EKS-ORL-00535

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00535

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/MAPK	402.0	1.5E-120	45	339	295

Status

Unreviewed

Ensembl Protein

ENSORLP00000008260

UniProt Accession

H2LQC0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPK7

Gene Synonyms/Alias

MAPK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000006580	ENSORLP00000008260	ENSORLT00000008261

Organism

Oryzias latipes

Functional Description

Protein Length

898

Protein Sequence
(FASTA)

MATEKGREAQ NQQGVEDADT STTAKNLALL KAHSLDVKFD VGEEYDIIET IGTGAYGVVS 60

SARRRDNDTG QQVAIKKISN AFEVVTNAKR TLRELKILKH FKHDNIIAIK DILQPNLPHS 120

AFKSVYVVLD LMESDLHQII HSTQTLTPEH TRYFLYQLLR GLKYVHSANV IHRDLKPSNL 180

LVNENCELKI GDFGMARGLS SHPEESYSFM TEYVATRWYR APELLLSLNH YSLAIDLWSV 240

GCIFAEMLGR KQLFPGKHYV HQLQLILSVL GTPPEGLISA IRAERVRSYV QSLPSRTAVP 300

LSKLYPQAEP DALDLLGAML RFDPRQRIGV TEALEHPYLA KYHDPDDEPI CVPAFDFEFD 360

KIAMSKEQIK DAILMEIQDF HKKKQSCRQK LQFKPLPRGN KGAAAQSNNQ SNAPTADNLT 420

ESSLLPMVPR AQQIQQHKTE SGPVDVDMPS ANSDSGQPET IDLTTPVSSQ GASSESLGKN 480

SRSSQPAAEG TRKEGAISED TKNALKAVLL KSAIRQKARS GGGASSSLSS VLESRRSVTA 540

QERQRDSLGG VLLSDNDKSL LQRWTRMMDS RCDKSQTPNN DGCKNKDCNE SSHTGAVTEI 600

TAETMNNKTD EARTFQAHNQ LISQVNPNQH GLFQSPSAQP PSLPFSMNQQ TPSADLVTVN 660

AGIDLMAMAG GFVKNALKPH PESGVQSRFG CLGNWSGQQL ATRPPHQPNR TTQPAPSSFL 720

QPQTKADPQP QLLPLESFLS RAATLNAQET NGNMGIGGQN NLNTMTGNSG QIEKPHPSLV 780

FTDTGQQGAP TAPDIHTVTL QLSKSQVEDI LPPVFSVTPK GSGAGYGVGF DLDDLLNQSL 840

TDLQNCDRDS YDSAPLSASL LSDWSEVHRM TPADLESLQQ ELQLGSPMIL SDGIAPDS 898

Nucleotide Sequence
(FASTA)

ATGGCCACGG AAAAGGGCAG AGAAGCCCAG AACCAACAAG GAGTGGAAGA CGCCGACACC 60

AGCACGACGG CAAAGAACCT GGCGTTGCTG AAAGCACACT CTCTCGATGT GAAGTTTGAC 120

GTTGGGGAGG AATATGATAT CATAGAAACC ATTGGTACCG GGGCATATGG AGTCGTTTCA 180

TCTGCCAGAA GACGGGACAA TGACACAGGC CAGCAGGTGG CAATAAAGAA AATCTCCAAC 240

GCTTTTGAGG TGGTGACAAA TGCCAAACGC ACCTTAAGAG AGCTTAAGAT TCTCAAACAT 300

TTCAAACATG ACAACATTAT CGCCATCAAA GACATCCTCC AGCCAAATCT TCCTCACTCA 360

GCCTTCAAGT CTGTGTATGT GGTGCTGGAC CTCATGGAGA GTGACCTTCA TCAGATCATC 420

CACTCCACCC AAACACTAAC CCCCGAGCAC ACGCGCTACT TTCTCTACCA GCTCCTCCGT 480

GGCCTCAAGT ACGTGCACTC TGCCAACGTC ATCCACCGCG ACCTCAAACC CTCCAACCTG 540

CTGGTGAATG AAAACTGTGA GCTGAAAATC GGGGACTTTG GCATGGCCAG GGGGCTAAGT 600

TCCCACCCCG AGGAGTCGTA CTCCTTCATG ACCGAGTATG TGGCAACTCG ATGGTACCGC 660

GCTCCTGAGC TGCTCCTCTC TCTGAACCAT TACAGTCTGG CTATTGACCT GTGGTCTGTG 720

GGCTGCATCT TTGCGGAAAT GTTGGGCCGA AAGCAGCTTT TTCCTGGGAA ACACTACGTC 780

CACCAGCTTC AGCTCATTTT AAGTGTGTTG GGCACACCTC CTGAGGGTTT AATAAGCGCT 840

ATAAGGGCTG AAAGAGTGCG CTCCTATGTT CAGAGCCTTC CATCACGAAC TGCTGTGCCT 900

TTGTCCAAAC TGTACCCACA AGCTGAACCA GATGCCCTGG ACTTGCTGGG GGCCATGTTG 960

CGCTTCGATC CCCGCCAACG AATCGGTGTG ACGGAGGCAC TCGAGCACCC ATACTTGGCG 1020

AAATACCACG ACCCGGATGA CGAGCCTATA TGCGTTCCAG CTTTTGACTT TGAATTTGAT 1080

AAGATTGCAA TGAGCAAGGA ACAAATCAAA GATGCCATTT TAATGGAAAT CCAGGACTTT 1140

CATAAAAAGA AACAAAGCTG CCGTCAGAAG CTGCAATTCA AGCCATTGCC GAGAGGGAAC 1200

AAGGGAGCCG CTGCGCAAAG TAATAACCAG AGTAATGCTC CAACTGCTGA CAATCTGACC 1260

GAATCCTCAC TGCTTCCAAT GGTACCAAGA GCACAACAGA TACAGCAGCA TAAAACTGAA 1320

AGTGGCCCAG TTGACGTGGA TATGCCCAGT GCCAACTCTG ACAGCGGCCA GCCGGAGACG 1380

ATAGATTTAA CGACCCCAGT GTCTAGTCAG GGTGCTTCAT CGGAATCACT TGGCAAGAAC 1440

TCGAGGAGTT CTCAACCTGC AGCAGAGGGA ACCAGGAAAG AGGGCGCCAT TTCAGAGGAC 1500

ACCAAAAATG CCCTTAAGGC AGTTTTATTA AAGTCTGCCA TCAGACAAAA AGCCAGGAGT 1560

GGAGGAGGCG CCTCATCCTC CCTGTCCTCT GTTCTAGAGT CCCGTCGGTC TGTCACAGCC 1620

CAGGAGCGTC AGCGGGACTC TTTGGGTGGG GTGTTGCTGA GTGACAACGA CAAGAGCTTG 1680

TTGCAGCGCT GGACGAGGAT GATGGACAGC CGCTGCGACA AATCTCAAAC TCCTAACAAC 1740

GATGGATGCA AGAACAAGGA TTGTAACGAG AGTTCTCACA CGGGTGCAGT TACAGAGATC 1800

ACCGCGGAAA CGATGAACAA TAAAACCGAC GAGGCGAGAA CGTTTCAGGC ACACAACCAG 1860

CTAATCTCTC AAGTAAACCC GAACCAGCAT GGCTTGTTTC AGTCGCCCAG CGCTCAACCA 1920

CCATCATTGC CTTTCTCCAT GAACCAGCAG ACCCCCTCAG CTGATCTAGT TACTGTGAAT 1980

GCAGGGATCG ACTTAATGGC CATGGCTGGT GGGTTCGTTA AAAACGCCCT GAAGCCTCAC 2040

CCTGAAAGTG GCGTCCAAAG CAGGTTTGGC TGTTTAGGGA ATTGGAGTGG CCAGCAACTG 2100

GCGACGAGGC CGCCACACCA ACCAAACAGA ACGACACAGC CGGCGCCATC CAGCTTCCTG 2160

CAGCCCCAAA CCAAGGCTGA CCCGCAGCCA CAGCTGCTCC CTTTAGAGAG TTTTTTGTCA 2220

AGAGCGGCAA CCCTCAACGC CCAAGAGACC AACGGGAACA TGGGCATCGG AGGTCAGAAT 2280

AACCTCAATA CGATGACAGG AAATTCAGGG CAAATAGAGA AGCCTCATCC CAGCCTGGTG 2340

TTCACCGATA CAGGACAGCA GGGAGCCCCT ACTGCTCCTG ACATCCACAC AGTCACCCTG 2400

CAGCTGTCCA AGTCCCAGGT GGAGGACATT TTACCGCCGG TGTTCTCAGT CACCCCTAAA 2460

GGCAGCGGTG CTGGGTATGG CGTGGGCTTT GATCTGGATG ACCTTCTGAA CCAATCTCTG 2520

ACGGACCTGC AAAACTGTGA CCGGGACAGC TATGACTCAG CCCCCCTCTC CGCCTCCCTC 2580

TTATCCGACT GGAGCGAGGT GCACCGCATG ACTCCAGCTG ACCTGGAGTC GCTGCAGCAG 2640

GAGCTACAGC TCGGCTCTCC CATGATCCTC TCTGATGGCA TAGCTCCCGA CTCCTAA 2697

Domain Profile

S: 1     yeslkplgeGaygvvvsav..dkrteervaikklsrpfqketsakrtlRElkllkelkhe  58

         y+ ++++g+Gaygvv sa   d++t+++vaikk+s++f+  t+akrtlRElk+lk++kh+

Q: 45    YDIIETIGTGAYGVVSSARrrDNDTGQQVAIKKISNAFEVVTNAKRTLRELKILKHFKHD  104

         677899***********9722567889*********************************

S: 59    NiiklldvftpeeeleelkdvYlvtelmetdLkkviksq.klsdehiklllyqilrglky  117

         Nii + d+++p+   +++k+vY+v +lme+dL+++i+s+ +l+ eh +++lyq+lrglky

Q: 105   NIIAIKDILQPNLPHSAFKSVYVVLDLMESDLHQIIHSTqTLTPEHTRYFLYQLLRGLKY  164

         *************************************998********************

S: 118   lHsanviHrDlKPsNllvnedcelkildFGlarsadkekekk...lteyvatrwYraPei  174

         +HsanviHrDlKPsNllvne+celki dFG+ar  +++ e++   +teyvatrwYraPe+

Q: 165   VHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLSSHPEESysfMTEYVATRWYRAPEL  224

         **********************************88887777789***************

S: 175   llslkeytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkiese  234

         llsl++y+ a+D+WsvGCI+aE+l +k+lfpgk++++ql++il+vlgtp e  +++i+ e

Q: 225   LLSLNHYSLAIDLWSVGCIFAEMLGRKQLFPGKHYVHQLQLILSVLGTPPEGLISAIRAE  284

         ************************************************************

S: 235   earnyikslpkkkkkdfeelfpkaseealdLleklLvldpdkRisveeaLehpYl  289

         ++r+y++slp++++ ++++l+p+a+++aldLl  +L +dp++Ri v+eaLehpYl

Q: 285   RVRSYVQSLPSRTAVPLSKLYPQAEPDALDLLGAMLRFDPRQRIGVTEALEHPYL  339

         ******************************************************7

Domain Sequence
(FASTA)

YDIIETIGTG AYGVVSSARR RDNDTGQQVA IKKISNAFEV VTNAKRTLRE LKILKHFKHD 60

NIIAIKDILQ PNLPHSAFKS VYVVLDLMES DLHQIIHSTQ TLTPEHTRYF LYQLLRGLKY 120

VHSANVIHRD LKPSNLLVNE NCELKIGDFG MARGLSSHPE ESYSFMTEYV ATRWYRAPEL 180

LLSLNHYSLA IDLWSVGCIF AEMLGRKQLF PGKHYVHQLQ LILSVLGTPP EGLISAIRAE 240

RVRSYVQSLP SRTAVPLSKL YPQAEPDALD LLGAMLRFDP RQRIGVTEAL EHPYL 295

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004707	; F:MAP kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR003527	; MAP_kinase_CS.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS01351	; MAPK; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013