EKS-ORL-00384

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00384

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	329.8	1.4E-98	478	725	248

Status

Unreviewed

Ensembl Protein

ENSORLP00000011994

UniProt Accession

H2M0R7;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK7

Gene Synonyms/Alias

PAK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000009567	ENSORLP00000011994	ENSORLT00000011995

Organism

Oryzias latipes

Functional Description

Protein Length

744

Protein Sequence
(FASTA)

MFGKKKKRLE ISAPSNFEHR VHTGFDPREQ KFTGLPQQWQ SLLADTANRP KPMVDPSYIT 60

PIQLAPMKTI VRGNRPPKDA SINGLLEEFD NISVTRSNSL RKESPPGLHQ AGIGSKPLGG 120

GHPPAPEENG FNHYYSRYSC DLDTSSRDFL LDPGKPSFSI DGDWAVGRHY RFTKQNGHSH 180

LIRSPFYPDA MPQKSDYGKL PPDYHTYLES KGRSADEVAS TVGSGVGSSG YYRASVGGSS 240

SQDYRDTSVG TPSRASLHSE QITYPDSEWS YGGLRDEYDK RPKSSYVTQT SPTPAIRQRS 300

RSGSGLQEQM VPYVAGGPFK NPPQAHSYSS YTYPRLSESL ANAQAAAKGD YERPPRSDIP 360

PVVGVDAGPR GPLKLPQSHA KPPGYPPAHL PYPPVFHHYK PSPYHHPPSQ PSPPYTPQGA 420

YSQPSSPYIL PGAYPPPSWG SSSDTQPSRV SHEQFRAALQ LVVNPGLGDP REYLDNFIKI 480

GEGSTGIVCI ASEKHSGKQV AVKKMDLRKQ QRRELLFNEV VIMRDYHHEN VVDMYNSYLV 540

GDELWVVMEF LEGGALTDIV THTRMNEEQI ATVCLSVLRA LSYLHTQGVI HRDIKSDSIL 600

LTSDGRIKLS DFGFCAQVSK EVPKRKSLVG TPYWMAPEVI SRLPYGTEVD IWSLGIMVIE 660

MVDGEPPYFN EPPLQAMRRI RDNLPPRLKE SHKVSSVLRS FLDMMLVREP SQRATAQELL 720

QHPFLKMSGP PSCIVPLMRH YRHR 744

Nucleotide Sequence
(FASTA)

ATGTTCGGCA AGAAGAAGAA ACGGCTGGAG ATCTCAGCTC CGTCGAACTT CGAGCACCGT 60

GTCCACACGG GCTTCGACCC GCGGGAGCAG AAGTTCACCG GACTGCCGCA GCAATGGCAG 120

AGCCTGCTGG CGGACACTGC CAACCGGCCC AAACCCATGG TGGACCCCTC CTACATCACC 180

CCCATCCAGC TGGCGCCCAT GAAGACCATC GTTCGGGGGA ACCGGCCGCC CAAAGATGCA 240

TCCATCAACG GCCTGCTGGA GGAGTTCGAC AACATCTCGG TGACGCGCTC CAACTCCCTG 300

CGGAAGGAGA GTCCGCCCGG CCTCCACCAG GCTGGAATTG GCTCCAAGCC CCTGGGAGGG 360

GGTCATCCCC CCGCTCCCGA GGAGAATGGA TTCAACCACT ACTACTCCCG CTACTCATGT 420

GACCTGGACA CGTCCAGCAG GGACTTTTTA CTGGATCCCG GGAAGCCCAG CTTCTCCATC 480

GACGGGGACT GGGCTGTTGG GAGGCACTAT CGATTCACCA AGCAGAATGG CCACTCGCAT 540

CTCATCCGTA GCCCCTTCTA CCCGGACGCC ATGCCTCAGA AGTCAGACTA TGGCAAGCTC 600

CCCCCAGACT ACCACACCTA CCTGGAGAGC AAAGGGCGCT CCGCCGACGA GGTGGCCTCC 660

ACGGTGGGGA GCGGAGTGGG CTCCAGTGGG TACTACCGCG CTTCGGTGGG GGGCTCGTCC 720

AGCCAGGACT ACCGGGACAC GTCAGTGGGC ACGCCGTCCC GCGCCTCCCT CCACAGCGAG 780

CAGATCACCT ACCCAGACAG CGAGTGGAGC TACGGCGGCC TGCGGGACGA ATACGACAAG 840

CGGCCCAAGA GTTCCTACGT GACCCAGACC AGTCCCACGC CAGCCATCCG ACAGAGGTCG 900

CGCTCAGGAT CCGGCCTGCA GGAGCAAATG GTCCCCTATG TGGCCGGGGG CCCTTTCAAG 960

AACCCCCCCC AGGCTCATTC ATACAGCTCC TACACCTACC CCCGCCTCTC TGAGAGTCTG 1020

GCTAACGCTC AGGCCGCAGC CAAGGGCGAC TACGAGCGAC CGCCTCGCAG CGACATTCCT 1080

CCGGTTGTAG GCGTTGACGC CGGCCCCCGA GGGCCTCTTA AGCTACCTCA GAGCCATGCC 1140

AAACCGCCTG GTTATCCCCC GGCACACCTA CCATACCCCC CTGTCTTTCA CCATTACAAA 1200

CCCTCTCCGT ACCATCACCC CCCCTCCCAG CCCAGCCCAC CGTACACCCC TCAGGGTGCC 1260

TACTCCCAGC CGTCGTCCCC CTACATTCTC CCGGGGGCTT ATCCCCCGCC CTCATGGGGC 1320

TCCAGTTCAG ACACTCAACC CTCCAGAGTC TCTCATGAGC AGTTCAGAGC TGCCCTCCAG 1380

CTGGTGGTCA ACCCAGGACT AGGTGACCCC CGGGAATACC TGGACAACTT CATCAAGATT 1440

GGCGAGGGCT CCACGGGTAT CGTGTGCATC GCCAGCGAGA AGCACAGCGG CAAGCAGGTG 1500

GCGGTGAAGA AGATGGACCT GAGGAAGCAG CAGAGGAGGG AGCTGCTCTT TAATGAGGTT 1560

GTGATCATGA GGGACTACCA TCATGAAAAC GTGGTGGACA TGTACAACAG CTATCTGGTG 1620

GGAGACGAGC TGTGGGTGGT CATGGAGTTC CTTGAGGGAG GGGCTCTCAC AGACATTGTG 1680

ACTCACACCA GGATGAACGA GGAGCAGATT GCCACCGTGT GCCTGTCGGT GCTGAGGGCT 1740

CTGTCCTACC TGCACACGCA GGGCGTCATC CACCGCGACA TCAAGAGCGA CTCCATTCTG 1800

CTGACCAGCG ACGGCCGGAT CAAGCTCTCC GACTTTGGCT TCTGCGCCCA AGTTTCCAAA 1860

GAAGTGCCCA AGAGGAAGTC TCTGGTGGGC ACGCCCTACT GGATGGCGCC AGAGGTCATT 1920

TCCAGACTGC CGTATGGCAC AGAGGTGGAC ATCTGGTCTT TGGGCATCAT GGTTATCGAG 1980

ATGGTGGACG GGGAGCCCCC TTACTTCAAT GAGCCCCCTC TGCAGGCCAT GAGGAGGATA 2040

CGGGACAACC TGCCCCCCCG GCTAAAAGAA TCACACAAGG TGTCGTCGGT GCTGCGGTCC 2100

TTCCTGGACA TGATGCTGGT CAGGGAGCCG TCACAGAGGG CCACCGCCCA GGAACTCCTC 2160

CAGCACCCCT TCCTGAAGAT GTCCGGCCCC CCCTCTTGCA TCGTTCCCCT CATGAGACAC 2220

TACCGCCATC GCTGA 2235

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a ek++g++va+kk++l+kq++ e+l++e+ ++++++h+n+v++++s

Q: 478   IKIGEGSTGIVCIASEKHSGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNS  537

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+ +elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi

Q: 538   YLVGDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHTQGVIHRDI  594

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ krk++vgtpywmAPEvi+  +  Y +++Diw

Q: 595   KSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVIS--RLPYGTEVDIW  652

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i +n pp+lk+++k+s+ +++f++ +l ++p++

Q: 653   SLGIMVIEMVDGEPPYFNEPPLQAMRRIRDNLPPRLKESHKVSSVLRSFLDMMLVREPSQ  712

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ell+h+Fl

Q: 713   RATAQELLQHPFL  725

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGI VCIASEKHSG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HENVVDMYNS 60

YLVGDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHTQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPKRKS LVGTPYWMAP EVISRLPYGT EVDIWSLGIM 180

VIEMVDGEPP YFNEPPLQAM RRIRDNLPPR LKESHKVSSV LRSFLDMMLV REPSQRATAQ 240

ELLQHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013