EKS-ORL-00437

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00437

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Src	439.7	3.4E-132	274	523	250

Status

Unreviewed

Ensembl Protein

ENSORLP00000014041

UniProt Accession

H2M6E5;

Protein Name

Protein Synonyms/Alias

Gene Name

YES1 (1 of 2)

Gene Synonyms/Alias

YES1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000011192	ENSORLP00000014039	ENSORLT00000014040
ENSORLG00000011192	ENSORLP00000014041	ENSORLT00000014042

Organism

Oryzias latipes

Functional Description

Protein Length

540

Protein Sequence
(FASTA)

MGCIKSKENK GPVLKYQPES SPMSDSTAGA ATAHQNQAPA PSSGSGVVNF NHNLAPFGGS 60

SSTITPFGGA STSFSGPLSN SFSGAVSSGV TFFVALYDYE ARTSDDLTFK KGDRFQIINN 120

TEGDWWEARS ITTGKKGYIP SNYVAPADSI QAEEWYFGKM GRKDAERLLL NPGNDRGTFL 180

VRESETTKGA YSLSIRDWDS AKGDNVKHYK IRKLDNGGYY ITTRAQFDTL QKLVKHYTEH 240

ADGLCHRLTT VCPTVKPQTQ GLAKDAWEIS RESLQLELKL GQGCFGEVWM GTWNGTTKVA 300

IKTLKPGTMS PEAFLQEAQI MKKLRHDKLV PLFAVVSEEP IYIVTEYMSK GSLLDFLKEG 360

EGKFLNLVML VDMAAKIADG MAFIERMNYI HRDLRAANIL VGDNLVCKIA DFGLARLIED 420

NEYTARQGAK FPIKWTAPEA ALYGRFTIKS DVWSFGILLT ELVTKGRVPY PGMVNREVLE 480

QVERGYRMPC PQGCPESLHE MMKLCWKKEP DERPTFEYLQ SFLEDYFTST EPQYQPGENL 540

Nucleotide Sequence
(FASTA)

ATGGGCTGTA TAAAGAGCAA AGAGAACAAA GGCCCTGTGC TGAAGTACCA GCCTGAAAGC 60

TCCCCCATGT CCGACTCCAC TGCCGGAGCC GCCACAGCCC ACCAGAATCA AGCCCCTGCA 120

CCGTCATCCG GGTCTGGAGT TGTAAACTTT AACCACAACC TTGCACCGTT TGGCGGCTCC 180

TCGTCCACCA TTACTCCCTT TGGAGGAGCG TCAACCTCCT TCTCTGGTCC TTTGTCCAAC 240

TCCTTCTCCG GGGCCGTCTC AAGCGGGGTT ACCTTCTTCG TGGCCTTGTA TGACTACGAA 300

GCCAGGACAT CAGACGATCT AACGTTCAAA AAGGGAGATC GCTTCCAGAT TATCAACAAT 360

ACAGAAGGAG ACTGGTGGGA GGCTCGCTCC ATCACCACGG GAAAGAAAGG CTACATCCCC 420

AGCAATTATG TTGCCCCCGC CGACTCCATC CAGGCTGAAG AATGGTACTT TGGAAAAATG 480

GGGCGTAAAG ATGCAGAGAG GCTGCTGCTA AATCCAGGGA ATGATCGAGG AACGTTTCTG 540

GTGCGAGAAA GTGAAACGAC TAAAGGCGCT TATTCTCTCT CAATACGAGA CTGGGACTCG 600

GCCAAAGGCG ACAACGTGAA ACACTACAAG ATCCGAAAGC TGGACAACGG AGGATACTAC 660

ATCACCACAC GAGCGCAGTT TGACACATTA CAGAAGCTGG TCAAACACTA CACAGAGCAT 720

GCAGACGGAC TCTGCCACAG GCTGACCACA GTGTGCCCCA CAGTCAAGCC TCAGACTCAG 780

GGACTCGCTA AAGATGCTTG GGAGATTTCC AGGGAGTCCC TGCAGCTGGA GTTGAAACTG 840

GGACAGGGCT GCTTCGGAGA GGTCTGGATG GGCACATGGA ACGGCACCAC CAAGGTGGCC 900

ATAAAGACGC TAAAGCCTGG GACCATGTCA CCTGAGGCAT TTCTCCAGGA GGCTCAGATC 960

ATGAAGAAGC TGAGGCATGA CAAGCTGGTG CCTCTTTTTG CCGTGGTGTC CGAGGAGCCC 1020

ATTTACATCG TCACGGAGTA CATGTCCAAA GGAAGCCTGT TGGATTTTCT TAAAGAAGGT 1080

GAAGGCAAAT TCCTGAACCT GGTCATGCTG GTGGACATGG CTGCAAAGAT TGCTGACGGC 1140

ATGGCTTTCA TCGAGAGGAT GAACTACATC CACAGGGACC TGCGCGCAGC CAACATCCTA 1200

GTGGGGGACA ACCTGGTCTG CAAGATCGCA GATTTTGGAC TGGCTCGGTT GATAGAAGAC 1260

AACGAGTACA CGGCAAGACA AGGAGCTAAG TTCCCCATCA AGTGGACGGC TCCTGAGGCT 1320

GCATTGTACG GCCGCTTCAC CATCAAGTCC GACGTCTGGT CTTTTGGCAT CCTGCTCACT 1380

GAGCTGGTCA CCAAAGGCAG AGTCCCCTAC CCAGGTATGG TGAATCGGGA GGTGCTGGAG 1440

CAGGTGGAGC GTGGTTACCG CATGCCCTGC CCGCAGGGGT GCCCCGAGTC CCTGCACGAG 1500

ATGATGAAGC TCTGCTGGAA GAAAGAACCG GACGAGAGGC CCACCTTCGA GTACCTGCAG 1560

TCCTTTTTGG AGGACTACTT TACCTCCACA GAGCCACAGT ACCAGCCCGG AGAAAACCTA 1620

TAG 1623

Domain Profile

S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60

         l+l+ klG+G+fGevw+g+w+g++kva+ktlk+gt+speafl+eaqi+kklrh+klv l+

Q: 274   LQLELKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMSPEAFLQEAQIMKKLRHDKLVPLF  333

         57899*******************************************************

S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120

         avvse ePiyivte+m+kGslldflke egk l+l  lvd+aa++a+Gma++e++n+ihr

Q: 334   AVVSE-EPIYIVTEYMSKGSLLDFLKEGEGKFLNLVMLVDMAAKIADGMAFIERMNYIHR  392

         ****9.******************************************************

S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180

         dl+a+n+lvg++lv+k+adfGlarlied+eyta++gak+PikWtaPea+ +g+ftiksdv

Q: 393   DLRAANILVGDNLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDV  452

         ************************************************************

S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240

         WsfGillte+vtkG+vPypGm n+evleqvergyr+p+p+ cpe+l+e+++ cwkk+p+e

Q: 453   WSFGILLTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHEMMKLCWKKEPDE  512

         ************************************************************

S: 241   rPtfetlqevl  251

         rPtfe+lq++l

Q: 513   RPTFEYLQSFL  523

         ********986

Domain Sequence
(FASTA)

LQLELKLGQG CFGEVWMGTW NGTTKVAIKT LKPGTMSPEA FLQEAQIMKK LRHDKLVPLF 60

AVVSEEPIYI VTEYMSKGSL LDFLKEGEGK FLNLVMLVDM AAKIADGMAF IERMNYIHRD 120

LRAANILVGD NLVCKIADFG LARLIEDNEY TARQGAKFPI KWTAPEAALY GRFTIKSDVW 180

SFGILLTELV TKGRVPYPGM VNREVLEQVE RGYRMPCPQG CPESLHEMMK LCWKKEPDER 240

PTFEYLQSFL 250

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013