EKS-ORL-00080

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00080

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	346.6	1.2E-103	15	298	284

Status

Unreviewed

Ensembl Protein

ENSORLP00000011090

UniProt Accession

H2LY76;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK7

Gene Synonyms/Alias

CDK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000008836	ENSORLP00000011092	ENSORLT00000011093
ENSORLG00000008836	ENSORLP00000011090	ENSORLT00000011091

Organism

Oryzias latipes

Functional Description

Protein Length

346

Protein Sequence
(FASTA)

LANMSVDVKT RSKRYEKLDF LGEGQFATVY KARDKLTDTI VAIKKIKVGH RTEAKDGINR 60

TALREIKLLQ ELHHSNIIGL LDAFGHKSNI SLVFDFMETD LEVVIKDTSL VLTPANIKAY 120

ILMTLQGLEY MHQHWILHRD LKPNNLLLDG SGVLKLADFG LAKAFGSPNR VYTHQVVTRW 180

YRSPELLFGA RMYGVGVDMW AVGCILAELL LRIPFLAGDS DLDQLTKIFE ALGTATDETW 240

PGMSSLPDFV SFKIFPGTPL EHIFSAAGDD LLELLQGLFT FNPTTRTTAT QALKMKYFSN 300

RPGPTPGPQL PRPNCSAEAL REKETVGLKR KIEGLETTVM KKKLVF 346

Nucleotide Sequence
(FASTA)

TTAGCTAACA TGTCTGTGGA TGTGAAAACA AGATCCAAAC GGTATGAGAA ACTGGACTTT 60

CTCGGAGAGG GTCAGTTCGC CACTGTGTAC AAAGCCAGAG ATAAATTGAC TGACACAATA 120

GTTGCCATTA AAAAGATTAA AGTAGGCCAC AGAACTGAGG CTAAAGATGG TATAAATCGA 180

ACTGCTCTCC GAGAGATCAA ATTGCTGCAG GAGCTGCATC ATTCAAATAT CATCGGGCTG 240

CTGGATGCAT TTGGGCATAA ATCAAACATT AGTCTGGTGT TTGATTTCAT GGAAACAGAT 300

CTAGAGGTTG TCATTAAAGA CACCAGCCTG GTGCTGACTC CAGCCAACAT CAAAGCCTAC 360

ATCCTTATGA CTCTACAGGG ATTAGAATAC ATGCACCAGC ACTGGATTCT ACATAGGGAT 420

CTGAAACCCA ATAATTTGCT GTTAGACGGT AGCGGAGTCT TGAAGTTGGC AGATTTTGGT 480

TTGGCCAAAG CTTTTGGGAG CCCTAACAGA GTCTACACAC ATCAAGTTGT TACCAGGTGG 540

TACCGCTCCC CTGAGCTCCT GTTTGGTGCC AGGATGTATG GGGTTGGCGT TGACATGTGG 600

GCGGTGGGAT GCATCCTGGC AGAGTTGCTT CTTCGGATAC CATTCCTTGC TGGAGACTCT 660

GATCTCGATC AGCTGACCAA AATCTTCGAG GCTCTTGGAA CCGCCACAGA TGAAACATGG 720

CCTGGAATGA GTAGTCTGCC AGACTTTGTG TCCTTCAAGA TATTTCCTGG CACACCGCTG 780

GAACATATAT TTAGTGCAGC TGGGGATGAT TTACTTGAGC TACTACAGGG CCTCTTTACC 840

TTCAACCCCA CAACCAGGAC CACAGCCACA CAGGCTCTAA AGATGAAGTA CTTCAGTAAT 900

CGGCCTGGAC CCACACCGGG TCCACAGCTC CCCAGACCAA ACTGCTCGGC TGAGGCTTTG 960

AGGGAAAAGG AAACTGTTGG GCTAAAGAGG AAAATTGAAG GCCTTGAAAC AACCGTAATG 1020

AAGAAGAAGC TCGTTTTCTG A 1041

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekeke...gvpitalrEisllkelkh  57

         yekl+ +geG++++vyka+dk t+++vA+Kki++ +++e   g++ talrEi+ll+el+h

Q: 15    YEKLDFLGEGQFATVYKARDKLTDTIVAIKKIKVGHRTEakdGINRTALREIKLLQELHH  74

         99********************************98765555******************

S: 58    knivkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylH  117

         +ni+ Ll+ +  +k+++ Lvf+f+e+dL+ ++k+++   l+++++k ++l+ l+gl+y+H

Q: 75    SNIIGLLDAFG-HKSNISLVFDFMETDLEVVIKDTSL-VLTPANIKAYILMTLQGLEYMH  132

         ***********.99***********************.**********************

S: 118   snkilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgake  177

         +++ilHRDlKp+NlL++ +g+lklaDfGla+af+sp++ yt++vvT+wYr+PelL+ga+

Q: 133   QHWILHRDLKPNNLLLDGSGVLKLADFGLAKAFGSPNRVYTHQVVTRWYRSPELLFGARM  192

         ************************************************************

S: 178   YstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykks  237

         Y+  vD+W+vgcilaell r p++ g+s+ dql++if+ lgt ++++wp++s+lp++  s

Q: 193   YGVGVDMWAVGCILAELLLRIPFLAGDSDLDQLTKIFEALGTATDETWPGMSSLPDFV-S  251

         *********************************************************8.9

S: 238   fpkkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         f+  + + l++ ++++ ++ l+ll+ l++++p++R++a++al+ kyf

Q: 252   FKIFPGTPLEHIFSAAGDDLLELLQGLFTFNPTTRTTATQALKMKYF  298

         999999********999*****************************9

Domain Sequence
(FASTA)

YEKLDFLGEG QFATVYKARD KLTDTIVAIK KIKVGHRTEA KDGINRTALR EIKLLQELHH 60

SNIIGLLDAF GHKSNISLVF DFMETDLEVV IKDTSLVLTP ANIKAYILMT LQGLEYMHQH 120

WILHRDLKPN NLLLDGSGVL KLADFGLAKA FGSPNRVYTH QVVTRWYRSP ELLFGARMYG 180

VGVDMWAVGC ILAELLLRIP FLAGDSDLDQ LTKIFEALGT ATDETWPGMS SLPDFVSFKI 240

FPGTPLEHIF SAAGDDLLEL LQGLFTFNPT TRTTATQALK MKYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013