EKS-ORL-00566

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00566

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/TBCK	349.8	8.9E-105	18	275	258

Status

Unreviewed

Ensembl Protein

ENSORLP00000008465

UniProt Accession

H2LQX0;

Protein Name

Protein Synonyms/Alias

Gene Name

TBCK

Gene Synonyms/Alias

TBCK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000006742	ENSORLP00000008465	ENSORLT00000008466

Organism

Oryzias latipes

Functional Description

Protein Length

623

Protein Sequence
(FASTA)

MRPLKDAKLG AFTFFASALP HDVCGSNGLP LTPNSIKILG RFQILKNITH PRLCQYIDIS 60

RGKHERLIVV AEHYERNLND FKQGQRASPE KVLQIAYEVL EGLEFMNRHG LVHRALSPNN 120

VLLDCKGNVK LAKFGLYHMT DHGADVDFPI GYPSYLAPEV IAQGSSHPSD PSHDEAPHPS 180

GPKTDVWSLG VLLFELCAGR RLLQNIDISE RLKFILTLGC MDDIVTVFAE EHGCLDTIKE 240

LPENVLDFLR KCLTFLPSKR NPRPTPAELL GDPVFGGISC QYRPFQRPVS LFSSSLRCAS 300

LELPEDISDL CKDDDGDYLA ERGIDEVYHL WCLAGGDLEK ELTNKEIIQS KPPICTLPNF 360

VVEDGESFGQ GRDRSFLLDD TTVTLSLCQL RNRLKDVAGE AYYPLLEDEQ STLSQSSSSN 420

ELSSTVTLPL IIRERDTEYQ LIRIILFDRL LKAYPYKKNL VWKEARLDVP PLVRGLAWAA 480

LLGIEGDIQA KYDSIDKDTP IPTDRQIEVD IPRCHQYDEL LSSPEGHTKF RRVLKAWVVS 540

HPDLVYWQGL DSLCAPFLYL NFNNEALAYA CMSAFIPKYL YNFFLKDNSH VIQEYLTVFS 600

QMIAFHDPEL SNHLNEIGFI PDV 623

Nucleotide Sequence
(FASTA)

ATGAGACCCC TCAAAGATGC CAAGCTGGGG GCCTTCACCT TCTTTGCGTC AGCTCTTCCT 60

CATGATGTCT GTGGCAGCAA TGGTCTTCCT CTCACTCCTA ACTCCATTAA AATCCTGGGG 120

CGCTTCCAGA TCCTGAAGAA CATCACCCAT CCCAGACTCT GCCAATACAT AGACATCTCC 180

AGAGGGAAAC ATGAAAGGCT TATTGTTGTT GCGGAGCACT ATGAAAGAAA CCTAAATGAC 240

TTCAAACAAG GACAAAGAGC AAGCCCAGAA AAAGTGCTGC AGATTGCCTA TGAGGTTCTC 300

GAAGGCCTGG AGTTTATGAA CAGACATGGT TTGGTGCACA GAGCACTCAG CCCTAACAAC 360

GTGCTCCTGG ACTGTAAGGG GAATGTCAAG CTGGCAAAGT TTGGCCTTTA TCACATGACT 420

GATCACGGCG CAGATGTCGA TTTCCCCATC GGCTACCCAT CATACCTTGC TCCAGAAGTG 480

ATCGCCCAGG GCTCTTCCCA CCCCAGCGAT CCATCACATG ACGAAGCTCC TCATCCCTCT 540

GGACCCAAGA CGGATGTCTG GTCTCTGGGA GTTTTGCTCT TTGAATTGTG TGCAGGAAGA 600

AGACTTCTGC AGAATATTGA TATAAGTGAG AGACTGAAGT TCATTTTGAC TCTTGGTTGC 660

ATGGATGACA TTGTCACAGT GTTCGCTGAG GAACATGGTT GTTTGGATAC CATAAAGGAA 720

CTCCCTGAGA ATGTGCTTGA CTTTTTAAGG AAGTGTTTGA CATTTCTTCC ATCCAAAAGA 780

AACCCTAGGC CGACCCCTGC AGAGCTGCTT GGAGACCCCG TTTTTGGAGG CATTTCCTGC 840

CAGTATAGAC CCTTCCAGAG GCCTGTGAGC CTCTTCTCCT CATCTCTGCG CTGTGCAAGT 900

TTGGAGCTCC CGGAAGACAT CAGTGATCTT TGCAAAGATG ATGATGGTGA TTACTTGGCT 960

GAGCGGGGCA TCGATGAAGT TTACCACCTG TGGTGTCTGG CGGGTGGAGA CTTGGAGAAG 1020

GAGCTGACCA ACAAAGAAAT CATCCAGTCC AAACCCCCCA TCTGCACACT GCCCAATTTT 1080

GTCGTGGAGG ATGGGGAGTC ATTCGGGCAG GGAAGAGATC GGAGCTTTTT GCTGGACGAC 1140

ACCACGGTGA CGCTGTCTTT GTGTCAACTC AGAAATAGAC TTAAGGATGT AGCTGGTGAA 1200

GCTTATTATC CCCTTCTTGA AGACGAACAG TCGACTTTGT CCCAATCCAG CAGCAGCAAT 1260

GAGCTGTCGT CCACAGTCAC GCTGCCACTC ATCATCCGTG AGAGAGACAC AGAGTATCAG 1320

CTCATCCGCA TCATCCTCTT TGACAGGCTG CTCAAGGCTT ATCCATATAA AAAGAACTTG 1380

GTGTGGAAAG AAGCCAGATT GGATGTTCCT CCTCTTGTTC GAGGACTGGC GTGGGCTGCT 1440

CTGCTCGGAA TTGAGGGGGA CATTCAGGCC AAGTACGACA GCATCGACAA GGACACCCCC 1500

ATTCCCACTG ACAGACAGAT TGAAGTGGAC ATCCCCCGCT GTCATCAGTA TGACGAGCTG 1560

CTGTCGTCTC CTGAGGGCCA CACCAAGTTC AGGCGTGTGT TGAAGGCCTG GGTGGTCTCA 1620

CACCCTGACC TAGTCTACTG GCAGGGTTTA GATTCCCTTT GCGCTCCGTT TCTATATTTG 1680

AACTTCAACA ACGAAGCTTT AGCCTACGCC TGCATGTCTG CCTTCATCCC TAAGTACCTG 1740

TACAACTTTT TCTTGAAGGA CAACTCCCAT GTCATTCAAG AGTACTTGAC TGTCTTCTCC 1800

CAAATGATTG CTTTTCACGA CCCAGAGCTA AGCAACCATC TGAATGAAAT TGGCTTCATT 1860

CCAGATGTA 1869

Domain Profile

S: 1     llaqdkdGsnGlplasnakkilGrfqiLkelqhdrLcqYldisrgkhervivvaehlels  60

         +l++d++GsnGlpl++n++kilGrfqiLk+++h+rLcqY+disrgkher+ivvaeh+e++

Q: 18    ALPHDVCGSNGLPLTPNSIKILGRFQILKNITHPRLCQYIDISRGKHERLIVVAEHYERN  77

         589*********************************************************

S: 61    LeDllkerkpvseslvlriayevlsgldylnkhnivhralepksilldrkgqkvkLakyG  120

         L+D+ k+++  s  +vl+iayevl+gl+++n+h++vhral+p+++lld kg+ vkLak+G

Q: 78    LNDF-KQGQRASPEKVLQIAYEVLEGLEFMNRHGLVHRALSPNNVLLDCKGN-VKLAKFG  135

         ***8.677888999**************************************.*******

S: 121   LyhltayGkdvdfpigygsylaPerilqd.........edkllaatvksDvWsLglille  171

         Lyh+t++G+dvdfpigy+sylaPe+i+q+         ++ + ++++k DvWsLg++l+e

Q: 136   LYHMTDHGADVDFPIGYPSYLAPEVIAQGsshpsdpshDEAPHPSGPKTDVWSLGVLLFE  195

         *************************************999********************

S: 172   lilgikLfaeldlserlkillklstvdetliklaeekkcldiikklderleallkkCLtl  231

         l+ g++L +++d+serlk++l+l++ d+ + ++aee++cld ik+l+e++ + l+kCLt+

Q: 196   LCAGRRLLQNIDISERLKFILTLGCMDDIVTVFAEEHGCLDTIKELPENVLDFLRKCLTF  255

         ************************************************************

S: 232   lpskR...pspdellkekvf  248

         lpskR   p+p ell ++vf

Q: 256   LPSKRnprPTPAELLGDPVF  275

         ***954449******99987

Domain Sequence
(FASTA)

ALPHDVCGSN GLPLTPNSIK ILGRFQILKN ITHPRLCQYI DISRGKHERL IVVAEHYERN 60

LNDFKQGQRA SPEKVLQIAY EVLEGLEFMN RHGLVHRALS PNNVLLDCKG NVKLAKFGLY 120

HMTDHGADVD FPIGYPSYLA PEVIAQGSSH PSDPSHDEAP HPSGPKTDVW SLGVLLFELC 180

AGRRLLQNID ISERLKFILT LGCMDDIVTV FAEEHGCLDT IKELPENVLD FLRKCLTFLP 240

SKRNPRPTPA ELLGDPVF 258

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0005097	; F:Rab GTPase activator activity
GO:0032851	; P:positive regulation of Rab GTPase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR000195	; Rab-GTPase-TBC_dom.

Pfam

PF00069	; Pkinase; 1.
PF00566	; RabGAP-TBC; 1.

SMARTs

SM00164

; TBC; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS50086	; TBC_RABGAP; 1.

Prints

Created Date

20-Feb-2013