EKS-ORL-00022

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00022

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/InsR	521.8	3.7E-157	997	1262	266

Status

Unreviewed

Ensembl Protein

ENSORLP00000010716

UniProt Accession

H2LX62;

Protein Name

Tyrosine-protein kinase receptor

Protein Synonyms/Alias

Gene Name

IGF1R (1 of 2)

Gene Synonyms/Alias

IGF1R (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000008532	ENSORLP00000010716	ENSORLT00000010717

Organism

Oryzias latipes

Functional Description

Protein Length

1404

Protein Sequence
(FASTA)

VVSVTSMGRL TLFWGLMLSV SAVCICSTYG EVCESMDIRN DISEFKVLEN CTVVEGYLHI 60

LLISKKTTNN VEALRSLSFP KLTVITDHLL LFRVAGLESL STLFPNLSVI RGRNLFYNYA 120

LVIYEMTSLK DIGLYNLRNI TRGAVRVAKN SELCYLDSVD WSLITDVVFN NVFDLNKKLE 180

ECDNVCPGIM KNSPLCPRTS YTNKLDYRCW SSNHCQKVCP DQCKLACTDD GQCCHSQCLG 240

GCSEPNSDRA CSVCLHYFHN ERCVPDCPPG TYKFEGWRCI TFEMCSQAHL PSDTHFVIHG 300

GECMPDCPSD FTRNKTNPML CTACNGPCDK FCTSPVIDSV DAAQTLKGCT VINGHLDINI 360

RRGDNIASEL ENFMGLIRTV KGYVKIRHSH ALGSLSFLRS LRYINGEELI ENTYSFFAIN 420

NQHLQSLWDW SQHNLTIRAG RLFFRQNPKL CMSEIHKMWE KTGITVKPEG GDFRNNGEKA 480

SCESHILKIK SNVTSSYTIK LTWERYQVPE YGGLINFIVF YKESPFQNIT EFDGQDGCGS 540

NSWHMVDVDL SQDEKLDPKV TLQHLNPWTQ YAIFVRAITL QVEDKHITGA KSDIIYIRTR 600

PSSPSVPKDA HAYANSSTKL LVKWSRPVFP NGNLTYYLVR WQQQPEDREL YQHNYCSKDL 660

KIPIRVSAGG FSDVEDGAKP TKSDLSGAKK GPCCTCQKTA EEKDREKDDR VFIKMFENYL 720

HNIVFYARPP DRQRRDVVGV ANNTLFPDGA QGNASLSPAE NGTDGVPPVI EYPFSEEKVS 780

TEYLEIPSLQ PFTVYRIDIH ACNEEVGLCG AGAFVFARTK PASEADDIPG KVVPERSDKV 840

EGCMVLHWPE PVVPNGLVLM YEVKYRLGTE PEKHGCVSRR QYRQNRGARL THLSPGNYSA 900

RVRAISLAGN GSWTESIYFY VPPPKRDDDV TFYLSIIIPI IVTLFIASLI TILFFINKKR 960

NSNRLGNGVL YASVNPEYIS AAEMYTPDEW EVAREKITMH KELGQGSFGM VYEGLAKGVV 1020

KDEPETRVAI KTVNESASMR ERIEFLNEAS VMKEFNCHHV VRLLGVVSQG QPTLVIMELM 1080

TRGDLKSHLR SLRNENSNSQ VLPPLKKMIQ MAGEIADGMA YLNANKFVHR DLAARNCMVT 1140

EDFTVKIGDF GMTRDIYETD YYRKGGKGLL PVRWMSPESL KDGVFTTMSD VWSFGVVLWE 1200

IATLSEQPYQ GMSNEQVLRF VMEGGLLDKP DNCPDMLFEL MRMCWQYNPK MRPTFLEIIN 1260

TIKDDLDPSF REVSFFYSEE NKPPDTEELD MEVENMENIP LDPVSTRQPA VIHPSGSTLP 1320

PSAQHLAPMQ GPSTPLLGPV SPSHPGYVAT TVGSPGHDKH SGHVLVNGPV VVLRPNFEEI 1380

QPYAHMNGGR KNERALPLPQ SSAC 1404

Nucleotide Sequence
(FASTA)

GTGGTATCAG TAACATCGAT GGGCAGGCTG ACCTTGTTTT GGGGTCTGAT GCTGTCTGTC 60

TCCGCTGTCT GCATTTGCTC CACATATGGA GAGGTCTGTG AAAGCATGGA CATCCGAAAC 120

GACATAAGTG AATTCAAGGT GCTGGAGAAC TGCACGGTGG TTGAGGGTTA CCTCCATATC 180

CTCCTCATCA GCAAAAAAAC CACCAACAAC GTAGAGGCCT TACGTTCCCT CAGTTTCCCA 240

AAGCTGACTG TCATCACTGA CCATCTGCTG CTGTTTCGCG TTGCCGGCTT GGAGAGCCTC 300

AGCACGCTGT TTCCCAACCT GAGTGTCATC CGTGGTCGCA ATCTGTTCTA CAACTACGCC 360

TTGGTGATTT ACGAGATGAC CAGCTTAAAG GACATAGGCT TGTACAACCT GAGAAACATC 420

ACGCGCGGGG CTGTACGGGT TGCGAAGAAC TCTGAACTTT GCTACCTGGA CTCGGTGGAC 480

TGGTCTTTGA TAACGGATGT TGTGTTCAAC AATGTTTTCG ATTTGAATAA GAAATTGGAA 540

GAGTGCGATA ACGTCTGCCC AGGCATCATG AAGAATAGCC CTCTTTGTCC CAGGACGTCG 600

TACACGAACA AGTTAGACTA TCGCTGCTGG AGCTCCAACC ATTGCCAGAA AGTGTGCCCA 660

GATCAGTGCA AGCTGGCCTG TACAGACGAC GGGCAGTGCT GCCACAGCCA GTGTTTGGGT 720

GGCTGCAGCG AGCCCAACAG CGACCGGGCC TGCTCCGTCT GCCTCCACTA TTTCCACAAT 780

GAGCGCTGCG TGCCAGACTG CCCACCAGGC ACGTACAAGT TTGAGGGCTG GCGCTGCATC 840

ACATTTGAGA TGTGCTCCCA GGCGCACCTG CCAAGTGATA CTCACTTTGT CATTCATGGG 900

GGAGAATGTA TGCCAGACTG CCCTTCTGAT TTCACCCGCA ACAAGACTAA TCCCATGCTT 960

TGTACTGCTT GCAACGGCCC GTGTGACAAG TTCTGCACTT CCCCTGTCAT CGACTCTGTG 1020

GATGCTGCTC AAACCTTAAA GGGGTGCACC GTCATCAATG GCCATTTGGA CATCAACATC 1080

CGCCGTGGAG ATAACATAGC CTCTGAGCTA GAGAACTTCA TGGGCCTGAT CCGGACAGTA 1140

AAGGGATATG TAAAGATACG ACACTCCCAT GCGCTCGGCT CCCTGTCCTT CCTCAGGAGT 1200

CTCCGATATA TCAACGGGGA GGAACTTATT GAGAACACAT ATTCGTTCTT TGCCATCAAC 1260

AACCAGCATC TGCAGTCCTT GTGGGACTGG AGTCAGCACA ACTTGACAAT CCGAGCTGGA 1320

CGTCTCTTCT TCCGCCAGAA CCCCAAGCTC TGCATGTCCG AGATCCACAA AATGTGGGAA 1380

AAGACGGGGA TCACTGTGAA ACCAGAGGGG GGAGACTTCC GTAACAATGG AGAGAAAGCC 1440

AGCTGTGAAA GTCACATTCT GAAGATCAAA TCTAACGTCA CATCAAGTTA TACAATCAAG 1500

CTGACATGGG AGCGCTATCA GGTTCCAGAA TATGGAGGCC TGATCAACTT CATCGTTTTC 1560

TACAAAGAGT CACCTTTCCA AAACATCACA GAGTTTGATG GCCAGGATGG CTGTGGCTCC 1620

AACAGCTGGC ACATGGTGGA TGTTGACCTT TCTCAGGATG AAAAACTTGA CCCAAAGGTT 1680

ACCCTCCAGC ACCTCAATCC CTGGACCCAG TACGCTATTT TTGTACGAGC AATCACCCTG 1740

CAGGTGGAGG ACAAACACAT CACCGGGGCA AAGAGTGACA TCATTTACAT CCGCACACGT 1800

CCATCATCGC CATCTGTGCC CAAAGATGCC CACGCCTATG CAAACTCCTC CACTAAGCTG 1860

CTGGTAAAGT GGTCGCGTCC GGTTTTTCCC AATGGCAATC TGACGTACTA CCTGGTGCGC 1920

TGGCAGCAGC AGCCTGAAGA CAGGGAGCTC TACCAGCATA ACTACTGTTC CAAAGACCTG 1980

AAGATCCCCA TTCGGGTGTC AGCTGGAGGA TTCTCAGACG TGGAAGACGG CGCAAAACCC 2040

ACCAAATCCG ACCTTTCAGG TGCCAAGAAG GGTCCTTGCT GCACTTGCCA GAAGACAGCT 2100

GAAGAGAAGG ACCGTGAGAA GGACGACCGA GTCTTTATCA AAATGTTTGA GAACTACCTC 2160

CACAATATCG TCTTTTATGC AAGGCCTCCA GACCGTCAAC GCAGGGACGT TGTTGGAGTC 2220

GCAAACAACA CTTTGTTTCC GGATGGAGCT CAGGGAAATG CTTCGCTCAG TCCAGCGGAG 2280

AACGGCACAG ATGGAGTTCC CCCCGTCATA GAGTACCCCT TCTCAGAGGA GAAGGTTTCC 2340

ACAGAATACC TGGAGATCCC CAGCCTGCAA CCTTTCACCG TCTACCGTAT CGACATCCAT 2400

GCCTGCAACG AGGAGGTGGG CCTCTGCGGT GCCGGAGCGT TCGTCTTCGC CAGGACCAAA 2460

CCCGCATCTG AAGCAGATGA CATCCCTGGA AAGGTCGTCC CTGAAAGGAG TGACAAGGTT 2520

GAGGGCTGTA TGGTGCTGCA CTGGCCAGAA CCCGTTGTCC CCAATGGACT CGTACTGATG 2580

TATGAGGTCA AGTACCGTCT GGGGACTGAG CCTGAGAAAC ACGGATGTGT GTCACGACGG 2640

CAATACCGGC AAAACAGAGG AGCTCGTCTG ACCCACCTGA GCCCCGGGAA TTATTCAGCT 2700

CGTGTGCGGG CCATCTCTCT GGCCGGAAAC GGATCCTGGA CAGAGAGCAT CTACTTTTAC 2760

GTGCCTCCCC CTAAACGAGA TGATGACGTT ACGTTCTACT TGTCCATTAT AATTCCCATT 2820

ATAGTGACGC TCTTCATCGC CAGCCTCATC ACCATTTTGT TCTTCATCAA CAAAAAGAGG 2880

AACAGCAACA GACTGGGCAA TGGAGTCCTG TATGCATCCG TCAACCCAGA GTACATAAGT 2940

GCAGCTGAGA TGTACACTCC AGACGAATGG GAGGTGGCTC GAGAGAAGAT CACCATGCAC 3000

AAGGAGCTGG GTCAGGGCTC TTTTGGCATG GTGTACGAGG GCCTCGCAAA GGGCGTCGTC 3060

AAGGATGAAC CTGAGACACG GGTGGCCATC AAGACGGTCA ATGAATCGGC CAGCATGAGG 3120

GAGCGGATCG AGTTTTTGAA CGAGGCGTCA GTCATGAAGG AGTTCAACTG TCACCATGTG 3180

GTGCGCCTGC TTGGTGTAGT CTCCCAGGGA CAACCAACCT TGGTGATCAT GGAGTTGATG 3240

ACCCGGGGAG ACCTCAAGAG CCACCTGCGC TCCCTACGCA ACGAAAACTC CAACAGCCAG 3300

GTCCTGCCAC CGCTTAAAAA GATGATCCAG ATGGCCGGAG AAATTGCAGA CGGCATGGCC 3360

TACCTGAATG CCAATAAGTT TGTCCACAGG GACCTGGCTG CCAGGAACTG CATGGTTACA 3420

GAGGATTTCA CAGTGAAGAT TGGAGATTTC GGCATGACGA GAGATATTTA TGAGACAGAT 3480

TATTATCGAA AAGGGGGGAA AGGCCTGCTT CCTGTTCGCT GGATGTCTCC AGAGTCACTA 3540

AAAGATGGCG TGTTCACAAC GATGTCTGAC GTCTGGTCAT TTGGCGTGGT GTTGTGGGAG 3600

ATCGCTACGC TGTCGGAGCA GCCCTACCAG GGAATGTCCA ATGAACAAGT GCTGCGCTTT 3660

GTCATGGAAG GAGGACTCCT GGACAAACCC GACAACTGCC CTGACATGCT GTTTGAGCTA 3720

ATGAGGATGT GCTGGCAGTA TAACCCCAAG ATGCGTCCGA CCTTCCTGGA GATAATCAAC 3780

ACCATCAAGG ACGATCTGGA TCCTTCCTTC AGGGAAGTCA GCTTCTTCTA CAGCGAGGAG 3840

AACAAGCCGC CGGACACAGA GGAGCTGGAT ATGGAGGTAG AAAACATGGA GAACATTCCA 3900

CTGGACCCCG TATCCACGAG GCAGCCGGCC GTTATTCACC CGTCCGGAAG CACACTGCCT 3960

CCTTCTGCCC AGCATTTGGC CCCCATGCAA GGCCCAAGTA CTCCTTTGCT GGGACCTGTG 4020

TCCCCCTCAC ACCCGGGCTA TGTAGCTACA ACTGTGGGAT CTCCGGGACA CGACAAGCAC 4080

TCAGGGCATG TTTTGGTCAA CGGACCTGTG GTGGTGCTGC GGCCCAACTT TGAGGAGATC 4140

CAACCATATG CACACATGAA CGGGGGCAGA AAGAATGAAC GGGCATTACC GCTGCCCCAG 4200

TCGTCGGCCT GCTGA 4215

Domain Profile

S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60

         i++ +elGqGsfGmvyeG+ak+vvk+e etrvaiktvne+as+reriefl+easvmkef+

Q: 997   ITMHKELGQGSFGMVYEGLAKGVVKDEPETRVAIKTVNESASMRERIEFLNEASVMKEFN  1056

         7899********************************************************

S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120

         +hhvvrllGvvs+gqp+lv+melm++Gdlks+lrslr+e+ n ++l+p  l+k+iqma+e

Q: 1057  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRNENSNSQVLPP--LKKMIQMAGE  1114

         **************************************9998877755..7*********

S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180

         iadGmayl+a+kfvhrdlaarncmv+ed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw

Q: 1115  IADGMAYLNANKFVHRDLAARNCMVTEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1174

         ************************************************************

S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240

         mspeslkdGvft+ sdvwsfGvvlwei+tl+eqpyqG+sneqvl+fv++gg+l+kp+ncp

Q: 1175  MSPESLKDGVFTTMSDVWSFGVVLWEIATLSEQPYQGMSNEQVLRFVMEGGLLDKPDNCP  1234

         ************************************************************

S: 241   elltelmrlcwqynpklrpsfleivell  268

         ++l+elmr+cwqynpk+rp+flei++++

Q: 1235  DMLFELMRMCWQYNPKMRPTFLEIINTI  1262

         *************************976

Domain Sequence
(FASTA)

ITMHKELGQG SFGMVYEGLA KGVVKDEPET RVAIKTVNES ASMRERIEFL NEASVMKEFN 60

CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SHLRSLRNEN SNSQVLPPLK KMIQMAGEIA 120

DGMAYLNANK FVHRDLAARN CMVTEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS 180

PESLKDGVFT TMSDVWSFGV VLWEIATLSE QPYQGMSNEQ VLRFVMEGGL LDKPDNCPDM 240

LFELMRMCWQ YNPKMRPTFL EIINTI 266

Keyword

ATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0004714	; F:transmembrane receptor protein tyrosine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0007169	; P:transmembrane receptor protein tyrosine kinase signaling pathway

KEGG

InterPros

IPR000494	; EGF_rcpt_L.
IPR003961	; Fibronectin_type3.
IPR006211	; Furin-like_Cys-rich_dom.
IPR006212	; Furin_repeat.
IPR009030	; Growth_fac_rcpt.
IPR013783	; Ig-like_fold.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016246	; Tyr_kinase_insulin-like_rcpt.
IPR002011	; Tyr_kinase_rcpt_2_CS.

Pfam

PF00757	; Furin-like; 1.
PF07714	; Pkinase_Tyr; 1.
PF01030	; Recep_L_domain; 2.

SMARTs

SM00060	; FN3; 3.
SM00261	; FU; 1.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 3.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS00239	; RECEPTOR_TYR_KIN_II; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013