EKS-ORL-00295

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00295

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	358.8	1.7E-107	21	272	252

Status

Unreviewed

Ensembl Protein

ENSORLP00000009359

UniProt Accession

H2LTE1;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK2

Gene Synonyms/Alias

SIK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000007465	ENSORLP00000009359	ENSORLT00000009360

Organism

Oryzias latipes

Functional Description

Protein Length

916

Protein Sequence
(FASTA)

MVMADGVQKP LTRGPVRVGF YDIERTLGKG NFAVVKLARH RITKTEVAIK IIDKTQLDAV 60

NLEKIYREVQ IMKMLDHPHI IKLYQVMETK NMLYLVTEYA KSGEIFDYLA KHGRLSELEA 120

RRKFWQILSA VEYCHNRNIV HRDLKAENLL LDGHMNIKIA DFGFGNFFKQ GEPLATWCGS 180

PPYAAPEVFE GQQYEGPQLD IWSMGVVLYV LVCGALPFDG PSLPVLRQRV LEGRFRIPYF 240

MTEDCEHLIR RMLVLDPSKR LSLAQIKEHK WMALDVPAQR PVLYQQPLSA EGEMGVGEYS 300

EQVLRLMHSL GIDQQKTIES LQNKSYNHFA AIYYLLVERL KAHRCSFPVE QRLDARQRRP 360

STIAEQTVIK STSGSAQVGL LPQGVRLLRS PAVPQPSSDA FTFPQTACPL EQNFLVEDVS 420

TPKVNGCLLD PLPPSTVLRK SSTSSPSNMM ETSIDEGIET EEPDTEDDTP HLLSAYQTTR 480

FGQRRHTLSE VSNHVFVSHP LGKYFTLGHN TSMGSVDSDI GYDMGSVHSD LSLLEDAPSL 540

SEVVPSNSSA PGIAAPFLSA RPPNPAMAAL TSQHREAHNR SPISFREGRR ASDTSLTQGL 600

VAFRQHLQNL ARTKGILDLN KVQMLVEQMG SVEGASMGPL GPQQHLHNLL EGEACKQQEG 660

LALYHGGLQP PLLSRRQSLE TQYLTHRLQK ANILANSPAS CQLFCKETPR SLEQQLQEHR 720

LHQKRMYLQQ HQSQGMGLQA YFNQMQIAEG SYAAPSMSAP HQPQSQQQGS PQASPPFSHT 780

HSLSPLMEPG EGLVYDPYMS HHHPYTQQLP PGAHLMHHPL HHQHSLEAPV GGLGFSYPAG 840

CDPHSPGPSA EALLPEQYEF SMDASLLPQP GPGEADAGGP VAAQTDGLGM PKLQASLLDS 900

EMMETVDSQH GFVLVN 916

Nucleotide Sequence
(FASTA)

ATGGTCATGG CTGACGGTGT CCAAAAGCCG CTGACCCGGG GTCCGGTCCG AGTGGGCTTC 60

TACGACATCG AACGCACTTT AGGAAAGGGC AATTTCGCCG TGGTGAAATT GGCTAGACAC 120

CGAATAACCA AGACCGAGGT GGCCATTAAG ATCATTGACA AGACCCAACT AGACGCTGTA 180

AACCTGGAGA AGATCTACAG GGAAGTTCAA ATCATGAAGA TGTTGGACCA CCCTCACATC 240

ATTAAGCTTT ACCAGGTGAT GGAAACAAAG AACATGCTTT ACTTAGTCAC GGAGTATGCC 300

AAGAGCGGGG AGATCTTCGA CTATCTGGCA AAGCATGGGC GTCTCAGTGA GCTGGAGGCC 360

AGGAGGAAGT TTTGGCAGAT TCTGTCTGCA GTCGAGTACT GTCACAACCG GAACATTGTC 420

CACAGAGACC TGAAGGCTGA AAATTTGCTG TTGGACGGTC ACATGAACAT CAAGATTGCA 480

GATTTTGGAT TTGGAAACTT CTTTAAACAA GGAGAGCCTT TGGCTACATG GTGTGGCAGC 540

CCGCCATACG CTGCTCCAGA GGTCTTTGAA GGACAACAGT ATGAGGGCCC ACAGCTGGAC 600

ATCTGGAGTA TGGGGGTGGT GCTTTATGTG CTGGTGTGCG GGGCGTTGCC CTTTGACGGG 660

CCCAGTCTGC CTGTCCTCCG ACAGAGAGTC CTAGAAGGAA GGTTCCGCAT CCCATACTTC 720

ATGACTGAAG ACTGTGAACA CTTGATCCGC AGGATGTTGG TCCTGGACCC GTCCAAACGC 780

CTGTCCTTGG CACAGATTAA GGAGCACAAA TGGATGGCTT TGGACGTCCC AGCACAGAGG 840

CCCGTCCTGT ACCAACAGCC ACTGTCAGCT GAGGGTGAGA TGGGTGTAGG AGAATACAGC 900

GAACAGGTCC TTCGCCTGAT GCACAGCCTT GGCATCGACC AACAAAAGAC TATAGAGTCT 960

CTTCAGAATA AAAGCTACAA CCACTTCGCT GCGATCTACT ACCTGCTGGT CGAGCGGCTG 1020

AAGGCCCATC GATGCAGCTT CCCTGTGGAA CAAAGGCTCG ACGCCCGCCA GCGGCGCCCC 1080

AGCACCATCG CTGAGCAGAC GGTCATCAAG TCAACCAGCG GCTCAGCCCA GGTGGGTTTG 1140

CTTCCACAGG GCGTTCGTCT GTTGCGTTCC CCCGCGGTTC CTCAGCCCTC GTCGGATGCT 1200

TTTACCTTCC CCCAGACTGC ATGTCCCCTG GAGCAGAACT TCCTTGTGGA GGATGTCAGC 1260

ACACCCAAAG TGAATGGCTG CCTTCTGGAC CCCCTTCCTC CCTCTACTGT CCTCCGCAAG 1320

TCCTCCACTT CGTCACCTAG CAACATGATG GAGACCTCGA TTGACGAAGG CATTGAGACT 1380

GAGGAGCCCG ACACGGAGGA CGACACGCCC CACCTTCTCT CAGCCTATCA GACGACTCGA 1440

TTTGGCCAGA GGCGGCACAC CTTATCTGAA GTTTCCAACC ATGTTTTTGT GTCTCATCCG 1500

TTAGGTAAAT ATTTCACTTT AGGCCACAAC ACCTCCATGG GCAGCGTGGA CTCGGACATT 1560

GGCTACGATA TGGGCTCCGT GCACAGCGAC CTCAGTCTGC TGGAGGACGC GCCCTCCCTC 1620

AGTGAGGTGG TACCATCCAA CAGCTCTGCT CCTGGCATAG CTGCACCTTT TCTGAGTGCC 1680

AGGCCACCCA ACCCAGCAAT GGCTGCCCTG ACTTCTCAGC ACAGGGAGGC GCACAACCGA 1740

TCCCCGATAA GCTTCCGAGA AGGACGCCGC GCCTCTGACA CCTCCCTCAC CCAAGGCCTG 1800

GTGGCGTTTC GGCAGCACCT CCAAAACTTG GCAAGGACCA AAGGCATCCT GGACCTCAAC 1860

AAAGTCCAGA TGCTGGTGGA GCAGATGGGC TCTGTGGAAG GGGCCAGCAT GGGGCCTCTG 1920

GGACCACAGC AACACTTGCA CAACCTCCTG GAGGGCGAGG CATGCAAGCA GCAGGAGGGC 1980

CTAGCTTTAT ACCACGGTGG GCTGCAGCCC CCCCTTCTCT CCCGCAGACA GAGTTTGGAA 2040

ACACAGTACC TCACCCACAG ACTTCAGAAG GCTAACATCC TGGCTAACAG CCCTGCGAGC 2100

TGCCAACTTT TCTGCAAGGA GACGCCGAGA AGTTTAGAGC AGCAGCTACA GGAACACAGG 2160

CTGCATCAGA AGAGGATGTA TCTGCAGCAG CACCAGTCAC AGGGCATGGG ACTCCAGGCC 2220

TACTTCAACC AGATGCAGAT AGCTGAGGGC TCCTACGCCG CCCCCTCCAT GTCGGCCCCC 2280

CACCAGCCTC AGTCCCAGCA GCAGGGCAGT CCCCAAGCCT CACCCCCTTT CAGCCACACC 2340

CACAGCTTGA GCCCTTTGAT GGAACCCGGC GAGGGCCTGG TTTACGACCC GTACATGAGC 2400

CACCACCACC CTTACACCCA ACAGCTGCCC CCCGGAGCTC ACCTCATGCA CCACCCACTC 2460

CACCATCAGC ATTCTCTGGA GGCCCCTGTT GGCGGCTTGG GCTTCAGCTA CCCAGCAGGC 2520

TGTGATCCAC ATTCCCCTGG TCCTTCCGCT GAGGCTCTCC TGCCAGAGCA ATACGAGTTC 2580

TCCATGGACG CCAGCCTGCT GCCTCAGCCT GGTCCAGGGG AGGCAGACGC TGGAGGCCCC 2640

GTGGCAGCGC AGACAGACGG CTTAGGCATG CCTAAACTGC AGGCGTCCCT CCTGGACAGT 2700

GAAATGATGG AGACCGTGGA CTCGCAGCAT GGCTTCGTGC TGGTCAACTA A 2751

Domain Profile

S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkklseeslekikrEieilkklkhpni  60

         y++ +tlG+g+f+ Vkla+h+ tk++va+Kii+k++l++ +leki+rE++i+k+l+hp+i

Q: 21    YDIERTLGKGNFAVVKLARHRITKTEVAIKIIDKTQLDAVNLEKIYREVQIMKMLDHPHI  80

         899*********************************************************

S: 61    ikllevietkkklylvleyasggeLfdyieekgrlkekearklfkqlvsavkYlhskgiv  120

         ikl++v+etk++lylv+eya+ ge+fdy+ ++grl+e ear+ f q++sav+Y+h+++iv

Q: 81    IKLYQVMETKNMLYLVTEYAKSGEIFDYLAKHGRLSELEARRKFWQILSAVEYCHNRNIV  140

         ************************************************************

S: 121   HrDlKpeNllldkkenikiaDFGlanlfkegklletfcGsppYaaPellkgkkYegpkvD  180

         HrDlK+eNllld ++nikiaDFG++n+fk+g+ l t+cGsppYaaPe+++g++Yegp++D

Q: 141   HRDLKAENLLLDGHMNIKIADFGFGNFFKQGEPLATWCGSPPYAAPEVFEGQQYEGPQLD  200

         ************************************************************

S: 181   vWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlrklLvvdpekR  240

         +Ws+GvvLy+lv+g+lPfd+++l  l++++l+g+++ip+ +++++e+L+r++Lv dp+kR

Q: 201   IWSMGVVLYVLVCGALPFDGPSLPVLRQRVLEGRFRIPYFMTEDCEHLIRRMLVLDPSKR  260

         ************************************************************

S: 241   atieeilkhewl  252

         +++ +i++h+w+

Q: 261   LSLAQIKEHKWM  272

         ***********8

Domain Sequence
(FASTA)

YDIERTLGKG NFAVVKLARH RITKTEVAIK IIDKTQLDAV NLEKIYREVQ IMKMLDHPHI 60

IKLYQVMETK NMLYLVTEYA KSGEIFDYLA KHGRLSELEA RRKFWQILSA VEYCHNRNIV 120

HRDLKAENLL LDGHMNIKIA DFGFGNFFKQ GEPLATWCGS PPYAAPEVFE GQQYEGPQLD 180

IWSMGVVLYV LVCGALPFDG PSLPVLRQRV LEGRFRIPYF MTEDCEHLIR RMLVLDPSKR 240

LSLAQIKEHK WM 252

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013