EKS-ORL-00227

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00227

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/LISK	450.0	2.9E-135	286	554	269

Status

Unreviewed

Ensembl Protein

ENSORLP00000009831

UniProt Accession

H2LUQ3;

Protein Name

Protein Synonyms/Alias

Gene Name

LIMK1 (1 of 2)

Gene Synonyms/Alias

LIMK1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000007848	ENSORLP00000009831	ENSORLT00000009832

Organism

Oryzias latipes

Functional Description

Protein Length

600

Protein Sequence
(FASTA)

RCCECSALLS NWYYEKDGQL FCKKDYWAKF GELCHGCSDP ITAGLIMVAG EQKYHPECFS 60

CLNCRVFIGD GDTYALVERS KLYCGNCYYR NIVTPVSPPD SPCSRIPHTV TLVSIPASAD 120

GSDESRGRGF SVAVEQPLTP TNSPEQERTV RVSEVDADCI SPDVKNSIHV GDKILEINGK 180

PIHNIPLDEI DLLIQETSRL LQLTLEHDPH TQRQDGGSSE ANEQTNGPLH PTAFTSFSFR 240

RSYSIDKSPG SSNAASPIAQ RKEINRSESL RVVSSRTHRI FRPSDLIHGE VLGKGCFGQA 300

IKVTHRETGE VMVMKELIRF DDETQRTFLK EVKVMRCLDH PNVLKFIGVL YKDKRLNFIA 360

EYIKGGTLRE IIKKMDSNYP WNQRVSFAKD IAAGMAYLHS MNIIHRDLNS YNCLVREDNT 420

VVVADFGLSR LMVDDKQDES LLQGKLSGLK RHDRRKRYTV VGNPYWMAPE MIHGKSYDER 480

VDIFSFGIML CEIIGRVNAD PDYLPRATDF GLNISGFLEH FCPPDCPPAF FPMAAVCCDL 540

DADKRPPFLK LEELLENLKM HLDIGLPLKS ELDQLHKAFW DQHSVKRPEN GLHTHPEQPE 600

Nucleotide Sequence
(FASTA)

AGGTGTTGTG AGTGCAGCGC CTTGCTGTCC AACTGGTATT ATGAAAAAGA TGGTCAGCTC 60

TTCTGCAAGA AGGACTACTG GGCCAAATTT GGGGAGCTGT GCCACGGCTG CAGCGACCCG 120

ATCACCGCCG GCCTCATCAT GGTCGCTGGG GAGCAGAAGT ATCACCCAGA ATGCTTCAGC 180

TGTCTGAACT GCAGGGTGTT CATCGGGGAT GGAGACACAT ACGCTTTGGT TGAGAGATCT 240

AAACTCTACT GTGGGAACTG TTACTACCGG AACATCGTGA CCCCGGTGTC GCCGCCAGAC 300

TCGCCGTGTT CTCGAATCCC TCACACCGTC ACACTGGTGT CCATCCCGGC CTCAGCCGAT 360

GGCAGCGATG AGTCCAGGGG GCGGGGTTTC TCTGTGGCCG TCGAGCAGCC GCTCACCCCA 420

ACGAACAGCC CGGAGCAGGA ACGCACTGTC AGAGTGTCCG AAGTGGATGC TGACTGCATT 480

AGTCCAGATG TGAAAAACTC CATTCATGTT GGAGACAAGA TTCTGGAAAT CAATGGGAAA 540

CCTATTCATA ACATTCCCCT GGATGAGATT GACCTCCTGA TCCAGGAGAC CAGCCGACTG 600

TTACAACTCA CCCTCGAGCA CGACCCTCAC ACCCAAAGGC AGGATGGCGG CTCTTCTGAG 660

GCGAATGAGC AGACGAATGG CCCCCTTCAT CCCACCGCCT TCACCTCTTT CTCTTTCAGG 720

CGGAGTTACA GCATTGATAA GTCGCCAGGT TCCAGCAACG CTGCATCGCC CATCGCTCAG 780

AGGAAGGAGA TCAATCGATC CGAGTCACTC CGAGTTGTCT CCAGTCGGAC TCACCGCATC 840

TTCCGCCCAT CTGACCTCAT CCACGGAGAA GTGCTTGGAA AGGGATGCTT TGGACAGGCC 900

ATCAAGGTGA CCCACAGGGA GACTGGGGAG GTGATGGTGA TGAAGGAGTT GATCCGCTTT 960

GACGATGAGA CGCAGAGAAC ATTCCTGAAA GAGGTGAAGG TGATGCGCTG TCTGGATCAC 1020

CCCAATGTGC TCAAGTTCAT CGGAGTCCTC TACAAAGACA AGAGACTCAA CTTTATTGCA 1080

GAGTACATCA AGGGAGGAAC TCTGAGGGAA ATAATCAAGA AAATGGACAG TAACTATCCC 1140

TGGAATCAGC GGGTCAGTTT TGCGAAAGAC ATAGCTGCTG GAATGGCTTA TCTACACTCC 1200

ATGAACATAA TCCATCGAGA CCTGAACTCC TACAACTGTC TTGTTCGAGA GGACAACACA 1260

GTGGTGGTGG CAGACTTTGG TCTGTCTCGG CTCATGGTGG ATGACAAGCA GGATGAATCG 1320

CTGCTGCAGG GAAAACTGTC CGGTTTAAAG AGGCATGACC GCAGGAAGCG GTACACTGTG 1380

GTGGGAAATC CCTACTGGAT GGCTCCTGAG ATGATCCATG GGAAGAGCTA TGATGAGAGA 1440

GTTGACATAT TTTCTTTTGG CATTATGCTC TGCGAGATTA TTGGCCGAGT GAACGCAGAC 1500

CCAGACTACC TCCCCAGGGC GACAGACTTT GGACTGAACA TTTCTGGTTT CCTGGAGCAC 1560

TTCTGTCCTC CTGACTGCCC CCCCGCCTTC TTCCCCATGG CTGCTGTTTG CTGTGACCTT 1620

GATGCAGACA AACGGCCTCC TTTCCTAAAA CTGGAGGAGT TGCTGGAGAA CCTAAAGATG 1680

CACTTAGACA TTGGTCTGCC CCTCAAGTCT GAACTGGACC AGCTACACAA GGCATTCTGG 1740

GATCAGCACA GCGTCAAACG CCCTGAGAAT GGCCTGCACA CTCACCCTGA GCAGCCAGAG 1800

Domain Profile

S: 1     livgeklGkGffsevfkvthrasGevmvlkeliradeenrknllkevkllrklehpnvlk  60

         li+ge+lGkG+f++++kvthr++Gevmv+kelir+d+e+++++lkevk++r+l+hpnvlk

Q: 286   LIHGEVLGKGCFGQAIKVTHRETGEVMVMKELIRFDDETQRTFLKEVKVMRCLDHPNVLK  345

         689*********************************************************

S: 61    fiGvlvkdkklhllteyiegGtlkellkskes.lpwtqrvrlakdiasGlsylhskgiih  119

         fiGvl+kdk+l++++eyi+gGtl+e++k+++s +pw+qrv++akdia+G++ylhs++iih

Q: 346   FIGVLYKDKRLNFIAEYIKGGTLREIIKKMDSnYPWNQRVSFAKDIAAGMAYLHSMNIIH  405

         *******************************99***************************

S: 120   rdlnsknclvredksvvvadfGlarlvveerkks....eklrslkkkdrkkrltvvGsPy  175

         rdlns nclvred++vvvadfGl+rl+v++++       kl  lk++dr+kr+tvvG+Py

Q: 406   RDLNSYNCLVREDNTVVVADFGLSRLMVDDKQDEsllqGKLSGLKRHDRRKRYTVVGNPY  465

         *****************************999877888999*******************

S: 176   wmaPevlkgksydekvdvfsfGivlceiiarveadPdylPrtedfgldvkafreklvaed  235

         wmaPe+++gksyde+vd+fsfGi+lceii+rv+adPdylPr++dfgl+++ f e++++ d

Q: 466   WMAPEMIHGKSYDERVDIFSFGIMLCEIIGRVNADPDYLPRATDFGLNISGFLEHFCPPD  525

         ************************************************************

S: 236   cPeaflklavvccdldpesrpsfeelekk  264

         cP+af+++a+vccdld+++rp+f +le+

Q: 526   CPPAFFPMAAVCCDLDADKRPPFLKLEEL  554

         *************************9976

Domain Sequence
(FASTA)

LIHGEVLGKG CFGQAIKVTH RETGEVMVMK ELIRFDDETQ RTFLKEVKVM RCLDHPNVLK 60

FIGVLYKDKR LNFIAEYIKG GTLREIIKKM DSNYPWNQRV SFAKDIAAGM AYLHSMNIIH 120

RDLNSYNCLV REDNTVVVAD FGLSRLMVDD KQDESLLQGK LSGLKRHDRR KRYTVVGNPY 180

WMAPEMIHGK SYDERVDIFS FGIMLCEIIG RVNADPDYLP RATDFGLNIS GFLEHFCPPD 240

CPPAFFPMAA VCCDLDADKR PPFLKLEEL 269

Keyword

Complete proteome; LIM domain; Metal-binding; Reference proteome; Zinc.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004672	; F:protein kinase activity
GO:0008270	; F:zinc ion binding

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR001478	; PDZ.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR001781	; Znf_LIM.

Pfam

PF00412	; LIM; 2.
PF00595	; PDZ; 1.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00132	; LIM; 1.
SM00228	; PDZ; 1.

Prosites

PS00478	; LIM_DOMAIN_1; 1.
PS50023	; LIM_DOMAIN_2; 1.
PS50106	; PDZ; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013