EKS-ORL-00274

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00274

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	375.9	1.2E-112	70	362	293

Status

Unreviewed

Ensembl Protein

ENSORLP00000008701

UniProt Accession

H2LRK2;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000006926	ENSORLP00000008701	ENSORLT00000008702

Organism

Oryzias latipes

Functional Description

Protein Length

394

Protein Sequence
(FASTA)

MQKRRKPEPI QLNPIPDGNT LNGTGASETN LESLQKKLEE LELDEQQRKR LEAFLTQKQK 60

VGELKDDDFE KICELGAGNG GVVFKVSHRP SGLIMARKLI HLEIKPAIRN QIIRELQVLH 120

ECNSPYIVGF YGAFYSDGEI SICMEHMDGG SLDQSLKKAG KIPEQILGKV SIAVIKGLSY 180

LREKHKIMHR DVKPSNILVN SRGEIKLCDF GVSGQLIDSM ANSFVGTRSY MSPERLQGTH 240

YSVQSDIWSM GLSLVEMAIG RFPIPPPDSR ELEKIFGFPV EGETASSESP KPRPPGRPGS 300

SYGPDSRPPM AIFELLDYIV NEPPPKLPAI FSSEFQDFVN KCLIKNPAER ADLKQLVVHP 360

FIKQSEAEEV DFAGWLCSTI GLSQPLTPTH TTTI 394

Nucleotide Sequence
(FASTA)

ATGCAGAAGA GAAGGAAGCC AGAACCGATC CAGCTGAACC CGATTCCCGA CGGAAACACA 60

CTGAACGGAA CCGGAGCCTC CGAGACGAAC CTGGAGTCTC TGCAGAAGAA GCTAGAGGAG 120

CTTGAGCTGG ATGAGCAGCA GCGAAAGCGC TTGGAGGCCT TCCTTACACA GAAGCAGAAA 180

GTGGGAGAAC TGAAGGACGA CGACTTTGAG AAAATCTGTG AGCTTGGTGC AGGCAACGGA 240

GGTGTCGTCT TCAAGGTCTC GCACAGACCT TCTGGTTTGA TCATGGCAAG GAAGCTGATC 300

CACCTGGAGA TCAAACCAGC CATCAGGAAC CAGATCATCC GGGAGCTGCA GGTTCTGCAT 360

GAGTGCAACT CTCCATACAT TGTAGGCTTC TATGGAGCTT TTTACAGCGA TGGAGAAATC 420

AGCATCTGCA TGGAACACAT GGACGGTGGC TCCCTGGACC AGTCTTTGAA GAAAGCAGGC 480

AAAATCCCAG AGCAGATCCT TGGCAAAGTC AGCATTGCTG TCATTAAAGG GCTGTCTTAC 540

CTGCGTGAGA AGCACAAGAT CATGCACAGA GATGTCAAAC CTTCTAACAT CCTGGTGAAT 600

TCCCGAGGTG AGATCAAGTT GTGTGACTTT GGAGTGAGCG GGCAGCTGAT TGACTCCATG 660

GCCAACTCCT TTGTGGGAAC TCGCTCCTAT ATGTCGCCAG AGCGCTTACA GGGAACTCAC 720

TACTCAGTTC AGTCAGACAT ATGGAGCATG GGCCTGTCTT TAGTAGAAAT GGCCATTGGA 780

CGCTTTCCTA TCCCTCCACC TGATTCAAGA GAGTTGGAAA AGATTTTTGG GTTCCCTGTG 840

GAAGGGGAAA CGGCCTCCAG TGAATCTCCA AAACCACGCC CACCTGGACG GCCGGGAAGT 900

TCATATGGAC CAGACAGTAG ACCGCCAATG GCCATATTTG AACTACTTGA TTACATAGTC 960

AATGAGCCTC CACCAAAGCT TCCTGCAATT TTCAGCTCTG AGTTTCAAGA TTTCGTCAAC 1020

AAGTGCTTGA TAAAGAATCC TGCAGAAAGG GCCGATCTGA AGCAGCTAGT GGTACATCCT 1080

TTCATCAAGC AGTCTGAAGC AGAGGAGGTG GACTTTGCTG GCTGGTTGTG TAGCACCATA 1140

GGACTCAGCC AGCCTCTGAC ACCCACCCAC ACCACCACCA TTTAA 1185

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek+ elGaGnggvV kv+h++sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 70    EKICELGAGNGGVVFKVSHRPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  128

         7899*************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+ lkk    +++ipe++lgk+++av+k+l+yl+ek

Q: 129   GFYGAFYSDGEISICMEHMDGGSLDQSLKK----AGKIPEQILGKVSIAVIKGLSYLREK  184

         **************************9988....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 185   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  243

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gr+p++++++

Q: 244   QSDIWSMGLSLVEMAIGRFPIPPPDSrelekifgfpvegetassespkprppgrpgssyg  303

         ************************999*********************************

S: 208   ........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhafi  259

                 i+ell++ivne+ppklp+  fs+efq+fv+kCl+k+++eR++lk+l+ h+fi

Q: 304   pdsrppmaIFELLDYIVNEPPPKLPA-IFSSEFQDFVNKCLIKNPAERADLKQLVVHPFI  362

         ************************96.8*******************************7

Domain Sequence
(FASTA)

EKICELGAGN GGVVFKVSHR PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQSLKKA GKIPEQILGK VSIAVIKGLS YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAI GRFPIPPPDS RELEKIFGFP VEGETASSES PKPRPPGRPG SSYGPDSRPP 240

MAIFELLDYI VNEPPPKLPA IFSSEFQDFV NKCLIKNPAE RADLKQLVVH PFI 293

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013