EKS-ORL-00375

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-ORL-00375

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	350.7	5.9E-105	248	499	252

Status

Unreviewed

Ensembl Protein

ENSORLP00000015479

UniProt Accession

H2MAC7;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK2 (1 of 2)

Gene Synonyms/Alias

PAK2 (1 of 2);

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSORLG00000012363	ENSORLP00000015479	ENSORLT00000015480

Organism

Oryzias latipes

Functional Description

Protein Length

523

Protein Sequence
(FASTA)

MCDSGVCEDK PPAPPVRMSS QGGGVKDTQS ANHSSRPLPS EPEEKKSRNK IISIFAPEKG 60

GRKKDRDKDR PEISSPSDFE HTIHVGFDSV TGEFTGMPEQ WARLLQTSNI SKLEQKQNPQ 120

TVLTILKFYD STSGKQKYIG SGQRFGRLSA DKDSQLPGKQ STAASPSGKD VDDEDDGDDT 180

PPPIVAPRPP NTISVYTRSV INPIPPPDAD SNSQAADKQK KKGGKMTDEE IMDKLRTIVS 240

IGDPKKKYTR YEKIGQGASG TVYTAIDVST GQEVAIKQIN LQKQPKKELI INEILVMKEL 300

KNPNIVNFVD SFLVGDELFV VMEYLAGGSL TDVVTETCMD EAQIAAVCRE VLQALEFLHA 360

NQVIHRDIKS DNVLLGMDGS VKLTDFGFCA QITPEQSKRS TMVGTPYWMA PEVVTRKAYG 420

PKVDIWSLGI MAIEMVEGEP PYLNENPLRA LYLIATNGTP ELQNPEKLSP VFKSFLSRCL 480

EMDVEKRGSG KELLQHPFLK IAKPLSSLTP LILAAKEAMK SNR 523

Nucleotide Sequence
(FASTA)

ATGTGTGACA GCGGAGTGTG TGAGGACAAG CCCCCCGCCC CCCCTGTCAG GATGAGCAGT 60

CAAGGAGGAG GAGTCAAGGA CACCCAGTCA GCCAATCACA GCTCTCGGCC GCTTCCATCC 120

GAACCGGAGG AGAAGAAGTC CAGAAACAAG ATCATCTCCA TTTTTGCCCC AGAGAAAGGA 180

GGCAGGAAGA AGGACAGAGA CAAGGACAGA CCTGAGATCT CCTCCCCGTC AGACTTTGAA 240

CACACCATCC ATGTGGGCTT TGACTCTGTT ACAGGAGAAT TCACTGGAAT GCCAGAGCAA 300

TGGGCTCGGC TCCTTCAAAC CTCCAACATC AGTAAGTTGG AGCAGAAGCA AAACCCTCAG 360

ACTGTCCTCA CCATTCTCAA ATTCTACGAC TCCACCAGTG GAAAGCAGAA ATACATCGGT 420

TCAGGTCAGC GTTTTGGCCG TCTCTCTGCA GATAAAGATT CGCAGTTGCC GGGAAAACAG 480

AGTACTGCAG CCTCACCGTC TGGGAAAGAT GTTGATGATG AGGATGATGG AGATGACACA 540

CCTCCTCCAA TTGTGGCTCC AAGACCACCT AATACAATAT CTGTGTATAC TAGATCAGTT 600

ATCAACCCAA TCCCACCTCC AGATGCAGAC AGTAACTCTC AGGCAGCAGA TAAACAGAAG 660

AAAAAAGGGG GAAAGATGAC CGATGAGGAA ATCATGGACA AACTAAGAAC TATTGTCAGT 720

ATTGGGGATC CCAAGAAAAA ATACACCCGC TATGAGAAGA TCGGCCAAGG GGCTTCCGGC 780

ACAGTTTACA CAGCCATAGA TGTTTCCACT GGTCAAGAGG TGGCCATCAA ACAGATCAAC 840

CTGCAGAAGC AGCCAAAGAA GGAACTCATC ATCAACGAGA TCTTGGTCAT GAAAGAGCTC 900

AAGAATCCCA ATATTGTCAA CTTTGTTGAT AGCTTCCTGG TCGGTGACGA GCTGTTTGTG 960

GTGATGGAGT ACTTAGCTGG AGGCTCTCTG ACTGATGTTG TTACAGAGAC GTGCATGGAT 1020

GAGGCTCAAA TTGCTGCCGT CTGTAGAGAG GTCCTGCAGG CTCTGGAGTT TCTTCATGCC 1080

AACCAGGTCA TCCACAGAGA CATCAAGAGT GACAATGTAC TGCTAGGAAT GGATGGATCA 1140

GTCAAACTCA CGGACTTTGG CTTCTGTGCC CAGATCACCC CAGAGCAGAG CAAGCGCAGC 1200

ACCATGGTGG GGACTCCATA CTGGATGGCT CCAGAAGTAG TGACCAGAAA AGCCTACGGC 1260

CCCAAAGTGG ACATTTGGTC CCTGGGGATC ATGGCCATAG AGATGGTGGA GGGGGAGCCT 1320

CCATATCTGA ACGAGAATCC TCTCAGAGCT TTGTATTTAA TCGCCACCAA TGGAACTCCT 1380

GAGCTTCAGA ATCCAGAGAA GCTGTCCCCT GTTTTCAAAT CCTTCCTATC CCGCTGTTTG 1440

GAGATGGACG TGGAGAAGCG AGGCTCAGGA AAAGAACTGC TGCAGCATCC ATTCCTGAAG 1500

ATTGCAAAAC CTCTTTCCAG CCTGACTCCT CTCATCCTGG CAGCCAAAGA AGCGATGAAG 1560

AGCAACCGTT AA 1572

Domain Profile

S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60

         y+ +e+ig+Ga+g+vy+a +++tg+ vaik+inl+kq+k+e++++ei v+k+lk+pniv+

Q: 248   YTRYEKIGQGASGTVYTAIDVSTGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVN  307

         7889********************************************************

S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120

         +++sfl+ +el++vmeylagGsl+d+v+   ++ ++E qia+++revl+aLe+lH+++vi

Q: 308   FVDSFLVGDELFVVMEYLAGGSLTDVVT---ETCMDEAQIAAVCREVLQALEFLHANQVI  364

         ****************************...9****************************

S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180

         Hrdik++n+Ll ++g+VkL+dfg++aq++ +++kr+t+vgtpywmAPEv++  +k Y  k

Q: 365   HRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVT--RKAYGPK  422

         ***************************************************..9******

S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240

         +DiwslGI+aie++egepP+ +++pl+al++i++n +p+l++++k+s+ fk+f+++cl+

Q: 423   VDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPVFKSFLSRCLEM  482

         ************************************************************

S: 241   npekRpsasellkhkFl  257

         ++ekR s +ell+h+Fl

Q: 483   DVEKRGSGKELLQHPFL  499

         ****************7

Domain Sequence
(FASTA)

YTRYEKIGQG ASGTVYTAID VSTGQEVAIK QINLQKQPKK ELIINEILVM KELKNPNIVN 60

FVDSFLVGDE LFVVMEYLAG GSLTDVVTET CMDEAQIAAV CREVLQALEF LHANQVIHRD 120

IKSDNVLLGM DGSVKLTDFG FCAQITPEQS KRSTMVGTPY WMAPEVVTRK AYGPKVDIWS 180

LGIMAIEMVE GEPPYLNENP LRALYLIATN GTPELQNPEK LSPVFKSFLS RCLEMDVEKR 240

GSGKELLQHP FL 252

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gallus gallus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013