EKS-ORL-00345

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00345

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/IRE	457.6	1.5E-137	563	827	265

Status

Unreviewed

Ensembl Protein

ENSORLP00000011214

UniProt Accession

H2LYJ6;

Protein Name

Protein Synonyms/Alias

Gene Name

ERN1

Gene Synonyms/Alias

ERN1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000008940	ENSORLP00000011214	ENSORLT00000011215

Organism

Oryzias latipes

Functional Description

Protein Length

962

Protein Sequence
(FASTA)

LHGLQTKPPA TWICICDLTF NYAVCSSSTV SLPESLLFVS TLDGNLHAVN KKSGSIKWTL 60

KEDPVLQVPT HVAEPAFLPD PNDGSLYSLG GKNNEGLTKL PFTIPELVQA SPCRSSDGVL 120

YMGKKQDLWY VVDLLTGEKQ QTLTSSFAEM LCPSSSLLYL GRTEYTITMY DTKSRELRWN 180

ATYSDYASTL PDDDAKYKMA HFVSNGDGLV VTVDSETGDV QWVQNYNSPV VAIYIWQREG 240

LRKVPHTNVA VETLRYLTFM SGEVGRITRW KYPFPKENKP KNKFMATLYV GKYSTSLYAS 300

PSLVHDGVTV VPRGSTFPLL EGPDSQEIEE DKECVITPST SVKFNAALLK CQHQFYLFSH 360

HETPPEAQNK NLEFPNSFSR SQGNVIPPTT DKKVEECFVQ KVNDSGMDGG SPSAVPKTSI 420

QEPGVGGRAI RPEAPVDSML KDMATVIFST FLFAGWVAFI IIYPKSVHRQ QQLQHQEFQR 480

QMEERLELLQ RQQPFSPADV TPDGDYLDVT RTRSDCSDNS SPNVTPRASN HSNLSVSELG 540

TWTNETEDGE DDSTIVRVGN ITFHPKQVLG HGAEGTIVYK SIRGQFDNRP VAVKRILPEC 600

FSFADREVQL LRESDEHPNV IRYFCTERDR QFQYIAIELC AATLQEYVER KDFNRHGLEP 660

VMVLQQTMSG LAHLHSLNIV HRDLKPHNIL VSMPNAHGRV RAMISDFGLC KKLAVGRHSF 720

SRRSGVPGTE GWIAPEVLSE DCQHNPTCAV DIFSAGCVFY YVVSQGSHPF GKSLQRQANI 780

LLGAYSIDHL QSDKHEDIVA RNLMEQMLSM DPHKRPSAES VLKHPFFWSL EKELQFFQDV 840

SDRIEKEPLD GPIVRQLERG GRAVVQGDWR EHITVPLQTD LRKFRSYKGG SVRDLLRAMR 900

NKKHHYRELP AEVQETLGSI PDDFVSYFTS RFPHLLMHTY LAMRTCASER TFLPYYSTVE 960

QH 962

Nucleotide Sequence
(FASTA)

CTTCATGGCC TTCAGACCAA ACCACCAGCA ACTTGGATCT GCATTTGCGA TTTAACTTTT 60

AACTATGCTG TTTGCAGCAG CAGCACAGTT TCCCTCCCCG AAAGTCTGCT CTTCGTCTCC 120

ACCTTGGATG GAAATTTGCA CGCTGTTAAC AAGAAATCAG GCTCTATCAA ATGGACGTTG 180

AAAGAAGATC CAGTTCTTCA GGTCCCCACA CATGTTGCAG AGCCAGCATT TCTGCCAGAT 240

CCCAACGATG GCAGCTTGTA CTCTTTAGGA GGAAAGAACA ACGAAGGCCT CACAAAACTG 300

CCTTTTACCA TCCCAGAGTT GGTGCAAGCA TCTCCCTGTC GCAGTTCAGA CGGAGTCCTC 360

TACATGGGGA AAAAGCAGGA CTTGTGGTAT GTGGTGGACC TGTTGACTGG TGAGAAACAG 420

CAGACTCTGA CGTCCTCCTT TGCTGAAATG CTCTGTCCCT CCTCATCTCT TCTTTATCTG 480

GGACGCACAG AATATACCAT CACCATGTAC GACACCAAAA GCAGAGAGCT GCGCTGGAAC 540

GCCACTTATT CCGATTACGC CTCCACCCTT CCTGACGACG ATGCCAAATA CAAGATGGCT 600

CATTTTGTTT CCAACGGGGA CGGCCTCGTG GTCACTGTGG ACAGCGAAAC GGGAGACGTT 660

CAGTGGGTGC AGAACTACAA CTCCCCGGTG GTGGCCATTT ACATCTGGCA GCGTGAGGGT 720

CTGCGGAAGG TTCCCCACAC TAACGTGGCT GTGGAGACGC TGCGTTACCT CACCTTCATG 780

TCTGGAGAAG TTGGCCGCAT CACCCGGTGG AAGTATCCCT TTCCAAAGGA GAACAAGCCC 840

AAGAATAAAT TTATGGCCAC TTTGTATGTG GGCAAATACT CCACAAGCCT GTATGCATCT 900

CCGTCTTTGG TGCACGATGG AGTTACCGTG GTGCCACGTG GCAGCACATT TCCCCTGCTG 960

GAAGGTCCCG ATAGCCAGGA GATAGAAGAG GACAAAGAGT GTGTCATAAC GCCCAGCACC 1020

AGTGTAAAAT TCAACGCTGC TCTTCTCAAA TGTCAACATC AATTTTATTT ATTTAGTCAT 1080

CATGAGACTC CTCCAGAGGC TCAGAATAAA AACCTGGAAT TCCCCAACAG TTTTTCTCGC 1140

AGTCAAGGAA ATGTCATCCC ACCCACCACT GACAAGAAAG TGGAGGAGTG CTTTGTCCAA 1200

AAGGTCAATG ACAGCGGCAT GGATGGTGGC TCACCTTCAG CAGTACCAAA AACATCAATT 1260

CAAGAGCCTG GGGTCGGTGG TCGCGCCATT CGTCCTGAAG CCCCAGTGGA CTCGATGCTC 1320

AAAGACATGG CCACCGTCAT CTTCTCTACT TTCCTTTTCG CTGGTTGGGT GGCCTTTATC 1380

ATCATATATC CCAAAAGCGT TCACAGGCAG CAGCAGCTGC AGCACCAAGA GTTCCAGAGG 1440

CAGATGGAGG AGAGGCTGGA GCTCCTCCAG AGGCAGCAGC CCTTCTCCCC AGCAGACGTG 1500

ACTCCTGACG GTGACTACCT AGATGTGACC CGCACCAGGT CTGACTGCTC TGACAACAGC 1560

AGCCCCAACG TCACCCCGCG CGCATCCAAT CACTCCAATT TGTCTGTTTC GGAGCTGGGG 1620

ACCTGGACTA ATGAGACTGA AGATGGAGAA GATGATTCCA CCATTGTCAG AGTAGGCAAC 1680

ATAACCTTCC ATCCCAAACA AGTATTAGGG CACGGAGCTG AAGGGACTAT TGTGTACAAG 1740

TCCATAAGGG GTCAGTTTGA CAACCGTCCA GTGGCAGTCA AGAGGATTCT CCCAGAATGC 1800

TTCAGCTTTG CAGATCGAGA GGTTCAGCTG CTGAGGGAAT CTGACGAACA CCCAAATGTC 1860

ATCCGGTACT TCTGCACCGA GAGAGACCGT CAGTTCCAGT ACATCGCCAT TGAGCTGTGT 1920

GCTGCCACTC TTCAGGAGTA TGTGGAGAGA AAAGATTTTA ACCGTCATGG ACTCGAGCCG 1980

GTCATGGTTC TGCAGCAGAC CATGTCTGGA CTGGCTCATT TACATTCTCT CAACATTGTT 2040

CACAGAGACC TAAAACCCCA CAATATTCTG GTGTCCATGC CCAACGCACA CGGCAGAGTG 2100

CGGGCCATGA TCTCAGACTT TGGTTTGTGC AAGAAGCTGG CAGTGGGGCG CCACAGTTTC 2160

AGCAGGAGGT CTGGGGTTCC AGGCACTGAG GGCTGGATTG CTCCAGAGGT TCTCAGTGAG 2220

GATTGTCAAC ACAACCCTAC TTGCGCTGTG GACATCTTCT CTGCTGGCTG TGTCTTCTAC 2280

TATGTGGTGT CCCAAGGAAG CCATCCATTC GGCAAATCCC TGCAGAGACA AGCTAACATA 2340

CTGCTAGGAG CGTACAGCAT AGACCACCTT CAAAGTGACA AACACGAGGA CATTGTCGCA 2400

AGAAACCTGA TGGAGCAGAT GCTGAGCATG GATCCCCACA AGAGGCCTTC AGCAGAAAGT 2460

GTTCTCAAAC ACCCGTTCTT CTGGAGTCTG GAAAAAGAGC TGCAGTTCTT TCAGGATGTG 2520

AGTGACCGAA TTGAAAAGGA ACCTCTGGAT GGACCAATTG TGAGGCAGCT GGAGAGGGGG 2580

GGGAGGGCAG TTGTTCAAGG TGACTGGAGG GAGCATATCA CTGTCCCCCT GCAGACAGAT 2640

CTTCGAAAAT TCCGTTCCTA TAAGGGGGGC TCGGTCAGAG ACCTGCTGCG TGCAATGAGA 2700

AACAAGAAAC ATCATTACAG AGAATTGCCT GCAGAGGTAC AGGAGACCCT GGGCTCCATC 2760

CCGGATGACT TTGTCTCTTA CTTCACGTCC CGTTTTCCAC ACCTGCTCAT GCACACCTAC 2820

CTGGCCATGC GGACCTGTGC TTCAGAGAGG ACATTCCTGC CTTACTACTC CACCGTGGAG 2880

CAGCAT 2886

Domain Profile

S: 1     fspkdvlGkGaeGtvvf...rGsfegrevavkrllsefvdlakrevkllresdehpnvir  57

         f pk+vlG+GaeGt+v+   rG+f++r+vavkr+l+e++++a+rev+llresdehpnvir

Q: 563   FHPKQVLGHGAEGTIVYksiRGQFDNRPVAVKRILPECFSFADREVQLLRESDEHPNVIR  622

         679**************55559**************************************

S: 58    yfctekdrqfryialelcaaslqdyvedkdlelqkelepisllkqiasGlahlhslkivh  117

         yfcte+drqf+yia+elcaa+lq+yve kd++ +++lep+ +l+q++sGlahlhsl+ivh

Q: 623   YFCTERDRQFQYIAIELCAATLQEYVERKDFN-RHGLEPVMVLQQTMSGLAHLHSLNIVH  681

         ********************************.99*************************

S: 118   rdlkpqnilislpdakgklrvlisdfGlckkldvGkssfsrrsgvsGteGwiapelleel  177

         rdlkp+nil+s+p+a+g++r++isdfGlckkl+vG++sfsrrsgv+GteGwiape+l+e+

Q: 682   RDLKPHNILVSMPNAHGRVRAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEVLSED  741

         ************************************************************

S: 178   tkerltsavdifslGcvfyyvlskGkhpfGdslkrqanilsgelsldklkeekdeeviae  237

         +++++t avdifs+Gcvfyyv+s+G+hpfG+sl+rqanil g++s+d+l+++k+e+++a+

Q: 742   CQHNPTCAVDIFSAGCVFYYVVSQGSHPFGKSLQRQANILLGAYSIDHLQSDKHEDIVAR  801

         ************************************************************

S: 238   dliskmidkdplkrpsakkvlkhplf  263

         +l+++m+++dp krpsa+ vlkhp+f

Q: 802   NLMEQMLSMDPHKRPSAESVLKHPFF  827

         *************************9

Domain Sequence
(FASTA)

FHPKQVLGHG AEGTIVYKSI RGQFDNRPVA VKRILPECFS FADREVQLLR ESDEHPNVIR 60

YFCTERDRQF QYIAIELCAA TLQEYVERKD FNRHGLEPVM VLQQTMSGLA HLHSLNIVHR 120

DLKPHNILVS MPNAHGRVRA MISDFGLCKK LAVGRHSFSR RSGVPGTEGW IAPEVLSEDC 180

QHNPTCAVDI FSAGCVFYYV VSQGSHPFGK SLQRQANILL GAYSIDHLQS DKHEDIVARN 240

LMEQMLSMDP HKRPSAESVL KHPFF 265

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0016891	; F:endoribonuclease activity, producing 5'-phosphomonoesters
GO:0004674	; F:protein serine/threonine kinase activity
GO:0006397	; P:mRNA processing

KEGG

InterPros

IPR010513	; KEN_RNase_activator.
IPR011009	; Kinase-like_dom.
IPR018391	; PQQ_beta_propeller_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR006567	; PUG-dom.
IPR011047	; Quinonprotein_ADH-like.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF06479	; Ribonuc_2-5A; 1.

SMARTs

SM00564	; PQQ; 5.
SM00580	; PUG; 1.

Prosites

PS51392	; KEN; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013