EKS-ORL-00081

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00081

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	337.5	6.8E-101	26	335	310

Status

Unreviewed

Ensembl Protein

ENSORLP00000011145

UniProt Accession

H2LYC9;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK8

Gene Synonyms/Alias

CDK8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000008885	ENSORLP00000011144	ENSORLT00000011145
ENSORLG00000008885	ENSORLP00000011145	ENSORLT00000011146

Organism

Oryzias latipes

Functional Description

Protein Length

463

Protein Sequence
(FASTA)

MDYDFKLKLT GERERVEDLF EYEGCKVGRG TYGHVYKAKR KDGKDDKDYA LKQIEGTGIS 60

MSACREIALL RELKHPNVIS LQKVFLSHAD RKVWLLFDYA EHDLWHIIKF HRASKANKKP 120

LQLPRGMVKS LLYQILDGIH YLHANWVLHR DLKPANILVM GEGPERGRVK IADMGFARLF 180

NSPLKPLADL DPVVVTFWYR APELLLGARH YTKAIDIWAI GCIFAELLTS EPIFHCRQED 240

IKTSNPYHHD QLDRIFNVMG FPADKDWEDI KKMPEHSTLM KDFRRNTYTN CSLIKYMEKH 300

KVKPDSKAFH LLQKLLTMDP IRRITSEQAM QDPYFFEEPL PTSDVFAGCQ IPYPKREFLT 360

EEEPEDKADK KNQQQQQGNN HTNGAGHTGN PENSHAQGPP LKKVRVVPPT TTSGGLIIPP 420

DYQRQNQHAA YQNPGPSTSL PQSSMGYSST SQQPPQYSQH PRY 463

Nucleotide Sequence
(FASTA)

ATGGACTATG ACTTTAAACT GAAGCTGACC GGTGAACGAG AGCGCGTCGA GGACCTGTTT 60

GAGTACGAAG GATGCAAAGT GGGAAGAGGC ACCTACGGTC ATGTGTACAA GGCGAAGAGA 120

AAAGATGGGA AGGATGATAA AGACTACGCC CTCAAGCAGA TAGAAGGCAC TGGCATCTCC 180

ATGTCAGCCT GCAGAGAGAT TGCACTGCTG CGGGAGCTGA AGCACCCCAA TGTCATCTCC 240

CTGCAGAAGG TTTTCCTGTC ACACGCGGAC CGTAAAGTAT GGCTGCTCTT TGACTATGCG 300

GAGCATGATC TCTGGCACAT TATAAAGTTT CACAGAGCAT CCAAGGCCAA CAAGAAGCCG 360

CTTCAGCTTC CCAGAGGAAT GGTGAAGTCT CTGCTCTACC AGATTCTGGA TGGCATCCAT 420

TACCTCCATG CCAACTGGGT CCTACACAGA GACCTTAAAC CTGCTAATAT TTTAGTGATG 480

GGAGAAGGGC CTGAGAGGGG CAGAGTAAAG ATCGCCGATA TGGGGTTTGC TCGTCTTTTC 540

AATTCACCGC TGAAGCCTTT AGCCGACCTG GACCCCGTGG TAGTCACTTT CTGGTACAGA 600

GCACCTGAAC TGCTGCTGGG AGCCCGGCAC TACACCAAAG CCATCGACAT TTGGGCAATT 660

GGCTGCATTT TCGCGGAGCT GCTGACATCT GAACCCATAT TCCACTGTCG CCAGGAGGAC 720

ATCAAGACTA GCAACCCCTA CCACCATGAC CAACTGGACC GCATCTTTAA TGTCATGGGC 780

TTTCCTGCTG ATAAAGATTG GGAAGACATC AAAAAGATGC CAGAGCACTC CACACTCATG 840

AAAGACTTTC GGAGGAACAC ATACACAAAC TGCAGCCTTA TAAAGTACAT GGAAAAACAT 900

AAAGTCAAAC CAGACAGTAA AGCATTCCAC TTGCTCCAAA AGCTTTTGAC CATGGACCCC 960

ATCCGCAGAA TCACTTCTGA GCAGGCGATG CAGGACCCTT ACTTTTTCGA GGAACCCTTA 1020

CCCACATCTG ATGTGTTCGC CGGATGTCAG ATTCCTTATC CCAAGAGGGA ATTCCTGACA 1080

GAAGAGGAGC CAGAAGACAA AGCGGACAAA AAAAACCAGC AGCAGCAACA AGGAAATAAC 1140

CACACAAATG GGGCGGGGCA CACAGGCAAC CCAGAAAACA GCCATGCACA GGGCCCTCCT 1200

CTGAAGAAAG TGAGAGTTGT CCCGCCCACC ACTACCTCAG GTGGCCTCAT CATCCCCCCA 1260

GACTACCAGC GCCAGAATCA GCATGCTGCC TACCAGAACC CTGGACCAAG CACATCACTG 1320

CCCCAAAGCA GCATGGGATA CTCCTCTACC TCCCAACAGC CACCCCAGTA CTCCCAACAC 1380

CCTCGCTACT GA 1392

Domain Profile

S: 6     kigeGtygkvykakdke..tgevvAlKkirlekekegvpitalrEisllkelkhknivkL  63

         k+g+Gtyg+vykak+k+  +++ +AlK+i    e +g++++a+rEi+ll+elkh+n+++L

Q: 26    KVGRGTYGHVYKAKRKDgkDDKDYALKQI----EGTGISMSACREIALLRELKHPNVISL  81

         79************986447778******....999************************

S: 64    levva.kdkkklyLvfefleqdLkkllkkkkkk.......klsleevkslllqlleglay  115

         ++v+  ++++k++L+f+++e+dL++++k ++++       +l++ +vksll+q+l+g++y

Q: 82    QKVFLsHADRKVWLLFDYAEHDLWHIIKFHRASkankkplQLPRGMVKSLLYQILDGIHY  141

         ****94555*********************9999999*9*********************

S: 116   lHsnkilHRDlKpqNlLiske....gklklaDfGlarafssplk...tytkevvTlwYra  168

         lH+n++lHRDlKp+N+L++ e    g++k+aD+G+ar f+splk   +++++vvT+wYra

Q: 142   LHANWVLHRDLKPANILVMGEgperGRVKIADMGFARLFNSPLKplaDLDPVVVTFWYRA  201

         *******************9988889*************99999665699**********

S: 169   PelLlgakeYstavDiWsvgcilaelltrkplfqgkse.........idqlerifkllgt  219

         PelLlga++Y++a+DiW++gci+aellt++p+f++++e         +dql+rif+++g

Q: 202   PELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEdiktsnpyhHDQLDRIFNVMGF  261

         ************************************************************

S: 220   psekvwpevsklpeyk...ksfpkkkkk..klkekvkklk....ekaldllekllaldpk  270

         p +k+w++++k+pe++   k+f++++++  +l ++++k k    +ka++ll+kll++dp

Q: 262   PADKDWEDIKKMPEHStlmKDFRRNTYTncSLIKYMEKHKvkpdSKAFHLLQKLLTMDPI  321

         ***************96644777777764455666644333354679*************

S: 271   kRisakealqhkyf  284

         +Ri++++a+q++yf

Q: 322   RRITSEQAMQDPYF  335

         *************9

Domain Sequence
(FASTA)

KVGRGTYGHV YKAKRKDGKD DKDYALKQIE GTGISMSACR EIALLRELKH PNVISLQKVF 60

LSHADRKVWL LFDYAEHDLW HIIKFHRASK ANKKPLQLPR GMVKSLLYQI LDGIHYLHAN 120

WVLHRDLKPA NILVMGEGPE RGRVKIADMG FARLFNSPLK PLADLDPVVV TFWYRAPELL 180

LGARHYTKAI DIWAIGCIFA ELLTSEPIFH CRQEDIKTSN PYHHDQLDRI FNVMGFPADK 240

DWEDIKKMPE HSTLMKDFRR NTYTNCSLIK YMEKHKVKPD SKAFHLLQKL LTMDPIRRIT 300

SEQAMQDPYF 310

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013