EKS-ORL-00435

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00435

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	442.9	3.8E-133	278	526	249

Status

Unreviewed

Ensembl Protein

ENSORLP00000008431

UniProt Accession

H2LQT5;

Protein Name

Protein Synonyms/Alias

Gene Name

SRC (2 of 2)

Gene Synonyms/Alias

SRC (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000006714	ENSORLP00000008431	ENSORLT00000008432
ENSORLG00000006714	ENSORLP00000008430	ENSORLT00000008431

Organism

Oryzias latipes

Functional Description

Protein Length

544

Protein Sequence
(FASTA)

MGAGKSKPKE LGSRSMSLDG TIGTGSDSGH FRHLSPAQQT LTPDRSPAVG SGRRGHQGQQ 60

QLAPTNTPVL ALFGGVDDTG TLTSPQRGPL SGGVTTFVAL YDYESRTASD LTFRKGDRLQ 120

IVNNTEGDWW LARSLTTGES GYIPSNYVAP SDSIQAEEWY FGKITRRDSE RLLLNLQNRR 180

GTFLVRESET TKGAYCLSVL DYDNAKGLNV KHYKIRKLDS GGFYITSRTQ FTSLQQLVFH 240

YRKHSDGLCH ALTDVCPVAK PQTQGLARDA WEIPRESLRL DVKLGQGCFG EVWMGTWNGT 300

TRVAIKTLKP GTMSPEAFLQ EAQVMKKLRH EKLVQLYAVV SEEPIYIVTE YMSQGSLLDF 360

LKGDTGKLLR LPQLVDMAAQ IAAGMAYVEK MNYVHRDLRA ANILVGDNLV CKVADFGLAR 420

LIEDNEYTAR QGAKFPIKWT APEAALYGRF TIKSDVWSFG VLLTELATKG RVPYPGMVNR 480

EVLDQVERGY RMPCPAECPS SLHELMLSCW RKDPEERPTF EYLQGFLEDY FTSTEPQYQP 540

GENL 544

Nucleotide Sequence
(FASTA)

ATGGGAGCAG GCAAGAGCAA GCCCAAGGAG CTGGGCTCGC GCTCCATGAG CCTGGATGGC 60

ACCATAGGTA CAGGATCAGA CAGTGGACAC TTCCGTCATC TGAGTCCCGC CCAGCAGACC 120

CTCACCCCCG ACCGGAGCCC TGCTGTAGGA TCAGGCAGAC GGGGGCATCA AGGGCAGCAG 180

CAGCTCGCCC CCACAAACAC TCCCGTGTTG GCTTTGTTTG GAGGGGTGGA TGACACGGGA 240

ACTCTCACGT CACCTCAGAG AGGACCTCTT TCAGGAGGTG TTACCACATT TGTGGCTTTA 300

TATGATTATG AGTCCCGGAC GGCCTCTGAT CTGACCTTTA GGAAAGGCGA CCGGTTGCAG 360

ATTGTCAACA ACACAGAAGG GGACTGGTGG CTCGCTCGCT CGCTGACAAC AGGAGAAAGT 420

GGTTACATCC CCAGCAACTA TGTGGCTCCC TCAGATTCCA TCCAAGCAGA AGAGTGGTAT 480

TTCGGGAAGA TCACTCGGCG TGACTCAGAG AGGCTCCTTC TGAACCTTCA GAACAGACGA 540

GGAACCTTCC TGGTGCGGGA GAGCGAGACC ACTAAAGGGG CTTATTGTCT GTCTGTGCTG 600

GATTATGACA ACGCCAAAGG CCTGAATGTG AAGCATTACA AGATCAGGAA ACTGGATAGC 660

GGCGGTTTCT ACATTACCTC CCGTACCCAG TTCACAAGCC TGCAGCAACT AGTCTTCCAC 720

TACCGCAAGC ACTCTGATGG CCTTTGCCAC GCCCTTACAG ACGTCTGTCC AGTGGCCAAA 780

CCTCAGACGC AGGGACTCGC TAGGGATGCC TGGGAAATTC CTCGAGAGTC CCTTCGCCTG 840

GACGTTAAAC TGGGACAGGG ATGCTTTGGA GAAGTCTGGA TGGGCACGTG GAACGGTACG 900

ACACGGGTAG CCATTAAGAC CTTGAAGCCT GGAACTATGT CTCCAGAGGC CTTTCTTCAG 960

GAAGCACAGG TCATGAAGAA GCTCCGGCAC GAGAAGCTGG TCCAGCTCTA CGCTGTTGTG 1020

TCTGAGGAGC CCATCTACAT CGTCACGGAA TATATGAGCC AAGGTAGCTT GTTGGACTTC 1080

CTGAAAGGAG ACACAGGAAA GTTGCTTCGA CTGCCACAGC TGGTAGACAT GGCAGCTCAG 1140

ATTGCAGCTG GCATGGCCTA TGTGGAGAAG ATGAACTACG TCCACAGAGA CCTGCGGGCT 1200

GCTAACATCC TAGTGGGGGA CAACCTTGTT TGTAAGGTAG CTGACTTTGG TCTGGCAAGA 1260

CTGATTGAAG ACAACGAGTA CACTGCAAGA CAGGGTGCAA AGTTCCCGAT CAAATGGACG 1320

GCACCAGAGG CAGCTCTGTA CGGTCGTTTC ACCATCAAGT CTGACGTGTG GTCCTTTGGT 1380

GTGCTGTTAA CAGAGCTGGC AACTAAAGGC AGAGTTCCTT ATCCAGGTAT GGTAAACCGT 1440

GAAGTGCTGG ATCAGGTGGA GCGTGGCTAC AGGATGCCTT GCCCCGCGGA GTGCCCTAGT 1500

TCCTTGCACG AGCTCATGCT GTCATGCTGG AGGAAGGACC CAGAGGAGAG GCCTACATTT 1560

GAGTACCTTC AAGGCTTCCT AGAGGACTAT TTCACCTCCA CAGAACCCCA GTATCAACCT 1620

GGGGAGAACC TATAG 1635

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l  klG+G+fGevw+g+w+g+++va+ktlk+gt+speafl+eaq++kklrheklv+ly

Q: 278   LRLDVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLY  337

         57889*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m++Gslldflk ++gk l+lp+lvd+aaq+a+Gmay+e++n++hr

Q: 338   AVVSE-EPIYIVTEYMSQGSLLDFLKGDTGKLLRLPQLVDMAAQIAAGMAYVEKMNYVHR  396

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvg++lv+kvadfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 397   DLRAANILVGDNLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  456

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfG+llte+ tkG+vPypGm n+evl+qvergyr+p+p+ecp++l+el+l+cw+kdpee

Q: 457   WSFGVLLTELATKGRVPYPGMVNREVLDQVERGYRMPCPAECPSSLHELMLSCWRKDPEE  516

         ************************************************************

S: 241   rPtfetlqev  250

         rPtfe+lq +

Q: 517   RPTFEYLQGF  526

         *******976

Domain Sequence
(FASTA)

LRLDVKLGQG CFGEVWMGTW NGTTRVAIKT LKPGTMSPEA FLQEAQVMKK LRHEKLVQLY 60

AVVSEEPIYI VTEYMSQGSL LDFLKGDTGK LLRLPQLVDM AAQIAAGMAY VEKMNYVHRD 120

LRAANILVGD NLVCKVADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGVLLTELA TKGRVPYPGM VNREVLDQVE RGYRMPCPAE CPSSLHELML SCWRKDPEER 240

PTFEYLQGF 249

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013