EKS-ORL-00228

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00228

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	447.5	1.7E-134	297	567	271

Status

Unreviewed

Ensembl Protein

ENSORLP00000008590

UniProt Accession

H2LR90;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK2

Gene Synonyms/Alias

LIMK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000006835	ENSORLP00000008590	ENSORLT00000008591
ENSORLG00000006835	ENSORLP00000008586	ENSORLT00000008587
ENSORLG00000006835	ENSORLP00000008588	ENSORLT00000008589

Organism

Oryzias latipes

Functional Description

Protein Length

606

Protein Sequence
(FASTA)

VSCIGCSVCS DLLTNWYYEN EGKLYCRKHY LEKFGEFCHG CSLLMTGPAM VAEEHKYHPE 60

CFVCLSCKVV IEDRDTYALV ERSKLYCGRC YKQEVLKPML EKHSQDSVIH SLPHTVTLIS 120

MPSAANGKRG FSVSVLRDVA GSANVQVKEV RGMLISPEVR NAIHVGDRIL EINGLPVETL 180

MEQQVDNLIH CTSHTLQLLI EHDPVRLRLG SPRNQLGVPA TSRMRLSSPS DAVLERTDVA 240

DEGTLKRRSL RRSNSTCKSP GPNSPKESPL FAKDIGRSES LRSPSSCSHR IFRPCDLIHD 300

EVLGKGFFGQ AIKVIHKATG EVMVMKELIR CDEETQKTFL KEVKVMRSLE HPHVLRFIGV 360

LYKDKRLNLI TEYIEGGTLK DVIRDTDPFP WEQRVNFAKG ITSGMAYLHS MSIIHRDLNS 420

HNCLVKLDNT VVVADFGLSR LIVEEKAKPP PEKPSNKKRL FRRIDRKKRY TVVGNPYWMA 480

PEMLNGKRYD EKVDVFSYGI VLCEIIGKVY ADPECLPRTL DFGLNVCKFA EKFLPEDCPP 540

AFFPMAVACC DLIPDNRPPF QKLEDWFEAL SLNQELRIPL PAELEELHQS LSRLYWFRDP 600

SPSTDE 606

Nucleotide Sequence
(FASTA)

GTTTCTTGCA TTGGATGTTC TGTGTGCTCT GACCTCCTGA CTAACTGGTA CTATGAGAAT 60

GAGGGCAAAC TGTACTGCCG AAAACATTAC CTGGAGAAGT TTGGAGAGTT CTGCCATGGC 120

TGCTCTCTGC TCATGACCGG ACCTGCTATG GTGGCTGAAG AACACAAGTA CCACCCTGAA 180

TGTTTTGTTT GTCTAAGCTG CAAGGTGGTG ATTGAGGATA GAGATACTTA TGCTTTGGTC 240

GAGCGGTCCA AACTCTACTG TGGAAGGTGC TACAAACAGG AGGTCCTCAA GCCAATGTTG 300

GAAAAACACT CTCAAGACTC CGTCATTCAC TCCCTGCCCC ACACAGTGAC CCTCATCTCC 360

ATGCCCTCTG CAGCCAACGG CAAGAGGGGC TTCTCGGTGT CGGTGCTAAG GGATGTCGCT 420

GGTTCTGCAA ATGTTCAAGT GAAAGAGGTC AGAGGCATGC TTATTAGTCC AGAAGTACGA 480

AATGCCATCC ATGTCGGGGA CAGGATCCTG GAGATCAATG GTCTTCCTGT TGAGACGCTG 540

ATGGAGCAGC AGGTGGATAA CCTCATTCAC TGCACCAGTC ACACACTGCA GCTGCTTATA 600

GAGCATGATC CAGTCAGGCT GAGGCTGGGG TCCCCCAGGA ACCAGCTGGG AGTCCCCGCA 660

ACCTCCCGTA TGCGACTGTC CTCTCCGTCT GATGCGGTGT TGGAGAGGAC AGATGTTGCA 720

GATGAAGGCA CGCTGAAACG CAGATCATTA CGGCGGAGCA ACAGCACATG CAAGTCTCCG 780

GGGCCAAATT CTCCAAAAGA GTCACCTTTG TTTGCAAAAG ACATCGGGCG CTCTGAATCT 840

TTGAGGTCTC CCAGCAGTTG CTCTCATCGC ATTTTCCGAC CATGTGACCT CATCCATGAC 900

GAGGTTTTAG GAAAAGGCTT TTTTGGACAG GCCATCAAGG TGATTCATAA AGCCACAGGG 960

GAAGTGATGG TGATGAAAGA GCTGATCCGA TGTGATGAGG AGACACAGAA AACCTTCCTA 1020

AAGGAGGTTA AAGTGATGCG AAGCCTCGAG CATCCCCATG TTTTGAGGTT TATCGGTGTG 1080

CTGTACAAAG ACAAGAGACT CAATTTAATC ACTGAGTACA TTGAGGGAGG CACCCTAAAG 1140

GATGTCATCA GAGATACGGA CCCGTTTCCA TGGGAACAGA GGGTCAATTT TGCCAAAGGC 1200

ATCACTTCTG GCATGGCCTA CCTTCACTCA ATGAGCATCA TCCACAGAGA TCTCAACTCT 1260

CACAATTGCC TTGTTAAACT GGACAACACC GTAGTGGTTG CAGACTTTGG ACTGTCCCGG 1320

CTCATTGTGG AGGAGAAAGC CAAACCTCCA CCTGAAAAAC CTTCAAACAA GAAGAGGTTG 1380

TTCAGGCGGA TTGACCGAAA GAAGCGCTAC ACTGTTGTGG GCAACCCTTA CTGGATGGCC 1440

CCAGAAATGC TCAATGGTAA ACGGTACGAT GAAAAGGTGG ATGTTTTCTC CTACGGAATT 1500

GTTCTTTGTG AGATCATTGG AAAAGTCTAC GCGGATCCCG AGTGCCTCCC CAGGACTTTG 1560

GACTTTGGCC TAAATGTTTG CAAGTTTGCA GAGAAGTTCC TCCCTGAAGA CTGTCCTCCA 1620

GCTTTCTTTC CCATGGCGGT GGCCTGCTGT GACCTCATAC CCGACAACCG GCCACCTTTC 1680

CAGAAGCTCG AGGACTGGTT TGAAGCTCTA TCACTCAACC AGGAGCTGAG AATCCCGCTG 1740

CCAGCCGAAC TGGAAGAACT GCATCAGAGC TTGAGTCGAC TGTACTGGTT TAGAGATCCA 1800

AGCCCAAGTA CGGATGAG 1818

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li++e+lGkGff++++kv h+a+Gevmv+kelir+dee++k++lkevk++r+lehp+vl+

Q: 297   LIHDEVLGKGFFGQAIKVIHKATGEVMVMKELIRCDEETQKTFLKEVKVMRSLEHPHVLR  356

         6899********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskeslpwtqrvrlakdiasGlsylhskgiihr  120

         fiGvl+kdk+l+l+teyiegGtlk+++++++++pw+qrv++ak+i+sG++ylhs++iihr

Q: 357   FIGVLYKDKRLNLITEYIEGGTLKDVIRDTDPFPWEQRVNFAKGITSGMAYLHSMSIIHR  416

         ************************************************************

S: 121   dlnsknclvredksvvvadfGlarlvveerkks......eklrslkkkdrkkrltvvGsP  174

         dlns+nclv+ d++vvvadfGl+rl+vee+ k+      +k+r  ++ drkkr+tvvG+P

Q: 417   DLNSHNCLVKLDNTVVVADFGLSRLIVEEKAKPppekpsNKKRLFRRIDRKKRYTVVGNP  476

         ******************************9988999989999*****************

S: 175   ywmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvae  234

         ywmaPe+l+gk ydekvdvfs+Givlceii++v+adP++lPrt dfgl+v +f ek+ +e

Q: 477   YWMAPEMLNGKRYDEKVDVFSYGIVLCEIIGKVYADPECLPRTLDFGLNVCKFAEKFLPE  536

         ************************************************************

S: 235   dcPeaflklavvccdldpesrpsfeelekkl  265

         dcP+af+++av ccdl p++rp+f++le+++

Q: 537   DCPPAFFPMAVACCDLIPDNRPPFQKLEDWF  567

         ****************************986

Domain Sequence
(FASTA)

LIHDEVLGKG FFGQAIKVIH KATGEVMVMK ELIRCDEETQ KTFLKEVKVM RSLEHPHVLR 60

FIGVLYKDKR LNLITEYIEG GTLKDVIRDT DPFPWEQRVN FAKGITSGMA YLHSMSIIHR 120

DLNSHNCLVK LDNTVVVADF GLSRLIVEEK AKPPPEKPSN KKRLFRRIDR KKRYTVVGNP 180

YWMAPEMLNG KRYDEKVDVF SYGIVLCEII GKVYADPECL PRTLDFGLNV CKFAEKFLPE 240

DCPPAFFPMA VACCDLIPDN RPPFQKLEDW F 271

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 2.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 2.
PS50023	; LIM_DOMAIN_2; 2.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013