EKS-ORL-00189

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00189

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/RSKb	416.5	4.7E-125	410	671	262

Status

Unreviewed

Ensembl Protein

ENSORLP00000010872

UniProt Accession

H2LXL1;

Protein Name

Ribosomal protein S6 kinase

Protein Synonyms/Alias

Gene Name

RPS6KA5

Gene Synonyms/Alias

RPS6KA5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000008665	ENSORLP00000010872	ENSORLT00000010873

Organism

Oryzias latipes

Functional Description

Protein Length

786

Protein Sequence
(FASTA)

GSSEEGGDLF TVKHELRNAN LTGHVERVGM ENFELLKVLG TGAYGKVFLV RKVSGHDAGK 60

LYAMKVLKKA TIVQKAKTAE HTRTERQVLE HIRQSPFLVT LHYAFQTDTK LHLILDYVNG 120

GELFTHLVQR VRFKEQEVAL YSGEIVLALE HLHALGIVYR DLKLENVLLD SNGHIVLTDF 180

GLSKEFDQAE RAFSVCGTIE YMAPEIVEGG KSGHDMAVDW WSLGVLMYEL LTGGSPYTVD 240

GGENSHSDIA RRILKKDPPF PKDMDPSAKD LIQRLLTKDP TKRLGSGPDG AENVKKHPFY 300

QNISWEDLAA KKVPAPFKPV IRDELDVSNF AEEFTEMDPT YSPAALPQNC DRIFQGYSFM 360

APSILFKRNV VMDDPIQLCG GADRPGSAAV ARSSMMKDSP FYLNYDMDLK DSALGEGSFS 420

ICRRCTHKKT GQKYAVKIVS KRIRMEAQTQ REIAALKLCD GHPNIVKLHE IYHDQLHTFL 480

VLELLGGGEL LERIRRKQHF SETEASRIMR RLVSAVSHMH DVGVVHRDLK PENLLFTDES 540

ENSGIKIIDF GFARLKPPDQ QLLKTPCFTL QYAAPEILKY DGYDESCDLW SLGVILYTML 600

SGQVPFQCQE PTLTHTSAEE IMKKIKQGDF SFEGEAWRNV SQQAKDLIQE LLTVDPNKRI 660

KMCGLRYNAW LQDDSQLSSN PLMTPDVLAS STATVHTCVK ATFNAFNKCK REGFRLQTVD 720

KAPLAKRRKM KKTSTSTETR SSSSESTHSS SSSSQSQEKT SPEDAHPHST PVSPPVTLVT 780

DSEAPP 786

Nucleotide Sequence
(FASTA)

GGGTCCTCTG AAGAAGGGGG TGACCTGTTC ACCGTCAAGC ACGAGCTGAG GAACGCAAAC 60

CTGACGGGTC ACGTGGAGCG GGTCGGCATG GAGAACTTTG AGCTGCTGAA GGTCCTGGGT 120

ACCGGAGCGT ACGGGAAAGT GTTCCTGGTC AGGAAGGTGA GCGGCCACGA CGCCGGGAAG 180

CTGTACGCCA TGAAGGTGCT GAAGAAGGCC ACCATCGTGC AGAAGGCCAA GACGGCCGAA 240

CACACGCGCA CGGAGCGCCA AGTGCTGGAG CACATTCGCC AGTCCCCCTT CCTCGTGACC 300

CTCCACTACG CCTTCCAGAC CGACACCAAG CTGCACCTCA TCCTGGATTA CGTGAACGGC 360

GGGGAGCTCT TCACTCACCT GGTGCAGAGG GTTCGCTTCA AGGAGCAGGA GGTGGCGCTC 420

TACAGCGGGG AGATCGTCTT GGCCCTGGAG CATCTCCACG CGCTCGGGAT CGTCTACCGG 480

GACCTAAAGC TGGAGAACGT CCTCCTGGAC TCCAACGGCC ACATCGTTCT CACCGACTTC 540

GGCCTCAGCA AAGAGTTTGA TCAGGCCGAG CGGGCGTTCT CCGTCTGTGG AACCATCGAG 600

TACATGGCTC CGGAAATCGT TGAAGGAGGA AAGTCTGGAC ACGACATGGC GGTGGACTGG 660

TGGAGCCTCG GCGTGTTGAT GTACGAGCTT CTGACGGGCG GGTCGCCCTA CACCGTGGAC 720

GGGGGCGAGA ACTCTCATTC GGACATCGCC AGGAGGATCC TAAAGAAGGA CCCCCCCTTC 780

CCCAAAGACA TGGATCCTTC CGCCAAAGAC TTGATCCAGC GCCTCCTCAC CAAAGACCCG 840

ACGAAGAGGC TGGGTTCCGG TCCCGACGGG GCGGAAAACG TGAAGAAGCA TCCCTTCTAT 900

CAGAACATCA GCTGGGAGGA CCTGGCGGCG AAGAAGGTCC CGGCCCCGTT CAAGCCCGTC 960

ATCCGGGACG AGCTGGACGT CAGCAACTTC GCGGAGGAGT TCACGGAGAT GGACCCCACC 1020

TACTCCCCCG CGGCGCTGCC CCAGAACTGC GACCGCATCT TTCAGGGTTA CTCCTTCATG 1080

GCGCCGTCCA TCCTCTTCAA GAGGAACGTG GTGATGGACG ACCCCATCCA GCTGTGCGGG 1140

GGGGCGGACA GGCCCGGGTC GGCGGCGGTG GCGCGCAGTT CCATGATGAA GGACTCCCCT 1200

TTCTACCTGA ACTACGACAT GGACCTGAAG GACAGCGCTC TGGGGGAGGG AAGCTTCTCC 1260

ATCTGCAGAC GCTGCACCCA CAAGAAGACC GGACAGAAGT ACGCCGTCAA GATCGTCAGC 1320

AAGAGGATCA GGATGGAGGC TCAGACTCAG CGGGAAATCG CCGCTCTGAA GCTCTGTGAC 1380

GGCCATCCCA ACATCGTGAA GCTACACGAG ATCTACCACG ACCAGCTCCA CACCTTCCTG 1440

GTCCTGGAGC TGCTGGGGGG CGGAGAGCTG CTGGAGCGCA TCCGCAGGAA GCAGCACTTC 1500

AGCGAGACGG AGGCCAGCCG CATCATGCGC AGGCTGGTGT CTGCGGTCAG CCACATGCAC 1560

GACGTGGGCG TGGTGCACCG GGACCTGAAG CCAGAGAACC TGCTCTTCAC AGATGAGAGT 1620

GAGAACTCGG GGATAAAAAT CATAGACTTT GGCTTTGCTC GTCTCAAACC ACCAGACCAG 1680

CAGCTGCTGA AGACGCCCTG CTTCACGCTG CAGTACGCCG CTCCCGAGAT CCTCAAGTAC 1740

GACGGCTACG ACGAGTCCTG CGACCTGTGG AGTCTGGGGG TCATTCTGTA CACCATGCTG 1800

TCCGGACAGG TGCCCTTCCA GTGTCAGGAG CCCACCCTGA CCCACACCAG CGCCGAGGAG 1860

ATCATGAAGA AGATCAAGCA GGGAGACTTT TCCTTTGAGG GGGAGGCGTG GAGGAACGTG 1920

TCCCAGCAGG CCAAAGACCT CATTCAAGAG CTGCTGACCG TGGATCCAAA CAAGAGGATC 1980

AAGATGTGTG GTCTGCGCTA CAACGCGTGG CTGCAGGACG ACAGCCAGCT GTCCTCCAAC 2040

CCGCTCATGA CGCCGGACGT CCTGGCGTCC TCCACCGCCA CCGTGCACAC CTGCGTCAAA 2100

GCCACCTTCA ACGCGTTCAA CAAGTGCAAG CGGGAAGGCT TCCGCCTCCA AACCGTGGAC 2160

AAGGCGCCGC TCGCCAAGAG GAGGAAAATG AAGAAGACGA GCACGAGCAC GGAGACGCGC 2220

AGCAGCTCCA GCGAGAGCAC ACACTCCTCC TCCTCCTCCT CCCAGTCTCA GGAGAAGACT 2280

TCTCCGGAAG ACGCCCACCC TCACAGCACC CCGGTCAGCC CTCCCGTCAC CCTGGTAACG 2340

GACTCCGAGG CCCCACCG 2358

Domain Profile

S: 3     vkedlGvGsysvckrcvhkatnqefavkiidks...krdtseeieillryeqhpnivtlk  59

         ++  lG+Gs+s+c+rc hk+t+q++avki++k+   +++t++ei++l+++++hpniv+l+

Q: 410   KDSALGEGSFSICRRCTHKKTGQKYAVKIVSKRirmEAQTQREIAALKLCDGHPNIVKLH  469

         6789****************************9878899*********************

S: 60    dvyddgkyvylvlellkGGelldrikkkkffsereasailrtlvkaveylheqGvvhrdl  119

         ++y+d+++++lvlell GGell+ri++k++fse+eas i+r lv+av+++h++Gvvhrdl

Q: 470   EIYHDQLHTFLVLELLGGGELLERIRRKQHFSETEASRIMRRLVSAVSHMHDVGVVHRDL  529

         ************************************************************

S: 120   kpenilyvdesdnaesikiidfGfaklkraengllktpcytlnfvapevlkrqGydeacd  179

         kpen+l++des+n+  ikiidfGfa+lk+++++llktpc+tl+++ape+lk +Gyde+cd

Q: 530   KPENLLFTDESENSG-IKIIDFGFARLKPPDQQLLKTPCFTLQYAAPEILKYDGYDESCD  588

         *************99.********************************************

S: 180   lwslGvllytmlaGyvpf....angpedtaeeilakikeGkfslsGeawdsvseeakdlv  235

         lwslGv+lytml+G+vpf      +++++aeei++kik+G+fs++Geaw++vs++akdl+

Q: 589   LWSLGVILYTMLSGQVPFqcqePTLTHTSAEEIMKKIKQGDFSFEGEAWRNVSQQAKDLI  648

         ******************8766678999********************************

S: 236   sklltvdpakrlkleqllkhswl  258

         ++lltvdp+kr+k+ +l+++ wl

Q: 649   QELLTVDPNKRIKMCGLRYNAWL  671

         **********************7

Domain Sequence
(FASTA)

KDSALGEGSF SICRRCTHKK TGQKYAVKIV SKRIRMEAQT QREIAALKLC DGHPNIVKLH 60

EIYHDQLHTF LVLELLGGGE LLERIRRKQH FSETEASRIM RRLVSAVSHM HDVGVVHRDL 120

KPENLLFTDE SENSGIKIID FGFARLKPPD QQLLKTPCFT LQYAAPEILK YDGYDESCDL 180

WSLGVILYTM LSGQVPFQCQ EPTLTHTSAE EIMKKIKQGD FSFEGEAWRN VSQQAKDLIQ 240

ELLTVDPNKR IKMCGLRYNA WL 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007243	; P:intracellular protein kinase cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016239	; Ribosomal_S6_kinase_II.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 2.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 2.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 2.
PS50011	; PROTEIN_KINASE_DOM; 2.
PS00108	; PROTEIN_KINASE_ST; 2.

Prints

Created Date

20-Feb-2013