EKS-ORL-00179

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00179

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	364.2	5.3E-109	67	328	262

Status

Unreviewed

Ensembl Protein

ENSORLP00000015390

UniProt Accession

H2MA41;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1 (1 of 2)

Gene Synonyms/Alias

RPS6KB1 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000012295	ENSORLP00000015389	ENSORLT00000015390
ENSORLG00000012295	ENSORLP00000015390	ENSORLT00000015391

Organism

Oryzias latipes

Functional Description

Protein Length

427

Protein Sequence
(FASTA)

DMAGVFDIDL DQPDDNVSDD ELEDGAQLGE YMEQCSSFDF NMDDCEKFEL SENNVNKGTE 60

QIRPECFELL KVLGKGGYGK VFQVRKVSGA SSGKIYAMKV LKKAMIVRNA KDTAHTKAER 120

NILEEVKHPF IVDLIYAFQT GGKLYLILEY LSGGELFMQL EREGIFMEDT ACFYLAEISM 180

ALGHLHQKGI IYRDLKPENI MLNDSGHVKL TDFGLCKESI HDGTVTHTFC GTIEYMAPEI 240

LMRSGHNRAV DWWSLGALMY DMLTGAPPFT GENRKKTIDK ILKCKLSLPP YLTQEARDLL 300

KKLLKRSASS RLGGGPGDAA EVQVHPFFRH INWDDLLARK VEPPFKPFLQ SADDVSQFDS 360

KFTSQTPVDS PDDSTLSESA NQVFLGFTYV APSVLENVKE KFSFEPKLRS PRKFPGSPRT 420

LLRTGLS 427

Nucleotide Sequence
(FASTA)

GACATGGCCG GGGTTTTCGA CATCGACCTG GATCAACCGG ATGACAATGT CTCTGACGAC 60

GAACTTGAGG ATGGGGCTCA GCTCGGTGAA TACATGGAGC AGTGCAGCAG CTTTGACTTT 120

AACATGGATG ACTGCGAGAA GTTTGAACTG TCAGAAAACA ATGTGAACAA GGGAACAGAG 180

CAGATCCGGC CGGAATGCTT TGAGCTGCTG AAGGTTTTGG GAAAAGGCGG CTATGGAAAG 240

GTGTTTCAGG TTCGGAAGGT ATCAGGAGCC AGTTCCGGGA AGATATACGC CATGAAAGTT 300

TTGAAGAAGG CCATGATTGT GCGCAATGCA AAGGACACGG CGCACACCAA AGCAGAGAGA 360

AACATTCTGG AGGAGGTGAA GCATCCGTTC ATTGTGGATC TCATTTATGC CTTCCAGACT 420

GGTGGGAAGC TGTACCTCAT TCTGGAGTAC TTAAGCGGGG GGGAGCTTTT TATGCAGCTG 480

GAAAGAGAGG GCATCTTCAT GGAGGACACA GCATGTTTTT ATCTGGCTGA AATCTCAATG 540

GCTCTGGGTC ATCTGCACCA GAAAGGCATC ATCTACAGAG ACCTGAAGCC AGAGAACATC 600

ATGCTCAACG ACAGCGGACA CGTGAAGCTG ACAGACTTTG GTTTGTGCAA AGAGTCCATC 660

CATGATGGAA CAGTCACTCA CACCTTCTGT GGCACCATCG AGTACATGGC CCCAGAGATC 720

TTAATGAGGA GCGGACACAA CCGGGCCGTG GACTGGTGGA GCCTGGGAGC TCTCATGTAC 780

GACATGCTGA CAGGAGCTCC TCCATTCACA GGCGAAAACA GAAAGAAGAC GATTGACAAA 840

ATCCTAAAAT GCAAACTCAG CCTTCCACCT TACCTCACAC AAGAAGCCAG GGACCTCCTA 900

AAGAAGCTGC TGAAACGAAG TGCCTCATCA CGACTTGGAG GCGGACCAGG AGATGCTGCC 960

GAAGTTCAGG TCCACCCGTT CTTCCGGCAT ATAAACTGGG ACGACCTCCT CGCTCGCAAA 1020

GTAGAACCTC CCTTCAAACC GTTTCTCCAA TCAGCTGATG ATGTGAGCCA GTTTGACTCC 1080

AAGTTCACCA GCCAGACTCC AGTAGACAGT CCTGACGACT CCACACTCAG CGAAAGCGCT 1140

AATCAAGTCT TCCTGGGCTT CACATATGTC GCCCCATCTG TGCTGGAAAA TGTCAAAGAG 1200

AAGTTCTCCT TCGAGCCAAA GCTCCGTTCA CCGCGGAAGT TCCCTGGAAG CCCCAGAACC 1260

CTTTTGAGAA CTGGACTGAG T 1281

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fellkvlgkG+ygkvf+vrkv++ ++gk+ya+Kvlkka +v+  k++++tk+er+iLeev

Q: 67    FELLKVLGKGGYGKVFQVRKVSGASSGKIYAMKVLKKAMIVRnaKDTAHTKAERNILEEV  126

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 127   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  186

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 187   QKGIIYRDLKPENIMLNDSGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  245

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 246   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LSLPPY--LTQEARDLLK  301

         ****************************************..99****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLk+  ++Rlg    +a+e++ h+f+

Q: 302   KLLKRSASSRLGGgpgDAAEVQVHPFF  328

         ***********99999*********97

Domain Sequence
(FASTA)

FELLKVLGKG GYGKVFQVRK VSGASSGKIY AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QKGIIYRDLK PENIMLNDSG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL SLPPYLTQEA RDLLKKLLKR 240

SASSRLGGGP GDAAEVQVHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Drosophila melanogaster"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Sarcophilus harrisii"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013