EKS-ORL-00361

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00361

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/EGFR	399.2	8.8E-120	698	954	257

Status

Unreviewed

Ensembl Protein

ENSORLP00000009628

UniProt Accession

H2LU54;

Protein Name

Protein Synonyms/Alias

Gene Name

ERBB3 (2 of 2)

Gene Synonyms/Alias

ERBB3 (2 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000007685	ENSORLP00000009628	ENSORLT00000009629

Organism

Oryzias latipes

Functional Description

Protein Length

1338

Protein Sequence
(FASTA)

WKRLLENVSS SLLVSEVCPG TQNGLSSTGS QQNQYNLIKE RYEGCEIVMG NLEITQIESN 60

WDFSFLKTIR EVTGYILIAM NHFQEIPLGQ LRVIRGNSLY EKRFALSVFF NYPKDGSSGL 120

RQLGLVNLTE ILEGGVQIIN NKYLSYGPWI FWRDIVQDST APIEIQYNGE KGSCHKSCGN 180

YCWGPNEHQC QILTKMVCAP QCNGRCFGTS PRDCCHIECA AGCRGPLDLD CYACRHFNDS 240

GACVSQCPQS LIYNKQKFQM ETNPNAKYQY GSICVSQCPT HFVVDGSSCV RVCPPDKMEV 300

DRDGQKQCEP CSGFCPKVCE GTGAEHRQTV DSSNIDSFIN CTKIQGSLHF LVTGILGDDF 360

KSIPPLDAKK LEVFHSVREI TDILNIQSWP EELKDLSVFS SLTTIQGRSL HKRFSLMVMR 420

IPTLTSLGLR SLREISDGSV YISQNANLCY HHTVDWTQLF RGHRVRVNSL NNNKPLTECV 480

AEGHVCDPLC SDSGCWGPGP QQCLSCRNHS RDGTCVGGCH FYSGTPRESA GSDGECVSCH 540

PECKPQRGEI SCTGPGANDC VACTNLRDGP YCVSSCPSGV NDGQRGLIFK YPTKEGLCEP 600

CHPNCTQGCF GPGLNDCLET SRLTVSSGQI TGIALGVPSG LIFCLVLFFL GVLYHRGLAI 660

QRKRAMRRYL ESGESFEPLG PGEKGAKVHA RILKPSELKK IKVLGFGVFG TVHKGFWTPE 720

GESVKIPVAI KTIQDISGQQ TFTEITDYML SMGSLDHPYI VRLLGICPGA SLQLVTALSS 780

QGSVLEHIRQ NRSSLDPQRL LNWCVQIAKG MFYLEEHCMV HKNLAARNVL LKNNYQVQIS 840

DYGMADLLYS NDKKYIYTDA KTPIKWMALE SILFRRYTHQ SDVWSYGVTV WEMMSFGAEP 900

YASVQPQDVP GLLEKGERLS QPHICTIDVY MVMVKCWMID EIVRPTFKEL ASDFTRMARD 960

PHRYLVMKLE GEDAAPSEIC RRESERGLLD PDLEDPDEEG LQDALATPPL QHSPSWSLPR 1020

SRINSYRMSA TISKQDLSVS SGTSQATPTG YLQMTPSPVN SIRQLWFHRA RLSSVRTLPD 1080

QSDFRRSGRE AELHVEGLPT GRGYRTRFDS ERSNLRDPVG QQRKLSTASS PSSYKVWTAG 1140

EEEEEVDRQG YVLPGSLSNS DRVFRICKSG QRNSRLKSNL VLVVTNPQEY ETMNTGPISS 1200

PCLTSNANPD INGQAETDHK SGRYEYMEIT RSNSSDEFDP KLDVNQSQVL AVKTEEANQA 1260

VEVLKNQHKE EEEMAKSHDP NHQEEYEEMV FGVVPAGWGC TDYENLPVKG RAFSNNTSFD 1320

NPDYWHSRLF LKPDAVLT 1338

Nucleotide Sequence
(FASTA)

TGGAAGCGTT TGCTTGAAAA TGTTTCTTCT TCCCTGCTGG TATCAGAGGT GTGTCCTGGT 60

ACTCAGAATG GACTGAGCTC CACCGGCTCA CAGCAGAATC AATACAACCT GATTAAAGAG 120

CGGTATGAAG GCTGTGAGAT TGTCATGGGA AACCTGGAGA TTACTCAGAT TGAAAGCAAC 180

TGGGACTTCT CCTTCCTCAA GACGATCCGA GAGGTGACCG GTTACATCCT TATTGCGATG 240

AACCACTTTC AGGAGATCCC CTTGGGTCAA CTGCGGGTCA TCAGAGGGAA CAGTTTGTAT 300

GAAAAACGCT TTGCCCTGTC AGTTTTCTTC AATTATCCCA AGGATGGCTC CAGTGGCCTG 360

CGGCAGTTAG GGCTTGTGAA TTTGACAGAA ATTCTGGAGG GCGGAGTACA GATTATCAAT 420

AACAAATATC TCAGTTATGG CCCCTGGATC TTCTGGCGAG ACATTGTACA GGACAGCACT 480

GCGCCAATAG AAATCCAGTA CAATGGAGAA AAAGGCTCCT GCCACAAATC CTGTGGAAAT 540

TATTGTTGGG GACCAAACGA GCATCAGTGT CAGATCTTGA CTAAGATGGT GTGTGCCCCG 600

CAGTGTAATG GCCGCTGCTT CGGAACCAGC CCTCGGGACT GCTGTCACAT AGAGTGTGCA 660

GCAGGATGCA GAGGCCCTCT GGATTTAGAC TGTTATGCGT GTCGTCATTT CAATGACTCT 720

GGAGCCTGCG TATCTCAGTG TCCCCAGTCT CTCATCTACA ACAAGCAGAA ATTTCAAATG 780

GAAACCAACC CCAATGCAAA GTATCAGTAT GGTTCAATCT GTGTGTCTCA ATGCCCCACT 840

CATTTTGTGG TGGATGGAAG CTCCTGTGTG AGGGTCTGTC CTCCAGACAA AATGGAGGTG 900

GACCGAGATG GTCAGAAGCA GTGTGAGCCA TGCAGTGGAT TCTGCCCAAA AGTTTGTGAG 960

GGTACAGGTG CAGAGCACAG GCAGACGGTG GACTCCAGCA ACATCGACAG CTTCATCAAC 1020

TGTACCAAGA TCCAGGGCAG CCTTCACTTC CTGGTCACAG GAATCCTCGG AGATGACTTT 1080

AAAAGCATCC CACCACTTGA CGCGAAAAAG CTAGAAGTTT TCCACTCTGT GAGGGAAATT 1140

ACAGACATTC TGAACATCCA GTCGTGGCCC GAAGAACTGA AAGATCTTTC TGTATTTTCT 1200

AGCCTTACCA CCATTCAAGG GCGGTCGCTC CACAAGCGTT TCTCCCTGAT GGTGATGCGC 1260

ATCCCCACTC TGACCTCGCT GGGTCTGCGC TCTCTCCGGG AAATCAGTGA TGGCAGTGTG 1320

TACATCAGCC AGAATGCCAA CCTCTGTTAT CACCACACTG TGGACTGGAC GCAGCTGTTC 1380

AGAGGCCACC GAGTTCGAGT CAACAGTCTG AACAACAACA AGCCACTCAC AGAGTGTGTT 1440

GCTGAGGGTC ACGTGTGTGA CCCTTTATGC TCAGACTCGG GCTGCTGGGG TCCAGGCCCG 1500

CAACAGTGTC TTTCCTGCAG GAACCACAGC CGCGACGGCA CATGTGTTGG AGGCTGTCAT 1560

TTTTACTCTG GCACTCCCAG AGAGTCTGCA GGTTCTGATG GAGAGTGTGT CAGCTGTCAT 1620

CCAGAATGCA AGCCTCAGCG GGGGGAAATC AGCTGCACAG GACCAGGGGC CAATGACTGT 1680

GTTGCTTGTA CCAATTTGCG AGATGGTCCG TACTGCGTGT CCTCCTGTCC CTCTGGAGTT 1740

AATGATGGGC AGAGAGGGCT GATTTTCAAA TATCCCACTA AGGAAGGTCT CTGTGAGCCA 1800

TGTCATCCAA ACTGCACACA GGGATGCTTT GGCCCGGGGT TAAATGACTG TTTAGAGACA 1860

TCAAGGCTGA CAGTGAGCAG CGGCCAGATC ACTGGCATTG CTTTGGGGGT CCCATCTGGC 1920

TTGATTTTCT GCCTGGTGTT GTTTTTCCTG GGAGTTCTGT ACCACAGGGG CCTCGCCATC 1980

CAACGCAAAA GAGCCATGAG GAGATATCTG GAGAGTGGAG AAAGTTTTGA GCCTCTGGGT 2040

CCTGGAGAAA AAGGGGCCAA AGTTCACGCC CGGATTCTGA AGCCATCAGA GTTGAAGAAA 2100

ATCAAAGTCC TCGGCTTTGG GGTCTTTGGC ACAGTGCACA AAGGCTTTTG GACTCCAGAG 2160

GGAGAGTCTG TGAAGATACC AGTGGCCATT AAGACTATCC AGGACATCTC AGGCCAACAG 2220

ACGTTCACAG AGATCACTGA TTACATGCTT TCCATGGGCA GTCTGGATCA CCCCTACATC 2280

GTCAGGCTGC TGGGAATTTG CCCTGGCGCC AGCCTGCAGC TGGTGACGGC GCTCAGCTCT 2340

CAGGGCTCCG TACTGGAACA CATCAGGCAG AACAGGAGCA GCCTGGACCC TCAGCGGCTG 2400

CTCAACTGGT GTGTGCAGAT CGCTAAGGGT ATGTTTTACC TGGAAGAACA CTGCATGGTT 2460

CACAAAAACC TGGCTGCCCG GAACGTCTTG TTGAAAAACA ACTACCAGGT CCAGATCTCG 2520

GACTACGGCA TGGCAGACCT CCTTTATTCC AATGACAAGA AATACATCTA CACAGATGCA 2580

AAGACACCCA TAAAATGGAT GGCACTTGAA AGCATCTTGT TCCGGAGATA CACCCATCAA 2640

AGCGATGTCT GGAGTTATGG GGTGACGGTG TGGGAGATGA TGTCCTTCGG GGCTGAGCCG 2700

TATGCCTCAG TGCAGCCTCA GGATGTACCC GGCCTCCTGG AAAAGGGAGA GCGTCTGTCA 2760

CAGCCTCACA TCTGCACCAT AGATGTCTAC ATGGTGATGG TTAAATGCTG GATGATTGAT 2820

GAAATTGTAA GGCCGACGTT CAAAGAACTG GCGAGTGACT TCACAAGGAT GGCGAGGGAT 2880

CCACACAGAT ACCTTGTTAT GAAGCTGGAA GGAGAAGATG CAGCTCCAAG TGAGATCTGC 2940

AGAAGAGAGT CTGAGAGAGG ACTTCTGGAT CCAGATTTAG AAGACCCAGA TGAGGAAGGA 3000

CTGCAGGACG CTCTGGCTAC TCCTCCTCTT CAGCACTCTC CATCCTGGAG TCTGCCCCGT 3060

TCCCGCATTA ATTCTTACAG GATGTCTGCC ACAATTTCTA AGCAAGATCT TTCAGTCAGT 3120

AGTGGGACAT CTCAGGCTAC ACCAACTGGA TACCTGCAAA TGACCCCGAG CCCTGTTAAC 3180

AGCATCCGCC AGCTTTGGTT TCACCGTGCC CGTCTGAGCT CAGTGCGCAC GCTCCCAGAC 3240

CAATCAGATT TCAGGAGAAG TGGTAGGGAG GCAGAGCTGC ATGTGGAGGG TTTACCGACT 3300

GGGAGAGGTT ACAGGACAAG GTTTGACTCG GAAAGAAGTA ATCTTCGTGA TCCCGTTGGC 3360

CAACAAAGAA AGCTTTCAAC TGCCTCAAGT CCATCCTCTT ACAAAGTGTG GACTGCAGGG 3420

GAAGAAGAGG AAGAAGTGGA CCGCCAGGGC TACGTTCTTC CTGGGTCACT AAGCAACTCA 3480

GACAGAGTTT TCAGGATCTG TAAGTCTGGA CAAAGGAACT CCAGGTTGAA AAGTAACCTG 3540

GTGCTTGTGG TGACAAACCC CCAAGAATAT GAAACCATGA ACACAGGACC AATTTCTTCC 3600

CCCTGTTTAA CCAGCAACGC AAATCCGGAC ATAAACGGCC AAGCAGAGAC AGACCACAAG 3660

AGTGGCAGGT ATGAATACAT GGAGATCACA AGGTCCAACT CTTCAGACGA GTTTGATCCG 3720

AAGTTGGATG TGAATCAAAG TCAGGTGTTG GCTGTAAAGA CAGAAGAAGC AAATCAAGCA 3780

GTTGAGGTTC TGAAAAACCA GCACAAGGAG GAGGAAGAAA TGGCGAAGAG CCATGACCCA 3840

AACCATCAGG AAGAGTATGA GGAGATGGTT TTTGGAGTGG TGCCTGCTGG GTGGGGGTGC 3900

ACAGATTATG AGAATCTCCC AGTGAAGGGA AGGGCTTTTA GCAACAACAC ATCCTTTGAT 3960

AACCCAGACT ACTGGCACAG CAGGCTGTTC CTCAAACCAG ATGCTGTGCT CACCTAA 4017

Domain Profile

S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60

         lkk+kvlG G+fGtv+kG w pege+vkipvaik +++ +g+++++e++d +l ++sldh

Q: 698   LKKIKVLGFGVFGTVHKGFWTPEGESVKIPVAIKTIQDISGQQTFTEITDYMLSMGSLDH  757

         69**********************************************************

S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120

         +++vrllg+c   +lqlvt l   G++l+++r+++ +l +q llnwcvqiakGm ylee+

Q: 758   PYIVRLLGICPGASLQLVTALSSQGSVLEHIRQNRSSLDPQRLLNWCVQIAKGMFYLEEH  817

         ************************************************************

S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180

          +vh++laarnvl+k+  +v+i+d+G+a+ll +++k++ + ++k+pikw+alesil+r+y

Q: 818   CMVHKNLAARNVLLKNNYQVQISDYGMADLLYSNDKKYIYTDAKTPIKWMALESILFRRY  877

         ************************************************************

S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240

         thqsdvwsyGvtvwe+++fGa+py++++ +++p llekGerl+qp+ictidvymv+vkcw

Q: 878   THQSDVWSYGVTVWEMMSFGAEPYASVQPQDVPGLLEKGERLSQPHICTIDVYMVMVKCW  937

         ************************************************************

S: 241   midaesrpkfkelaeef  257

         mid+ +rp+fkela++f

Q: 938   MIDEIVRPTFKELASDF  954

         **************998

Domain Sequence
(FASTA)

LKKIKVLGFG VFGTVHKGFW TPEGESVKIP VAIKTIQDIS GQQTFTEITD YMLSMGSLDH 60

PYIVRLLGIC PGASLQLVTA LSSQGSVLEH IRQNRSSLDP QRLLNWCVQI AKGMFYLEEH 120

CMVHKNLAAR NVLLKNNYQV QISDYGMADL LYSNDKKYIY TDAKTPIKWM ALESILFRRY 180

THQSDVWSYG VTVWEMMSFG AEPYASVQPQ DVPGLLEKGE RLSQPHICTI DVYMVMVKCW 240

MIDEIVRPTF KELASDF 257

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Callithrix jacchus"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016020	; C:membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00261	; FU; 4.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013