EKS-ORL-00583

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00583

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Atypical/BCR	N/A	N/A	N/A	N/A	N/A

Status

Unreviewed

Ensembl Protein

ENSORLP00000013381

UniProt Accession

H2M4L3;

Protein Name

Protein Synonyms/Alias

Gene Name

BCR (3 of 3)

Gene Synonyms/Alias

BCR (3 of 3);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000010674	ENSORLP00000013382	ENSORLT00000013383
ENSORLG00000010674	ENSORLP00000013381	ENSORLT00000013382

Organism

Oryzias latipes

Functional Description

Protein Length

1312

Protein Sequence
(FASTA)

RDVVGSNGHR KLTMVEPVGF IEAWKAQFPE SEPPKMELRS VGGIEQELEK CKASIRRLEQ 60

EVNKERFRMI YLQTLLAKER KSYDKQRWGF RKTPPLGDGR SKPRPPPARK SASHGDGLEA 120

AFDIPPQAES SSCEHLDGLS PSKQRCGVTM SPRRPTLPPP DKELPSDPKD KLGMGLGVAA 180

LRSNFERIKR ANSHSAGDVT KGQEKHLPPP PPPPPFYTNM EFHHERGLVR VNDRELSEKI 240

SSLGSQAMQI ERKRSLHSLP GNLATVAGDL RPKPVYRGRS TESTCGYDAE YEDGEPNQRH 300

SGRANGGKPP PPWQPSEFQA YSSVYVGGVM MGEGGSGDGR GSGAVTMRDH GGGDDHLLTW 360

PRRSYSPGSF EDAGGGGGYT PDCSSNENLT SSEEDFSSGQ SSHISPSPTT AFRRPLREKS 420

RSPSQNSQNS QHSFDSSSPP TPQSQKRHHR QHGGHVVMSE ATIVSVRKTG QIWPPAAHHD 480

LMSHGRTSHD NSFHGDHLGS FCTPPPYGYD ADRAEEQRRH HDILPFIDDS PSSSPHLSSK 540

SRSSRDTLSS GSLESSKSTE CDLEKGLEMR KWVLSGILAT EETYLSHLEA LLLPMKPLKA 600

AATTSQPVLT VAQIETIFFK VPELYEIHKD FYDALLPRVQ QWSHHQRVGD LFQKLAGQLG 660

VYRAFLDNYE LAVETAEKCC QANAQFSEIS ENLKVRSPKD CKETAKTSLE ALLYKPVDRV 720

TRSTLVLHDL LKHTPTSHPD HPLLLDALRI SQNFLSSINE ETTPRRQSMT VKKGENRQLL 780

KDSFMVELVE GARKLRHVFL FTDLLLCAKL KKQIGGKNQQ YDSKWYIPLT ELTFQGPEEA 840

DPLTIPQVPD EELDAIKVKI SHLRSEIQKE KVIDFNVLPN SKQSYSFLIS SDYERAEWRE 900

VIKEQHKKCL KATSLTSMEL QMLTSSCLKL QTVHHIPLST NKDEDESSGL YGFLNVIVHS 960

ASGLKQSLNL YCTLEVDSFG FFSNKAKTRV YRYTTEPKWN EEFEIELEGS QTLRLLCYEK 1020

CYNKTKQNKE DGDGTDRIMG KGQIPLEPQS LQGKDWQRTV IPMNGIEVKL SMKFTSREFS 1080

LKRTPTRKPM GVFGVKISSV TKRERSKVPY IVRQCLEEIE RRGMEEVGIY RVSGVATDIQ 1140

ALKTAFDTNN KDVSVMMSEM DVNAIAGTLK LYFRELPEPL FTDELYPNFT GGITLSDSVA 1200

KESCMLNLLL SLPEPNLVTF LFLLDHLKRV AEKESVNKMS LHNLATVFGP TLLRPSEKDS 1260

KIPTNPTQPI SMGDSWSQEV MAQVQVLLYF LQLETIPTPD SKRQSILFST EV 1312

Nucleotide Sequence
(FASTA)

CGTGACGTAG TGGGGTCAAA TGGACACCGA AAATTAACTA TGGTGGAGCC TGTGGGGTTC 60

ATTGAGGCAT GGAAGGCCCA GTTCCCAGAG TCCGAGCCCC CAAAGATGGA GCTGAGGTCA 120

GTAGGGGGCA TTGAGCAGGA GTTGGAAAAG TGCAAAGCGT CCATCAGACG CCTGGAGCAG 180

GAAGTGAATA AGGAGCGCTT CCGCATGATC TACCTGCAGA CCCTTTTGGC CAAAGAGAGG 240

AAAAGCTATG ACAAACAGCG GTGGGGCTTC AGGAAGACAC CTCCTCTCGG AGATGGAAGG 300

TCCAAGCCCA GACCACCACC AGCCAGGAAG TCGGCCTCTC ATGGTGACGG CCTGGAAGCA 360

GCCTTTGACA TTCCACCACA GGCTGAATCC AGCTCCTGTG AACACCTTGA CGGCCTCTCG 420

CCGTCCAAGC AGAGATGCGG CGTTACGATG TCACCACGCA GGCCCACCTT ACCACCCCCA 480

GACAAAGAAC TGCCCTCTGA CCCCAAGGAC AAGCTAGGAA TGGGACTTGG TGTGGCAGCT 540

CTTCGATCCA ACTTTGAGAG GATCAAACGG GCCAACTCTC ACTCTGCTGG GGATGTAACC 600

AAGGGGCAGG AGAAGCACCT GCCACCACCA CCTCCTCCCC CACCATTTTA CACCAACATG 660

GAATTCCATC ACGAGAGGGG TTTGGTTCGT GTTAATGACC GGGAGTTGTC TGAGAAGATC 720

AGCTCCCTGG GTAGTCAGGC TATGCAGATA GAGCGGAAGA GATCCCTACA TTCGCTTCCT 780

GGTAATTTGG CCACAGTGGC AGGCGATCTC AGACCCAAAC CGGTGTACAG AGGACGATCC 840

ACTGAGAGCA CATGTGGGTA CGACGCAGAA TATGAAGATG GTGAACCCAA TCAGCGACAT 900

TCAGGGAGGG CCAACGGTGG TAAACCTCCA CCTCCTTGGC AGCCTTCAGA ATTTCAGGCC 960

TACTCTAGTG TCTACGTTGG AGGGGTAATG ATGGGTGAAG GTGGTAGTGG AGATGGAAGA 1020

GGGAGTGGTG CGGTCACAAT GAGAGACCAC GGGGGAGGGG ACGACCACCT CCTGACCTGG 1080

CCGCGCCGTT CATACTCTCC AGGCAGCTTT GAGGATGCAG GAGGAGGTGG CGGCTACACG 1140

CCGGACTGCA GCTCCAACGA GAACCTGACA TCCAGTGAGG AGGACTTCTC GTCCGGCCAG 1200

TCCAGTCACA TCTCACCCAG CCCCACCACG GCCTTCCGGC GGCCCTTGAG GGAGAAGAGC 1260

CGCTCCCCGT CTCAGAATTC CCAAAACTCG CAACACTCCT TTGACAGCAG CAGCCCGCCG 1320

ACGCCACAGT CACAAAAACG TCACCACCGG CAGCATGGAG GACATGTCGT CATGTCTGAG 1380

GCCACCATTG TAAGCGTTCG CAAGACTGGT CAAATATGGC CACCTGCTGC CCATCATGAC 1440

CTCATGTCTC ATGGGAGAAC ATCCCACGAC AACAGTTTCC ATGGAGACCA CCTCGGATCT 1500

TTCTGCACCC CTCCACCATA CGGCTACGAT GCAGACCGAG CAGAAGAGCA GCGGAGGCAC 1560

CACGACATCC TGCCGTTCAT CGACGACTCG CCTTCCTCCT CTCCCCACCT CAGCTCCAAG 1620

AGTCGCAGCA GCAGGGACAC GCTCTCCTCC GGGTCTCTGG AGTCCTCCAA GTCGACCGAG 1680

TGTGACTTGG AAAAAGGGTT GGAGATGAGG AAGTGGGTCC TGTCTGGAAT CCTGGCTACA 1740

GAAGAAACAT ACCTCAGTCA CCTGGAGGCT TTGCTGCTGC CTATGAAGCC TCTGAAGGCC 1800

GCTGCTACGA CGTCCCAACC TGTTCTCACT GTGGCCCAGA TAGAAACCAT CTTCTTCAAA 1860

GTGCCTGAGC TGTACGAGAT CCACAAGGAC TTCTACGACG CACTTTTGCC CCGCGTCCAG 1920

CAGTGGAGCC ACCACCAGCG AGTCGGGGAC CTCTTCCAGA AACTGGCTGG CCAGTTAGGA 1980

GTTTACCGGG CGTTCCTGGA CAACTACGAG CTGGCTGTAG AGACGGCAGA GAAGTGCTGC 2040

CAAGCCAATG CGCAGTTTTC TGAAATCTCA GAGAATCTAA AAGTGAGGAG TCCAAAGGAC 2100

TGTAAAGAGA CAGCCAAGAC CTCTTTAGAA GCTTTATTAT ACAAACCCGT GGACAGAGTG 2160

ACTCGCAGCA CATTGGTGTT ACATGACTTG CTCAAACACA CCCCGACCAG TCATCCAGAC 2220

CACCCCCTCC TGCTGGACGC CTTGAGGATC TCCCAGAACT TTCTGTCCAG CATCAACGAG 2280

GAGACGACCC CCAGGCGCCA GTCTATGACC GTCAAGAAGG GAGAGAACCG TCAGCTCCTG 2340

AAGGACAGCT TCATGGTGGA GCTAGTCGAA GGAGCCAGGA AGCTTCGGCA CGTCTTCCTC 2400

TTTACGGACT TGCTGCTCTG CGCCAAGCTG AAAAAACAGA TCGGAGGTAA AAACCAGCAA 2460

TACGACAGCA AGTGGTACAT CCCCCTGACT GAGCTGACCT TCCAGGGTCC CGAGGAGGCA 2520

GATCCTCTTA CAATCCCCCA AGTCCCCGAT GAAGAGTTGG ATGCCATTAA GGTCAAGATC 2580

TCCCATCTTC GGAGTGAGAT ACAGAAAGAG AAGGTAATAG ATTTTAATGT CCTTCCCAAT 2640

TCCAAACAAA GCTACAGCTT CCTTATTTCA TCTGACTATG AGCGTGCAGA GTGGAGGGAG 2700

GTCATCAAAG AGCAGCACAA GAAGTGTTTA AAAGCCACCT CCCTGACTTC CATGGAGCTG 2760

CAGATGCTGA CCAGCTCCTG TCTCAAACTG CAAACTGTAC ACCACATTCC ACTTAGCACA 2820

AACAAAGATG AGGATGAATC CTCCGGTCTC TATGGATTCC TGAATGTTAT CGTCCACTCT 2880

GCCTCCGGCC TCAAACAGAG CCTGAATCTC TACTGCACAT TGGAGGTGGA CTCTTTTGGT 2940

TTCTTCTCAA ACAAAGCCAA GACGAGAGTG TATCGATATA CCACCGAACC AAAGTGGAAT 3000

GAGGAGTTTG AGATCGAGCT GGAGGGCTCT CAGACCCTGA GGCTCCTCTG CTATGAGAAG 3060

TGTTACAACA AGACCAAGCA GAACAAAGAG GATGGAGACG GAACAGACCG CATCATGGGG 3120

AAAGGACAGA TCCCGCTGGA GCCTCAGAGT CTTCAAGGCA AAGATTGGCA GAGAACAGTC 3180

ATTCCTATGA ATGGGATTGA GGTGAAACTT TCCATGAAGT TCACCAGCAG AGAGTTCAGT 3240

CTAAAGCGGA CGCCTACAAG GAAGCCCATG GGCGTGTTTG GTGTAAAGAT CTCTTCCGTG 3300

ACCAAGCGAG AGCGCTCCAA GGTGCCATAC ATCGTTCGGC AGTGCTTAGA GGAGATAGAG 3360

CGGAGGGGAA TGGAGGAGGT GGGAATATAC CGCGTCTCAG GAGTGGCCAC TGACATCCAG 3420

GCTCTGAAGA CCGCCTTCGA CACCAATAAC AAAGATGTAT CAGTGATGAT GAGTGAGATG 3480

GACGTGAATG CCATTGCGGG GACCCTGAAG CTGTACTTCA GAGAGCTGCC CGAGCCCCTC 3540

TTCACCGATG AGCTCTATCC TAATTTCACA GGCGGAATCA CCCTCTCGGA CAGCGTTGCC 3600

AAGGAGAGCT GTATGTTAAA CTTGCTGCTG TCACTGCCAG AACCCAACCT CGTCACGTTC 3660

CTCTTCCTCC TGGATCACTT GAAAAGAGTG GCAGAAAAGG AAAGTGTCAA CAAGATGTCT 3720

CTCCACAACT TGGCGACGGT GTTTGGGCCG ACGTTGCTGA GGCCCTCAGA GAAGGACAGT 3780

AAGATCCCCA CTAACCCCAC GCAGCCCATC AGCATGGGCG ACAGCTGGTC CCAGGAGGTC 3840

ATGGCACAGG TCCAGGTGCT GCTGTACTTC CTCCAGCTGG AGACCATCCC CACCCCAGAC 3900

AGTAAACGAC AGAGCATCCT CTTCTCCACT GAAGTATAG 3939

Domain Profile

N/A

Domain Sequence
(FASTA)

N/A

Keyword

Complete proteome; GTPase activation; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005622	; C:intracellular
GO:0005096	; F:GTPase activator activity
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005089	; F:Rho guanyl-nucleotide exchange factor activity
GO:0035556	; P:intracellular signal transduction
GO:0043547	; P:positive regulation of GTPase activity
GO:0035023	; P:regulation of Rho protein signal transduction

KEGG

InterPros

IPR015123	; Bcr-Abl_oncoprot_oligo.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR018029	; C2_membr_targeting.
IPR000219	; DH-domain.
IPR001331	; GDS_CDC24_CS.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR008936	; Rho_GTPase_activation_prot.
IPR000198	; RhoGAP_dom.

Pfam

PF09036	; Bcr-Abl_Oligo; 1.
PF00168	; C2; 1.
PF00169	; PH; 1.
PF00620	; RhoGAP; 1.
PF00621	; RhoGEF; 1.

SMARTs

SM00239	; C2; 1.
SM00233	; PH; 1.
SM00324	; RhoGAP; 1.
SM00325	; RhoGEF; 1.

Prosites

PS50004	; C2; 1.
PS00741	; DH_1; 1.
PS50010	; DH_2; 1.
PS50003	; PH_DOMAIN; 1.
PS50238	; RHOGAP; 1.

Prints

Created Date

20-Feb-2013