIGKG NFAKVKLARH VLTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKLLNHPNI 120

VKLFEVIETD KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 180

HRDLKAENLL LDAEMNIKIA DFGFSNEFTL GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 240

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 300

GSLEQIMRDR WMNVGYEEEE LKPYIEPQPD YKDPRRTDVM LQMGYSQEEI KDSLVNQKYN 360

EVMATYLLLD YKNSELEEGC IKPRPGSDAS TINASSPSHK VQRSVSSNQK AQSRRPTDQV 420

SSYSKRGGPG DSRSAAEDSG KKSVSGSSTT KVPASPLVSS DRKKSATPST NSILSTGTSR 480

SRNSPLTDRA TLGQGIQNGK DSSFTFQCRS FSSSVDDLSP TVTDKRRPRH YKSLSSSNHP 540

CQSDLHAPRP SGAPQRAPVA SPSAHNISSA AVSDRTNFSR GGVRSTFHAG QQRGARDQQG 600

STYTGGPASP SLSHGNSQAR RTHGATGIFS KFTSKFVRKS PYEGEGRDEG SSGGTGTPPA 660

NASQKDSAKP RSLRFTWSMK TTSSMEPAEM MREIRKVLDS NNCDYDERER YMLLCTSSDP 720

HNFVQWEMEV CKLPRLSLNG VRFKRISGTS IAFKNIASKI ANELKL 766

Nucleotide Sequence
(FASTA)

GTGGGAGCAA GGGGCAAACC TACCCGGACA CAGCTGGAAA CTGAACTGAC TGAAAGCTGC 60

CCTACAGGCT ACAAAACAAT GCATTATGAG CAAAAATCCT CGTCCGGCCG ACACAGCATG 120

TCACGATGCC GAAACTCCGT GGCCACGACC ACATCAGATG AGCAGCCACA TATCGGCCAA 180

TACCGGTTGC TGAAAACCAT CGGCAAGGGC AACTTTGCTA AAGTCAAACT GGCTCGACAT 240

GTTCTCACTG GAAAAGAGGT GGCCGTAAAG ATCATAGATA AGACGCAGCT CAACTCATCC 300

AGTTTGCAAA AGCTCTTTCG GGAGGTGAGA ATCATGAAAT TGTTGAATCA TCCCAACATA 360

GTCAAGCTTT TTGAGGTGAT AGAGACGGAC AAGACTCTGT ACCTGGTAAT GGAGTATGCT 420

AGTGGAGGAG AGGTCTTTGA TTACCTGGTG GCCCACGGAA GAATGAAGGA AAAAGAAGCC 480

CGTGCCAAAT TCAGACAGAT CGTGTCGGCC GTGCAGTATT GCCACCAGAA GTGTATAGTG 540

CACAGGGACC TTAAGGCAGA GAACCTGCTG CTAGACGCGG AGATGAACAT CAAGATAGCG 600

GACTTTGGTT TCAGTAATGA GTTTACTCTG GGGAACAAGC TGGACACATT CTGTGGATCT 660

CCACCCTATG CAGCCCCAGA ACTCTTCCAG GGCAAGAAGT ACGACGGGCC TGAGGTGGAT 720

GTCTGGAGTC TGGGAGTGAT CCTCTACACG CTGGTCAGTG GCTCGCTGCC CTTTGATGGA 780

CAAAACCTTA AGGAGCTGAG GGAGCGAGTG CTGCGCGGTA AATACAGGAT TCCTTTCTAC 840

ATGTCCACCG ACTGCGAGAA CCTGCTTAAA AAATTTCTGA TCCTGAACCC TTCCAAAAGA 900

GGCAGCCTGG AGCAGATTAT GAGGGACCGA TGGATGAATG TGGGCTATGA GGAAGAGGAA 960

CTCAAGCCCT ACATTGAACC TCAGCCAGAT TATAAAGACC CCAGAAGGAC AGACGTTATG 1020

CTTCAAATGG GATATTCTCA AGAGGAGATC AAAGATTCGC TTGTGAACCA GAAGTACAAC 1080

GAGGTGATGG CCACGTACCT GCTTCTGGAC TACAAGAACT CTGAGCTTGA AGAAGGTTGT 1140

ATCAAACCAC GGCCAGGAAG TGATGCAAGC ACCATCAACG CCTCCTCTCC ATCTCACAAG 1200

GTACAACGCA GCGTATCTTC CAACCAGAAG GCTCAGAGCC GCAGACCCAC CGATCAGGTG 1260

TCCTCCTATT CCAAGAGAGG AGGTCCCGGG GATAGTCGGT CTGCAGCGGA GGATTCTGGG 1320

AAGAAAAGTG TATCAGGCAG CTCCACGACC AAGGTGCCAG CCAGCCCTCT GGTGTCTTCA 1380

GACCGCAAGA AGAGCGCCAC GCCTTCCACT AATAGCATCC TTTCCACTGG TACCAGTCGC 1440

AGTCGGAACT CTCCGCTGAC TGACAGAGCC ACGCTCGGCC AGGGTATCCA GAACGGCAAG 1500

GACAGCTCAT TTACCTTTCA GTGCCGAAGC TTCAGCTCCA GTGTTGACGA TCTTTCGCCA 1560

ACCGTAACCG ACAAACGTCG TCCCCGCCAC TACAAGTCCT TGTCCTCCTC CAACCATCCA 1620

TGCCAATCTG ACCTGCACGC ACCACGGCCC AGTGGGGCGC CGCAGCGGGC GCCCGTCGCC 1680

TCCCCGTCTG CCCACAACAT CAGCAGCGCG GCTGTGTCGG ACCGAACCAA CTTCTCCAGA 1740

GGGGGAGTCC GCAGCACGTT CCACGCCGGC CAGCAGCGGG GCGCACGGGA CCAGCAGGGC 1800

TCCACCTACA CCGGCGGCCC GGCCTCCCCG TCTCTGTCAC ACGGCAACAG CCAGGCCCGC 1860

AGGACGCACG GGGCGACCGG GATTTTCAGC AAGTTCACAT CCAAGTTTGT ACGCAAGAGT 1920

CCTTATGAGG GAGAGGGTCG GGATGAGGGG AGCAGTGGTG GCACAGGCAC CCCTCCTGCC 1980

AACGCCAGCC AGAAGGACTC GGCGAAGCCG CGCTCGCTGC GCTTCACCTG GTCCATGAAG 2040

ACCACTTCGT CCATGGAGCC CGCGGAGATG ATGCGCGAGA TCCGCAAAGT GCTGGACTCC 2100

AACAACTGCG ACTACGACGA GCGCGAGCGC TACATGCTGC TGTGCACGTC CAGCGACCCG 2160

CACAACTTTG TGCAGTGGGA GATGGAGGTG TGCAAGCTGC CGCGGCTCTC CCTCAACGGC 2220

GTGCGCTTCA AGCGCATCTC GGGCACCTCG ATTGCCTTCA AGAACATCGC CTCAAAGATC 2280

GCCAACGAGC TCAAACTGTG A 2301

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y+llkt+G+g+f+kVkla+h +t+++vavKii+k++l+++sl+k++rE++i+k l+hpni

Q: 61    YRLLKTIGKGNFAKVKLARHVLTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKLLNHPNI  120

         99**********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         +kl+eviet+k+lylv+eyasgge+fdy++++gr+kekear+ f+q+vsav+Y+h+k iv

Q: 121   VKLFEVIETDKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIV  180

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld+++nikiaDFG++n+f+ g++l+tfcGsppYaaPel++gkkY+gp+vD

Q: 181   HRDLKAENLLLDAEMNIKIADFGFSNEFTLGNKLDTFCGSPPYAAPELFQGKKYDGPEVD  240

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         vWslGv+Ly+lv+g+lPfd++nlkel+e++l+gk++ip+++s+++e+Ll+k+L  +p+kR

Q: 241   VWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKR  300

         ************************************************************

S: 241   atieeilkhewl  252

          ++e+i++++w+

Q: 301   GSLEQIMRDRWM  312

         ***********8

Domain Sequence
(FASTA)

YRLLKTIGKG NFAKVKLARH VLTGKEVAVK IIDKTQLNSS SLQKLFREVR IMKLLNHPNI 60

VKLFEVIETD KTLYLVMEYA SGGEVFDYLV AHGRMKEKEA RAKFRQIVSA VQYCHQKCIV 120

HRDLKAENLL LDAEMNIKIA DFGFSNEFTL GNKLDTFCGS PPYAAPELFQ GKKYDGPEVD 180

VWSLGVILYT LVSGSLPFDG QNLKELRERV LRGKYRIPFY MSTDCENLLK KFLILNPSKR 240

GSLEQIMRDR WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Microcebus murinus"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR001772	; Kinase-assoc_KA1.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF02149	; KA1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220	; S_TKc; 1.
SM00165	; UBA; 1.

Prosites

PS50032	; KA1; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013