EKS-ORL-00317

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00317

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/PLK	414.2	2.5E-124	48	300	253

Status

Unreviewed

Ensembl Protein

ENSORLP00000012039

UniProt Accession

H2M0W2;

Protein Name

Protein Synonyms/Alias

Gene Name

PLK1

Gene Synonyms/Alias

PLK1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000009603	ENSORLP00000012039	ENSORLT00000012040

Organism

Oryzias latipes

Functional Description

Protein Length

592

Protein Sequence
(FASTA)

NAERALLKYT MSAAIAKPAQ PSGHVDPKSA PLKEIPEVLV DPRTLRRYSK GRFLGKGGFA 60

KCFEITDMET KQVFAGKIVP KSLILKQHQR EKMSSEISIH KSLNHANIVG FHGFFEDDDF 120

VYVVLEICRR RSLLELHKRR KAVTEPEARY YMTQLLKGVH YLHSNKVIHR DLKLGNIFLN 180

DDMEVKIGDF GLATKIEFDG ERKKTLCGTP NYIAPEVLCK KGHSYEVDVW SLGCILYTLL 240

VGKPPFETSC LKDTYNRIKK NNYTIPWQIN PSASALIKRM LHADPAQRPT ITDLQTDEFF 300

TSGYVPLRLP TTCLTVPPRF SIAPSMAAEL SQRRPLTAIN NKAGTEKVDM KDEPAPLEAE 360

PEECYLKDML QQLNSIISAK PSEKAVIRQE EAEDPACIPI FWISKWVDYS DKYGLGYQLC 420

DNSVGVLFND FTRLIMYADG DSLQYIDKKA AESYLSVRSF PASLNKKITL LKYFRNYMSE 480

HLLKAGANIA RREGDELARL PYLCLWFRTK SAIILHLSNG TVQINFFQDH TKLILCPLMA 540

AVTYINEKRD FRTYKLSLLE EFGCSKELAS RMRYAKLMVE KLLETKPTPA AH 592

Nucleotide Sequence
(FASTA)

AACGCGGAAA GAGCACTTTT AAAGTACACC ATGAGTGCTG CTATCGCAAA GCCGGCGCAG 60

CCGTCCGGAC ACGTCGACCC AAAATCGGCT CCTCTGAAAG AAATCCCAGA GGTTTTGGTG 120

GATCCCCGCA CCCTGAGGAG ATACTCCAAG GGCAGGTTCC TCGGCAAGGG GGGCTTCGCC 180

AAATGCTTCG AAATTACAGA CATGGAGACC AAGCAGGTTT TCGCTGGCAA AATAGTGCCC 240

AAGTCGTTGA TCCTGAAGCA GCACCAAAGG GAGAAGATGA GCTCGGAAAT CTCCATTCAC 300

AAGAGCCTCA ATCATGCTAA CATCGTGGGC TTCCACGGCT TCTTTGAGGA CGACGACTTT 360

GTCTATGTGG TCCTGGAGAT CTGCAGGAGA AGGTCCCTGT TGGAGTTGCA CAAGCGCAGG 420

AAGGCGGTCA CGGAGCCGGA GGCTCGCTAC TACATGACCC AGCTGCTGAA GGGGGTCCAT 480

TATCTGCACA GCAACAAGGT CATCCACAGA GACCTGAAAC TGGGGAACAT CTTCCTCAAC 540

GACGACATGG AAGTCAAGAT AGGTGACTTT GGTTTGGCCA CAAAGATTGA GTTTGATGGT 600

GAACGGAAGA AGACCTTGTG TGGAACGCCC AACTATATCG CTCCGGAAGT GCTGTGCAAG 660

AAAGGCCACA GCTATGAAGT GGATGTCTGG TCACTTGGGT GCATATTGTA CACTTTGTTA 720

GTCGGCAAGC CTCCGTTTGA AACCTCATGC CTGAAAGACA CATACAACCG GATCAAGAAG 780

AACAATTACA CCATCCCCTG GCAAATCAAC CCGTCAGCCT CGGCTCTCAT CAAGAGGATG 840

CTGCATGCCG ATCCTGCCCA GAGGCCCACC ATCACTGACC TGCAGACGGA TGAGTTCTTC 900

ACATCGGGAT ACGTCCCCCT GCGGCTGCCC ACCACTTGTC TCACTGTGCC CCCGCGGTTC 960

TCCATTGCCC CCTCCATGGC TGCAGAGCTC AGCCAGAGGC GCCCCCTGAC TGCCATAAAC 1020

AACAAAGCCG GCACAGAGAA GGTGGACATG AAAGACGAGC CTGCTCCACT AGAGGCGGAG 1080

CCAGAAGAAT GCTACCTGAA GGACATGCTG CAGCAGCTCA ACAGCATCAT CTCTGCCAAG 1140

CCTTCAGAGA AGGCGGTCAT TCGGCAAGAG GAAGCAGAGG ATCCTGCGTG TATTCCCATC 1200

TTTTGGATCA GTAAATGGGT CGACTACTCT GACAAATATG GATTAGGATA CCAGCTTTGT 1260

GACAACAGTG TTGGTGTTCT ATTCAACGAT TTCACCCGAC TCATCATGTA TGCTGATGGC 1320

GACAGTCTGC AGTACATTGA CAAGAAGGCT GCAGAGTCCT ATTTAAGCGT TCGCTCATTC 1380

CCTGCTTCTC TCAACAAAAA GATTACATTA CTGAAATATT TCCGCAACTA CATGAGTGAG 1440

CATCTCCTGA AAGCTGGTGC CAACATTGCG CGCCGTGAAG GTGATGAACT GGCCCGGCTG 1500

CCTTACCTCT GCCTCTGGTT TCGAACCAAG AGCGCCATCA TCCTGCACCT CAGCAATGGA 1560

ACGGTTCAGA TCAACTTCTT CCAGGACCAC ACTAAGCTGA TTCTGTGTCC ACTGATGGCC 1620

GCGGTGACCT ACATCAACGA GAAGCGAGAC TTCCGCACCT ACAAGCTCTC CCTGCTGGAG 1680

GAGTTTGGTT GTAGCAAAGA ACTAGCCAGT CGCATGCGTT ACGCCAAACT CATGGTGGAG 1740

AAGCTGCTAG AAACCAAACC AACGCCCGCT GCTCATTAG 1779

Domain Profile

S: 1     yergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkn  60

         y++g++lGkGgfakc+e++d+etk+vfa k+vpksl+ k++qrek+++ei+ih+sl+h n

Q: 48    YSKGRFLGKGGFAKCFEITDMETKQVFAGKIVPKSLILKQHQREKMSSEISIHKSLNHAN  107

         89**********************************************************

S: 61    ivklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekri  120

         iv ++ ffed+++vy+vle+c+rrsl el+krrka+tepe+ryy++q+++g++ylh++++

Q: 108   IVGFHGFFEDDDFVYVVLEICRRRSLLELHKRRKAVTEPEARYYMTQLLKGVHYLHSNKV  167

         ************************************************************

S: 121   lhrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslev  180

         +hrdlklgn+fln+++evkigdfGlat++e ++erkktlcGtPnyiaPevl kkghs+ev

Q: 168   IHRDLKLGNIFLNDDMEVKIGDFGLATKIEFDGERKKTLCGTPNYIAPEVLCKKGHSYEV  227

         ************************************************************

S: 181   diWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePee  240

         d+WslGcilytllvGkPPfet++lk+ty++ikk++y++P +++++a+ li+++l+++P++

Q: 228   DVWSLGCILYTLLVGKPPFETSCLKDTYNRIKKNNYTIPWQINPSASALIKRMLHADPAQ  287

         ************************************************************

S: 241   rpsleevlkdefl  253

         rp+++++ +def+

Q: 288   RPTITDLQTDEFF  300

         **********998

Domain Sequence
(FASTA)

YSKGRFLGKG GFAKCFEITD METKQVFAGK IVPKSLILKQ HQREKMSSEI SIHKSLNHAN 60

IVGFHGFFED DDFVYVVLEI CRRRSLLELH KRRKAVTEPE ARYYMTQLLK GVHYLHSNKV 120

IHRDLKLGNI FLNDDMEVKI GDFGLATKIE FDGERKKTLC GTPNYIAPEV LCKKGHSYEV 180

DVWSLGCILY TLLVGKPPFE TSCLKDTYNR IKKNNYTIPW QINPSASALI KRMLHADPAQ 240

RPTITDLQTD EFF 253

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000959	; POLO_box_duplicated_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00659	; POLO_box; 2.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50078	; POLO_BOX; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013