EKS-ORL-00125
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00125
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec407.91.6E-122373620248
StatusUnreviewed
Ensembl ProteinENSORLP00000009739
UniProt AccessionH2LUG2;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000007773ENSORLP00000009739ENSORLT00000009740
OrganismOryzias latipes
Functional Description
Protein Length631
Protein Sequence
(FASTA)
MFPRVILKGT MIKKSQQKKR TSPCNYKERF FVLDTQELKY SERRSGKKPM LKGCIQLSSI 60
KCVEIVCSDI PIPCQYKYPF QVLHDNYYLY IFAPDNDCRM RWVKALKEET KYNSLVAKYH 120
TNFWMDGKWR CCLQTDKLAA GCRVYHIFIS YLFTFVNILP ITKKPLPQLP DPEMSLQPST 180
QGMVIALQDY VPMGDDDLPL QKDQEYLLIN SSHSEWWAVQ DDKGKTGFVP STYVAEKCGK 240
NFERFQWYNK HINRAEAEDL LMKKGKEGAF MVRDSRQAGV YTVSVYTKAP GSKGEKNPRV 300
KHYQIRQEEG GQFYLAEKYL FNTIPELIHY HQHNAAGLIT RLRYPVLPDG CCFQEAAEVS 360
TDQWDILPEE LILGEEIGSG QFGLVLEGRW RETKVAVKMV REECMTDDEF KEEAKVMMKL 420
SHCKLVQLFG VCAQRSPMCL VFEYMEKGCL TDYLLEKRGH LSQETLLGMC LDVSEGMAYL 480
ESSNFIHRDL AARNCLISKN NEVKVSDFGM TRYVLDDQYT SSLCSKFPVK WSAPEVIKYS 540
KFSSKSDVWS FGVLMWEVYN EGRLPYDNRS NSEVVESLNA GLRLLKPRLA SDAVYMLMDW 600
CWKEKPDDRP SFALLLHELS ELSGIQPTFC Q 631
Nucleotide Sequence
(FASTA)
ATGTTTCCTC GGGTGATTTT GAAGGGAACC ATGATCAAAA AATCTCAGCA AAAGAAGAGA 60
ACGTCACCGT GTAATTACAA AGAGAGATTT TTTGTTTTGG ACACACAGGA GCTGAAGTAT 120
TCTGAGCGCC GTTCGGGGAA GAAGCCCATG CTAAAAGGTT GCATTCAACT GTCCAGTATT 180
AAGTGTGTGG AAATTGTGTG TAGTGACATC CCCATACCAT GCCAATACAA GTACCCATTT 240
CAGGTTCTTC ATGACAACTA TTACCTCTAC ATTTTTGCTC CAGACAACGA CTGTCGTATG 300
AGATGGGTCA AAGCCCTCAA GGAGGAGACT AAATATAACA GTTTGGTTGC AAAATACCAC 360
ACAAACTTCT GGATGGATGG AAAATGGAGA TGCTGCCTAC AAACTGACAA ACTGGCAGCA 420
GGTTGTCGTG TTTATCATAT ATTTATTTCT TATTTGTTTA CCTTTGTGAA TATTCTCCCT 480
ATCACTAAGA AGCCACTTCC CCAACTCCCA GATCCAGAGA TGTCATTACA ACCTTCAACA 540
CAGGGGATGG TCATAGCTTT GCAAGATTAT GTGCCCATGG GAGACGACGA TTTGCCCCTC 600
CAGAAAGATC AGGAGTACCT GTTGATCAAC AGCTCCCACT CTGAGTGGTG GGCTGTGCAG 660
GACGACAAGG GTAAAACTGG TTTTGTGCCC AGTACGTACG TTGCGGAAAA ATGTGGCAAA 720
AACTTTGAGA GATTTCAATG GTACAACAAG CACATTAACA GAGCCGAGGC AGAAGACTTG 780
TTAATGAAAA AGGGAAAAGA AGGTGCATTC ATGGTGCGGG ACTCAAGACA AGCAGGAGTC 840
TACACGGTGT CCGTTTACAC CAAAGCGCCC GGATCAAAAG GTGAAAAGAA TCCCAGGGTG 900
AAACATTATC AGATAAGGCA GGAGGAAGGA GGACAGTTCT ACTTGGCTGA AAAGTATCTG 960
TTCAACACCA TTCCTGAGCT CATCCACTAT CACCAACACA ATGCTGCTGG TCTGATAACA 1020
CGGCTGAGAT ACCCCGTTTT GCCAGATGGA TGCTGCTTCC AGGAAGCTGC TGAAGTCTCA 1080
ACAGATCAGT GGGACATCCT CCCTGAGGAG CTGATCCTGG GGGAGGAGAT AGGCAGCGGG 1140
CAGTTTGGGC TTGTACTGGA GGGGAGGTGG AGGGAGACGA AGGTGGCGGT GAAGATGGTG 1200
CGAGAAGAGT GCATGACCGA TGACGAGTTC AAAGAGGAGG CAAAAGTTAT GATGAAGTTG 1260
TCTCACTGTA AACTGGTGCA GCTCTTTGGA GTGTGCGCAC AGCGCTCTCC CATGTGTCTG 1320
GTGTTTGAGT ACATGGAGAA AGGGTGTCTG ACAGATTACC TGCTGGAGAA GAGAGGCCAC 1380
TTGTCTCAGG AAACGCTGCT GGGAATGTGT CTGGATGTCA GCGAAGGGAT GGCGTACCTG 1440
GAAAGCTCCA ATTTTATCCA CAGGGATCTG GCAGCTCGGA ATTGCCTCAT CTCAAAGAAT 1500
AACGAGGTAA AGGTGTCAGA CTTTGGCATG ACCAGGTACG TTCTTGATGA CCAATACACA 1560
AGCTCCCTGT GCTCCAAGTT TCCTGTGAAG TGGTCAGCCC CAGAGGTGAT CAAATATTCC 1620
AAGTTCAGCA GCAAGTCTGA CGTCTGGTCA TTTGGTGTGC TTATGTGGGA GGTGTACAAC 1680
GAGGGCCGTC TTCCGTACGA TAACCGTTCA AACTCAGAAG TGGTGGAGTC GCTGAACGCA 1740
GGCCTGAGGC TCCTAAAACC TCGCCTGGCC TCGGACGCAG TCTACATGCT GATGGATTGG 1800
TGCTGGAAGG AGAAACCCGA TGACCGTCCA TCTTTCGCTC TCCTCTTGCA TGAACTGTCC 1860
GAGCTTTCTG GCATACAGCC AACATTTTGT CAA 1893
Domain Profile
S: 3     llkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqlygv  62
         l +e+gsgqfg+v  g+wr+ ++va+k+++e +m++++f eeakvmmklsh klvql+gv
Q: 373   LGEEIGSGQFGLVLEGRWRE-TKVAVKMVREECMTDDEFKEEAKVMMKLSHCKLVQLFGV  431
         568***************96.69*************************************
S: 63    clkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrdla  122
         c+++ p+++v+ey+e+gcl +yl ek+++l++e+ll mc dv+egm+yle+++fihrdla
Q: 432   CAQRSPMCLVFEYMEKGCLTDYLLEKRGHLSQETLLGMCLDVSEGMAYLESSNFIHRDLA  491
         ************************************************************
S: 123   arnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvwaf  182
         arncl+++++ vkvsdfg++ryvlddqy+ss  +kfpvkws+pev++ysk+ssksdvw+f
Q: 492   ARNCLISKNNEVKVSDFGMTRYVLDDQYTSSLCSKFPVKWSAPEVIKYSKFSSKSDVWSF  551
         ************************************************************
S: 183   gvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeerpt  242
         gvlmwev+ eg+lpy+++snsevve+++ glrl +p+las+ vy +m  cwkekp++rp+
Q: 552   GVLMWEVYNEGRLPYDNRSNSEVVESLNAGLRLLKPRLASDAVYMLMDWCWKEKPDDRPS  611
         ************************************************************
S: 243   fkellsale  251
         f+ ll++l+
Q: 612   FALLLHELS  620
         *****9885
Domain Sequence
(FASTA)
LGEEIGSGQF GLVLEGRWRE TKVAVKMVRE ECMTDDEFKE EAKVMMKLSH CKLVQLFGVC 60
AQRSPMCLVF EYMEKGCLTD YLLEKRGHLS QETLLGMCLD VSEGMAYLES SNFIHRDLAA 120
RNCLISKNNE VKVSDFGMTR YVLDDQYTSS LCSKFPVKWS APEVIKYSKF SSKSDVWSFG 180
VLMWEVYNEG RLPYDNRSNS EVVESLNAGL RLLKPRLASD AVYMLMDWCW KEKPDDRPSF 240
ALLLHELS 248
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAG-00090
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORN-00134
EKS-ORA-00089
EKS-ORC-00102
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
EKS-XIM-00131
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004713; F:protein tyrosine kinase activity
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013