EKS-ORL-00465
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-ORL-00465
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl475.36.3E-143494758265
StatusUnreviewed
Ensembl ProteinENSORLP00000012612
UniProt AccessionH2M2H0;
Protein Name
Protein Synonyms/Alias
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSORLG00000010056ENSORLP00000012612ENSORLT00000012613
OrganismOryzias latipes
Functional Description
Protein Length865
Protein Sequence
(FASTA)
MKLLLWSLVV WLRAPAGICG GGGVVFTKHP TNQTVSQGKE VRLGCAVKGV SEPDITWMKD 60
GEKLYSTDQV FLTLGEQHWE TSHSVKSVQQ QDAGQYWCEV EFHGLTFSSK AAWITVEGVP 120
HFIQEPQDVA TFPNTPFNLS CAAVGPPEPV EVQWSLGGVR EEESRRSPAV LHVPGVNTSM 180
KFYCEAKNAR GISVSRTGTA YIKAAPVDLQ VIWMTDSNVR LSWTPGFSGH SELSTCVVQV 240
QRSTGRRGDL PQQEEVQVPP HLHRLPALRS HSNYSARVSC VNEVGASPFS PWLHFSTPES 300
VPSAPPRNLT FDLLERHLSL RWAELHEEEL QGKLQAYKLQ WILGGELQEP LLFKQNYAEL 360
SGAGRFFNAS FQVSACTSAG CGPWSTPVLV LPASDPAVQV QAQRSHIWVG LLLGLLVAVV 420
AGLLLTTVAR RRGKETQFGS AFKDPGPESS VCFTAARSFN RNVADSQEST LDSLCINSEL 480
KNKLQDVLIP ENLLTLGHML GKGEFGSVRE AVLKNQDSTV QKVAVKVLKT DITSSSDIEQ 540
CLKEAAHMKD FHHPNVIQLI GVSLHRRTGQ RLPIPMVVLP FMKHGDLHTF LLLSRLGDQP 600
FDLPQQTLVQ FMLDIAKGME YLSSKNIIHR DLAARNCMLH ENMVVCVADF GLSKKIYSGD 660
YYRQGSVSKL PVKWIALESL ADNVYTTQSD VWAFGVTIWE IMTRGQTPYP GVENSEIYEF 720
LIKGERLKRP SDCRDDIYEI MHSCWSPVPK CRPSFQQLVS QLEALHLNLS PRQPPKEPLL 780
YVNLEGEESG ADAGGGAWTP DAEGAADSCS WRVPWQQQVE ETDWLMPVSR AALGDYRYIF 840
GPQGIPEEEE TAGEVQDEED TVINL 865
Nucleotide Sequence
(FASTA)
ATGAAGCTGC TGCTCTGGAG CCTGGTCGTG TGGTTGCGGG CTCCGGCGGG GATCTGCGGC 60
GGCGGCGGCG TGGTCTTCAC CAAGCACCCG ACCAATCAGA CGGTGTCTCA GGGGAAGGAG 120
GTGCGGCTGG GATGCGCCGT GAAGGGTGTG AGCGAGCCGG ACATCACCTG GATGAAGGAC 180
GGAGAGAAGC TGTACAGCAC CGACCAGGTC TTCCTCACCC TGGGGGAGCA GCACTGGGAG 240
ACGTCCCACA GCGTGAAGTC GGTCCAGCAG CAGGACGCGG GTCAGTACTG GTGTGAGGTG 300
GAGTTCCACG GTCTGACCTT CTCCTCCAAA GCGGCCTGGA TCACAGTGGA AGGAGTCCCT 360
CACTTCATCC AGGAGCCTCA GGATGTGGCC ACGTTCCCCA ACACCCCCTT CAACCTGTCC 420
TGTGCCGCCG TTGGCCCCCC CGAGCCCGTG GAGGTGCAGT GGTCGCTGGG AGGAGTCCGT 480
GAGGAGGAAT CCAGACGGTC CCCGGCTGTC CTCCACGTTC CTGGTGTGAA CACCAGCATG 540
AAGTTCTACT GCGAAGCAAA AAACGCTCGA GGGATTTCTG TCTCCAGAAC CGGAACGGCC 600
TACATCAAAG CAGCGCCGGT TGACCTGCAG GTCATCTGGA TGACGGACAG CAACGTGAGG 660
TTGTCATGGA CACCAGGATT CTCGGGTCAC TCCGAGTTGT CCACCTGCGT CGTCCAGGTG 720
CAGAGGAGCA CGGGCCGCAG GGGGGACCTC CCCCAGCAGG AGGAGGTGCA GGTTCCTCCT 780
CACCTTCACA GGCTCCCCGC TCTGCGGAGC CACTCCAACT ACAGCGCCCG CGTGTCCTGT 840
GTGAACGAGG TGGGGGCGTC GCCGTTCTCC CCGTGGCTGC ACTTCAGCAC ACCTGAGTCA 900
GTGCCGTCGG CGCCGCCCCG GAACCTGACC TTTGATCTGT TGGAGCGTCA CCTGAGTCTG 960
CGGTGGGCGG AGCTACATGA AGAGGAGCTT CAGGGCAAGT TGCAGGCCTA CAAGCTGCAG 1020
TGGATTCTGG GAGGAGAGCT TCAGGAGCCG CTGCTGTTCA AGCAGAACTA TGCTGAACTC 1080
TCTGGGGCGG GGCGCTTTTT TAACGCCTCC TTCCAGGTGT CGGCGTGCAC CTCGGCGGGC 1140
TGTGGACCTT GGAGCACCCC GGTGCTGGTT CTGCCCGCCT CAGATCCCGC AGTGCAAGTC 1200
CAGGCGCAGC GCAGCCACAT TTGGGTCGGC CTTCTGCTCG GCCTGCTGGT GGCCGTCGTG 1260
GCCGGCCTGC TACTAACTAC TGTTGCTCGG CGCCGAGGAA AAGAGACGCA GTTTGGGTCG 1320
GCCTTCAAAG ATCCGGGTCC TGAGAGTTCG GTCTGCTTCA CGGCGGCCCG ATCGTTCAAC 1380
AGGAACGTCG CCGATTCGCA GGAGTCCACC CTGGACAGTC TGTGCATCAA CAGCGAGCTG 1440
AAGAACAAAC TTCAGGATGT TTTGATTCCA GAGAACCTGC TGACTCTGGG CCACATGCTG 1500
GGCAAAGGTG AGTTCGGCTC TGTGCGTGAA GCCGTCCTGA AAAACCAAGA CTCCACTGTC 1560
CAGAAGGTGG CGGTTAAAGT ACTAAAAACT GACATCACCT CATCAAGTGA CATTGAGCAG 1620
TGTCTGAAGG AGGCGGCCCA CATGAAGGAC TTCCACCATC CCAACGTCAT CCAGCTCATT 1680
GGAGTGAGTC TGCACCGGCG CACCGGCCAG CGGCTGCCCA TACCCATGGT GGTTCTTCCG 1740
TTCATGAAGC ACGGAGATCT GCACACTTTC CTGCTGCTGT CTCGTCTGGG AGACCAGCCC 1800
TTTGACCTTC CCCAGCAGAC TTTAGTCCAG TTCATGCTGG ACATCGCCAA AGGGATGGAG 1860
TACCTCAGCA GCAAGAACAT CATCCATAGA GACCTTGCTG CCCGCAACTG CATGTTGCAT 1920
GAGAACATGG TGGTGTGCGT CGCAGACTTT GGACTCTCCA AGAAGATCTA CAGTGGCGAT 1980
TACTACAGAC AGGGCTCCGT GTCCAAGCTG CCTGTCAAGT GGATCGCTCT GGAGAGTCTG 2040
GCTGACAACG TCTACACAAC ACAGAGTGAC GTGTGGGCGT TCGGTGTGAC CATTTGGGAG 2100
ATCATGACTC GCGGTCAAAC TCCATATCCT GGAGTAGAAA ACTCTGAGAT CTACGAGTTC 2160
CTGATCAAAG GGGAGCGACT GAAGAGACCT TCAGACTGCA GAGATGACAT ATATGAGATC 2220
ATGCACAGCT GCTGGAGTCC CGTCCCCAAG TGCCGCCCCA GTTTCCAACA GTTGGTCAGC 2280
CAGCTGGAGG CGCTGCACCT CAATCTTTCC CCCCGCCAAC CTCCAAAGGA GCCTTTACTC 2340
TATGTGAACC TGGAGGGGGA GGAGAGCGGA GCGGATGCCG GGGGAGGAGC TTGGACCCCG 2400
GACGCTGAGG GGGCAGCAGA CTCCTGCAGC TGGCGCGTCC CGTGGCAGCA GCAGGTGGAG 2460
GAGACGGACT GGCTGATGCC CGTATCAAGG GCCGCACTTG GAGACTATAG GTACATCTTT 2520
GGACCACAAG GCATCCCAGA GGAAGAGGAG ACAGCGGGGG AGGTCCAGGA TGAGGAAGAC 2580
ACGGTTATTA ACCTGTGA 2598
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         l+lg++lg+gefgsv+e+ lk++d++++kvavk+lk di+++s+ie+ l+eaa mk+f+h
Q: 494   LTLGHMLGKGEFGSVREAVLKNQDSTVQKVAVKVLKTDITSSSDIEQCLKEAAHMKDFHH  553
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         pnvi+l+gvsl+ ++ +rlp+p+v+lpfmk+gdlh+fll srlg++p+ lp qtlv+fm+
Q: 554   PNVIQLIGVSLHRRTGQRLPIPMVVLPFMKHGDLHTFLLLSRLGDQPFDLPQQTLVQFML  613
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         dia+gmeylss+n+ihrdlaarncml+e+m vcvadfglskkiysgdyyrqg ++klpvk
Q: 614   DIAKGMEYLSSKNIIHRDLAARNCMLHENMVVCVADFGLSKKIYSGDYYRQGSVSKLPVK  673
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         wia+eslad+vyt++sdvwafgvt+wei+trgqtpy+gven+eiy++l++g+rlk+p+dc
Q: 674   WIALESLADNVYTTQSDVWAFGVTIWEIMTRGQTPYPGVENSEIYEFLIKGERLKRPSDC  733
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvl  265
          d++y++m++cw+  pk rpsf +l
Q: 734   RDDIYEIMHSCWSPVPKCRPSFQQL  758
         **********************876
Domain Sequence
(FASTA)
LTLGHMLGKG EFGSVREAVL KNQDSTVQKV AVKVLKTDIT SSSDIEQCLK EAAHMKDFHH 60
PNVIQLIGVS LHRRTGQRLP IPMVVLPFMK HGDLHTFLLL SRLGDQPFDL PQQTLVQFML 120
DIAKGMEYLS SKNIIHRDLA ARNCMLHENM VVCVADFGLS KKIYSGDYYR QGSVSKLPVK 180
WIALESLADN VYTTQSDVWA FGVTIWEIMT RGQTPYPGVE NSEIYEFLIK GERLKRPSDC 240
RDDIYEIMHS CWSPVPKCRP SFQQL 265
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CII-00235
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAM-00236
EKS-GAG-00338
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-OTG-00402
EKS-PAT-00374
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00047
EKS-TEN-00500
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013